4J7HA

Crystal structure of evaa, a 2,3-dehydratase in complex with dtdp-benzene and dtdp-rhamnose
Total Genus 141
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
141
Knots found
sequence length
458
structure length
446
Chain Sequence
AVRPRDHHDYADRIALSAATTDGVQMRTEDVRAWIAERRDANVFHVERIPFADLDQWWFEGVTGNLVHRSGRFFTIEGLHVIEHDGPHGDGPYREWQQPVIRQPEVGILGILAKEFDGVLHFLMQAKMEPGNPNLVQLSPTVQATRSNYNVKLIEYFAPPDPERVIVDVLQAEQGSWFFRKSNRNMIVETVDDVPLWDDFCWLTLGQIAELMHEDETINMNSRSVLSCLPYQDITPRALFSDVQLLSWFTNERSRHDVRVRRIPLADVCGWKQGAEEIEHEDGRYFKVLAVAVKKISWTQPLVESVDLGVVAFLVRKIDGVPHVLVQARVDGGFLDTVELAPTVQCTPLNYAHLPAEEAPPFLDLVQNAPRSRIRYEAIHSEEGGRFLGVRARYLVIDADEAIDPPPGYAWVTPAQLTALTRHGHYVNVEARTLLACINAAAAQPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of EvaA: A Paradigm for Sugar 2,3-Dehydratases.
pubmed doi rcsb
molecule tags Biosynthetic protein
source organism Amycolatopsis orientalis
molecule keywords EvaA 2,3-dehydratase
total genus 141
structure length 446
sequence length 458
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 4.2.1.159: dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase.
pdb deposition date 2013-02-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03559 Hexose_dehydrat NDP-hexose 2,3-dehydratase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.79.40 Alpha Beta Alpha-Beta Complex Nucleoside Triphosphate Pyrophosphohydrolase Nucleoside Triphosphate Pyrophosphohydrolase 4j7hA02
4J7HA 4J7GA
chains in the Genus database with same CATH superfamily
3CNGA 1V8SA 3FK9A 1X51A 3F6AA 4J7GA 5FSIA 1X83A 5ANWA 1VHZA 2A6TA 3GG6A 4NFXA 1PUSA 1VK6A 1GA7A 1XSAA 4C9XA 3A6VA 3X0SA 2QJTA 5GHIA 1JRKA 5C8LA 5C7TA 3O8SA 1NQYA 5ANUA 5FSLA 1V8TA 3GWYA 3X0MA 5CFIA 5GHOA 2JVBA 2A8PA 4J7HA 5IW5A 3X0KA 1PUNA 2ICJA 2J8QA 3DUPA 2GT2A 4KG3A 4MPOA 3O69A 1VIQA 1R67A 1TUMA 2W4EA 1V8LA 5FSKA 1SJYA 4S2XA 1HZTA 1SOIA 4YPRA 2R5WA 3N77A 3Q91A 3QSJA 2FMLA 4KYXA 3EXQA 3X0OA 4JZUA 2B06A 5CFJA 2QKMB 1NFSA 3X0LA 3MDGA 5FSNA 1V8NA 3BAPA 3DKUA 3F13A 1RRQA 4K6EA 5ANSA 5GHJA 1NQZA 3X0NA 1PPVA 2DSBA 1VCDA 2Q9PA 3P5TA 4IJXA 3COUA 