4LLXA

Crystal structure of pde10a2 with fragment zt434
Total Genus 136
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
136
sequence length
330
structure length
330
Chain Sequence
AGTSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase
total genus 136
structure length 330
sequence length 330
chains with identical sequence B
ec nomenclature ec 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
pdb deposition date 2013-07-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00233 PDEase_I 3'5'-cyclic nucleotide phosphodiesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1300.10 Mainly Alpha Orthogonal Bundle Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 4llxA00
3V9BA 4LLXA 2OVVA 1PTWA 4NPVA 1ZKLA 2QYKA 3IADA 5K1IA 3G45A 3WI2A 4I9ZA 5C2EA 3IBJA 4AJDA 3SHYA 3TGGA 4PHLA 1RORA 3JWQA 4IA0A 3N3ZA 1Y2DA 4E90A 1XOZA 3BJCA 4D08A 5K9RA 2OUQA 2PW3A 3SHZA 4OEWA 1Y2CA 2R8QA 4ZO5A 3V93A 1OYNA 4HTXA 1XMUB 3LXGA 3HR1A 4MSCA 1ZKNA 1T9SA 4WCUA 1XOMA 3G4GA 3K3EA 3DYNA 3SNIA 3SNLA 3UI7A 4FCBA 5B4KA 2OUVA 3HMVA 2O8HA 4XY2A 3DYLA 4OEXA 3G58A 1XN0A 1XLZA 2H42A 4WN1A 2H44A 5EDEA 3V94A 1SOJA 4LM3A 2CHMA 1XOSA 3QPNA 3QPPA 4LLJA 2OURA 3SL6A 5DH5A 2WEYA 2QYLA 1Y2BA 4MYQA 1Y2HA 1TB7A 2H40A 3IAKA 3K4SA 3QI4A 2OUNA 3JSIA 3QPOA 1RO6A 1XMYA 3SIEA 3ITMA 4MSEA 4G2JA 1Y2JA 4G2LA 3ITUA 4AJMA 4YQHA 4BBXA 3TGEA 4PHWA 4HTZA 4G2WA 4GH6A 3WYKA 4AELA 3WYLA 4HEUA 5EDEB 5EDGA 4I15A 2FM0A 3UUOA 1Q9MA 5B25A 4P1RA 3LY2A 1F0JA 4OGBA 4DDLA 3G3NA 4JIBA 4NW7A 4D09A 3QI3A 1TB5A 2QYNA 4MUWA 3DY8A 4C1IA 5B4LA 3SL4A 3GWTA 1XP0A 1RO9A 4X0FA 1XM4A 1XLXA 3FRGA 3G4LA 1XOTA 3WS9A 2Y0JA 3O56A 4MRZA 4LKQA 4TPMA 5EDGB 3SL8A 3SL3A 1Z1LA 2OUPA 4AJFA 5DH4A 2OVYA 3WYMA 4WZIA 1UHOA 5EDIA 2YY2A 4Y86A 4MRWA 3ECNA 4HF4A 4Y2BA 3WS8A 1MKDA 4LLKA 1Y2EA 1XOQA 2HD1A 3B2RA 4LM0A 1UDUA 5AXPA 5C1WA 4TPPA 2FM5A 3TVXA 3KKTA 4MD6A 1XMUA 3DYQA 3HQWA 4MVHA 4AJGA 1TAZA 3ECMA 3O57A 1Y2KA 3W5EA 3DYSA 4DFFA 1XMYB 5C29A 4Y8CA 2OUYA 4P0NA 4G2YA 4MSNA 4Y87A 5EDIB 3HDZA 1UDTA 4KP6A 1T9RA 1RKPA 4LM2A 3SN7A 2OUSA 1XM6A 3I8VA 4MSAA 5C2AA 5AXQA 5C28A 4LM1A 2OUUA 5I2RA 4PM0A 4W1OA 4MSHA 3D3PA 4NPWA 3G4KA 4QGEA 5K32A 1SO2A 3JSWA 1XONA 4MS0A 1XM4B 3SL5A 4FCDA 3G4IA 3K3HA 3WD9A 5C2HA 5EDHA 3HQZA 4LM4A 2QYMA 3HC8A 3O0JA 4YS7A 1XORA 3JWRA 3HQYA 4LLPA 1TBBA 1TBFA
