4IXVA

Crystal structure of human arginase-2 complexed with inhibitor 2d: {(5r)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-)
Total Genus 116
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
116
sequence length
306
structure length
306
Chain Sequence
HSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Arginase-2, mitochondrial
publication title Synthesis of quaternary alpha-amino acid-based arginase inhibitors via the Ugi reaction.
pubmed doi rcsb
source organism Homo sapiens
total genus 116
structure length 306
sequence length 306
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2013-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4ixvA00
3CEVA 2EIVA 2ZAVA 5RLAA 3LP7A 4MYKA 4RHIA 3THEA 1CEVA 1T4PA 2PHOA 3E8ZA 1HQGA 4Q40A 1P8PA 4Q3RA 1T5GA 2PLLA 4G3HA 4MYLA 3MJLA 3GMZA 4GSMA 1D3VA 1ZPGA 3F80A 3SL0A 5HJ9A 3E6VA 4IE3A 3THJA 4IXVA 3NIOA 1HQFA 4RHMA 3NIQA 1ZPEA 4IXUA 1PQ3A 1P8SA 3M1RA 4GWDA 1P8OA 3SKKA 4IU5A 1P8NA 3KV2A 4IE2A 1P8QA 3E6KA 1T4SA 2EF5A 4Q42A 4RHQA 1WOGA 1GQ6A 3DJ8A 4Q3TA 4HXQA 4RHLA 3THHA 3NIPA 4Q41A 1TBJA 3PZLA 1T4RA 4Q3UA 3MFVA 1TA1A 1WVBA 4IE1A 4GSVA 4RHKA 4I06A 1P8MA 1RLAA 3RLAA 4Q3QA 4HWWA 1HQHA 1TBHA 2EF4A 3TH7A 2AEBA 1GQ7A 2CEVA 4Q3RC 2A0MA 3SL1A 4IU4A 1HQXA 2RLAA 4MYFA 3TF3A 1T5FA 4GWCA 4MYNA 1WOHA 3GN0A 4RHJA 4DZ4A 5HJAA 1HQ5A 4CEVA 3MFWA 4RLAA 3E9BA 1R1OA 4Q3VA 1T4TA 1WVAA 4IU1A 1XFKA 3E8QA 4FCKA 1TBLA 1WOIA 3LHLA 4Q3PA 4Q3SA 4FCIA 1P8RA 4HZEA 4IU0A 3LP4A 4MXRA 3SJTA 4ITYA 2PHAA 5CEVA 3MMRA 4GSZA
chains in the Genus database with same CATH superfamily
3CEVA 4RN1A 2EIVA 5EFJD 4BZ5A 3Q9BA 2ZAVA 5RLAA 3EW8A 3LP7A 3Q9FA 4MYKA 5G0IA 4RHIA 5DC6A 3THEA 1CEVA 1T64A 1T4PA 5A2SA 5THSA 3F07A 2PHOA 3E8ZA 5FCWA 5G17A 1HQGA 4Q40A 5G0GA 5D1DA 1P8PA 5EFGA 4Q3RA 1T5GA 2PLLA 4QA5A 3MENA 4G3HA 4MYLA 3MJLA 4QA6A 4QA2A 4BZ7A 2GH6A 3GMZA 4GSMA 3F0RA 5EFNA 5G1BA 4BZ9A 3EZTA 1D3VA 4RN2A 1ZPGA 1ZZ0A 3F80A 4LXZA 4GSZA 3SL0A 2VQJA 5HJ9A 3E6VA 4IE3A 4QA3A 3THJA 4IXVA 3NIOA 5EEKA 4ZURA 1HQFA 5JI5A 4RHMA 3NIQA 1ZPEA 4IXUA 2VQQA 1PQ3A 1P8SA 5DC8A 5G1AA 4GWDA 5G3WA 1P8OA 3SKKA 5EENA 5THTA 3EWFA 1VKGA 5EFBD 4IU5A 1P8NA 3KV2A 4IE2A 5EFHA 5LI3A 1P8QA 3MZ3A 4ZUQA 3E6KA 1T4SA 2EF5A 2VQWG 4CQFA 4Q42A 4RHQA 1WOGA 3MZ7A 1GQ6A 1C3PA 3DJ8A 4Q3TA 4HXQA 4RHLA 3THHA 