4QA7A

Crystal structure of h334r/y306f hdac8 in complex with a tetrapeptide substrate
Total Genus 129
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
129
sequence length
365
structure length
365
Chain Sequence
SLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGFNLANTARCWTYLTGVILGKTLSSEIPDREFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Histone deacetylase 8
publication title Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
pubmed doi rcsb
source organism Homo sapiens
total genus 129
structure length 365
sequence length 365
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2014-05-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 4qa7A00
4ZURA 5G13A 1C3RA 5DC5A 5G12A 5IWGA 4BZ8A 5THVA 2VQWG 3MZ6A 5ICNB 3Q9CA 3ZNSA 4QA3A 5LI3A 5DC7A 4QA1A 2VQVA 3MZ4A 5EEKA 3Q9BA 1C3PA 2V5WA 5G0IA 5EFBD 1ZZ0A 3F07A 5BWZA 5EF8A 4QA2A 5IX0A 5JI5A 4LXZA 5G1CA 4QA7A 5G17A 1T64A 2V5XA 5EFJD 5DC8A 1W22A 5G11A 2GH6A 4QA6A 3Q9FA 4RN0A 5G10A 5G0JA 4CBYA 4BZ9A 2VQQA 3Q9EA 1C3SA 5G0XA 3MAXA 2VQOA 4ZUOA 2VQJA 3EZPA 3MZ7A 5EEFA 3C0YA 1ZZ1A 5G0HA 5EFHA 4ZUQA 3ZNRA 4BZ7A 4QA5A 5D1DA 3MZ3A 4BZ6A 1T69A 3EZTA 4RN2A 4ZUPA 5THUA 5D1CA 3F0RA 3C0ZA 3SFFA 5A2SA 3MENA 5D1BA 5G3WA 5EFKB 5G1BA 1T67A 4BZ5A 5DC6A 4A69A 4RN1A 1ZZ3A 5EEIA 5G0YA 4LY1A 1VKGA 5THSA 4QA0A 5EENA 4CQFA 5EFNA 2VQMA 5EEMA 4CBTA 5EF7A 5G0GA 3F06A 3EWFA 5FUEA 5G1AA 3EW8A 4QA4A 5EFGA 4ZUMA 3C10A 5THTA 5FCWA 2VCGA 3SFHA 4ZUNA 3RQDA 4BKXB
chains in the Genus database with same CATH superfamily
4CEVA 2RLAA 4ZURA 1HQGA 5G13A 4GSVA 4IU0A 3SKKA 1C3RA 5DC5A 5G12A 5IWGA 4BZ8A 5THVA 2VQWG 3MZ6A 4IXUA 1TBLA 3Q9CA 3ZNSA 5ICNB 4IE2A 5RLAA 1HQHA 4QA3A 5LI3A 1WOGA 4IU5A 5DC7A 4QA1A 1T4PA 2VQVA 3MZ4A 5EEKA 3Q9BA 4Q3VA 1C3PA 4RHJA 2PLLA 2V5WA 5G0IA 5EFBD 1T5FA 4MYNA 1ZZ0A 3F07A 5BWZA 5EF8A 4Q40A 4QA2A 1T4TA 4Q3RA 1PQ3A 5IX0A 5JI5A 4I06A 2EF4A 1TBHA 4LXZA 3KV2A 5G1CA 4QA7A 4FCKA 5G17A 1T64A 2V5XA 5EFJD 1T4SA 1P8PA 4MYKA 1P8QA 1W22A 5DC8A 4GSZA 4RHIA 5G11A 3E8ZA 2GH6A 1GQ7A 1HQXA 3CEVA 4Q3SA 4Q3QA 4QA6A 3Q9FA 4RN0A 1CEVA 5G10A 3RQDA 1HQFA 5G0JA 4GWDA 3F80A 4MYLA 4BZ9A 4CBYA 4G3HA 4GWCA 4HXQA 4IXVA 2VQQA 4Q3RC 1P8SA 3Q9EA 4MYFA 1C3SA 1TA1A 3MFWA 5G0XA 3PZLA 3MAXA 1WVBA 