chains in the Genus database with same CATH superfamily
3V9BA 4LLXA 2OVVA 1PTWA 4NPVA 1ZKLA 2QYKA 3IADA 5K1IA 3G45A 3WI2A 4I9ZA 5C2EA 3IBJA 4AJDA 3SHYA 3TGGA 4PHLA 1RORA 3JWQA 4IA0A 3N3ZA 1Y2DA 4E90A 1XOZA 3BJCA 4D08A 5K9RA 2OUQA 2PW3A 3SHZA 4OEWA 1Y2CA 2R8QA 4ZO5A 3V93A 1OYNA 4HTXA 1XMUB 3LXGA 3HR1A 4MSCA 1ZKNA 1T9SA 4WCUA 1XOMA 3G4GA 3K3EA 3DYNA 3SNIA 3SNLA 3UI7A 4FCBA 5B4KA 2OUVA 3HMVA 2O8HA 4XY2A 3DYLA 4OEXA 3G58A 1XN0A 1XLZA 2H42A 4WN1A 2H44A 5EDEA 3V94A 1SOJA 4LM3A 2CHMA 1XOSA 3QPNA 3QPPA 4LLJA 2OURA 3SL6A 5DH5A 2WEYA 2QYLA 1Y2BA 4MYQA 1Y2HA 1TB7A 2H40A 3IAKA 3K4SA 3QI4A 2OUNA 3JSIA 3QPOA 1RO6A 1XMYA 3SIEA 3ITMA 4MSEA 4G2JA 1Y2JA 4G2LA 3ITUA 4AJMA 4YQHA 4BBXA 3TGEA 4PHWA 4HTZA 4G2WA 4GH6A 3WYKA 4AELA 3WYLA 4HEUA 5EDEB 5EDGA 4I15A 2FM0A 3UUOA 1Q9MA 5B25A 4P1RA 3LY2A 1F0JA 4OGBA 4DDLA 3G3NA 4JIBA 4NW7A 4D09A 3QI3A 1TB5A 2QYNA 4MUWA 3DY8A 4C1IA 5B4LA 3SL4A 3GWTA 1XP0A 1RO9A 4X0FA 1XM4A 1XLXA 3FRGA 3G4LA 1XOTA 3WS9A 2Y0JA 3O56A 4MRZA 4LKQA 4TPMA 5EDGB 3SL8A 3SL3A 1Z1LA 2OUPA 4AJFA 5DH4A 2OVYA 3WYMA 4WZIA 1UHOA 5EDIA 2YY2A 4Y86A 4MRWA 3ECNA 4HF4A 4Y2BA 3WS8A 1MKDA 4LLKA 1Y2EA 1XOQA 2HD1A 3B2RA 4LM0A 1UDUA 5AXPA 5C1WA 4TPPA 2FM5A 3TVXA 3KKTA 4MD6A 1XMUA 3DYQA 3HQWA 4MVHA 4AJGA 1TAZA 3ECMA 3O57A 1Y2KA 3W5EA 3DYSA 4DFFA 1XMYB 5C29A 4Y8CA 2OUYA 4P0NA 4G2YA 4MSNA 4Y87A 5EDIB 3HDZA 1UDTA 4KP6A 1T9RA 1RKPA 4LM2A 3SN7A 2OUSA 1XM6A 3I8VA 4MSAA 5C2AA 5AXQA 5C28A 4LM1A 2OUUA 5I2RA 4PM0A 4W1OA 4MSHA 3D3PA 4NPWA 3G4KA 4QGEA 5K32A 1SO2A 3JSWA 1XONA 4MS0A 1XM4B 3SL5A 4FCDA 3G4IA 3K3HA 3WD9A 5C2HA 5EDHA 3HQZA 4LM4A 2QYMA 3HC8A 3O0JA 4YS7A 1XORA 3JWRA 3HQYA 4LLPA 1TBBA 1TBFA
chains in the Genus database with same CATH topology
3V9BA 4LLXA 2OVVA 1PTWA 4NPVA 1ZKLA 2QYKA 3IADA 5K1IA 3G45A 3WI2A 4I9ZA 5C2EA 3IBJA 4AJDA 3SHYA 3TGGA 4PHLA 1RORA 3JWQA 4IA0A 3N3ZA 1Y2DA 4E90A 1XOZA 3BJCA 4D08A 5K9RA 2OUQA 2PW3A 3SHZA 4OEWA 1Y2CA 2R8QA 4ZO5A 3V93A 1OYNA 4HTXA 1XMUB 3LXGA 3HR1A 4MSCA 1ZKNA 1T9SA 4WCUA 1XOMA 3G4GA 3K3EA 3DYNA 3SNIA 3SNLA 3UI7A 4FCBA 