4HVYA 1V8RA 3GZ8A 1Q54A 2KDVA 2DUKA 2KDWA 4DYWA 3ZR0A 1G9QA 5GHMA 3SONA 3ZR1A 2DSCA 2ICKA 1G0SA 3FJYA 1IRYA 3U53A 3KVHA 5DD4A 3MGMA 3FFUA 2VNPA 3EESA 1OW2A 2VNQA 3Q93A 4YOQA 4JZSA 3EF5A 3OGAA 5DDGA 3I9XA 3BM4A 1XSCA 1X84A 3H95A 1MQEA 3X0IA 5GHNA 1K26A 1V8UA 4V14A 1VHGA 1K2EA 3AC9A 3Q1PA 3GZ5A 5C7QA 4KTBA 3MCFA 2O5WA 1MQWA 3FSPA 4N1UA 2GB5A 5LPGA 2DSDA 4JZVA 3RH7A 3MDIA 3WHWA 1MK1A 5DEQA 3X0PA 5HZXA 2YVNA 3O6ZA 3X0JA 2A8QA 3EEUA 2G73A 3E57A 2FKBA 2PNYA 3Q2SA 1VC8A 3HHJA 3SMDA 2CL3A 3A6UA 2RRKA 3A6SA 3N9UA 1RYAA 4ICKA 5BS6A 1V8VA 3BHOA 1V8WA 2CZRA 2FVVA 2QJOA 3I7UA 2O5FA 3I7VA 1V8YA 3J7Ye 3A6TA 3G0QA 3HYQA 4N1TA 1V8IA 3Q4IA 3R03A 1V8MA 1MR2A 1Q27A 5IW4A 1U20A 4YPHA 1MUTA 3Q2TA 3FCMA 2AZWA 5FSOA 3P6YA 3X0QA 1MP2A 2B2KA 3ACAA 2YYHA 1F3YA 4NFWA 2PQVA 2I8UA 4KG4A 2G74A 1QVJA 2B0VA 2DHOA 2O1CA 3L85A 2I8TA 1NFZA 1KTGA 2A8RA 1KHZA 1VC9A 2GT4A 4C9WA 4ILQA 2A8SA 3SHDA 2YVOA 4S2VA 1PPWA 4ZG0A 5GHPA 5ANTA 1VRLA 1Q33A 3GRNA 5ANVA 4HFQA 1SZ3A 5FSMA 2A8TA 1JKNA 1HX3A 2YVMA 4JZTA 2I6KA 3O52A 2XSQA 1RRSA 1PVFA 5BONA 1I9AA 5ISYA 3GZ6A 5I8UA 3O61A 3X0RA 1SU2A 2YVPA 3ID9A 5DPKA 1KT9A 1VIUA 1PUQA 4S2WA 1XSBA 4S2YA 5GHQA 1PPXA
chains in the Genus database with same CATH topology
3CNGA 1V8SA 3FK9A 1X51A 3F6AA 4J7GA 5FSIA 1X83A 5ANWA 1VHZA 2A6TA 3GG6A 4NFXA 1PUSA 1VK6A 1GA7A 1XSAA 4C9XA 3A6VA 3X0SA 2QJTA 5GHIA 1JRKA 5C8LA 5C7TA 3O8SA 1NQYA 5ANUA 5FSLA 1V8TA 3GWYA 3X0MA 5CFIA 5GHOA 2JVBA 2A8PA 4J7HA 5IW5A 3X0KA 1PUNA 2ICJA 2J8QA 3DUPA 2GT2A 4KG3A 4MPOA 3O69A 1VIQA 1R67A 1TUMA 2W4EA 1V8LA 5FSKA 1SJYA 4S2XA 1HZTA 1SOIA 4YPRA 2R5WA 3N77A 3Q91A 3QSJA 2FMLA 4KYXA 3EXQA 3X0OA 4JZUA 2B06A 5CFJA 2QKMB 1NFSA 3X0LA 3MDGA 5FSNA 1V8NA 3BAPA 3DKUA 3F13A 1RRQA 4K6EA 5ANSA 5GHJA 1NQZA 3X0NA 1PPVA 2DSBA 1VCDA 2Q9PA 3P5TA 4IJXA 3COUA 4HVYA 1V8RA 3GZ8A 1Q54A 2KDVA 2DUKA 2KDWA 4DYWA 3ZR0A 1G9QA 5GHMA 3SONA 3ZR1A 2DSCA 2ICKA 1G0SA 3FJYA 1IRYA 3U53A 3KVHA 5DD4A 3MGMA 3FFUA 2VNPA 3EESA 1OW2A 2VNQA 3Q93A 4YOQA 4JZSA 3EF5A 3OGAA 5DDGA 3I9XA 3BM4A 1XSCA 1X84A 3H95A 1MQEA 3X0IA 5GHNA 1K26A 1V8UA 4V14A 1VHGA 1K2EA 3AC9A 3Q1PA 3GZ5A 5C7QA 4KTBA 3MCFA 