5EF8A

Crystal structure of danio rerio histone deacetylase 6 catalytic domain 2 in complex with panobinostat
Total Genus 143
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
143
sequence length
357
structure length
357
Chain Sequence
PITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Hdac6 protein
publication title Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
pubmed doi rcsb
source organism Danio rerio
total genus 143
structure length 357
sequence length 357
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2015-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5ef8A00
3F0RA 1ZZ1A 5G0IA 3C10A 5G1CA 1T69A 4ZUMA 5DC7A 5FUEA 5D1DA 5DC6A 4ZUOA 4QA4A 5D1BA 3MZ4A 5G0HA 1ZZ3A 4QA1A 4BKXB 3MENA 5IX0A 5THUA 1ZZ0A 3EZPA 2V5WA 4CBTA 5G17A 3C0YA 3Q9CA 5G0XA 5EENA 5EEIA 3MZ6A 3MZ7A 4QA6A 4ZURA 5G13A 2V5XA 3F07A 2VCGA 5EFJD 5G11A 3ZNSA 1W22A 5DC8A 5EEKA 5EF8A 4QA5A 3EW8A 5G3WA 3C0ZA 5EFKB 3F06A 5ICNB 4BZ6A 4RN2A 5EFHA 4ZUNA 5EEMA 2VQJA 5EEFA 4RN0A 4BZ5A 4LY1A 1C3SA 5EFBD 3MAXA 4LXZA 3EWFA 5G0GA 2GH6A 4BZ8A 3ZNRA 4QA2A 3SFHA 2VQQA 4CBYA 5JI5A 2VQMA 3EZTA 1C3PA 5G10A 4QA0A 3RQDA 5EF7A 3Q9BA 2VQVA 4QA3A 4BZ7A 5THTA 3Q9EA 5G0YA 4A69A 5EFGA 5THSA 4RN1A 3MZ3A 5THVA 1T64A 2VQWG 3Q9FA 5EFNA 5G1AA 2VQOA 1T67A 4ZUQA 5D1CA 5G12A 3SFFA 5G0JA 1VKGA 5A2SA 4BZ9A 5DC5A 5LI3A 4QA7A 1C3RA 5G1BA 5IWGA 5BWZA 4ZUPA 5FCWA 4CQFA
chains in the Genus database with same CATH superfamily
3SL0A 3F0RA 1ZZ1A 4G3HA 1TA1A 3C10A 5G1CA 4FCIA 1WVBA 1T69A 5G0IA 1P8PA 1XFKA 4IE1A 4IU1A 4ZUMA 4RHIA 5DC7A 5FUEA 3GMZA 1P8RA 3LP7A 5D1DA 5DC6A 4ZUOA 5HJ9A 1WVAA 4QA4A 1ZPGA 5D1BA 3KV2A 3MZ4A 5G0HA 3MJLA 1RLAA 1ZZ3A 4QA1A 4IE3A 3THJA 4BKXB 3MENA 4MXRA 5HJAA 4BZ7A 3LHLA 4DZ4A 5IX0A 1TBHA 2CEVA 1HQXA 5THUA 1ZZ0A 3EZPA 2V5WA 3NIOA 2PHOA 2EIVA 3E8QA 4CBTA 5G17A 4Q42A 3C0YA 3Q9CA 5G0XA 3MFVA 5EENA 4RHKA 5EEIA 4RHQA 3MZ6A 3MZ7A 1T4TA 1TBJA 4QA6A 4Q3RC 4ZURA 4Q3QA 2V5XA 5G13A 3F07A 2VCGA 3TH7A 5EFJD 5G11A 2PHAA 4Q3RA 3ZNSA 1HQGA 1T4PA 4Q3VA 1W22A 4MYLA 4Q41A 1WOHA 4Q3UA 5DC8A 5EEKA 1P8NA 3MMRA 4RHLA 1HQFA 5EF8A 4QA5A 4Q3PA 3SJTA 2RLAA 4I06A 3EW8A 2PLLA 5G3WA 4FCKA 4IXUA 3C0ZA 5EFKB 3F06A 5ICNB 4BZ6A 4HWWA 4GWDA 4RN2A 5EFHA 