5EFHA

Crystal structure of danio rerio histone deacetylase 6 catalytic domain 2 in complex with trifluoroketone transition state analogue
Total Genus 141
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
141
sequence length
356
structure length
356
Chain Sequence
ITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Hdac6 protein
publication title Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
pubmed doi rcsb
source organism Danio rerio
total genus 141
structure length 356
sequence length 356
chains with identical sequence D
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2015-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5efhA00
4ZURA 5IWGA 1T64A 5G3WA 5G0XA 5G12A 3Q9EA 5D1DA 5THTA 3EW8A 4QA2A 5EEMA 3F06A 5EENA 4QA7A 4QA0A 4RN2A 1ZZ0A 3SFHA 3SFFA 4ZUOA 3MZ7A 5G0HA 5G17A 5EF8A 3F07A 5G1CA 3Q9BA 3EZPA 5IX0A 1C3SA 2VQJA 1ZZ1A 1C3PA 2VQOA 4CBYA 3C0YA 3F0RA 1VKGA 5EFJD 4ZUPA 3ZNRA 5EEIA 3ZNSA 5G0JA 4RN1A 4QA3A 2VQMA 5EEKA 4ZUNA 5D1BA 4ZUQA 5JI5A 3RQDA 2V5XA 2GH6A 5ICNB 5G11A 5THVA 1ZZ3A 4BZ7A 5LI3A 5A2SA 2VCGA 3MZ6A 4BZ5A 5G0IA 5FUEA 4A69A 1T67A 5EFKB 5THSA 5G13A 3MZ3A 4RN0A 3Q9FA 5DC8A 4LXZA 4BZ9A 5EEFA 3MZ4A 5G1AA 5FCWA 4BZ6A 3EZTA 5G0GA 4QA1A 5EFGA 5D1CA 3EWFA 4BKXB 5G0YA 2VQVA 5EFBD 5EFHA 4ZUMA 5EF7A 4CBTA 1T69A 5DC7A 5THUA 3C0ZA 3MAXA 3MENA 5G10A 5EFNA 4CQFA 4LY1A 4QA4A 3C10A 4QA5A 5BWZA 5DC5A 5G1BA 2V5WA 4QA6A 3Q9CA 1W22A 2VQQA 2VQWG 5DC6A 1C3RA 4BZ8A
chains in the Genus database with same CATH superfamily
4ZURA 5IWGA 1T64A 4IU5A 5G3WA 1ZPGA 4Q3TA 5G0XA 5G12A 3Q9EA 3SJTA 1HQGA 4Q3VA 5D1DA 5THTA 3TF3A 3EW8A 1HQFA 4QA2A 5EEMA 3F06A 4GSZA 4RHKA 5EENA 1ZPEA 4BZ8A 4CEVA 4QA7A 3MJLA 4QA0A 4IU4A 4IE3A 4RN2A 1HQ5A 1WOHA 1ZZ0A 3SFHA 1P8OA 4Q3SA 3E9BA 3SFFA 4IXUA 3NIPA 3MZ7A 4ZUOA 1P8NA 5G0HA 3TH7A 4Q41A 5G17A 5EF8A 1T5GA 3F07A 4RLAA 5G1CA 3Q9BA 3EZPA 3NIQA 5IX0A 1C3SA 2VQJA 1ZZ1A 2VQOA 1C3PA 4I06A 5CEVA 4CBYA 2PHAA 3C0YA 3F0RA 4ITYA 3KV2A 4MXRA 5HJ9A 1VKGA 4MYFA 5EFJD 4ZUPA 3ZNRA 5EEIA 3ZNSA 5G0JA 4RN1A 3THJA 4QA3A 2VQMA 1WOGA 3NIOA 1P8SA 5EEKA 1TBJA 4ZUNA 5D1BA 4ZUQA 4Q3UA 4RHIA 3RQDA 3THEA 5JI5A 1T4SA 2V5XA 1P8RA 2GH6A 5ICNB 1HQXA 5G11A 4RHJA 3PZLA 5THVA 1ZZ3A 4BZ7A 5LI3A 5A2SA 