2O5WA 1MQWA 3FSPA 4N1UA 2GB5A 5LPGA 2DSDA 4JZVA 3RH7A 3MDIA 3WHWA 1MK1A 5DEQA 3X0PA 5HZXA 2YVNA 3O6ZA 3X0JA 2A8QA 3EEUA 2G73A 3E57A 2FKBA 2PNYA 3Q2SA 1VC8A 3HHJA 3SMDA 2CL3A 3A6UA 2RRKA 3A6SA 3N9UA 1RYAA 4ICKA 5BS6A 1V8VA 3BHOA 1V8WA 2CZRA 2FVVA 2QJOA 3I7UA 2O5FA 3I7VA 1V8YA 3J7Ye 3A6TA 3G0QA 3HYQA 4N1TA 1V8IA 3Q4IA 3R03A 1V8MA 1MR2A 1Q27A 5IW4A 1U20A 4YPHA 1MUTA 3Q2TA 3FCMA 2AZWA 5FSOA 3P6YA 3X0QA 1MP2A 2B2KA 3ACAA 2YYHA 1F3YA 4NFWA 2PQVA 2I8UA 4KG4A 2G74A 1QVJA 2B0VA 2DHOA 2O1CA 3L85A 2I8TA 1NFZA 1KTGA 2A8RA 1KHZA 1VC9A 2GT4A 4C9WA 4ILQA 2A8SA 3SHDA 2YVOA 4S2VA 1PPWA 4ZG0A 5GHPA 5ANTA 1VRLA 1Q33A 3GRNA 5ANVA 4HFQA 1SZ3A 5FSMA 2A8TA 1JKNA 1HX3A 2YVMA 4JZTA 2I6KA 3O52A 2XSQA 1RRSA 1PVFA 5BONA 1I9AA 5ISYA 3GZ6A 5I8UA 3O61A 3X0RA 1SU2A 2YVPA 3ID9A 5DPKA 1KT9A 1VIUA 1PUQA 4S2WA 1XSBA 4S2YA 5GHQA 1PPXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J7H A;  4J7G A; 
#chains in the Genus database with same CATH topology
 3CNG A;  1V8S A;  3FK9 A;  1X51 A;  3F6A A;  4J7G A;  5FSI A;  1X83 A;  5ANW A;  1VHZ A;  2A6T A;  3GG6 A;  4NFX A;  1PUS A;  1VK6 A;  1GA7 A;  1XSA A;  4C9X A;  3A6V A;  3X0S A;  2QJT A;  5GHI A;  1JRK A;  5C8L A;  5C7T A;  3O8S A;  1NQY A;  5ANU A;  5FSL A;  1V8T A;  3GWY A;  3X0M A;  5CFI A;  5GHO A;  2JVB A;  2A8P A;  4J7H A;  5IW5 A;  3X0K A;  1PUN A;  2ICJ A;  2J8Q A;  3DUP A;  2GT2 A;  4KG3 A;  4MPO A;  3O69 A;  1VIQ A;  1R67 A;  1TUM A;  2W4E A;  1V8L A;  5FSK A;  1SJY A;  4S2X A;  1HZT A;  1SOI A;  4YPR A;  2R5W A;  3N77 A;  3Q91 A;  3QSJ A;  2FML A;  4KYX A;  3EXQ A;  3X0O A;  4JZU A;  2B06 A;  5CFJ A;  2QKM B;  1NFS A;  3X0L A;  3MDG A;  5FSN A;  1V8N A;  3BAP A;  3DKU A;  3F13 A;  1RRQ A;  4K6E A;  5ANS A;  5GHJ A;  1NQZ A;  3X0N A;  1PPV A;  2DSB A;  1VCD A;  2Q9P A;  3P5T A;  4IJX A;  3COU A;  4HVY A;  1V8R A;  3GZ8 A;  1Q54 A;  2KDV A;  2DUK A;  2KDW A;  4DYW A;  3ZR0 A;  1G9Q A;  5GHM A;  3SON A;  3ZR1 A;  2DSC A;  2ICK A;  1G0S A;  3FJY A;  1IRY A;  3U53 A;  3KVH A;  5DD4 A;  3MGM A;  3FFU A;  2VNP A;  3EES A;  1OW2 A;  2VNQ A;  3Q93 A;  4YOQ A;  4JZS A;  3EF5 A;  