4N1KA

Crystal structures of nlrp14 pyrin domain reveal a conformational switch mechanism, regulating its molecular interactions
Total Genus 30
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
30
sequence length
88
structure length
88
Chain Sequence
SSSFFPDFGLLLYLEELNKEELNTFKLFLKETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAWSVSLKIFGKMNLKVLCERAKE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
molecule keywords NACHT, LRR and PYD domains-containing protein 14
publication title Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions.
pubmed doi rcsb
source organism Homo sapiens
total genus 30
structure length 88
sequence length 88
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2013-10-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02758 PYRIN PAAD/DAPIN/Pyrin domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 4n1kA00
2YVIA 2LWEA 4DWNA 2N1FA 4N1LA 1YGOA 4FH0A 4IZ5E 1DGNA 1WH4A 1WMGA 3J63A 2BBRA 1WXPA 2M5VA 1E3YA 2L6AA 2A5YB 4RHWA 2N83A 2B1WA 1A1ZA 1ICHA 2GF5A 4O9FA 2VGQA 2MS8A 2BBZA 2OF5A 2F1SA 1UCPA 2N7ZA 2NSNA 3MOPK 4A2QA 1FADA 4O9LA 4N1JA 3J6JA 2L9MA 2A9IA 2OF5H 2LS7A 4M9SA 2NAQA 3YGSC 4I16A 2IB1A 3YGSP 2N00A 1C15A 1Z6TA 3LQQA 2NZ7A 4JQWA 2G7RA 1DDFA 1NGRA 2HM2Q 1PN5A 4LWDA 4ZBWA 4IZ7B 4E9MA 2DBDA 4O7QA 3MOPA 2LWDA 4N1KA 4P4HI 3T6PA 2KN6A 4NQKA 2D96A 4A2WA 3QF2A 2YGSA 3LQRA 4RHWE 4UZ0A 1E41A 2YQFA 4O6XA 3CRDA 2YU0A 4P4HA 4D8OA 4JUPA 4EWIA 2MB9A 4F42A 2MS7A 1N3KA 3EZQA 1CWWA 4IZAB 4M9XA 2O71A 1A1WA 3EZQB 2DBGA 2DBHA 2N97A 4F44A 4QOBA 2DBFA 2MPCA 2MN4A 2N80A 4M9ZA 2P1HA 1D2ZA 1CY5A 3CL3A 2KM6A 3KATA 1D2ZB 3MOPG 2DO9A
chains in the Genus database with same CATH superfamily
2YVIA 2LWEA 4DWNA 2N1FA 4N1LA 1YGOA 4FH0A 4IZ5E 1DGNA 1WH4A 1WMGA 3J63A 2BBRA 1WXPA 2M5VA 1E3YA 2L6AA 2XV9A 2A5YB 4RHWA 2N83A 2B1WA 1A1ZA 2MJMA 1ICHA 2GF5A 4O9FA 2VGQA 2MS8A 2BBZA 2OF5A 2F1SA 1UCPA 2N7ZA 2NSNA 3MOPK 4A2QA 1FADA 4O9LA 4N1JA 3J6JA 2L9MA 2A9IA 2OF5H 2LS7A 4M9SA 2NAQA 3YGSC 4I16A 2IB1A 3YGSP 2N00A 1C15A 1Z6TA 3LQQA 2NZ7A 4JQWA 2G7RA 1DDFA 1NGRA 2HM2Q 1PN5A 4LWDA 4ZBWA 4IZ7B 4E9MA 2DBDA 4O7QA 3MOPA 2LWDA 4N1KA 4P4HI 3T6PA 2KN6A 4NQKA 2D96A 4A2WA 3QF2A 2YGSA 3LQRA 4RHWE 4UZ0A 1E41A 2YQFA 4O6XA 3CRDA 2YU0A 4P4HA 4D8OA 4JUPA 4EWIA 2MB9A 4F42A 2MS7A 1N3KA 3EZQA 1CWWA 4IZAB 4M9XA 2O71A 1A1WA 3EZQB 2DBGA 2DBHA 2N97A 4F44A 4QOBA 2DBFA 2MPCA 2MN4A 2N80A 4M9ZA 2P1HA 1D2ZA 1CY5A 3CL3A 2KM6A 3KATA 1D2ZB 3MOPG 2DO9A