4Q40A 5HJAA 4Q42A 1WVBA 4GWDA 4MYLA 2VCGA 2CEVA 1GQ6A 3LP7A 3MZ6A 5G0IA 5FUEA 4BZ5A 1T4PA 1CEVA 4A69A 1T67A 3MFVA 2PLLA 5EFKB 4GWCA 4Q3QA 1P8QA 4DZ4A 5THSA 5G13A 3MZ3A 4MYKA 1P8PA 3MMRA 4FCIA 4RHMA 3E6KA 4RN0A 2A0MA 1D3VA 1R1OA 3Q9FA 5DC8A 1TBLA 3CEVA 3GN0A 3E6VA 4LXZA 2EF5A 4Q3RA 1WVAA 4BZ9A 1TA1A 4MYNA 4HXQA 5EEFA 3MZ4A 5G1AA 5FCWA 3THHA 4HZEA 3SL0A 4BZ6A 3EZTA 4FCKA 3LP4A 2ZAVA 5G0GA 4QA1A 5EFGA 2AEBA 3EWFA 3M1RA 5D1CA 4BKXB 1PQ3A 2RLAA 5G0YA 2VQVA 5EFBD 3GMZA 1HQHA 5EFHA 5EF7A 4ZUMA 4GSMA 5RLAA 4CBTA 1T69A 5DC7A 1WOIA 5THUA 3E8ZA 4G3HA 1T5FA 2EIVA 4IXVA 1P8MA 1RLAA 3MFWA 4IE1A 1T4TA 3C0ZA 3SL1A 4Q3PA 3MAXA 3DJ8A 3MENA 4RHQA 5G10A 3E8QA 5EFNA 3SKKA 4Q3RC 2EF4A 4IU1A 4CQFA 4HWWA 4LY1A 4QA4A 4RHLA 4GSVA 3C10A 1GQ7A 2PHOA 3F80A 4IU0A 4QA5A 5BWZA 5DC5A 1XFKA 5G1BA 4IE2A 3RLAA 2V5WA 3Q9CA 4QA6A 1W22A 1TBHA 2VQWG 1T4RA 2VQQA 3LHLA 1C3RA 5DC6A
chains in the Genus database with same CATH topology
4ZURA 5IWGA 1T64A 5G3WA 5G0XA 5G12A 3Q9EA 5D1DA 5THTA 3EW8A 4QA2A 5EEMA 3F06A 5EENA 4QA7A 4QA0A 4RN2A 1ZZ0A 3SFHA 3SFFA 4ZUOA 3MZ7A 5G0HA 5G17A 5EF8A 3F07A 5G1CA 3Q9BA 3EZPA 5IX0A 1C3SA 2VQJA 1ZZ1A 1C3PA 2VQOA 4CBYA 3C0YA 3F0RA 1VKGA 5EFJD 4ZUPA 3ZNRA 5EEIA 3ZNSA 5G0JA 4RN1A 4QA3A 2VQMA 5EEKA 4ZUNA 5D1BA 4ZUQA 5JI5A 3RQDA 2V5XA 2GH6A 5ICNB 5G11A 5THVA 1ZZ3A 4BZ7A 5LI3A 5A2SA 2VCGA 3MZ6A 4BZ5A 5G0IA 5FUEA 4A69A 1T67A 5EFKB 5THSA 5G13A 3MZ3A 4RN0A 3Q9FA 5DC8A 4LXZA 4BZ9A 5EEFA 3MZ4A 5G1AA 5FCWA 4BZ6A 3EZTA 5G0GA 4QA1A 5EFGA 5D1CA 3EWFA 4BKXB 5G0YA 2VQVA 5EFBD 5EFHA 4ZUMA 5EF7A 4CBTA 1T69A 5DC7A 5THUA 3C0ZA 3MAXA 3MENA 5G10A 5EFNA 4CQFA 4LY1A 4QA4A 3C10A 4QA5A 5BWZA 5DC5A 5G1BA 2V5WA 4QA6A 3Q9CA 1W22A 2VQQA 2VQWG 5DC6A 1C3RA 4BZ8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZUR A;  5IWG A;  1T64 A;  5G3W A;  5G0X A;  5G12 A;  3Q9E A;  5D1D A;  5THT A;  3EW8 A;  4QA2 A;  5EEM A;  3F06 A;  5EEN A;  4QA7 A;  4QA0 A;  4RN2 A;  1ZZ0 A;  3SFH A;  3SFF A;  4ZUO A;  3MZ7 A;  5G0H A;  5G17 A;  5EF8 A;  3F07 A;  5G1C A;  3Q9B A;  3EZP A;  5IX0 A;  1C3S A;  2VQJ A;  1ZZ1 A;  1C3P A;  2VQO A;  4CBY A;  3C0Y A;  3F0R A;  1VKG A;  5EFJ D;  4ZUP A;  3ZNR A;  5EEI A;  3ZNS A;  5G0J A;  4RN1 A;  4QA3 A;  2VQM A;  5EEK A;  4ZUN