2VQOA 4ZUOA 3E8QA 4RHMA 2VQJA 3EZPA 3MFVA 3MZ7A 3SL1A 3THJA 5EEFA 4GSMA 1R1OA 4RHKA 2ZAVA 4RHQA 3MMRA 4RLAA 3C0YA 1RLAA 1ZZ1A 5G0HA 1ZPGA 5EFHA 5HJ9A 3M1RA 4ZUQA 4Q3TA 3LP4A 4Q42A 3SJTA 3THEA 3ZNRA 4BZ7A 4QA5A 5D1DA 3MZ3A 1ZPEA 4ITYA 1T4RA 4Q3UA 1T69A 4BZ6A 3GN0A 3GMZA 1WOHA 3EZTA 4RN2A 2EF5A 4IE1A 2PHAA 3TF3A 3DJ8A 3THHA 4ZUPA 5THUA 3TH7A 5HJAA 5D1CA 1P8RA 1TBJA 3RLAA 4MXRA 3F0RA 3C0ZA 1T5GA 3SFFA 5A2SA 3MENA 5D1BA 5G3WA 5EFKB 5G1BA 1T67A 3MJLA 4RHLA 4BZ5A 5DC6A 4A69A 3NIPA 3SL0A 4HWWA 5CEVA 4RN1A 1ZZ3A 1P8OA 5EEIA 5G0YA 4LY1A 1VKGA 4Q41A 5THSA 3E6VA 1WVAA 1D3VA 4DZ4A 3LHLA 3NIOA 4QA0A 2AEBA 5EENA 4HZEA 1P8NA 4CQFA 1GQ6A 1XFKA 1WOIA 2VQMA 4IU4A 5EFNA 3E9BA 5EEMA 5EF7A 4CBTA 5G0GA 2EIVA 3F06A 3EWFA 4Q3PA 5FUEA 1P8MA 5G1AA 3NIQA 3EW8A 4QA4A 5EFGA 4ZUMA 2CEVA 3C10A 3LP7A 4FCIA 5THTA 4IE3A 4IU1A 1HQ5A 5FCWA 2VCGA 3SFHA 4ZUNA 2PHOA 2A0MA 4BKXB 3E6KA
chains in the Genus database with same CATH topology
4ZURA 5G13A 1C3RA 5DC5A 5G12A 5IWGA 4BZ8A 5THVA 2VQWG 3MZ6A 5ICNB 3Q9CA 3ZNSA 4QA3A 5LI3A 5DC7A 4QA1A 2VQVA 3MZ4A 5EEKA 3Q9BA 1C3PA 2V5WA 5G0IA 5EFBD 1ZZ0A 3F07A 5BWZA 5EF8A 4QA2A 5IX0A 5JI5A 4LXZA 5G1CA 4QA7A 5G17A 1T64A 2V5XA 5EFJD 5DC8A 1W22A 5G11A 2GH6A 4QA6A 3Q9FA 4RN0A 5G10A 5G0JA 4CBYA 4BZ9A 2VQQA 3Q9EA 1C3SA 5G0XA 3MAXA 2VQOA 4ZUOA 2VQJA 3EZPA 3MZ7A 5EEFA 3C0YA 1ZZ1A 5G0HA 5EFHA 4ZUQA 3ZNRA 4BZ7A 4QA5A 5D1DA 3MZ3A 4BZ6A 1T69A 3EZTA 4RN2A 4ZUPA 5THUA 5D1CA 3F0RA 3C0ZA 3SFFA 5A2SA 3MENA 5D1BA 5G3WA 5EFKB 5G1BA 1T67A 4BZ5A 5DC6A 4A69A 4RN1A 1ZZ3A 5EEIA 5G0YA 4LY1A 1VKGA 5THSA 4QA0A 5EENA 4CQFA 5EFNA 2VQMA 5EEMA 4CBTA 5EF7A 5G0GA 3F06A 3EWFA 5FUEA 5G1AA 3EW8A 4QA4A 5EFGA 4ZUMA 3C10A 5THTA 5FCWA 2VCGA 3SFHA 4ZUNA 3RQDA 4BKXB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZUR A;  5G13 A;  1C3R A;  5DC5 A;  5G12 A;  5IWG A;  4BZ8 A;  5THV A;  2VQW G;  3MZ6 A;  5ICN B;  3Q9C A;  3ZNS A;  4QA3 A;  5LI3 A;  5DC7 A;  4QA1 A;  2VQV A;  3MZ4 A;  5EEK A;  3Q9B A;  1C3P A;  2V5W A;  5G0I A;  5EFB D;  1ZZ0 A;  3F07 A;  5BWZ A;  5EF8 A;  4QA2 A;  5IX0 A;  5JI5 A;  4LXZ A;  5G1C A;  4QA7 A;  5G17 A;  1T64 A;  2V5X A;  5EFJ D;  5DC8 A;  1W22 A;  5G11 A;  2GH6 A;  4QA6 A;  3Q9F A;  4RN0 A;  5G10 A;  5G0J A;  4CBY A;  