4TZUA

Crystal structure of murine cereblon in complex with pomalidomide
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
106
structure length
90
Chain Sequence
TSLCCKQCQETEITTKNEIFSLSETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Ligase
molecule keywords Protein cereblon
publication title Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
rcsb
source organism Mus musculus
total genus 18
structure length 90
sequence length 106
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2014-07-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 4tzuA00
3E0MA 3HCHA 3E0OA 3WX2A 5AMHA 4V30A 3CEZA 3HCJA 3WX1A 1L1DA 2KZNA 4CI1B 4V2YA 2K8DA 4CI3B 3HCGA 4TZUA 4V31A 3MAOA 4CI2B 4TZ4C 4TZCA 3HCIA 2KV1A 3CXKA 4V2ZA
chains in the Genus database with same CATH superfamily
3OG8A 1HXRA 3E0MA 3HCHA 5F98A 3EQTA 3E0OA 3NCUA 2QFBA 2RQBA 2LOYA 3GA3A 5E3HA 1H7YA 3WX2A 5AMHA 4A2XA 1YZ1A 4V30A 1TXJA 2FU5A 3CEZA 5F9HA 3LRNA 3HCJA 3EBMA 3LRRA 2RMJA 3WX1A 1L1DA 1H6QA 2W4RA 2QFDA 3P3KA 2HR9A 2YKGA 4CI1B 2LVLA 3ZD7A 4V2YA 2K8DA 4CI3B 2RQAA 3HCGA 3ZD6A 1FWQA 4TZUA 3DJMA 4V31A 5F9FA 3FACA 3CXKA 3MAOA 4TZ4C 4TZCA 2KWBA 4A2VA 4CI2B 4BPBA 4AY2A 3HCIA 2KV1A 2KZNA 4V2ZA
chains in the Genus database with same CATH topology
3E0MA 3HCHA 3E0OA 3WX2A 5AMHA 4V30A 3CEZA 3HCJA 3WX1A 1L1DA 2KZNA 4CI1B 4V2YA 2K8DA 4CI3B 3HCGA 4TZUA 4V31A 3MAOA 4CI2B 4TZ4C 4TZCA 3HCIA 2KV1A 3CXKA 4V2ZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3E0M A;  3HCH A;  3E0O A;  3WX2 A;  5AMH A;  4V30 A;  3CEZ A;  3HCJ A;  3WX1 A;  1L1D A;  2KZN A;  4CI1 B;  4V2Y A;  2K8D A;  4CI3 B;  3HCG A;  4TZU A;  4V31 A;  3MAO A;  4CI2 B;  4TZ4 C;  4TZC A;  3HCI A;  2KV1 A;  3CXK A;  4V2Z A; 
#chains in the Genus database with same CATH topology
 3OG8 A;  1HXR A;  3E0M A;  3HCH A;  5F98 A;  3EQT A;  3E0O A;  3NCU A;  2QFB A;  2RQB A;  2LOY A;  3GA3 A;  5E3H A;  1H7Y A;  3WX2 A;  5AMH A;  4A2X A;  1YZ1 A;  4V30 A;  1TXJ A;  2FU5 A;  3CEZ A;  5F9H A;  3LRN A;  3HCJ A;  3EBM A;  3LRR A;  2RMJ A;  3WX1 A;  1L1D A;  1H6Q A;  2W4R A;  2QFD A;  3P3K A;  2HR9 A;  2YKG A;  4CI1 B;  2LVL A;  3ZD7 A;  4V2Y A;  2K8D A;  4CI3 B;  2RQA A;  3HCG A;  3ZD6 A;  1FWQ A;  4TZU A;  3DJM A;  4V31 A;  5F9F A;  3FAC A;  3CXK A;  3MAO A;  4TZ4 C;  4TZC A;  2KWB A;  4A2V A;  4CI2 B;  4BPB A;  4AY2 A;  3HCI A;  2KV1 A;  2KZN A;  4V2Z A; 
#chains in the Genus database with same CATH homology
 3E0M A;  3HCH A;  3E0O A;  3WX2 A;  5AMH A;  4V30 A;  3CEZ A;  3HCJ A;  3WX1 A;  1L1D A;  2KZN A;  4CI1 B;  4V2Y A;  2K8D A;  4CI3 B;  3HCG A;  4TZU A;  4V31 A;  3MAO A;  4CI2 B;  4TZ4 C;  4TZC A;  3HCI A;  2KV1 A;  3CXK A;  4V2Z A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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