5AMHA

Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with thalidomide, trigonal crystal form
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
106
structure length
106
Chain Sequence
GASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
molecule keywords CEREBLON ISOFORM 4
publication title Structural Dynamics of the Cereblon Ligand Binding Domain.
pubmed doi rcsb
source organism Magnetospirillum gryphiswaldense
total genus 21
structure length 106
sequence length 106
ec nomenclature
pdb deposition date 2015-03-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 5amhA00
4CI1B 5AMHA 3WX1A 3MAOA 2KZNA 4V30A 3CXKA 3HCHA 4TZCA 3E0MA 4V2ZA 4CI2B 3E0OA 2KV1A 3HCJA 1L1DA 4TZ4C 4V31A 3WX2A 3HCGA 2K8DA 3CEZA 4V2YA 4TZUA 4CI3B 3HCIA
chains in the Genus database with same CATH superfamily
4CI1B 3LRNA 2W4RA 5AMHA 3WX1A 2QFDA 3MAOA 2KZNA 4V30A 3CXKA 3OG8A 2RQAA 3ZD7A 2YKGA 3HCHA 4TZCA 1HXRA 5F98A 3E0MA 4V2ZA 4CI2B 2QFBA 3E0OA 3GA3A 3ZD6A 3LRRA 5E3HA 2KV1A 2RMJA 1H6QA 3EBMA 4A2XA 3HCJA 1L1DA 4TZ4C 4V31A 2LOYA 4BPBA 3EQTA 5F9HA 4A2VA 3WX2A 3DJMA 2RQBA 3HCGA 3P3KA 4AY2A 1H7YA 2K8DA 1YZ1A 1TXJA 2LVLA 3NCUA 2HR9A 3CEZA 4V2YA 4TZUA 3FACA 3HCIA 4CI3B 5F9FA 2FU5A 2KWBA 1FWQA
chains in the Genus database with same CATH topology
4CI1B 5AMHA 3WX1A 3MAOA 2KZNA 4V30A 3CXKA 3HCHA 4TZCA 3E0MA 4V2ZA 4CI2B 3E0OA 2KV1A 3HCJA 1L1DA 4TZ4C 4V31A 3WX2A 3HCGA 2K8DA 3CEZA 4V2YA 4TZUA 4CI3B 3HCIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4CI1 B;  5AMH A;  3WX1 A;  3MAO A;  2KZN A;  4V30 A;  3CXK A;  3HCH A;  4TZC A;  3E0M A;  4V2Z A;  4CI2 B;  3E0O A;  2KV1 A;  3HCJ A;  1L1D A;  4TZ4 C;  4V31 A;  3WX2 A;  3HCG A;  2K8D A;  3CEZ A;  4V2Y A;  4TZU A;  4CI3 B;  3HCI A; 
#chains in the Genus database with same CATH topology
 4CI1 B;  3LRN A;  2W4R A;  5AMH A;  3WX1 A;  2QFD A;  3MAO A;  2KZN A;  4V30 A;  3CXK A;  3OG8 A;  2RQA A;  3ZD7 A;  2YKG A;  3HCH A;  4TZC A;  1HXR A;  5F98 A;  3E0M A;  4V2Z A;  4CI2 B;  2QFB A;  3E0O A;  3GA3 A;  3ZD6 A;  3LRR A;  5E3H A;  2KV1 A;  2RMJ A;  1H6Q A;  3EBM A;  4A2X A;  3HCJ A;  1L1D A;  4TZ4 C;  4V31 A;  2LOY A;  4BPB A;  3EQT A;  5F9H A;  4A2V A;  3WX2 A;  3DJM A;  2RQB A;  3HCG A;  3P3K A;  4AY2 A;  1H7Y A;  2K8D A;  1YZ1 A;  1TXJ A;  2LVL A;  3NCU A;  2HR9 A;  3CEZ A;  4V2Y A;  4TZU A;  3FAC A;  3HCI A;  4CI3 B;  5F9F A;  2FU5 A;  2KWB A;  1FWQ A; 
#chains in the Genus database with same CATH homology
 4CI1 B;  5AMH A;  3WX1 A;  3MAO A;  2KZN A;  4V30 A;  3CXK A;  3HCH A;  4TZC A;  3E0M A;  4V2Z A;  4CI2 B;  3E0O A;  2KV1 A;  3HCJ A;  1L1D A;  4TZ4 C;  4V31 A;  3WX2 A;  3HCG A;  2K8D A;  3CEZ A;  4V2Y A;  4TZU A;  4CI3 B;  3HCI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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