4BZ9 A;  2VQQ A;  3Q9E A;  1C3S A;  5G0X A;  3MAX A;  2VQO A;  4ZUO A;  2VQJ A;  3EZP A;  3MZ7 A;  5EEF A;  3C0Y A;  1ZZ1 A;  5G0H A;  5EFH A;  4ZUQ A;  3ZNR A;  4BZ7 A;  4QA5 A;  5D1D A;  3MZ3 A;  4BZ6 A;  1T69 A;  3EZT A;  4RN2 A;  4ZUP A;  5THU A;  5D1C A;  3F0R A;  3C0Z A;  3SFF A;  5A2S A;  3MEN A;  5D1B A;  5G3W A;  5EFK B;  5G1B A;  1T67 A;  4BZ5 A;  5DC6 A;  4A69 A;  4RN1 A;  1ZZ3 A;  5EEI A;  5G0Y A;  4LY1 A;  1VKG A;  5THS A;  4QA0 A;  5EEN A;  4CQF A;  5EFN A;  2VQM A;  5EEM A;  4CBT A;  5EF7 A;  5G0G A;  3F06 A;  3EWF A;  5FUE A;  5G1A A;  3EW8 A;  4QA4 A;  5EFG A;  4ZUM A;  3C10 A;  5THT A;  5FCW A;  2VCG A;  3SFH A;  4ZUN A;  3RQD A;  4BKX B; 
#chains in the Genus database with same CATH topology
 4CEV A;  2RLA A;  4ZUR A;  1HQG A;  5G13 A;  4GSV A;  4IU0 A;  3SKK A;  1C3R A;  5DC5 A;  5G12 A;  5IWG A;  4BZ8 A;  5THV A;  2VQW G;  3MZ6 A;  4IXU A;  1TBL A;  3Q9C A;  3ZNS A;  5ICN B;  4IE2 A;  5RLA A;  1HQH A;  4QA3 A;  5LI3 A;  1WOG A;  4IU5 A;  5DC7 A;  4QA1 A;  1T4P A;  2VQV A;  3MZ4 A;  5EEK A;  3Q9B A;  4Q3V A;  1C3P A;  4RHJ A;  2PLL A;  2V5W A;  5G0I A;  5EFB D;  1T5F A;  4MYN A;  1ZZ0 A;  3F07 A;  5BWZ A;  5EF8 A;  4Q40 A;  4QA2 A;  1T4T A;  4Q3R A;  1PQ3 A;  5IX0 A;  5JI5 A;  4I06 A;  2EF4 A;  1TBH A;  4LXZ A;  3KV2 A;  5G1C A;  4QA7 A;  4FCK A;  5G17 A;  1T64 A;  2V5X A;  5EFJ D;  1T4S A;  1P8P A;  4MYK A;  1P8Q A;  1W22 A;  5DC8 A;  4GSZ A;  4RHI A;  5G11 A;  3E8Z A;  2GH6 A;  1GQ7 A;  1HQX A;  3CEV A;  4Q3S A;  4Q3Q A;  4QA6 A;  3Q9F A;  4RN0 A;  1CEV A;  5G10 A;  3RQD A;  1HQF A;  5G0J A;  4GWD A;  3F80 A;  4MYL A;  4BZ9 A;  4CBY A;  4G3H A;  4GWC A;  4HXQ A;  4IXV A;  2VQQ A;  4Q3R C;  1P8S A;  3Q9E A;  4MYF A;  1C3S A;  1TA1 A;  3MFW A;  5G0X A;  3PZL A;  3MAX A;  1WVB A;  2VQO A;  4ZUO A;  3E8Q A;  4RHM A;  2VQJ A;  3EZP A;  3MFV A;  3MZ7 A;  3SL1 A;  3THJ A;  5EEF A;  4GSM A;  1R1O A;  4RHK A;  2ZAV A;  4RHQ A;  3MMR A;  4RLA A;  3C0Y A;  1RLA A;  1ZZ1 A;  5G0H A;  1ZPG A;  5EFH A;  5HJ9 A;  3M1R A;  4ZUQ A;  4Q3T A;  3LP4 A;  4Q42 A;  3SJT A;  3THE A;  3ZNR A;  4BZ7 A;  4QA5 A;  5D1D A;  3MZ3 A;  1ZPE A;  4ITY A;  1T4R A;  4Q3U A;  1T69 A;  4BZ6 A;  3GN0 A;  3GMZ A;  1WOH