4ZUNA 1R1OA 2VQJA 4IU0A 4Q40A 5EEFA 5EEMA 1HQHA 4RN0A 4IU4A 2AEBA 3M1RA 4BZ5A 1P8SA 4RLAA 4LY1A 3LP4A 1C3SA 5EFBD 1T5FA 2EF5A 3MAXA 4LXZA 3EWFA 5G0GA 2GH6A 3F80A 3MFWA 3ZNRA 4BZ8A 4QA2A 3SFHA 2VQQA 5CEVA 4CBYA 5JI5A 2VQMA 3E8ZA 3TF3A 3EZTA 1C3PA 5G10A 4QA0A 3RQDA 5EF7A 3THHA 3Q9BA 4MYKA 4IU5A 3E9BA 4IE2A 4RHMA 3RLAA 2VQVA 3GN0A 1P8MA 4QA3A 3DJ8A 4IXVA 4Q3TA 3CEVA 3Q9EA 5G0YA 1TBLA 5THTA 4A69A 5EFGA 1P8QA 3E6KA 4HZEA 5THSA 1ZPEA 1T5GA 4RN1A 3MZ3A 5THVA 1T64A 1WOIA 1T4RA 2VQWG 3Q9FA 5EFNA 5G1AA 4GSVA 5RLAA 3SL1A 3THEA 2VQOA 4RHJA 1D3VA 1T4SA 1T67A 4ZUQA 5D1CA 5G12A 3SFFA 3SKKA 3PZLA 3NIQA 2A0MA 1PQ3A 4GWCA 2EF4A 5G0JA 1VKGA 4GSZA 1WOGA 3NIPA 4GSMA 1P8OA 1GQ7A 4MYFA 5A2SA 1HQ5A 4BZ9A 4HXQA 1CEVA 5DC5A 1GQ6A 3E6VA 4QA7A 1C3RA 5G1BA 5IWGA 4MYNA 5LI3A 5BWZA 4ZUPA 4CEVA 2ZAVA 5FCWA 4Q3SA 4ITYA 4CQFA
chains in the Genus database with same CATH topology
3F0RA 1ZZ1A 5G0IA 3C10A 5G1CA 1T69A 4ZUMA 5DC7A 5FUEA 5D1DA 5DC6A 4ZUOA 4QA4A 5D1BA 3MZ4A 5G0HA 1ZZ3A 4QA1A 4BKXB 3MENA 5IX0A 5THUA 1ZZ0A 3EZPA 2V5WA 4CBTA 5G17A 3C0YA 3Q9CA 5G0XA 5EENA 5EEIA 3MZ6A 3MZ7A 4QA6A 4ZURA 5G13A 2V5XA 3F07A 2VCGA 5EFJD 5G11A 3ZNSA 1W22A 5DC8A 5EEKA 5EF8A 4QA5A 3EW8A 5G3WA 3C0ZA 5EFKB 3F06A 5ICNB 4BZ6A 4RN2A 5EFHA 4ZUNA 5EEMA 2VQJA 5EEFA 4RN0A 4BZ5A 4LY1A 1C3SA 5EFBD 3MAXA 4LXZA 3EWFA 5G0GA 2GH6A 4BZ8A 3ZNRA 4QA2A 3SFHA 2VQQA 4CBYA 5JI5A 2VQMA 3EZTA 1C3PA 5G10A 4QA0A 3RQDA 5EF7A 3Q9BA 2VQVA 4QA3A 4BZ7A 5THTA 3Q9EA 5G0YA 4A69A 5EFGA 5THSA 4RN1A 3MZ3A 5THVA 1T64A 2VQWG 3Q9FA 5EFNA 5G1AA 2VQOA 1T67A 4ZUQA 5D1CA 5G12A 3SFFA 5G0JA 1VKGA 5A2SA 4BZ9A 5DC5A 5LI3A 4QA7A 1C3RA 5G1BA 5IWGA 5BWZA 4ZUPA 5FCWA 4CQFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3F0R A;  1ZZ1 A;  5G0I A;  3C10 A;  5G1C A;  1T69 A;  4ZUM A;  5DC7 A;  5FUE A;  5D1D A;  5DC6 A;  4ZUO A;  4QA4 A;  5D1B A;  3MZ4 A;  5G0H A;  1ZZ3 A;  4QA1 A;  4BKX B;  3MEN A;  5IX0 A;  5THU A;  1ZZ0 A;  3EZP A;  2V5W A;  4CBT A;  5G17 A;  3C0Y A;  3Q9C A;  5G0X A;  5EEN A;  5EEI A;  3MZ6 A;  3MZ7 A;  4QA6 A;  4ZUR A;  5G13 A;  2V5X A;  3F07 A;  2VCG A;  5EFJ D;  5G11 A;  3ZNS A;  1W22 A;  5DC8 A;  5EEK A;  5EF8 A;  4QA5 A;  3EW8 A;  5G3W A;  3C0Z A;  5EFK B;  3F06 A;  