5B4KA 2OUVA 3HMVA 2O8HA 4XY2A 3DYLA 4OEXA 3G58A 1XN0A 1XLZA 2H42A 4WN1A 2H44A 5EDEA 3V94A 1SOJA 4LM3A 2CHMA 1XOSA 3QPNA 3QPPA 4LLJA 2OURA 3SL6A 5DH5A 2WEYA 2QYLA 1Y2BA 4MYQA 1Y2HA 1TB7A 2H40A 3IAKA 3K4SA 3QI4A 2OUNA 3JSIA 3QPOA 1RO6A 1XMYA 3SIEA 3ITMA 4MSEA 4G2JA 1Y2JA 4G2LA 3ITUA 4AJMA 4YQHA 4BBXA 3TGEA 4PHWA 4HTZA 4G2WA 4GH6A 3WYKA 4AELA 3WYLA 4HEUA 5EDEB 5EDGA 4I15A 2FM0A 3UUOA 1Q9MA 5B25A 4P1RA 3LY2A 1F0JA 4OGBA 4DDLA 3G3NA 4JIBA 4NW7A 4D09A 3QI3A 1TB5A 2QYNA 4MUWA 3DY8A 4C1IA 5B4LA 3SL4A 3GWTA 1XP0A 1RO9A 4X0FA 1XM4A 1XLXA 3FRGA 3G4LA 1XOTA 3WS9A 2Y0JA 3O56A 4MRZA 4LKQA 4TPMA 5EDGB 3SL8A 3SL3A 1Z1LA 2OUPA 4AJFA 5DH4A 2OVYA 3WYMA 4WZIA 1UHOA 5EDIA 2YY2A 4Y86A 4MRWA 3ECNA 4HF4A 4Y2BA 3WS8A 1MKDA 4LLKA 1Y2EA 1XOQA 2HD1A 3B2RA 4LM0A 1UDUA 5AXPA 5C1WA 4TPPA 2FM5A 3TVXA 3KKTA 4MD6A 1XMUA 3DYQA 3HQWA 4MVHA 4AJGA 1TAZA 3ECMA 3O57A 1Y2KA 3W5EA 3DYSA 4DFFA 1XMYB 5C29A 4Y8CA 2OUYA 4P0NA 4G2YA 4MSNA 4Y87A 5EDIB 3HDZA 1UDTA 4KP6A 1T9RA 1RKPA 4LM2A 3SN7A 2OUSA 1XM6A 3I8VA 4MSAA 5C2AA 5AXQA 5C28A 4LM1A 2OUUA 5I2RA 4PM0A 4W1OA 4MSHA 3D3PA 4NPWA 3G4KA 4QGEA 5K32A 1SO2A 3JSWA 1XONA 4MS0A 1XM4B 3SL5A 4FCDA 3G4IA 3K3HA 3WD9A 5C2HA 5EDHA 3HQZA 4LM4A 2QYMA 3HC8A 3O0JA 4YS7A 1XORA 3JWRA 3HQYA 4LLPA 1TBBA 1TBFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3V9B A;  4LLX A;  2OVV A;  1PTW A;  4NPV A;  1ZKL A;  2QYK A;  3IAD A;  5K1I A;  3G45 A;  3WI2 A;  4I9Z A;  5C2E A;  3IBJ A;  4AJD A;  3SHY A;  3TGG A;  4PHL A;  1ROR A;  3JWQ A;  4IA0 A;  3N3Z A;  1Y2D A;  4E90 A;  1XOZ A;  3BJC A;  4D08 A;  5K9R A;  2OUQ A;  2PW3 A;  3SHZ A;  4OEW A;  1Y2C A;  2R8Q A;  4ZO5 A;  3V93 A;  1OYN A;  4HTX A;  1XMU B;  3LXG A;  3HR1 A;  4MSC A;  1ZKN A;  1T9S A;  4WCU A;  1XOM A;  3G4G A;  3K3E A;  3DYN A;  3SNI A;  3SNL A;  3UI7 A;  4FCB A;  5B4K A;  2OUV A;  3HMV A;  2O8H A;  4XY2 A;  3DYL A;  4OEX A;  3G58 A;  1XN0 A;  1XLZ A;  2H42 A;  4WN1 A;  2H44 A;  5EDE A;  3V94 A;  1SOJ A;  4LM3 A;  2CHM A;  1XOS A;  3QPN A;  3QPP A;  4LLJ A;  2OUR A;  3SL6 A;  5DH5 A;  2WEY A;  2QYL A;  1Y2B A;  4MYQ A;  1Y2H A;  1TB7 A;  2H40 A;  3IAK A;  3K4S A;  3QI4 A;  2OUN A;  3JSI A;  3QPO A;  1RO6 A;  