4MCCA

Hintrmd in complex with n-[4-(aminomethyl)benzyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
Total Genus 52
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
Knots found
sequence length
219
structure length
206
Chain Sequence
MWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Haemophilus influenzae
molecule keywords tRNA (guanine-N(1)-)-methyltransferase
total genus 52
structure length 206
sequence length 219
chains with identical sequence B
other databases KnotProt 2.0: K +31
ec nomenclature ec 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
pdb deposition date 2013-08-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01746 tRNA_m1G_MT tRNA (Guanine-1)-methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1270.20 Mainly Alpha Orthogonal Bundle Trp Operon Repressor; Chain A tRNA(m1g37)methyltransferase, domain 2 4mccA02
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 4mccA01
3QUVA 5CO4A 1X7OA 3ILKA 4YPZA 3KY7A 3IC6A 3OINA 4YQDA 1UALA 4MCDA 4YQTA 4H3YA 1TO0A 1UAMA 4YQOA 3NK6A 4YPXA 4YQ4A 1Z85A 4YQCA 3N4KA 1J85A 4YVHA 2HA8A 4YVJA 2V3KA 2QMMA 4X3MA 3BBEA 2QWVA 4YQRA 4YQJA 2CX8A 3E5YA 1O6DA 4YQ8A 4YQPA 1OY5A 4YPWA 4YPYA 5GMBA 1VH0A 1V2XA 4KGNA 4YVKA 1IPAA 5FAIA 4YQLA 3KNUA 1V6ZA 2O3AA 3GYQA 4YQNA 4YQAA 4YQ0A 3AXZA 1P9PA 4YVIA 4YQSA 4RG1A 2Z0YA 4L69A 1MXIA 4MCBA 4YQIA 4YVGA 2EGWA 3N4JA 3BBDA 4IG6A 4YQGA 2EGVA 4PZKA 1UAKA 1ZJRA 1VHYA 4YQ1A 5GM8A 4YQQA 3DCMX 3NK7A 4CNGA 3KW2A 4H3ZA 4YQ3A 3IEFA 1NS5A 4XBOA 4J3CA 1VHKA 1X7PA 3AIAA 3OIIA 4YQ7A 3O7BA 4CNDA 5D9FA 4JAKA 1UAJA 1GZ0A 3BBHA 4JALA 4FAKA 4MCCA 3OIJA 3L8UA 4YQKA 4YQ2A 2V3JA 4YQ6A 4E8BA 4CNFA 1K3RA 2I6DA 4YQBA 4YQ5A 1NXZA 4CNEA 3AI9X 5GMCA 2YY8A 4KDZA 4X3LA 3KTYA 4YQ9A 3ONPA
chains in the Genus database with same CATH superfamily
3QUVA 5CO4A 1X7OA 1TROA 3ILKA 4YPZA 3KY7A 3SSWN 3IC6A 3OINA 3KORA 4YQDA 1UALA 4MCDA 4YQTA 4H3YA 1TO0A 1UAMA 4YQOA 3NK6A 4YPXA 4YQ4A 1Z85A 4YQCA 1CO0A 3N4KA 1J85A 4YVHA 1TRRA 2HA8A 4YVJA 2V3KA 2QMMA 3WRPA 4X3MA 1RCSA 3BBEA 1WRPR 3G1CA 1JHGA 4YQRA 2QWVA 3FRWA 4YQJA 2CX8A 3E5YA 1O6DA 4YQ8A 4YQPA 1OY5A 4YPWA 4YPYA 5GMBA 1VH0A 1V2XA 4KGNA 4YVKA 1IPAA 5FAIA 2OZ9R 4YQLA 4FMWA 3KNUA 1V6ZA 2O3AA 1ZT9A 3GYQA 4YQNA 4YQAA 4YQ0A 3AXZA 1P9PA 4YVIA 4YQSA 4RG1A 2Z0YA 4L69A 1MXIA 4MCBA 4YQIA 4YVGA 2EGWA 3N4JA 3BBDA 4IG6A 4JWFA 4YQGA 2EGVA 4PZKA 1UAKA 1ZJRA 1VHYA 4YQ1A 5GM8A 1WRSR 4YQQA 3DCMX 3NK7A 4JWHA 3KW2A 4CNGA 4H3ZA 4YQ3A 3IEFA 1NS5A 4XBOA 4J3CA 1VHKA 1X7PA 3AIAA 3OIIA 4YQ7A 3O7BA 4CNDA 5D9FA 4JAKA 1UAJA 1GZ0A 3BBHA 4JALA 4FAKA 4MCCA 3OIJA 3L8UA 4YQKA 4YQ2A 1WRTR 2V3JA 4YQ6A 2XDIA 4E8BA 4CNFA 1MI7R 3SSXN 1K3RA 2I6DA 4YQBA 4YQ5A 1NXZA 4JWJA 4CNEA 3AI9X 5GMCA 2YY8A 4KDZA 4X3LA 3KTYA 4YQ9A 3ONPA 4JWGA