5ICN B;  4BZ6 A;  4RN2 A;  5EFH A;  4ZUN A;  5EEM A;  2VQJ A;  5EEF A;  4RN0 A;  4BZ5 A;  4LY1 A;  1C3S A;  5EFB D;  3MAX A;  4LXZ A;  3EWF A;  5G0G A;  2GH6 A;  4BZ8 A;  3ZNR A;  4QA2 A;  3SFH A;  2VQQ A;  4CBY A;  5JI5 A;  2VQM A;  3EZT A;  1C3P A;  5G10 A;  4QA0 A;  3RQD A;  5EF7 A;  3Q9B A;  2VQV A;  4QA3 A;  4BZ7 A;  5THT A;  3Q9E A;  5G0Y A;  4A69 A;  5EFG A;  5THS A;  4RN1 A;  3MZ3 A;  5THV A;  1T64 A;  2VQW G;  3Q9F A;  5EFN A;  5G1A A;  2VQO A;  1T67 A;  4ZUQ A;  5D1C A;  5G12 A;  3SFF A;  5G0J A;  1VKG A;  5A2S A;  4BZ9 A;  5DC5 A;  5LI3 A;  4QA7 A;  1C3R A;  5G1B A;  5IWG A;  5BWZ A;  4ZUP A;  5FCW A;  4CQF A; 
#chains in the Genus database with same CATH topology
 3SL0 A;  3F0R A;  1ZZ1 A;  4G3H A;  1TA1 A;  3C10 A;  5G1C A;  4FCI A;  1WVB A;  1T69 A;  5G0I A;  1P8P A;  1XFK A;  4IE1 A;  4IU1 A;  4ZUM A;  4RHI A;  5DC7 A;  5FUE A;  3GMZ A;  1P8R A;  3LP7 A;  5D1D A;  5DC6 A;  4ZUO A;  5HJ9 A;  1WVA A;  4QA4 A;  1ZPG A;  5D1B A;  3KV2 A;  3MZ4 A;  5G0H A;  3MJL A;  1RLA A;  1ZZ3 A;  4QA1 A;  4IE3 A;  3THJ A;  4BKX B;  3MEN A;  4MXR A;  5HJA A;  4BZ7 A;  3LHL A;  4DZ4 A;  5IX0 A;  1TBH A;  2CEV A;  1HQX A;  5THU A;  1ZZ0 A;  3EZP A;  2V5W A;  3NIO A;  2PHO A;  2EIV A;  3E8Q A;  4CBT A;  5G17 A;  4Q42 A;  3C0Y A;  3Q9C A;  5G0X A;  3MFV A;  5EEN A;  4RHK A;  5EEI A;  4RHQ A;  3MZ6 A;  3MZ7 A;  1T4T A;  1TBJ A;  4QA6 A;  4Q3R C;  4ZUR A;  4Q3Q A;  2V5X A;  5G13 A;  3F07 A;  2VCG A;  3TH7 A;  5EFJ D;  5G11 A;  2PHA A;  4Q3R A;  3ZNS A;  1HQG A;  1T4P A;  4Q3V A;  1W22 A;  4MYL A;  4Q41 A;  1WOH A;  4Q3U A;  5DC8 A;  5EEK A;  1P8N A;  3MMR A;  4RHL A;  1HQF A;  5EF8 A;  4QA5 A;  4Q3P A;  3SJT A;  2RLA A;  4I06 A;  3EW8 A;  2PLL A;  5G3W A;  4FCK A;  4IXU A;  3C0Z A;  5EFK B;  3F06 A;  5ICN B;  4BZ6 A;  4HWW A;  4GWD A;  4RN2 A;  5EFH A;  4ZUN A;  1R1O A;  2VQJ A;  4IU0 A;  4Q40 A;  5EEF A;  5EEM A;  1HQH A;  4RN0 A;  4IU4 A;  2AEB A;  3M1R A;  4BZ5 A;  1P8S A;  4RLA A;  4LY1 A;  3LP4 A;  1C3S A;  5EFB D;  1T5F A;  2EF5 A;  3MAX A;  4LXZ A;  3EWF A;  5G0G A;  2GH6 A;  3F80 A;  3MFW A;  3ZNR A;  4BZ8 A;  4QA2 A;  3SFH A;  2VQQ A;  5CEV A;  4CBY A;  5JI5 A;  2VQM A;  3E8Z A;  3TF3 