5JSBB

Crystal structure of mcl1-inhibitor complex
Total Genus 50
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
116
structure length
116
Chain Sequence
DPKKVLDKAKDQAENRVRELKQVLEELYKEARKLDLTQEMRKKLIERYAAAIIRAIGDINNAIYQAKQEAEKLKKAGLVNSQQLDELLRRLDELQKEASRKANEYGREFELKLEYG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Viral protein/inhibitor
molecule keywords Induced myeloid leukemia cell differentiation protein Mcl-1
publication title Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer.
pubmed doi rcsb
source organism Homo sapiens
total genus 50
structure length 116
sequence length 116
chains with identical sequence D, F, H, J, L
ec nomenclature
pdb deposition date 2016-05-07
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.132.20 Mainly Alpha Orthogonal Bundle Topoisomerase I; Chain A, domain 4 Topoisomerase I; Chain A, domain 4 5jsbB00
4KC6A 4OYDB 4KAWX 4KB4A 1ISEA 5MLC9 5JSNB 1Y698 1EH1A 1WQGA 1WQHA 4L8IA 4GFQA 3LF9A 1IS1A 1GE9A 4KB2A 4JLRC 3LHPS 1EK8A 5JSBB 1DD5A 1WQFA 4KDDA
chains in the Genus database with same CATH superfamily
3WVOA 4KC6A 1I6VD 2R92A 4KAWX 3HKZA 3GTLA 4LMOA 4NOLA 1Y698 1A35A 1WQGA 1WCMA 2VUMA 5CQGA 3SJRA 4D3ZA 2YU9A 1NH3A 1IS1A 2NVXA 1K4SA 1SFOA 4KB2A 4EJ3A 4QIWA 1RRJA 4D3YA 1TWCA 4F3EA 3K57A 2R93A 2A6ED 2JA6A 3GTKA 2Y0SA 3IAYA 3KYLA 3CQZA 3GTQA 1ISEA 1A31A 1R9TA 1HQMD 1WQHA 1RR8C 1EJ9A 4Q5VA 4O26A 3MAQA 4NOKA 1SMYD 1LPQA 1K4TA 2JA7A 4C2MA 3LHPS 4KDDA 2B9SB 1MIUA 1Y1VA 1TL8A 2A6HD 4KB4A 1SC7A 5MLC9 5JSNB 2WB1A 1R49A 1I50A 2A69D 4L8IA 3FKIA 2B63A 3K58A 3LF9A 1TGOA 2E2HA 1Y1WA 1K83A 2JA5A 2BE5D 2R4GA 3K5OA 1T8IA 3K5NA 1TWFA 3P9AA 4FGUA 2F4QA 4AN8A 1I3QA 2R7ZA 2E2IA 3K5MA 3DU5A 4IP9A 4Q5GA 3GTJA 5JSBB 1WQFA 1V9MA 2A68D 2WAQA 3GTPA 1TWGA 1YNJD 4OYDB 1TWHA 1Q8IA 4FXDA 4QCLA 4AHCA 1EH1A 3H0GA 4AYBA 1A36A 4GFQA 3DU6A 3GTOA 2PMZA 1YNND 3K5LA 2O5JD 1IW7D 1GE9A 1ZYRD 4IP8A 5C9HA 1R5ZA 4FYDA 4NOMA 1TWAA 2NVYA 3K59A 4JLRC 4H3TA 1EK8A 3M4AA 1SEUA 3GTMA 3GTGA 1DD5A 2CW0D
chains in the Genus database with same CATH topology
3WVOA 4KC6A 1I6VD 2R92A 4KAWX 3HKZA 3GTLA 4LMOA 4NOLA 1Y698 1A35A 1WQGA 1WCMA 2VUMA 5CQGA 3SJRA 4D3ZA 2YU9A 1NH3A 1IS1A 2NVXA 1K4SA 1SFOA 4KB2A 4EJ3A 4QIWA 1RRJA 4D3YA 1TWCA 4F3EA 3K57A 2R93A 2A6ED 2JA6A 3GTKA 2Y0SA 3IAYA 3KYLA 3CQZA 3GTQA 1ISEA 1A31A 1R9TA 1HQMD 1WQHA 1RR8C 1EJ9A 4Q5VA 4O26A 3MAQA 4NOKA 1SMYD 1LPQA 1K4TA 2JA7A 4C2MA 3LHPS 4KDDA 2B9SB 1MIUA 1Y1VA 1TL8A 2A6HD 4KB4A 1SC7A 5MLC9 5JSNB 2WB1A 1R49A 1I50A 2A69D 4L8IA 3FKIA 2B63A 3K58A 3LF9A 1TGOA 2E2HA 1Y1WA 1K83A 2JA5A 2BE5D 2R4GA 3K5OA 1T8IA 3K5NA 1TWFA 3P9AA 4FGUA 2F4QA 4AN8A 1I3QA 2R7ZA 2E2IA 3K5MA 3DU5A 4IP9A 4Q5GA 3GTJA 5JSBB 1WQFA 1V9MA 2A68D 2WAQA 3GTPA 1TWGA 1YNJD 4OYDB 1TWHA 1Q8IA 4FXDA 4QCLA 4AHCA 1EH1A 3H0GA 4AYBA 1A36A 4GFQA 3DU6A 3GTOA 2PMZA 1YNND 3K5LA 2O5JD 1IW7D 1GE9A 1ZYRD 4IP8A 5C9HA 1R5ZA 4FYDA 4NOMA 1TWAA 2NVYA 3K59A 4JLRC 4H3TA 1EK8A 3M4AA 1SEUA 3GTMA 3GTGA 1DD5A 2CW0D
