4YQSA

Crystal structure of trmd, a m1g37 trna methyltransferase with sam-competitive compounds
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
Knots found
sequence length
248
structure length
237
Chain Sequence
SHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGDGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds
rcsb
molecule tags Transferase/transferase inhibitor
source organism Haemophilus influenzae (strain atcc 51907 / dsm 11121 / kw20 / rd)
molecule keywords tRNA (guanine-N(1)-)-methyltransferase
total genus 71
structure length 237
sequence length 248
other databases KnotProt 2.0: K +31
ec nomenclature ec 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
pdb deposition date 2015-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01746 tRNA_m1G_MT tRNA (Guanine-1)-methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1270.20 Mainly Alpha Orthogonal Bundle Trp Operon Repressor; Chain A tRNA(m1g37)methyltransferase, domain 2 4yqsA02
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 4yqsA01
2Z0YA 5D9FA 4YQ9A 4KGNA 5GMCA 4YPYA 3BBEA 3O7BA 4YVJA 3IC6A 1OY5A 5GM8A 4YQDA 4L69A 3AI9X 1K3RA 2QMMA 5CO4A 3QUVA 4YPWA 1GZ0A 4YQCA 4YQAA 4YQBA 3KTYA 1NXZA 4YVKA 3BBHA 3KW2A 1UAKA 3N4KA 4YQ2A 4YVGA 2V3KA 3NK6A 4H3ZA 1NS5A 2QWVA 3AIAA 3OIIA 3DCMX 2O3AA 4YQSA 4YQ6A 4IG6A 4X3MA 2EGVA 4X3LA 1VHKA 4E8BA 4YQ8A 4FAKA 3BBDA 1VH0A 4YQJA 4CNFA 3AXZA 4YVIA 4YQ4A 4YQ1A 1UAMA 1P9PA 4YQ7A 4YVHA 4YQTA 4MCCA 3IEFA 4YPZA 3KNUA 1Z85A 4RG1A 1UAJA 1V6ZA 4MCBA 1IPAA 2YY8A 4KDZA 4XBOA 3ONPA 4H3YA 4YQ3A 2EGWA 4YQRA 4YQOA 1J85A 4CNDA 1X7OA 1V2XA 3N4JA 1VHYA 3NK7A 1UALA 1TO0A 2I6DA 4CNGA 1MXIA 3GYQA 3OIJA 1ZJRA 1X7PA 4YQ0A 4YPXA 5FAIA 4YQNA 2CX8A 2V3JA 4J3CA 3OINA 4YQLA 3L8UA 4PZKA 3E5YA 3ILKA 1O6DA 4YQGA 4JAKA 3KY7A 4YQPA 4YQQA 4MCDA 4YQKA 4CNEA 5GMBA 2HA8A 4JALA 4YQIA 4YQ5A
chains in the Genus database with same CATH superfamily
2Z0YA 1MI7R 1WRSR 5D9FA 4YQ9A 4KGNA 5GMCA 4YPYA 3BBEA 1JHGA 3O7BA 4YVJA 3IC6A 1OY5A 3SSXN 5GM8A 4YQDA 4L69A 3AI9X 1K3RA 2QMMA 3SSWN 5CO4A 3QUVA 4YPWA 1GZ0A 4YQCA 4YQAA 4YQBA 3KTYA 1NXZA 4YVKA 3BBHA 3KW2A 1UAKA 3N4KA 3FRWA 4YQ2A 4YVGA 2V3KA 3NK6A 1TRRA 4H3ZA 1NS5A 2QWVA 3AIAA 4JWFA 3OIIA 3DCMX 2O3AA 4YQSA 4YQ6A 4IG6A 4X3MA 2EGVA 4X3LA 1VHKA 4E8BA 4YQ8A 4FAKA 3BBDA 1VH0A 4YQJA 4CNFA 1RCSA 3AXZA 4YVIA 4YQ4A 4YQ1A 1UAMA 3G1CA 1P9PA 4YQ7A 1WRPR 4YVHA 4JWJA 4YQTA 4MCCA 3IEFA 4YPZA 3KNUA 1Z85A 4RG1A 4MCBA 1UAJA 1V6ZA 1IPAA 2YY8A 4KDZA 4XBOA 3ONPA 4H3YA 4YQ3A 2EGWA 4YQRA 4YQOA 1J85A 2XDIA 4CNDA 1X7OA 3WRPA 1V2XA 3N4JA 1VHYA 4FMWA 3NK7A 1UALA 1TO0A 2I6DA 4CNGA 1MXIA 3GYQA 2OZ9R 3OIJA 1ZJRA 1X7PA 4YQ0A 1ZT9A 4YPXA 5FAIA 4YQNA 2CX8A 2V3JA 4J3CA 3OINA 3KORA 4YQLA 3L8UA 4PZKA 3E5YA 3ILKA 4JWGA 1O6DA 4YQGA 4JAKA 1WRTR 3KY7A 4YQPA 4YQQA 1TROA 4MCDA 4YQKA 4JWHA 4CNEA 5GMBA 2HA8A 4JALA 4YQIA 1CO0A 4YQ5A