3OGA A;  5DDG A;  3I9X A;  3BM4 A;  1XSC A;  1X84 A;  3H95 A;  1MQE A;  3X0I A;  5GHN A;  1K26 A;  1V8U A;  4V14 A;  1VHG A;  1K2E A;  3AC9 A;  3Q1P A;  3GZ5 A;  5C7Q A;  4KTB A;  3MCF A;  2O5W A;  1MQW A;  3FSP A;  4N1U A;  2GB5 A;  5LPG A;  2DSD A;  4JZV A;  3RH7 A;  3MDI A;  3WHW A;  1MK1 A;  5DEQ A;  3X0P A;  5HZX A;  2YVN A;  3O6Z A;  3X0J A;  2A8Q A;  3EEU A;  2G73 A;  3E57 A;  2FKB A;  2PNY A;  3Q2S A;  1VC8 A;  3HHJ A;  3SMD A;  2CL3 A;  3A6U A;  2RRK A;  3A6S A;  3N9U A;  1RYA A;  4ICK A;  5BS6 A;  1V8V A;  3BHO A;  1V8W A;  2CZR A;  2FVV A;  2QJO A;  3I7U A;  2O5F A;  3I7V A;  1V8Y A;  3J7Y e;  3A6T A;  3G0Q A;  3HYQ A;  4N1T A;  1V8I A;  3Q4I A;  3R03 A;  1V8M A;  1MR2 A;  1Q27 A;  5IW4 A;  1U20 A;  4YPH A;  1MUT A;  3Q2T A;  3FCM A;  2AZW A;  5FSO A;  3P6Y A;  3X0Q A;  1MP2 A;  2B2K A;  3ACA A;  2YYH A;  1F3Y A;  4NFW A;  2PQV A;  2I8U A;  4KG4 A;  2G74 A;  1QVJ A;  2B0V A;  2DHO A;  2O1C A;  3L85 A;  2I8T A;  1NFZ A;  1KTG A;  2A8R A;  1KHZ A;  1VC9 A;  2GT4 A;  4C9W A;  4ILQ A;  2A8S A;  3SHD A;  2YVO A;  4S2V A;  1PPW A;  4ZG0 A;  5GHP A;  5ANT A;  1VRL A;  1Q33 A;  3GRN A;  5ANV A;  4HFQ A;  1SZ3 A;  5FSM A;  2A8T A;  1JKN A;  1HX3 A;  2YVM A;  4JZT A;  2I6K A;  3O52 A;  2XSQ A;  1RRS A;  1PVF A;  5BON A;  1I9A A;  5ISY A;  3GZ6 A;  5I8U A;  3O61 A;  3X0R A;  1SU2 A;  2YVP A;  3ID9 A;  5DPK A;  1KT9 A;  1VIU A;  1PUQ A;  4S2W A;  1XSB A;  4S2Y A;  5GHQ A;  1PPX A; 
#chains in the Genus database with same CATH homology
 3CNG A;  1V8S A;  3FK9 A;  1X51 A;  3F6A A;  4J7G A;  5FSI A;  1X83 A;  5ANW A;  1VHZ A;  2A6T A;  3GG6 A;  4NFX A;  1PUS A;  1VK6 A;  1GA7 A;  1XSA A;  4C9X A;  3A6V A;  3X0S A;  2QJT A;  5GHI A;  1JRK A;  5C8L A;  5C7T A;  3O8S A;  1NQY A;  5ANU A;  5FSL A;  1V8T A;  3GWY A;  3X0M A;  5CFI A;  5GHO A;  2JVB A;  2A8P A;  4J7H A;  5IW5 A;  3X0K A;  1PUN A;  2ICJ A;  2J8Q A;  3DUP A;  2GT2 A;  4KG3 A;  4MPO A;  3O69 A;  1VIQ A;  1R67 A;  1TUM A;  2W4E A;  1V8L A;  5FSK A;  1SJY A;  4S2X A;  1HZT A;  1SOI A;  4YPR A;  2R5W A;  3N77 A;  3Q91 A;  3QSJ A;  2FML A;  4KYX