A;  3EZT A;  4RN2 A;  2EF5 A;  4IE1 A;  2PHA A;  3TF3 A;  3DJ8 A;  3THH A;  4ZUP A;  5THU A;  3TH7 A;  5HJA A;  5D1C A;  1P8R A;  1TBJ A;  3RLA A;  4MXR A;  3F0R A;  3C0Z A;  1T5G A;  3SFF A;  5A2S A;  3MEN A;  5D1B A;  5G3W A;  5EFK B;  5G1B A;  1T67 A;  3MJL A;  4RHL A;  4BZ5 A;  5DC6 A;  4A69 A;  3NIP A;  3SL0 A;  4HWW A;  5CEV A;  4RN1 A;  1ZZ3 A;  1P8O A;  5EEI A;  5G0Y A;  4LY1 A;  1VKG A;  4Q41 A;  5THS A;  3E6V A;  1WVA A;  1D3V A;  4DZ4 A;  3LHL A;  3NIO A;  4QA0 A;  2AEB A;  5EEN A;  4HZE A;  1P8N A;  4CQF A;  1GQ6 A;  1XFK A;  1WOI A;  2VQM A;  4IU4 A;  5EFN A;  3E9B A;  5EEM A;  5EF7 A;  4CBT A;  5G0G A;  2EIV A;  3F06 A;  3EWF A;  4Q3P A;  5FUE A;  1P8M A;  5G1A A;  3NIQ A;  3EW8 A;  4QA4 A;  5EFG A;  4ZUM A;  2CEV A;  3C10 A;  3LP7 A;  4FCI A;  5THT A;  4IE3 A;  4IU1 A;  1HQ5 A;  5FCW A;  2VCG A;  3SFH A;  4ZUN A;  2PHO A;  2A0M A;  4BKX B;  3E6K A; 
#chains in the Genus database with same CATH homology
 4ZUR A;  5G13 A;  1C3R A;  5DC5 A;  5G12 A;  5IWG A;  4BZ8 A;  5THV A;  2VQW G;  3MZ6 A;  5ICN B;  3Q9C A;  3ZNS A;  4QA3 A;  5LI3 A;  5DC7 A;  4QA1 A;  2VQV A;  3MZ4 A;  5EEK A;  3Q9B A;  1C3P A;  2V5W A;  5G0I A;  5EFB D;  1ZZ0 A;  3F07 A;  5BWZ A;  5EF8 A;  4QA2 A;  5IX0 A;  5JI5 A;  4LXZ A;  5G1C A;  4QA7 A;  5G17 A;  1T64 A;  2V5X A;  5EFJ D;  5DC8 A;  1W22 A;  5G11 A;  2GH6 A;  4QA6 A;  3Q9F A;  4RN0 A;  5G10 A;  5G0J A;  4CBY A;  4BZ9 A;  2VQQ A;  3Q9E A;  1C3S A;  5G0X A;  3MAX A;  2VQO A;  4ZUO A;  2VQJ A;  3EZP A;  3MZ7 A;  5EEF A;  3C0Y A;  1ZZ1 A;  5G0H A;  5EFH A;  4ZUQ A;  3ZNR A;  4BZ7 A;  4QA5 A;  5D1D A;  3MZ3 A;  4BZ6 A;  1T69 A;  3EZT A;  4RN2 A;  4ZUP A;  5THU A;  5D1C A;  3F0R A;  3C0Z A;  3SFF A;  5A2S A;  3MEN A;  5D1B A;  5G3W A;  5EFK B;  5G1B A;  1T67 A;  4BZ5 A;  5DC6 A;  4A69 A;  4RN1 A;  1ZZ3 A;  5EEI A;  5G0Y A;  4LY1 A;  1VKG A;  5THS A;  4QA0 A;  5EEN A;  4CQF A;  5EFN A;  2VQM A;  5EEM A;  4CBT A;  5EF7 A;  5G0G A;  3F06 A;  3EWF A;  5FUE A;  5G1A A;  3EW8 A;  4QA4 A;  5EFG A;  4ZUM A;  3C10 A;  5THT A;  5FCW A;  2VCG A;  3SFH A;  4ZUN A;  3RQD A;  4BKX B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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