chains in the Genus database with same CATH topology
2Z0YA 5D9FA 4YQ9A 4KGNA 5GMCA 4YPYA 3BBEA 3O7BA 4YVJA 3IC6A 1OY5A 5GM8A 4YQDA 4L69A 3AI9X 1K3RA 2QMMA 5CO4A 3QUVA 4YPWA 1GZ0A 4YQCA 4YQAA 4YQBA 3KTYA 1NXZA 4YVKA 3BBHA 3KW2A 1UAKA 3N4KA 4YQ2A 4YVGA 2V3KA 3NK6A 4H3ZA 1NS5A 2QWVA 3AIAA 4JWFA 3OIIA 3DCMX 2O3AA 4YQSA 4YQ6A 4IG6A 4X3MA 2EGVA 4X3LA 1VHKA 4E8BA 4YQ8A 4FAKA 3BBDA 1VH0A 4YQJA 4CNFA 3AXZA 4YVIA 4YQ4A 4YQ1A 1UAMA 1P9PA 4YQ7A 4YVHA 4JWJA 4YQTA 4MCCA 3IEFA 4YPZA 3KNUA 1Z85A 4RG1A 1UAJA 1V6ZA 4MCBA 1IPAA 2YY8A 4KDZA 4XBOA 3ONPA 4H3YA 4YQ3A 2EGWA 4YQRA 4YQOA 1J85A 4CNDA 1X7OA 1V2XA 3N4JA 1VHYA 4FMWA 3NK7A 1UALA 1TO0A 2I6DA 4CNGA 1MXIA 3GYQA 3OIJA 1ZJRA 1X7PA 4YQ0A 4YPXA 5FAIA 4YQNA 2CX8A 2V3JA 4J3CA 3OINA 4YQLA 3L8UA 4PZKA 3E5YA 3ILKA 4JWGA 1O6DA 4YQGA 4JAKA 3KY7A 4YQPA 4YQQA 4MCDA 4YQKA 4JWHA 4CNEA 5GMBA 2HA8A 4JALA 4YQIA 4YQ5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Z0Y A;  5D9F A;  4YQ9 A;  4KGN A;  5GMC A;  4YPY A;  3BBE A;  3O7B A;  4YVJ A;  3IC6 A;  1OY5 A;  5GM8 A;  4YQD A;  4L69 A;  3AI9 X;  1K3R A;  2QMM A;  5CO4 A;  3QUV A;  4YPW A;  1GZ0 A;  4YQC A;  4YQA A;  4YQB A;  3KTY A;  1NXZ A;  4YVK A;  3BBH A;  3KW2 A;  1UAK A;  3N4K A;  4YQ2 A;  4YVG A;  2V3K A;  3NK6 A;  4H3Z A;  1NS5 A;  2QWV A;  3AIA A;  3OII A;  3DCM X;  2O3A A;  4YQS A;  4YQ6 A;  4IG6 A;  4X3M A;  2EGV A;  4X3L A;  1VHK A;  4E8B A;  4YQ8 A;  4FAK A;  3BBD A;  1VH0 A;  4YQJ A;  4CNF A;  3AXZ A;  4YVI A;  4YQ4 A;  4YQ1 A;  1UAM A;  1P9P A;  4YQ7 A;  4YVH A;  4YQT A;  4MCC A;  3IEF A;  4YPZ A;  3KNU A;  1Z85 A;  4RG1 A;  1UAJ A;  1V6Z A;  4MCB A;  1IPA A;  2YY8 A;  4KDZ A;  4XBO A;  3ONP A;  4H3Y A;  4YQ3 A;  2EGW A;  4YQR A;  4YQO A;  1J85 A;  4CND A;  1X7O A;  1V2X A;  3N4J A;  1VHY A;  3NK7 A;  1UAL A;  1TO0 A;  2I6D A;  4CNG A;  1MXI A;  3GYQ A;  3OIJ A;  1ZJR A;  1X7P A;  4YQ0 A;  4YPX A;  5FAI A;  4YQN A;  2CX8 A;  2V3J A;  4J3C A;  3OIN A;  4YQL A;  3L8U A;  4PZK A;  3E5Y A;  3ILK A;  1O6D A;  4YQG A;  4JAK A;  3KY7 A;  4YQP A;  4YQQ A;  4MCD A;  4YQK A;  4CNE A;  5GMB A;  2HA8 A;  4JAL A;  4YQI A;  4YQ5 A; 
#chains in the Genus database with same CATH topology