chains in the Genus database with same CATH topology
2YVIA 2LWEA 4DWNA 2N1FA 4N1LA 1YGOA 4FH0A 4IZ5E 1DGNA 1WH4A 1WMGA 3J63A 2BBRA 1WXPA 2M5VA 1E3YA 2L6AA 2XV9A 2A5YB 4RHWA 2N83A 2B1WA 1A1ZA 2MJMA 1ICHA 2GF5A 4O9FA 2VGQA 2MS8A 2BBZA 2OF5A 2F1SA 1UCPA 2N7ZA 2NSNA 3MOPK 4A2QA 1FADA 4O9LA 4N1JA 3J6JA 2L9MA 2A9IA 2OF5H 2LS7A 4M9SA 2NAQA 3YGSC 4I16A 2IB1A 3YGSP 2N00A 1C15A 1Z6TA 3LQQA 2NZ7A 4JQWA 2G7RA 1DDFA 1NGRA 2HM2Q 1PN5A 4LWDA 4ZBWA 4IZ7B 4E9MA 2DBDA 4O7QA 3MOPA 2LWDA 4N1KA 4P4HI 3T6PA 2KN6A 4NQKA 2D96A 4A2WA 3QF2A 2YGSA 3LQRA 4RHWE 4UZ0A 1E41A 2YQFA 4O6XA 3CRDA 2YU0A 4P4HA 4D8OA 4JUPA 4EWIA 2MB9A 4F42A 2MS7A 1N3KA 3EZQA 1CWWA 4IZAB 4M9XA 2O71A 1A1WA 3EZQB 2DBGA 2DBHA 2N97A 4F44A 4QOBA 2DBFA 2MPCA 2MN4A 2N80A 4M9ZA 2P1HA 1D2ZA 1CY5A 3CL3A 2KM6A 3KATA 1D2ZB 3MOPG 2DO9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2YVI A;  2LWE A;  4DWN A;  2N1F A;  4N1L A;  1YGO A;  4FH0 A;  4IZ5 E;  1DGN A;  1WH4 A;  1WMG A;  3J63 A;  2BBR A;  1WXP A;  2M5V A;  1E3Y A;  2L6A A;  2A5Y B;  4RHW A;  2N83 A;  2B1W A;  1A1Z A;  1ICH A;  2GF5 A;  4O9F A;  2VGQ A;  2MS8 A;  2BBZ A;  2OF5 A;  2F1S A;  1UCP A;  2N7Z A;  2NSN A;  3MOP K;  4A2Q A;  1FAD A;  4O9L A;  4N1J A;  3J6J A;  2L9M A;  2A9I A;  2OF5 H;  2LS7 A;  4M9S A;  2NAQ A;  3YGS C;  4I16 A;  2IB1 A;  3YGS P;  2N00 A;  1C15 A;  1Z6T A;  3LQQ A;  2NZ7 A;  4JQW A;  2G7R A;  1DDF A;  1NGR A;  2HM2 Q;  1PN5 A;  4LWD A;  4ZBW A;  4IZ7 B;  4E9M A;  2DBD A;  4O7Q A;  3MOP A;  2LWD A;  4N1K A;  4P4H I;  3T6P A;  2KN6 A;  4NQK A;  2D96 A;  4A2W A;  3QF2 A;  2YGS A;  3LQR A;  4RHW E;  4UZ0 A;  1E41 A;  2YQF A;  4O6X A;  3CRD A;  2YU0 A;  4P4H A;  4D8O A;  4JUP A;  4EWI A;  2MB9 A;  4F42 A;  2MS7 A;  1N3K A;  3EZQ A;  1CWW A;  4IZA B;  4M9X A;  2O71 A;  1A1W A;  3EZQ B;  2DBG A;  2DBH A;  2N97 A;  4F44 A;  4QOB A;  2DBF A;  2MPC A;  2MN4 A;  2N80 A;  4M9Z A;  2P1H A;  1D2Z A;  1CY5 A;  3CL3 A;  2KM6 A;  3KAT A;  1D2Z B;  3MOP G;  2DO9 A; 
#chains in the Genus database with same CATH topology