A;  3EXQ A;  3X0O A;  4JZU A;  2B06 A;  5CFJ A;  2QKM B;  1NFS A;  3X0L A;  3MDG A;  5FSN A;  1V8N A;  3BAP A;  3DKU A;  3F13 A;  1RRQ A;  4K6E A;  5ANS A;  5GHJ A;  1NQZ A;  3X0N A;  1PPV A;  2DSB A;  1VCD A;  2Q9P A;  3P5T A;  4IJX A;  3COU A;  4HVY A;  1V8R A;  3GZ8 A;  1Q54 A;  2KDV A;  2DUK A;  2KDW A;  4DYW A;  3ZR0 A;  1G9Q A;  5GHM A;  3SON A;  3ZR1 A;  2DSC A;  2ICK A;  1G0S A;  3FJY A;  1IRY A;  3U53 A;  3KVH A;  5DD4 A;  3MGM A;  3FFU A;  2VNP A;  3EES A;  1OW2 A;  2VNQ A;  3Q93 A;  4YOQ A;  4JZS A;  3EF5 A;  3OGA A;  5DDG A;  3I9X A;  3BM4 A;  1XSC A;  1X84 A;  3H95 A;  1MQE A;  3X0I A;  5GHN A;  1K26 A;  1V8U A;  4V14 A;  1VHG A;  1K2E A;  3AC9 A;  3Q1P A;  3GZ5 A;  5C7Q A;  4KTB A;  3MCF A;  2O5W A;  1MQW A;  3FSP A;  4N1U A;  2GB5 A;  5LPG A;  2DSD A;  4JZV A;  3RH7 A;  3MDI A;  3WHW A;  1MK1 A;  5DEQ A;  3X0P A;  5HZX A;  2YVN A;  3O6Z A;  3X0J A;  2A8Q A;  3EEU A;  2G73 A;  3E57 A;  2FKB A;  2PNY A;  3Q2S A;  1VC8 A;  3HHJ A;  3SMD A;  2CL3 A;  3A6U A;  2RRK A;  3A6S A;  3N9U A;  1RYA A;  4ICK A;  5BS6 A;  1V8V A;  3BHO A;  1V8W A;  2CZR A;  2FVV A;  2QJO A;  3I7U A;  2O5F A;  3I7V A;  1V8Y A;  3J7Y e;  3A6T A;  3G0Q A;  3HYQ A;  4N1T A;  1V8I A;  3Q4I A;  3R03 A;  1V8M A;  1MR2 A;  1Q27 A;  5IW4 A;  1U20 A;  4YPH A;  1MUT A;  3Q2T A;  3FCM A;  2AZW A;  5FSO A;  3P6Y A;  3X0Q A;  1MP2 A;  2B2K A;  3ACA A;  2YYH A;  1F3Y A;  4NFW A;  2PQV A;  2I8U A;  4KG4 A;  2G74 A;  1QVJ A;  2B0V A;  2DHO A;  2O1C A;  3L85 A;  2I8T A;  1NFZ A;  1KTG A;  2A8R A;  1KHZ A;  1VC9 A;  2GT4 A;  4C9W A;  4ILQ A;  2A8S A;  3SHD A;  2YVO A;  4S2V A;  1PPW A;  4ZG0 A;  5GHP A;  5ANT A;  1VRL A;  1Q33 A;  3GRN A;  5ANV A;  4HFQ A;  1SZ3 A;  5FSM A;  2A8T A;  1JKN A;  1HX3 A;  2YVM A;  4JZT A;  2I6K A;  3O52 A;  2XSQ A;  1RRS A;  1PVF A;  5BON A;  1I9A A;  5ISY A;  3GZ6 A;  5I8U A;  3O61 A;  3X0R A;  1SU2 A;  2YVP A;  3ID9 A;  5DPK A;  1KT9 A;  1VIU A;  1PUQ A;  4S2W A;  1XSB A;  4S2Y A;  5GHQ A;  1PPX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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