 2Z0Y A;  1MI7 R;  1WRS R;  5D9F A;  4YQ9 A;  4KGN A;  5GMC A;  4YPY A;  3BBE A;  1JHG A;  3O7B A;  4YVJ A;  3IC6 A;  1OY5 A;  3SSX N;  5GM8 A;  4YQD A;  4L69 A;  3AI9 X;  1K3R A;  2QMM A;  3SSW N;  5CO4 A;  3QUV A;  4YPW A;  1GZ0 A;  4YQC A;  4YQA A;  4YQB A;  3KTY A;  1NXZ A;  4YVK A;  3BBH A;  3KW2 A;  1UAK A;  3N4K A;  3FRW A;  4YQ2 A;  4YVG A;  2V3K A;  3NK6 A;  1TRR A;  4H3Z A;  1NS5 A;  2QWV A;  3AIA A;  4JWF A;  3OII A;  3DCM X;  2O3A A;  4YQS A;  4YQ6 A;  4IG6 A;  4X3M A;  2EGV A;  4X3L A;  1VHK A;  4E8B A;  4YQ8 A;  4FAK A;  3BBD A;  1VH0 A;  4YQJ A;  4CNF A;  1RCS A;  3AXZ A;  4YVI A;  4YQ4 A;  4YQ1 A;  1UAM A;  3G1C A;  1P9P A;  4YQ7 A;  1WRP R;  4YVH A;  4JWJ A;  4YQT A;  4MCC A;  3IEF A;  4YPZ A;  3KNU A;  1Z85 A;  4RG1 A;  4MCB A;  1UAJ A;  1V6Z A;  1IPA A;  2YY8 A;  4KDZ A;  4XBO A;  3ONP A;  4H3Y A;  4YQ3 A;  2EGW A;  4YQR A;  4YQO A;  1J85 A;  2XDI A;  4CND A;  1X7O A;  3WRP A;  1V2X A;  3N4J A;  1VHY A;  4FMW A;  3NK7 A;  1UAL A;  1TO0 A;  2I6D A;  4CNG A;  1MXI A;  3GYQ A;  2OZ9 R;  3OIJ A;  1ZJR A;  1X7P A;  4YQ0 A;  1ZT9 A;  4YPX A;  5FAI A;  4YQN A;  2CX8 A;  2V3J A;  4J3C A;  3OIN A;  3KOR A;  4YQL A;  3L8U A;  4PZK A;  3E5Y A;  3ILK A;  4JWG A;  1O6D A;  4YQG A;  4JAK A;  1WRT R;  3KY7 A;  4YQP A;  4YQQ A;  1TRO A;  4MCD A;  4YQK A;  4JWH A;  4CNE A;  5GMB A;  2HA8 A;  4JAL A;  4YQI A;  1CO0 A;  4YQ5 A; 
#chains in the Genus database with same CATH homology
 2Z0Y A;  5D9F A;  4YQ9 A;  4KGN A;  5GMC A;  4YPY A;  3BBE A;  3O7B A;  4YVJ A;  3IC6 A;  1OY5 A;  5GM8 A;  4YQD A;  4L69 A;  3AI9 X;  1K3R A;  2QMM A;  5CO4 A;  3QUV A;  4YPW A;  1GZ0 A;  4YQC A;  4YQA A;  4YQB A;  3KTY A;  1NXZ A;  4YVK A;  3BBH A;  3KW2 A;  1UAK A;  3N4K A;  4YQ2 A;  4YVG A;  2V3K A;  3NK6 A;  4H3Z A;  1NS5 A;  2QWV A;  3AIA A;  4JWF A;  3OII A;  3DCM X;  2O3A A;  4YQS A;  4YQ6 A;  4IG6 A;  4X3M A;  2EGV A;  4X3L A;  1VHK A;  4E8B A;  4YQ8 A;  4FAK A;  3BBD A;  1VH0 A;  4YQJ A;  4CNF A;  3AXZ A;  4YVI A;  4YQ4 A;  4YQ1 A;  1UAM A;  1P9P A;  4YQ7 A;  4YVH A;  4JWJ A;  4YQT A;  4MCC A;  3IEF A;  4YPZ A;  3KNU A;  1Z85 A;  4RG1 A;  1UAJ A;  1V6Z A;  4MCB A;  1IPA A;  2YY8 A;  4KDZ A;  4XBO A;  3ONP A;  4H3Y A;  4YQ3 A;  2EGW A;  4YQR A;  4YQO A;  1J85 A;  4CND A;  1X7O A;  1V2X A;  3N4J A;  1VHY A;  4FMW A;  3NK7 A;  1UAL A;  1TO0 A;  2I6D A;  4CNG A;  1MXI A;  3GYQ A;  3OIJ A;  1ZJR A;  1X7P A;  4YQ0 A;  4YPX A;  5FAI A;  4YQN A;  2CX8 A;  2V3J A;  4J3C A;  3OIN A;  4YQL A;  3L8U A;  4PZK A;  3E5Y A;  3ILK A;  4JWG A;  1O6D A;  4YQG A;  4JAK A;  3KY7 A;  4YQP A;  4YQQ A;  4MCD A;  4YQK A;  4JWH A;  4CNE A;  5GMB A;  2HA8 A;  4JAL A;  4YQI A;  4YQ5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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