 2YVI A;  2LWE A;  4DWN A;  2N1F A;  4N1L A;  1YGO A;  4FH0 A;  4IZ5 E;  1DGN A;  1WH4 A;  1WMG A;  3J63 A;  2BBR A;  1WXP A;  2M5V A;  1E3Y A;  2L6A A;  2XV9 A;  2A5Y B;  4RHW A;  2N83 A;  2B1W A;  1A1Z A;  2MJM A;  1ICH A;  2GF5 A;  4O9F A;  2VGQ A;  2MS8 A;  2BBZ A;  2OF5 A;  2F1S A;  1UCP A;  2N7Z A;  2NSN A;  3MOP K;  4A2Q A;  1FAD A;  4O9L A;  4N1J A;  3J6J A;  2L9M A;  2A9I A;  2OF5 H;  2LS7 A;  4M9S A;  2NAQ A;  3YGS C;  4I16 A;  2IB1 A;  3YGS P;  2N00 A;  1C15 A;  1Z6T A;  3LQQ A;  2NZ7 A;  4JQW A;  2G7R A;  1DDF A;  1NGR A;  2HM2 Q;  1PN5 A;  4LWD A;  4ZBW A;  4IZ7 B;  4E9M A;  2DBD A;  4O7Q A;  3MOP A;  2LWD A;  4N1K A;  4P4H I;  3T6P A;  2KN6 A;  4NQK A;  2D96 A;  4A2W A;  3QF2 A;  2YGS A;  3LQR A;  4RHW E;  4UZ0 A;  1E41 A;  2YQF A;  4O6X A;  3CRD A;  2YU0 A;  4P4H A;  4D8O A;  4JUP A;  4EWI A;  2MB9 A;  4F42 A;  2MS7 A;  1N3K A;  3EZQ A;  1CWW A;  4IZA B;  4M9X A;  2O71 A;  1A1W A;  3EZQ B;  2DBG A;  2DBH A;  2N97 A;  4F44 A;  4QOB A;  2DBF A;  2MPC A;  2MN4 A;  2N80 A;  4M9Z A;  2P1H A;  1D2Z A;  1CY5 A;  3CL3 A;  2KM6 A;  3KAT A;  1D2Z B;  3MOP G;  2DO9 A; 
#chains in the Genus database with same CATH homology
 2YVI A;  2LWE A;  4DWN A;  2N1F A;  4N1L A;  1YGO A;  4FH0 A;  4IZ5 E;  1DGN A;  1WH4 A;  1WMG A;  3J63 A;  2BBR A;  1WXP A;  2M5V A;  1E3Y A;  2L6A A;  2XV9 A;  2A5Y B;  4RHW A;  2N83 A;  2B1W A;  1A1Z A;  2MJM A;  1ICH A;  2GF5 A;  4O9F A;  2VGQ A;  2MS8 A;  2BBZ A;  2OF5 A;  2F1S A;  1UCP A;  2N7Z A;  2NSN A;  3MOP K;  4A2Q A;  1FAD A;  4O9L A;  4N1J A;  3J6J A;  2L9M A;  2A9I A;  2OF5 H;  2LS7 A;  4M9S A;  2NAQ A;  3YGS C;  4I16 A;  2IB1 A;  3YGS P;  2N00 A;  1C15 A;  1Z6T A;  3LQQ A;  2NZ7 A;  4JQW A;  2G7R A;  1DDF A;  1NGR A;  2HM2 Q;  1PN5 A;  4LWD A;  4ZBW A;  4IZ7 B;  4E9M A;  2DBD A;  4O7Q A;  3MOP A;  2LWD A;  4N1K A;  4P4H I;  3T6P A;  2KN6 A;  4NQK A;  2D96 A;  4A2W A;  3QF2 A;  2YGS A;  3LQR A;  4RHW E;  4UZ0 A;  1E41 A;  2YQF A;  4O6X A;  3CRD A;  2YU0 A;  4P4H A;  4D8O A;  4JUP A;  4EWI A;  2MB9 A;  4F42 A;  2MS7 A;  1N3K A;  3EZQ A;  1CWW A;  4IZA B;  4M9X A;  2O71 A;  1A1W A;  3EZQ B;  2DBG A;  2DBH A;  2N97 A;  4F44 A;  4QOB A;  2DBF A;  2MPC A;  2MN4 A;  2N80 A;  4M9Z A;  2P1H A;  1D2Z A;  1CY5 A;  3CL3 A;  2KM6 A;  3KAT A;  1D2Z B;  3MOP G;  2DO9 A; 
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similar chains in the Genus database (?% sequence similarity)
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