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KC6 A;  4OYD B;  4KAW X;  4KB4 A;  1ISE A;  5MLC 9;  5JSN B;  1Y69 8;  1EH1 A;  1WQG A;  1WQH A;  4L8I A;  4GFQ A;  3LF9 A;  1IS1 A;  1GE9 A;  4KB2 A;  4JLR C;  3LHP S;  1EK8 A;  5JSB B;  1DD5 A;  1WQF A;  4KDD A; 
#chains in the Genus database with same CATH topology
 3WVO A;  4KC6 A;  1I6V D;  2R92 A;  4KAW X;  3HKZ A;  3GTL A;  4LMO A;  4NOL A;  1Y69 8;  1A35 A;  1WQG A;  1WCM A;  2VUM A;  5CQG A;  3SJR A;  4D3Z A;  2YU9 A;  1NH3 A;  1IS1 A;  2NVX A;  1K4S A;  1SFO A;  4KB2 A;  4EJ3 A;  4QIW A;  1RRJ A;  4D3Y A;  1TWC A;  4F3E A;  3K57 A;  2R93 A;  2A6E D;  2JA6 A;  3GTK A;  2Y0S A;  3IAY A;  3KYL A;  3CQZ A;  3GTQ A;  1ISE A;  1A31 A;  1R9T A;  1HQM D;  1WQH A;  1RR8 C;  1EJ9 A;  4Q5V A;  4O26 A;  3MAQ A;  4NOK A;  1SMY D;  1LPQ A;  1K4T A;  2JA7 A;  4C2M A;  3LHP S;  4KDD A;  2B9S B;  1MIU A;  1Y1V A;  1TL8 A;  2A6H D;  4KB4 A;  1SC7 A;  5MLC 9;  5JSN B;  2WB1 A;  1R49 A;  1I50 A;  2A69 D;  4L8I A;  3FKI A;  2B63 A;  3K58 A;  3LF9 A;  1TGO A;  2E2H A;  1Y1W A;  1K83 A;  2JA5 A;  2BE5 D;  2R4G A;  3K5O A;  1T8I A;  3K5N A;  1TWF A;  3P9A A;  4FGU A;  2F4Q A;  4AN8 A;  1I3Q A;  2R7Z A;  2E2I A;  3K5M A;  3DU5 A;  4IP9 A;  4Q5G A;  3GTJ A;  5JSB B;  1WQF A;  1V9M A;  2A68 D;  2WAQ A;  3GTP A;  1TWG A;  1YNJ D;  4OYD B;  1TWH A;  1Q8I A;  4FXD A;  4QCL A;  4AHC A;  1EH1 A;  3H0G A;  4AYB A;  1A36 A;  4GFQ A;  3DU6 A;  3GTO A;  2PMZ A;  1YNN D;  3K5L A;  2O5J D;  1IW7 D;  1GE9 A;  1ZYR D;  4IP8 A;  5C9H A;  1R5Z A;  4FYD A;  4NOM A;  1TWA A;  2NVY A;  3K59 A;  4JLR C;  4H3T A;  1EK8 A;  3M4A A;  1SEU A;  3GTM A;  3GTG A;  1DD5 A;  2CW0 D; 
#chains in the Genus database with same CATH homology
 3WVO A;  4KC6 A;  1I6V D;  2R92 A;  4KAW X;  3HKZ A;  3GTL A;  4LMO A;  4NOL A;  1Y69 8;  1A35 A;  1WQG A;  1WCM A;  2VUM A;  5CQG A;  3SJR A;  4D3Z A;  2YU9 A;  1NH3 A;  1IS1 A;  2NVX A;  1K4S A;  1SFO A;  4KB2 A;  4EJ3 A;  4QIW A;  1RRJ A;  4D3Y A;  1TWC A;  4F3E A;  3K57 A;  2R93 A;  2A6E D;  2JA6 A;  3GTK A;  2Y0S A;  3IAY A;  3KYL A;  3CQZ A;  3GTQ A;  1ISE A;  1A31 A;  1R9T A;  1HQM D;  1WQH A;  1RR8 C;  1EJ9 A;  4Q5V A;  4O26 A;  3MAQ A;  4NOK A;  1SMY D;  1LPQ A;  1K4T A;  2JA7 A;  4C2M A;  3LHP S;  4KDD A;  2B9S B;  1MIU A;  1Y1V A;  1TL8 A;  2A6H D;  4KB4 A;  1SC7 A;  5MLC 9;  5JSN B;  2WB1 A;  1R49 A;  1I50 A;  2A69 D;  4L8I A;  3FKI A;  2B63 A;  3K58 A;  3LF9 A;  1TGO A;  2E2H A;  1Y1W A;  1K83 A;  2JA5 A;  2BE5 D;  2R4G A;  3K5O A;  1T8I A;  3K5N A;  1TWF A;  3P9A A;  4FGU A;  2F4Q A;  4AN8 A;  1I3Q A;  2R7Z A;  2E2I A;  3K5M A;  3DU5 A;  4IP9 A;  4Q5G A;  3GTJ A;  5JSB B;  1WQF A;  1V9M A;  2A68 D;  2WAQ A;  3GTP A;  1TWG A;  1YNJ D;  4OYD B;  1TWH A;  1Q8I A;  4FXD A;  4QCL A;  4AHC A;  1EH1 A;  3H0G A;  4AYB A;  1A36 A;  4GFQ A;  3DU6 A;  3GTO A;  2PMZ A;  1YNN D;  3K5L A;  2O5J D;  1IW7 D;  1GE9 A;  1ZYR D;  4IP8 A;  5C9H A;  1R5Z A;  4FYD A;  4NOM A;  1TWA A;  2NVY A;  3K59 A;  4JLR C;  4H3T A;  1EK8 A;  3M4A A;  1SEU A;  3GTM A;  3GTG A;  1DD5 A;  2CW0 D; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...