A;  5D1B A;  4ZUQ A;  5JI5 A;  3RQD A;  2V5X A;  2GH6 A;  5ICN B;  5G11 A;  5THV A;  1ZZ3 A;  4BZ7 A;  5LI3 A;  5A2S A;  2VCG A;  3MZ6 A;  4BZ5 A;  5G0I A;  5FUE A;  4A69 A;  1T67 A;  5EFK B;  5THS A;  5G13 A;  3MZ3 A;  4RN0 A;  3Q9F A;  5DC8 A;  4LXZ A;  4BZ9 A;  5EEF A;  3MZ4 A;  5G1A A;  5FCW A;  4BZ6 A;  3EZT A;  5G0G A;  4QA1 A;  5EFG A;  5D1C A;  3EWF A;  4BKX B;  5G0Y A;  2VQV A;  5EFB D;  5EFH A;  4ZUM A;  5EF7 A;  4CBT A;  1T69 A;  5DC7 A;  5THU A;  3C0Z A;  3MAX A;  3MEN A;  5G10 A;  5EFN A;  4CQF A;  4LY1 A;  4QA4 A;  3C10 A;  4QA5 A;  5BWZ A;  5DC5 A;  5G1B A;  2V5W A;  4QA6 A;  3Q9C A;  1W22 A;  2VQQ A;  2VQW G;  5DC6 A;  1C3R A;  4BZ8 A; 
#chains in the Genus database with same CATH topology
 4ZUR A;  5IWG A;  1T64 A;  4IU5 A;  5G3W A;  1ZPG A;  4Q3T A;  5G0X A;  5G12 A;  3Q9E A;  3SJT A;  1HQG A;  4Q3V A;  5D1D A;  5THT A;  3TF3 A;  3EW8 A;  1HQF A;  4QA2 A;  5EEM A;  3F06 A;  4GSZ A;  4RHK A;  5EEN A;  1ZPE A;  4BZ8 A;  4CEV A;  4QA7 A;  3MJL A;  4QA0 A;  4IU4 A;  4IE3 A;  4RN2 A;  1HQ5 A;  1WOH A;  1ZZ0 A;  3SFH A;  1P8O A;  4Q3S A;  3E9B A;  3SFF A;  4IXU A;  3NIP A;  3MZ7 A;  4ZUO A;  1P8N A;  5G0H A;  3TH7 A;  4Q41 A;  5G17 A;  5EF8 A;  1T5G A;  3F07 A;  4RLA A;  5G1C A;  3Q9B A;  3EZP A;  3NIQ A;  5IX0 A;  1C3S A;  2VQJ A;  1ZZ1 A;  2VQO A;  1C3P A;  4I06 A;  5CEV A;  4CBY A;  2PHA A;  3C0Y A;  3F0R A;  4ITY A;  3KV2 A;  4MXR A;  5HJ9 A;  1VKG A;  4MYF A;  5EFJ D;  4ZUP A;  3ZNR A;  5EEI A;  3ZNS A;  5G0J A;  4RN1 A;  3THJ A;  4QA3 A;  2VQM A;  1WOG A;  3NIO A;  1P8S A;  5EEK A;  1TBJ A;  4ZUN A;  5D1B A;  4ZUQ A;  4Q3U A;  4RHI A;  3RQD A;  3THE A;  5JI5 A;  1T4S A;  2V5X A;  1P8R A;  2GH6 A;  5ICN B;  1HQX A;  5G11 A;  4RHJ A;  3PZL A;  5THV A;  1ZZ3 A;  4BZ7 A;  5LI3 A;  5A2S A;  4Q40 A;  5HJA A;  4Q42 A;  1WVB A;  4GWD A;  4MYL A;  2VCG A;  2CEV A;  1GQ6 A;  3LP7 A;  3MZ6 A;  5G0I A;  5FUE A;  4BZ5 A;  1T4P A;  1CEV A;  4A69 A;  1T67 A;  3MFV A;  2PLL A;  5EFK B;  4GWC A;  4Q3Q A;  1P8Q A;  4DZ4 A;  5THS A;  5G13 A;  3MZ3 A;  4MYK A;  1P8P A;  3MMR A;  4FCI A;  4RHM A;  3E6K A;  4RN0 A;  2A0M A;  1D3V A;  1R1O A;  3Q9F A;  5DC8 A;  1TBL A;  3CEV A;  3GN0 A;  3E6V A;  4LXZ A;  