chains in the Genus database with same CATH topology
3QUVA 5CO4A 1X7OA 3ILKA 4YPZA 3KY7A 3IC6A 3OINA 4YQDA 1UALA 4MCDA 4YQTA 4H3YA 1TO0A 1UAMA 4YQOA 3NK6A 4YPXA 4YQ4A 1Z85A 4YQCA 3N4KA 1J85A 4YVHA 2HA8A 4YVJA 2V3KA 2QMMA 4X3MA 3BBEA 2QWVA 4YQRA 4YQJA 2CX8A 3E5YA 1O6DA 4YQ8A 4YQPA 1OY5A 4YPWA 4YPYA 5GMBA 1VH0A 1V2XA 4KGNA 4YVKA 1IPAA 5FAIA 4YQLA 4FMWA 3KNUA 1V6ZA 2O3AA 3GYQA 4YQNA 4YQAA 4YQ0A 3AXZA 1P9PA 4YVIA 4YQSA 4RG1A 2Z0YA 4L69A 1MXIA 4MCBA 4YQIA 4YVGA 2EGWA 3N4JA 3BBDA 4IG6A 4JWFA 4YQGA 2EGVA 4PZKA 1UAKA 1ZJRA 1VHYA 4YQ1A 5GM8A 4YQQA 3DCMX 3NK7A 4JWHA 3KW2A 4CNGA 4H3ZA 4YQ3A 3IEFA 1NS5A 4XBOA 4J3CA 1VHKA 1X7PA 3AIAA 3OIIA 4YQ7A 3O7BA 4CNDA 5D9FA 4JAKA 1UAJA 1GZ0A 3BBHA 4JALA 4FAKA 4MCCA 3OIJA 3L8UA 4YQKA 4YQ2A 2V3JA 4YQ6A 4E8BA 4CNFA 1K3RA 2I6DA 4YQBA 4YQ5A 1NXZA 4JWJA 4CNEA 3AI9X 5GMCA 2YY8A 4KDZA 4X3LA 3KTYA 4YQ9A 3ONPA 4JWGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QUV A;  5CO4 A;  1X7O A;  3ILK A;  4YPZ A;  3KY7 A;  3IC6 A;  3OIN A;  4YQD A;  1UAL A;  4MCD A;  4YQT A;  4H3Y A;  1TO0 A;  1UAM A;  4YQO A;  3NK6 A;  4YPX A;  4YQ4 A;  1Z85 A;  4YQC A;  3N4K A;  1J85 A;  4YVH A;  2HA8 A;  4YVJ A;  2V3K A;  2QMM A;  4X3M A;  3BBE A;  2QWV A;  4YQR A;  4YQJ A;  2CX8 A;  3E5Y A;  1O6D A;  4YQ8 A;  4YQP A;  1OY5 A;  4YPW A;  4YPY A;  5GMB A;  1VH0 A;  1V2X A;  4KGN A;  4YVK A;  1IPA A;  5FAI A;  4YQL A;  3KNU A;  1V6Z A;  2O3A A;  3GYQ A;  4YQN A;  4YQA A;  4YQ0 A;  3AXZ A;  1P9P A;  4YVI A;  4YQS A;  4RG1 A;  2Z0Y A;  4L69 A;  1MXI A;  4MCB A;  4YQI A;  4YVG A;  2EGW A;  3N4J A;  3BBD A;  4IG6 A;  4YQG A;  2EGV A;  4PZK A;  1UAK A;  1ZJR A;  1VHY A;  4YQ1 A;  5GM8 A;  4YQQ A;  3DCM X;  3NK7 A;  4CNG A;  3KW2 A;  4H3Z A;  4YQ3 A;  3IEF A;  1NS5 A;  4XBO A;  4J3C A;  1VHK A;  1X7P A;  3AIA A;  3OII A;  4YQ7 A;  3O7B A;  4CND A;  5D9F A;  4JAK A;  1UAJ A;  1GZ0 A;  3BBH A;  4JAL A;  4FAK A;  4MCC A;  3OIJ A;  3L8U A;  4YQK A;  4YQ2 A;  2V3J A;  4YQ6 A;  4E8B A;  4CNF A;  1K3R A;  2I6D A;  4YQB A;  4YQ5 A;  1NXZ A;  4CNE A;  3AI9 X;  5GMC A;  2YY8 A;  4KDZ A;  4X3L A;  3KTY A;  4YQ9 A;  3ONP A; 
#chains in the Genus database with same CATH topology
