4TZCA

Crystal structure of murine cereblon in complex with thalidomide
Total Genus 20
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
20
sequence length
106
structure length
91
Chain Sequence
TSLCCKQCQETEITTKNEIFSLSLETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Ligase
molecule keywords Protein cereblon
publication title Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
rcsb
source organism Mus musculus
total genus 20
structure length 91
sequence length 106
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2014-07-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4tzcA00
4CI2B 3HCGA 4TZUA 3WX1A 4TZ4C 2KZNA 2KV1A 4V30A 2K8DA 4V31A 4TZCA 1L1DA 3CEZA 3E0MA 4V2YA 3HCIA 4V2ZA 3CXKA 4CI3B 3HCJA 5AMHA 3WX2A 3MAOA 4CI1B 3E0OA 3HCHA
chains in the Genus database with same CATH superfamily
2FU5A 4CI2B 5E3HA 3HCGA 4TZUA 3WX1A 4TZ4C 2RQAA 2YKGA 3OG8A 3DJMA 1TXJA 2KZNA 2LVLA 2RQBA 2KV1A 3HCHA 3EBMA 3GA3A 4A2VA 4BPBA 3NCUA 2QFDA 4V30A 2K8DA 3FACA 4AY2A 2HR9A 3P3KA 5F98A 4V31A 3ZD6A 4TZCA 1L1DA 3EQTA 3ZD7A 3CEZA 2LOYA 3E0MA 5F9FA 4V2YA 5F9HA 3HCIA 4V2ZA 3CXKA 2QFBA 3LRNA 1YZ1A 1HXRA 3HCJA 2KWBA 5AMHA 1FWQA 4CI3B 1H7YA 3WX2A 3MAOA 2W4RA 2RMJA 4CI1B 3LRRA 4A2XA 3E0OA 1H6QA
chains in the Genus database with same CATH topology
4CI2B 3HCGA 4TZUA 3WX1A 4TZ4C 2KZNA 2KV1A 4V30A 2K8DA 4V31A 4TZCA 1L1DA 3CEZA 3E0MA 4V2YA 3HCIA 4V2ZA 3CXKA 4CI3B 3HCJA 5AMHA 3WX2A 3MAOA 4CI1B 3E0OA 3HCHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4CI2 B;  3HCG A;  4TZU A;  3WX1 A;  4TZ4 C;  2KZN A;  2KV1 A;  4V30 A;  2K8D A;  4V31 A;  4TZC A;  1L1D A;  3CEZ A;  3E0M A;  4V2Y A;  3HCI A;  4V2Z A;  3CXK A;  4CI3 B;  3HCJ A;  5AMH A;  3WX2 A;  3MAO A;  4CI1 B;  3E0O A;  3HCH A; 
#chains in the Genus database with same CATH topology
 2FU5 A;  4CI2 B;  5E3H A;  3HCG A;  4TZU A;  3WX1 A;  4TZ4 C;  2RQA A;  2YKG A;  3OG8 A;  3DJM A;  1TXJ A;  2KZN A;  2LVL A;  2RQB A;  2KV1 A;  3HCH A;  3EBM A;  3GA3 A;  4A2V A;  4BPB A;  3NCU A;  2QFD A;  4V30 A;  2K8D A;  3FAC A;  4AY2 A;  2HR9 A;  3P3K A;  5F98 A;  4V31 A;  3ZD6 A;  4TZC A;  1L1D A;  3EQT A;  3ZD7 A;  3CEZ A;  2LOY A;  3E0M A;  5F9F A;  4V2Y A;  5F9H A;  3HCI A;  4V2Z A;  3CXK A;  2QFB A;  3LRN A;  1YZ1 A;  1HXR A;  3HCJ A;  2KWB A;  5AMH A;  1FWQ A;  4CI3 B;  1H7Y A;  3WX2 A;  3MAO A;  2W4R A;  2RMJ A;  4CI1 B;  3LRR A;  4A2X A;  3E0O A;  1H6Q A; 
#chains in the Genus database with same CATH homology
 4CI2 B;  3HCG A;  4TZU A;  3WX1 A;  4TZ4 C;  2KZN A;  2KV1 A;  4V30 A;  2K8D A;  4V31 A;  4TZC A;  1L1D A;  3CEZ A;  3E0M A;  4V2Y A;  3HCI A;  4V2Z A;  3CXK A;  4CI3 B;  3HCJ A;  5AMH A;  3WX2 A;  3MAO A;  4CI1 B;  3E0O A;  3HCH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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