A;  3EZT A;  1C3P A;  5G10 A;  4QA0 A;  3RQD A;  5EF7 A;  3THH A;  3Q9B A;  4MYK A;  4IU5 A;  3E9B A;  4IE2 A;  4RHM A;  3RLA A;  2VQV A;  3GN0 A;  1P8M A;  4QA3 A;  3DJ8 A;  4IXV A;  4Q3T A;  3CEV A;  3Q9E A;  5G0Y A;  1TBL A;  5THT A;  4A69 A;  5EFG A;  1P8Q A;  3E6K A;  4HZE A;  5THS A;  1ZPE A;  1T5G A;  4RN1 A;  3MZ3 A;  5THV A;  1T64 A;  1WOI A;  1T4R A;  2VQW G;  3Q9F A;  5EFN A;  5G1A A;  4GSV A;  5RLA A;  3SL1 A;  3THE A;  2VQO A;  4RHJ A;  1D3V A;  1T4S A;  1T67 A;  4ZUQ A;  5D1C A;  5G12 A;  3SFF A;  3SKK A;  3PZL A;  3NIQ A;  2A0M A;  1PQ3 A;  4GWC A;  2EF4 A;  5G0J A;  1VKG A;  4GSZ A;  1WOG A;  3NIP A;  4GSM A;  1P8O A;  1GQ7 A;  4MYF A;  5A2S A;  1HQ5 A;  4BZ9 A;  4HXQ A;  1CEV A;  5DC5 A;  1GQ6 A;  3E6V A;  4QA7 A;  1C3R A;  5G1B A;  5IWG A;  4MYN A;  5LI3 A;  5BWZ A;  4ZUP A;  4CEV A;  2ZAV A;  5FCW A;  4Q3S A;  4ITY A;  4CQF A; 
#chains in the Genus database with same CATH homology
 3F0R A;  1ZZ1 A;  5G0I A;  3C10 A;  5G1C A;  1T69 A;  4ZUM A;  5DC7 A;  5FUE A;  5D1D A;  5DC6 A;  4ZUO A;  4QA4 A;  5D1B A;  3MZ4 A;  5G0H A;  1ZZ3 A;  4QA1 A;  4BKX B;  3MEN A;  5IX0 A;  5THU A;  1ZZ0 A;  3EZP A;  2V5W A;  4CBT A;  5G17 A;  3C0Y A;  3Q9C A;  5G0X A;  5EEN A;  5EEI A;  3MZ6 A;  3MZ7 A;  4QA6 A;  4ZUR A;  5G13 A;  2V5X A;  3F07 A;  2VCG A;  5EFJ D;  5G11 A;  3ZNS A;  1W22 A;  5DC8 A;  5EEK A;  5EF8 A;  4QA5 A;  3EW8 A;  5G3W A;  3C0Z A;  5EFK B;  3F06 A;  5ICN B;  4BZ6 A;  4RN2 A;  5EFH A;  4ZUN A;  5EEM A;  2VQJ A;  5EEF A;  4RN0 A;  4BZ5 A;  4LY1 A;  1C3S A;  5EFB D;  3MAX A;  4LXZ A;  3EWF A;  5G0G A;  2GH6 A;  4BZ8 A;  3ZNR A;  4QA2 A;  3SFH A;  2VQQ A;  4CBY A;  5JI5 A;  2VQM A;  3EZT A;  1C3P A;  5G10 A;  4QA0 A;  3RQD A;  5EF7 A;  3Q9B A;  2VQV A;  4QA3 A;  4BZ7 A;  5THT A;  3Q9E A;  5G0Y A;  4A69 A;  5EFG A;  5THS A;  4RN1 A;  3MZ3 A;  5THV A;  1T64 A;  2VQW G;  3Q9F A;  5EFN A;  5G1A A;  2VQO A;  1T67 A;  4ZUQ A;  5D1C A;  5G12 A;  3SFF A;  5G0J A;  1VKG A;  5A2S A;  4BZ9 A;  5DC5 A;  5LI3 A;  4QA7 A;  1C3R A;  5G1B A;  5IWG A;  5BWZ A;  4ZUP A;  5FCW A;  4CQF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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