 3QUV A;  5CO4 A;  1X7O A;  1TRO A;  3ILK A;  4YPZ A;  3KY7 A;  3SSW N;  3IC6 A;  3OIN A;  3KOR A;  4YQD A;  1UAL A;  4MCD A;  4YQT A;  4H3Y A;  1TO0 A;  1UAM A;  4YQO A;  3NK6 A;  4YPX A;  4YQ4 A;  1Z85 A;  4YQC A;  1CO0 A;  3N4K A;  1J85 A;  4YVH A;  1TRR A;  2HA8 A;  4YVJ A;  2V3K A;  2QMM A;  3WRP A;  4X3M A;  1RCS A;  3BBE A;  1WRP R;  3G1C A;  1JHG A;  4YQR A;  2QWV A;  3FRW A;  4YQJ A;  2CX8 A;  3E5Y A;  1O6D A;  4YQ8 A;  4YQP A;  1OY5 A;  4YPW A;  4YPY A;  5GMB A;  1VH0 A;  1V2X A;  4KGN A;  4YVK A;  1IPA A;  5FAI A;  2OZ9 R;  4YQL A;  4FMW A;  3KNU A;  1V6Z A;  2O3A A;  1ZT9 A;  3GYQ A;  4YQN A;  4YQA A;  4YQ0 A;  3AXZ A;  1P9P A;  4YVI A;  4YQS A;  4RG1 A;  2Z0Y A;  4L69 A;  1MXI A;  4MCB A;  4YQI A;  4YVG A;  2EGW A;  3N4J A;  3BBD A;  4IG6 A;  4JWF A;  4YQG A;  2EGV A;  4PZK A;  1UAK A;  1ZJR A;  1VHY A;  4YQ1 A;  5GM8 A;  1WRS R;  4YQQ A;  3DCM X;  3NK7 A;  4JWH A;  3KW2 A;  4CNG A;  4H3Z A;  4YQ3 A;  3IEF A;  1NS5 A;  4XBO A;  4J3C A;  1VHK A;  1X7P A;  3AIA A;  3OII A;  4YQ7 A;  3O7B A;  4CND A;  5D9F A;  4JAK A;  1UAJ A;  1GZ0 A;  3BBH A;  4JAL A;  4FAK A;  4MCC A;  3OIJ A;  3L8U A;  4YQK A;  4YQ2 A;  1WRT R;  2V3J A;  4YQ6 A;  2XDI A;  4E8B A;  4CNF A;  1MI7 R;  3SSX N;  1K3R A;  2I6D A;  4YQB A;  4YQ5 A;  1NXZ A;  4JWJ A;  4CNE A;  3AI9 X;  5GMC A;  2YY8 A;  4KDZ A;  4X3L A;  3KTY A;  4YQ9 A;  3ONP A;  4JWG A; 
#chains in the Genus database with same CATH homology
 3QUV A;  5CO4 A;  1X7O A;  3ILK A;  4YPZ A;  3KY7 A;  3IC6 A;  3OIN A;  4YQD A;  1UAL A;  4MCD A;  4YQT A;  4H3Y A;  1TO0 A;  1UAM A;  4YQO A;  3NK6 A;  4YPX A;  4YQ4 A;  1Z85 A;  4YQC A;  3N4K A;  1J85 A;  4YVH A;  2HA8 A;  4YVJ A;  2V3K A;  2QMM A;  4X3M A;  3BBE A;  2QWV A;  4YQR A;  4YQJ A;  2CX8 A;  3E5Y A;  1O6D A;  4YQ8 A;  4YQP A;  1OY5 A;  4YPW A;  4YPY A;  5GMB A;  1VH0 A;  1V2X A;  4KGN A;  4YVK A;  1IPA A;  5FAI A;  4YQL A;  4FMW A;  3KNU A;  1V6Z A;  2O3A A;  3GYQ A;  4YQN A;  4YQA A;  4YQ0 A;  3AXZ A;  1P9P A;  4YVI A;  4YQS A;  4RG1 A;  2Z0Y A;  4L69 A;  1MXI A;  4MCB A;  4YQI A;  4YVG A;  2EGW A;  3N4J A;  3BBD A;  4IG6 A;  4JWF A;  4YQG A;  2EGV A;  4PZK A;  1UAK A;  1ZJR A;  1VHY A;  4YQ1 A;  5GM8 A;  4YQQ A;  3DCM X;  3NK7 A;  4JWH A;  3KW2 A;  4CNG A;  4H3Z A;  4YQ3 A;  3IEF A;  1NS5 A;  4XBO A;  4J3C A;  1VHK A;  1X7P A;  3AIA A;  3OII A;  4YQ7 A;  3O7B A;  4CND A;  5D9F A;  4JAK A;  1UAJ A;  1GZ0 A;  3BBH A;  4JAL A;  4FAK A;  4MCC A;  3OIJ A;  3L8U A;  4YQK A;  4YQ2 A;  2V3J A;  4YQ6 A;  4E8B A;  4CNF A;  1K3R A;  2I6D A;  4YQB A;  4YQ5 A;  1NXZ A;  4JWJ A;  4CNE A;  3AI9 X;  5GMC A;  2YY8 A;  4KDZ A;  4X3L A;  3KTY A;  4YQ9 A;  3ONP A;  4JWG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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