2EF5 A;  4Q3R A;  1WVA A;  4BZ9 A;  1TA1 A;  4MYN A;  4HXQ A;  5EEF A;  3MZ4 A;  5G1A A;  5FCW A;  3THH A;  4HZE A;  3SL0 A;  4BZ6 A;  3EZT A;  4FCK A;  3LP4 A;  2ZAV A;  5G0G A;  4QA1 A;  5EFG A;  2AEB A;  3EWF A;  3M1R A;  5D1C A;  4BKX B;  1PQ3 A;  2RLA A;  5G0Y A;  2VQV A;  5EFB D;  3GMZ A;  1HQH A;  5EFH A;  5EF7 A;  4ZUM A;  4GSM A;  5RLA A;  4CBT A;  1T69 A;  5DC7 A;  1WOI A;  5THU A;  3E8Z A;  4G3H A;  1T5F A;  2EIV A;  4IXV A;  1P8M A;  1RLA A;  3MFW A;  4IE1 A;  1T4T A;  3C0Z A;  3SL1 A;  4Q3P A;  3MAX A;  3DJ8 A;  3MEN A;  4RHQ A;  5G10 A;  3E8Q A;  5EFN A;  3SKK A;  4Q3R C;  2EF4 A;  4IU1 A;  4CQF A;  4HWW A;  4LY1 A;  4QA4 A;  4RHL A;  4GSV A;  3C10 A;  1GQ7 A;  2PHO A;  3F80 A;  4IU0 A;  4QA5 A;  5BWZ A;  5DC5 A;  1XFK A;  5G1B A;  4IE2 A;  3RLA A;  2V5W A;  3Q9C A;  4QA6 A;  1W22 A;  1TBH A;  2VQW G;  1T4R A;  2VQQ A;  3LHL A;  1C3R A;  5DC6 A; 
#chains in the Genus database with same CATH homology
 4ZUR A;  5IWG A;  1T64 A;  5G3W A;  5G0X A;  5G12 A;  3Q9E A;  5D1D A;  5THT A;  3EW8 A;  4QA2 A;  5EEM A;  3F06 A;  5EEN A;  4QA7 A;  4QA0 A;  4RN2 A;  1ZZ0 A;  3SFH A;  3SFF A;  4ZUO A;  3MZ7 A;  5G0H A;  5G17 A;  5EF8 A;  3F07 A;  5G1C A;  3Q9B A;  3EZP A;  5IX0 A;  1C3S A;  2VQJ A;  1ZZ1 A;  1C3P A;  2VQO A;  4CBY A;  3C0Y A;  3F0R A;  1VKG A;  5EFJ D;  4ZUP A;  3ZNR A;  5EEI A;  3ZNS A;  5G0J A;  4RN1 A;  4QA3 A;  2VQM A;  5EEK A;  4ZUN A;  5D1B A;  4ZUQ A;  5JI5 A;  3RQD A;  2V5X A;  2GH6 A;  5ICN B;  5G11 A;  5THV A;  1ZZ3 A;  4BZ7 A;  5LI3 A;  5A2S A;  2VCG A;  3MZ6 A;  4BZ5 A;  5G0I A;  5FUE A;  4A69 A;  1T67 A;  5EFK B;  5THS A;  5G13 A;  3MZ3 A;  4RN0 A;  3Q9F A;  5DC8 A;  4LXZ A;  4BZ9 A;  5EEF A;  3MZ4 A;  5G1A A;  5FCW A;  4BZ6 A;  3EZT A;  5G0G A;  4QA1 A;  5EFG A;  5D1C A;  3EWF A;  4BKX B;  5G0Y A;  2VQV A;  5EFB D;  5EFH A;  4ZUM A;  5EF7 A;  4CBT A;  1T69 A;  5DC7 A;  5THU A;  3C0Z A;  3MAX A;  3MEN A;  5G10 A;  5EFN A;  4CQF A;  4LY1 A;  4QA4 A;  3C10 A;  4QA5 A;  5BWZ A;  5DC5 A;  5G1B A;  2V5W A;  4QA6 A;  3Q9C A;  1W22 A;  2VQQ A;  2VQW G;  5DC6 A;  1C3R A;  4BZ8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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