3NIPA 4Q41A 4ZUOA 1TBJA 3PZLA 1T4RA 4Q3UA 5EFKB 3C0ZA 5G0YA 3MFVA 3RQDA 5G1CA 3C0YA 1TA1A 1WVBA 3Q9CA 4IE1A 5G0XA 5G0JA 4GSVA 4RHKA 4I06A 1P8MA 1RLAA 5G12A 2VQMA 3EZPA 1T67A 3RLAA 4Q3QA 4A69A 4HWWA 1HQHA 1TBHA 5EEIA 2EF4A 2V5WA 3TH7A 2AEBA 1GQ7A 2CEVA 4Q3RC 2A0MA 3SL1A 4IU4A 5D1BA 1HQXA 2RLAA 2VQVA 3F06A 4MYFA 5D1CA 1C3SA 4BKXB 3TF3A 1T5FA 5EF7A 4GWCA 5G0HA 4MYNA 5THVA 1WOHA 1ZZ1A 3C10A 3MZ4A 5DC5A 5IX0A 4BZ6A 3GN0A 5EEMA 4RHJA 4CBYA 3MAXA 5EF8A 5EEFA 4DZ4A 5THUA 1ZZ3A 5HJAA 1HQ5A 4CEVA 5G10A 3MFWA 4RLAA 3SFFA 3E9BA 1R1OA 4Q3VA 3SFHA 3ZNSA 2V5XA 5BWZA 5FUEA 1T4TA 1WVAA 4IU1A 1W22A 1XFKA 3E8QA 4FCKA 5G11A 4CBTA 1TBLA 1WOIA 3LHLA 4Q3PA 2VQOA 5G13A 4Q3SA 4FCIA 1P8RA 4RN0A 3MZ6A 1C3RA 4HZEA 2VCGA 4IU0A 4QA1A 4ZUNA 4QA4A 4QA0A 3LP4A 4MXRA 4QA7A 3ZNRA 4BZ8A 1T69A 5ICNB 3SJTA 5IWGA 4ITYA 4ZUMA 4ZUPA 4LY1A 2PHAA 5CEVA 3Q9EA 3MMRA 3M1RA 5DC7A
chains in the Genus database with same CATH topology
3CEVA 2EIVA 2ZAVA 5RLAA 3LP7A 4MYKA 4RHIA 3THEA 1CEVA 1T4PA 2PHOA 3E8ZA 1HQGA 4Q40A 1P8PA 4Q3RA 1T5GA 2PLLA 4G3HA 4MYLA 3MJLA 3GMZA 4GSMA 1D3VA 1ZPGA 3F80A 3SL0A 5HJ9A 3E6VA 4IE3A 3THJA 4IXVA 3NIOA 1HQFA 4RHMA 3NIQA 1ZPEA 4IXUA 1PQ3A 1P8SA 3M1RA 4GWDA 1P8OA 3SKKA 4IU5A 1P8NA 3KV2A 4IE2A 1P8QA 3E6KA 1T4SA 2EF5A 4Q42A 4RHQA 1WOGA 1GQ6A 3DJ8A 4Q3TA 4HXQA 4RHLA 3THHA 3NIPA 4Q41A 1TBJA 3PZLA 1T4RA 4Q3UA 3MFVA 1TA1A 1WVBA 4IE1A 4GSVA 4RHKA 4I06A 1P8MA 1RLAA 3RLAA 4Q3QA 4HWWA 1HQHA 1TBHA 2EF4A 3TH7A 2AEBA 1GQ7A 2CEVA 4Q3RC 2A0MA 3SL1A 4IU4A 1HQXA 2RLAA 4MYFA 3TF3A 1T5FA 4GWCA 4MYNA 1WOHA 3GN0A 4RHJA 4DZ4A 5HJAA 1HQ5A 4CEVA 3MFWA 4RLAA 3E9BA 1R1OA 4Q3VA 1T4TA 1WVAA 4IU1A 1XFKA 3E8QA 4FCKA 1TBLA 1WOIA 3LHLA 4Q3PA 4Q3SA 4FCIA 1P8RA 4HZEA 4IU0A 3LP4A 4MXRA 3SJTA 4ITYA 2PHAA 5CEVA 3MMRA 4GSZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CEV A;  2EIV A;  2ZAV A;  5RLA A;  3LP7 A;  4MYK A;  4RHI A;  3THE A;  1CEV A;  1T4P A;  2PHO A;  3E8Z A;  1HQG A;  4Q40 A;  1P8P A;  4Q3R A;  1T5G A;  2PLL A;  4G3H A;  4MYL A;  3MJL A;  3GMZ A;  4GSM A;  1D3V A;  1ZPG A;  3F80 A;  3SL0 A;  5HJ9 A;  3E6V A;  4IE3 A;  3THJ A;  4IXV A;  3NIO A;  1HQF A;  4RHM A;  3NIQ A;  1ZPE A;  4IXU A;  1PQ3 A;  1P8S A;  3M1R A;  4GWD A;  1P8O A;  3SKK A;  4IU5 A;  1P8N A;  3KV2 A;  4IE2 A;  1P8Q A;  3E6K A;  1T4S A;  2EF5 A;  