1XMY A;  3SIE A;  3ITM A;  4MSE A;  4G2J A;  1Y2J A;  4G2L A;  3ITU A;  4AJM A;  4YQH A;  4BBX A;  3TGE A;  4PHW A;  4HTZ A;  4G2W A;  4GH6 A;  3WYK A;  4AEL A;  3WYL A;  4HEU A;  5EDE B;  5EDG A;  4I15 A;  2FM0 A;  3UUO A;  1Q9M A;  5B25 A;  4P1R A;  3LY2 A;  1F0J A;  4OGB A;  4DDL A;  3G3N A;  4JIB A;  4NW7 A;  4D09 A;  3QI3 A;  1TB5 A;  2QYN A;  4MUW A;  3DY8 A;  4C1I A;  5B4L A;  3SL4 A;  3GWT A;  1XP0 A;  1RO9 A;  4X0F A;  1XM4 A;  1XLX A;  3FRG A;  3G4L A;  1XOT A;  3WS9 A;  2Y0J A;  3O56 A;  4MRZ A;  4LKQ A;  4TPM A;  5EDG B;  3SL8 A;  3SL3 A;  1Z1L A;  2OUP A;  4AJF A;  5DH4 A;  2OVY A;  3WYM A;  4WZI A;  1UHO A;  5EDI A;  2YY2 A;  4Y86 A;  4MRW A;  3ECN A;  4HF4 A;  4Y2B A;  3WS8 A;  1MKD A;  4LLK A;  1Y2E A;  1XOQ A;  2HD1 A;  3B2R A;  4LM0 A;  1UDU A;  5AXP A;  5C1W A;  4TPP A;  2FM5 A;  3TVX A;  3KKT A;  4MD6 A;  1XMU A;  3DYQ A;  3HQW A;  4MVH A;  4AJG A;  1TAZ A;  3ECM A;  3O57 A;  1Y2K A;  3W5E A;  3DYS A;  4DFF A;  1XMY B;  5C29 A;  4Y8C A;  2OUY A;  4P0N A;  4G2Y A;  4MSN A;  4Y87 A;  5EDI B;  3HDZ A;  1UDT A;  4KP6 A;  1T9R A;  1RKP A;  4LM2 A;  3SN7 A;  2OUS A;  1XM6 A;  3I8V A;  4MSA A;  5C2A A;  5AXQ A;  5C28 A;  4LM1 A;  2OUU A;  5I2R A;  4PM0 A;  4W1O A;  4MSH A;  3D3P A;  4NPW A;  3G4K A;  4QGE A;  5K32 A;  1SO2 A;  3JSW A;  1XON A;  4MS0 A;  1XM4 B;  3SL5 A;  4FCD A;  3G4I A;  3K3H A;  3WD9 A;  5C2H A;  5EDH A;  3HQZ A;  4LM4 A;  2QYM A;  3HC8 A;  3O0J A;  4YS7 A;  1XOR A;  3JWR A;  3HQY A;  4LLP A;  1TBB A;  1TBF A; 
#chains in the Genus database with same CATH topology
 3V9B A;  4LLX A;  2OVV A;  1PTW A;  4NPV A;  1ZKL A;  2QYK A;  3IAD A;  5K1I A;  3G45 A;  3WI2 A;  4I9Z A;  5C2E A;  3IBJ A;  4AJD A;  3SHY A;  3TGG A;  4PHL A;  1ROR A;  3JWQ A;  4IA0 A;  3N3Z A;  1Y2D A;  4E90 A;  1XOZ A;  3BJC A;  4D08 A;  5K9R A;  2OUQ A;  2PW3 A;  3SHZ A;  4OEW A;  1Y2C A;  2R8Q A;  4ZO5 A;  3V93 A;  1OYN A;  4HTX A;  1XMU B;  3LXG A;  3HR1 A;  4MSC A;  1ZKN A;  1T9S A;  4WCU A;  1XOM A;  3G4G A;  3K3E A;  3DYN A;  3SNI A;  3SNL A;  3UI7 A;  4FCB A;  5B4K A;  2OUV A;  3HMV A;  2O8H A;  4XY2 A;  3DYL A;  4OEX A;  3G58 A;  1XN0 A;  1XLZ A;  