4Q42 A;  4RHQ A;  1WOG A;  1GQ6 A;  3DJ8 A;  4Q3T A;  4HXQ A;  4RHL A;  3THH A;  3NIP A;  4Q41 A;  1TBJ A;  3PZL A;  1T4R A;  4Q3U A;  3MFV A;  1TA1 A;  1WVB A;  4IE1 A;  4GSV A;  4RHK A;  4I06 A;  1P8M A;  1RLA A;  3RLA A;  4Q3Q A;  4HWW A;  1HQH A;  1TBH A;  2EF4 A;  3TH7 A;  2AEB A;  1GQ7 A;  2CEV A;  4Q3R C;  2A0M A;  3SL1 A;  4IU4 A;  1HQX A;  2RLA A;  4MYF A;  3TF3 A;  1T5F A;  4GWC A;  4MYN A;  1WOH A;  3GN0 A;  4RHJ A;  4DZ4 A;  5HJA A;  1HQ5 A;  4CEV A;  3MFW A;  4RLA A;  3E9B A;  1R1O A;  4Q3V A;  1T4T A;  1WVA A;  4IU1 A;  1XFK A;  3E8Q A;  4FCK A;  1TBL A;  1WOI A;  3LHL A;  4Q3P A;  4Q3S A;  4FCI A;  1P8R A;  4HZE A;  4IU0 A;  3LP4 A;  4MXR A;  3SJT A;  4ITY A;  2PHA A;  5CEV A;  3MMR A;  4GSZ A; 
#chains in the Genus database with same CATH topology
 3CEV A;  4RN1 A;  2EIV A;  5EFJ D;  4BZ5 A;  3Q9B A;  2ZAV A;  5RLA A;  3EW8 A;  3LP7 A;  3Q9F A;  4MYK A;  5G0I A;  4RHI A;  5DC6 A;  3THE A;  1CEV A;  1T64 A;  1T4P A;  5A2S A;  5THS A;  3F07 A;  2PHO A;  3E8Z A;  5FCW A;  5G17 A;  1HQG A;  4Q40 A;  5G0G A;  5D1D A;  1P8P A;  5EFG A;  4Q3R A;  1T5G A;  2PLL A;  4QA5 A;  3MEN A;  4G3H A;  4MYL A;  3MJL A;  4QA6 A;  4QA2 A;  4BZ7 A;  2GH6 A;  3GMZ A;  4GSM A;  3F0R A;  5EFN A;  5G1B A;  4BZ9 A;  3EZT A;  1D3V A;  4RN2 A;  1ZPG A;  1ZZ0 A;  3F80 A;  4LXZ A;  4GSZ A;  3SL0 A;  2VQJ A;  5HJ9 A;  3E6V A;  4IE3 A;  4QA3 A;  3THJ A;  4IXV A;  3NIO A;  5EEK A;  4ZUR A;  1HQF A;  5JI5 A;  4RHM A;  3NIQ A;  1ZPE A;  4IXU A;  2VQQ A;  1PQ3 A;  1P8S A;  5DC8 A;  5G1A A;  4GWD A;  5G3W A;  1P8O A;  3SKK A;  5EEN A;  5THT A;  3EWF A;  1VKG A;  5EFB D;  4IU5 A;  1P8N A;  3KV2 A;  4IE2 A;  5EFH A;  5LI3 A;  1P8Q A;  3MZ3 A;  4ZUQ A;  3E6K A;  1T4S A;  2EF5 A;  2VQW G;  4CQF A;  4Q42 A;  4RHQ A;  1WOG A;  3MZ7 A;  1GQ6 A;  1C3P A;  3DJ8 A;  4Q3T A;  4HXQ A;  4RHL A;  3THH A;  3NIP A;  4Q41 A;  4ZUO A;  1TBJ A;  3PZL A;  1T4R A;  4Q3U A;  5EFK B;  3C0Z A;  5G0Y A;  3MFV A;  3RQD A;  5G1C A;  3C0Y A;  1TA1 A;  1WVB A;  3Q9C A;  4IE1 A;  5G0X A;  5G0J A;  4GSV A;  4RHK A;  4I06 A;  1P8M A;  1RLA A;  5G12 A;  2VQM A;  3EZP A;  1T67 A;  3RLA A;  4Q3Q A;  4A69 A;  4HWW A;  1HQH A;  1TBH A;  5EEI A;  2EF4 A;  2V5W A;  3TH7 A;  2AEB A;  1GQ7 A;  2CEV A;  4Q3R C;  2A0M A;  3SL1 A;  