2H42 A;  4WN1 A;  2H44 A;  5EDE A;  3V94 A;  1SOJ A;  4LM3 A;  2CHM A;  1XOS A;  3QPN A;  3QPP A;  4LLJ A;  2OUR A;  3SL6 A;  5DH5 A;  2WEY A;  2QYL A;  1Y2B A;  4MYQ A;  1Y2H A;  1TB7 A;  2H40 A;  3IAK A;  3K4S A;  3QI4 A;  2OUN A;  3JSI A;  3QPO A;  1RO6 A;  1XMY A;  3SIE A;  3ITM A;  4MSE A;  4G2J A;  1Y2J A;  4G2L A;  3ITU A;  4AJM A;  4YQH A;  4BBX A;  3TGE A;  4PHW A;  4HTZ A;  4G2W A;  4GH6 A;  3WYK A;  4AEL A;  3WYL A;  4HEU A;  5EDE B;  5EDG A;  4I15 A;  2FM0 A;  3UUO A;  1Q9M A;  5B25 A;  4P1R A;  3LY2 A;  1F0J A;  4OGB A;  4DDL A;  3G3N A;  4JIB A;  4NW7 A;  4D09 A;  3QI3 A;  1TB5 A;  2QYN A;  4MUW A;  3DY8 A;  4C1I A;  5B4L A;  3SL4 A;  3GWT A;  1XP0 A;  1RO9 A;  4X0F A;  1XM4 A;  1XLX A;  3FRG A;  3G4L A;  1XOT A;  3WS9 A;  2Y0J A;  3O56 A;  4MRZ A;  4LKQ A;  4TPM A;  5EDG B;  3SL8 A;  3SL3 A;  1Z1L A;  2OUP A;  4AJF A;  5DH4 A;  2OVY A;  3WYM A;  4WZI A;  1UHO A;  5EDI A;  2YY2 A;  4Y86 A;  4MRW A;  3ECN A;  4HF4 A;  4Y2B A;  3WS8 A;  1MKD A;  4LLK A;  1Y2E A;  1XOQ A;  2HD1 A;  3B2R A;  4LM0 A;  1UDU A;  5AXP A;  5C1W A;  4TPP A;  2FM5 A;  3TVX A;  3KKT A;  4MD6 A;  1XMU A;  3DYQ A;  3HQW A;  4MVH A;  4AJG A;  1TAZ A;  3ECM A;  3O57 A;  1Y2K A;  3W5E A;  3DYS A;  4DFF A;  1XMY B;  5C29 A;  4Y8C A;  2OUY A;  4P0N A;  4G2Y A;  4MSN A;  4Y87 A;  5EDI B;  3HDZ A;  1UDT A;  4KP6 A;  1T9R A;  1RKP A;  4LM2 A;  3SN7 A;  2OUS A;  1XM6 A;  3I8V A;  4MSA A;  5C2A A;  5AXQ A;  5C28 A;  4LM1 A;  2OUU A;  5I2R A;  4PM0 A;  4W1O A;  4MSH A;  3D3P A;  4NPW A;  3G4K A;  4QGE A;  5K32 A;  1SO2 A;  3JSW A;  1XON A;  4MS0 A;  1XM4 B;  3SL5 A;  4FCD A;  3G4I A;  3K3H A;  3WD9 A;  5C2H A;  5EDH A;  3HQZ A;  4LM4 A;  2QYM A;  3HC8 A;  3O0J A;  4YS7 A;  1XOR A;  3JWR A;  3HQY A;  4LLP A;  1TBB A;  1TBF A; 
#chains in the Genus database with same CATH homology