4IU4 A;  5D1B A;  1HQX A;  2RLA A;  2VQV A;  3F06 A;  4MYF A;  5D1C A;  1C3S A;  4BKX B;  3TF3 A;  1T5F A;  5EF7 A;  4GWC A;  5G0H A;  4MYN A;  5THV A;  1WOH A;  1ZZ1 A;  3C10 A;  3MZ4 A;  5DC5 A;  5IX0 A;  4BZ6 A;  3GN0 A;  5EEM A;  4RHJ A;  4CBY A;  3MAX A;  5EF8 A;  5EEF A;  4DZ4 A;  5THU A;  1ZZ3 A;  5HJA A;  1HQ5 A;  4CEV A;  5G10 A;  3MFW A;  4RLA A;  3SFF A;  3E9B A;  1R1O A;  4Q3V A;  3SFH A;  3ZNS A;  2V5X A;  5BWZ A;  5FUE A;  1T4T A;  1WVA A;  4IU1 A;  1W22 A;  1XFK A;  3E8Q A;  4FCK A;  5G11 A;  4CBT A;  1TBL A;  1WOI A;  3LHL A;  4Q3P A;  2VQO A;  5G13 A;  4Q3S A;  4FCI A;  1P8R A;  4RN0 A;  3MZ6 A;  1C3R A;  4HZE A;  2VCG A;  4IU0 A;  4QA1 A;  4ZUN A;  4QA4 A;  4QA0 A;  3LP4 A;  4MXR A;  4QA7 A;  3ZNR A;  4BZ8 A;  1T69 A;  5ICN B;  3SJT A;  5IWG A;  4ITY A;  4ZUM A;  4ZUP A;  4LY1 A;  2PHA A;  5CEV A;  3Q9E A;  3MMR A;  3M1R A;  5DC7 A; 
#chains in the Genus database with same CATH homology
 3CEV A;  2EIV A;  2ZAV A;  5RLA A;  3LP7 A;  4MYK A;  4RHI A;  3THE A;  1CEV A;  1T4P A;  2PHO A;  3E8Z A;  1HQG A;  4Q40 A;  1P8P A;  4Q3R A;  1T5G A;  2PLL A;  4G3H A;  4MYL A;  3MJL A;  3GMZ A;  4GSM A;  1D3V A;  1ZPG A;  3F80 A;  3SL0 A;  5HJ9 A;  3E6V A;  4IE3 A;  3THJ A;  4IXV A;  3NIO A;  1HQF A;  4RHM A;  3NIQ A;  1ZPE A;  4IXU A;  1PQ3 A;  1P8S A;  3M1R A;  4GWD A;  1P8O A;  3SKK A;  4IU5 A;  1P8N A;  3KV2 A;  4IE2 A;  1P8Q A;  3E6K A;  1T4S A;  2EF5 A;  4Q42 A;  4RHQ A;  1WOG A;  1GQ6 A;  3DJ8 A;  4Q3T A;  4HXQ A;  4RHL A;  3THH A;  3NIP A;  4Q41 A;  1TBJ A;  3PZL A;  1T4R A;  4Q3U A;  3MFV A;  1TA1 A;  1WVB A;  4IE1 A;  4GSV A;  4RHK A;  4I06 A;  1P8M A;  1RLA A;  3RLA A;  4Q3Q A;  4HWW A;  1HQH A;  1TBH A;  2EF4 A;  3TH7 A;  2AEB A;  1GQ7 A;  2CEV A;  4Q3R C;  2A0M A;  3SL1 A;  4IU4 A;  1HQX A;  2RLA A;  4MYF A;  3TF3 A;  1T5F A;  4GWC A;  4MYN A;  1WOH A;  3GN0 A;  4RHJ A;  4DZ4 A;  5HJA A;  1HQ5 A;  4CEV A;  3MFW A;  4RLA A;  3E9B A;  1R1O A;  4Q3V A;  1T4T A;  1WVA A;  4IU1 A;  1XFK A;  3E8Q A;  4FCK A;  1TBL A;  1WOI A;  3LHL A;  4Q3P A;  4Q3S A;  4FCI A;  1P8R A;  4HZE A;  4IU0 A;  3LP4 A;  4MXR A;  3SJT A;  4ITY A;  2PHA A;  5CEV A;  3MMR A;  4GSZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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