 3V9B A;  4LLX A;  2OVV A;  1PTW A;  4NPV A;  1ZKL A;  2QYK A;  3IAD A;  5K1I A;  3G45 A;  3WI2 A;  4I9Z A;  5C2E A;  3IBJ A;  4AJD A;  3SHY A;  3TGG A;  4PHL A;  1ROR A;  3JWQ A;  4IA0 A;  3N3Z A;  1Y2D A;  4E90 A;  1XOZ A;  3BJC A;  4D08 A;  5K9R A;  2OUQ A;  2PW3 A;  3SHZ A;  4OEW A;  1Y2C A;  2R8Q A;  4ZO5 A;  3V93 A;  1OYN A;  4HTX A;  1XMU B;  3LXG A;  3HR1 A;  4MSC A;  1ZKN A;  1T9S A;  4WCU A;  1XOM A;  3G4G A;  3K3E A;  3DYN A;  3SNI A;  3SNL A;  3UI7 A;  4FCB A;  5B4K A;  2OUV A;  3HMV A;  2O8H A;  4XY2 A;  3DYL A;  4OEX A;  3G58 A;  1XN0 A;  1XLZ A;  2H42 A;  4WN1 A;  2H44 A;  5EDE A;  3V94 A;  1SOJ A;  4LM3 A;  2CHM A;  1XOS A;  3QPN A;  3QPP A;  4LLJ A;  2OUR A;  3SL6 A;  5DH5 A;  2WEY A;  2QYL A;  1Y2B A;  4MYQ A;  1Y2H A;  1TB7 A;  2H40 A;  3IAK A;  3K4S A;  3QI4 A;  2OUN A;  3JSI A;  3QPO A;  1RO6 A;  1XMY A;  3SIE A;  3ITM A;  4MSE A;  4G2J A;  1Y2J A;  4G2L A;  3ITU A;  4AJM A;  4YQH A;  4BBX A;  3TGE A;  4PHW A;  4HTZ A;  4G2W A;  4GH6 A;  3WYK A;  4AEL A;  3WYL A;  4HEU A;  5EDE B;  5EDG A;  4I15 A;  2FM0 A;  3UUO A;  1Q9M A;  5B25 A;  4P1R A;  3LY2 A;  1F0J A;  4OGB A;  4DDL A;  3G3N A;  4JIB A;  4NW7 A;  4D09 A;  3QI3 A;  1TB5 A;  2QYN A;  4MUW A;  3DY8 A;  4C1I A;  5B4L A;  3SL4 A;  3GWT A;  1XP0 A;  1RO9 A;  4X0F A;  1XM4 A;  1XLX A;  3FRG A;  3G4L A;  1XOT A;  3WS9 A;  2Y0J A;  3O56 A;  4MRZ A;  4LKQ A;  4TPM A;  5EDG B;  3SL8 A;  3SL3 A;  1Z1L A;  2OUP A;  4AJF A;  5DH4 A;  2OVY A;  3WYM A;  4WZI A;  1UHO A;  5EDI A;  2YY2 A;  4Y86 A;  4MRW A;  3ECN A;  4HF4 A;  4Y2B A;  3WS8 A;  1MKD A;  4LLK A;  1Y2E A;  1XOQ A;  2HD1 A;  3B2R A;  4LM0 A;  1UDU A;  5AXP A;  5C1W A;  4TPP A;  2FM5 A;  3TVX A;  3KKT A;  4MD6 A;  1XMU A;  3DYQ A;  3HQW A;  4MVH A;  4AJG A;  1TAZ A;  3ECM A;  3O57 A;  1Y2K A;  3W5E A;  3DYS A;  4DFF A;  1XMY B;  5C29 A;  4Y8C A;  2OUY A;  4P0N A;  4G2Y A;  4MSN A;  4Y87 A;  5EDI B;  3HDZ A;  1UDT A;  4KP6 A;  1T9R A;  1RKP A;  4LM2 A;  3SN7 A;  2OUS A;  1XM6 A;  3I8V A;  4MSA A;  5C2A A;  5AXQ A;  5C28 A;  4LM1 A;  2OUU A;  5I2R A;  4PM0 A;  4W1O A;  4MSH A;  3D3P A;  4NPW A;  3G4K A;  4QGE A;  5K32 A;  1SO2 A;  3JSW A;  1XON A;  4MS0 A;  1XM4 B;  3SL5 A;  4FCD A;  3G4I A;  3K3H A;  3WD9 A;  5C2H A;  5EDH A;  3HQZ A;  4LM4 A;  2QYM A;  3HC8 A;  3O0J A;  4YS7 A;  1XOR A;  3JWR A;  3HQY A;  4LLP A;  1TBB A;  1TBF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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