5C2AA

Pde10 complexed with 6-chloro-2-cyclopropyl-n-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-pyrimidin-4-amine
Total Genus 133
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
133
sequence length
323
structure length
323
Chain Sequence
HMSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/hydrolase inhibitor
molecule keywords cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase
publication title Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis.
pubmed doi rcsb
source organism Homo sapiens
total genus 133
structure length 323
sequence length 323
chains with identical sequence B
ec nomenclature ec 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
pdb deposition date 2015-06-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00233 PDEase_I 3'5'-cyclic nucleotide phosphodiesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1300.10 Mainly Alpha Orthogonal Bundle Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 5c2aA00
1XORA 3DYQA 4LM0A 4PHLA 1XOTA 3TGEA 2YY2A 1XM4A 4MVHA 1TB7A 4Y87A 4OEWA 3HQWA 1Y2DA 4MRWA 4ZO5A 2OUUA 5DH5A 3FRGA 4W1OA 3SL6A 5EDIA 4WCUA 4D09A 3WYKA 2OUQA 3LXGA 3I8VA 4NPWA 5C29A 1XLZA 3SN7A 3GWTA 1TB5A 3HQYA 4NW7A 4AJDA 3HDZA 4C1IA 3ECNA 4G2LA 4LM1A 4OEXA 4YQHA 4YS7A 5AXPA 3IBJA 3TGGA 1XLXA 3O57A 4MSCA 2Y0JA 4MYQA 3DYLA 4MSHA 2OVVA 4FCDA 5EDHA 4LM4A 5EDEA 4MD6A 1PTWA 3JSIA 3ECMA 2OUVA 3WS8A 3V93A 3TVXA 4PM0A 5I2RA 3ITUA 1RO6A 3G58A 3HR1A 3D3PA 5DH4A 2OUNA 3WYLA 3UUOA 5B4KA 5K9RA 5B4LA 1Y2JA 3QI4A 4JIBA 4MSNA 4BBXA 4XY2A 3K3EA 5C1WA 3QPOA 3G4GA 1Y2EA 5C2HA 4HTXA 1SO2A 4LLPA 1RKPA 3JWQA 3O56A 3QPNA 4HF4A 4DDLA 4GH6A 2H40A 3G4IA 4LKQA 3SL4A 4HTZA 3WS9A 5B25A 3SL5A 1ZKLA 4PHWA 3HC8A 3IAKA 4AELA 3G3NA 2H44A 2OUPA 1MKDA 1RORA 3JWRA 4I9ZA 4Y8CA 1T9SA 4E90A 4TPPA 2CHMA 2QYKA 4P0NA 3SL8A 4WZIA 4Y86A 4G2YA 1SOJA 1XOQA 3G4LA 5C2AA 4G2WA 4TPMA 1XMUB 3DYNA 1TBBA 1XN0A 1Y2HA 3IADA 4OGBA 2WEYA 4MS0A 1XOSA 3DY8A 4AJFA 1T9RA 2OURA 3DYSA 5C2EA 3SHZA 1UDTA 1OYNA 4LLXA 3SL3A 3ITMA 1Q9MA 3KKTA 3WD9A 4IA0A 1UDUA 5EDGB 3W5EA 4KP6A 3SNLA 3SHYA 2OUYA 4MUWA 2O8HA 2R8QA 2QYMA 1TAZA 2H42A 3QI3A 2OVYA 4HEUA 3G4KA 3SNIA 3JSWA 4AJGA 1XM4B 3V9BA 4MSEA 1XMYB 2QYLA 1Y2BA 3HMVA 4MRZA 1Y2CA 3HQZA 5AXQA 3B2RA 3BJCA 4P1RA 5EDIB 5K32A 3V94A 1XMYA 1Y2KA 4X0FA 3SIEA 4D08A 3K4SA 3N3ZA 4MSAA 4WN1A 3LY2A 4G2JA 4LM3A 1UHOA 2FM5A 4NPVA 1ZKNA 2FM0A 1XP0A 4I15A 1XMUA 4LM2A 4LLJA 4LLKA 1F0JA 3K3HA 4AJMA 5C28A 1TBFA 1XOZA 4DFFA 4Y2BA 1RO9A 3QPPA 3WYMA 4FCBA 3O0JA 5EDEB 1XM6A 1XOMA 1Z1LA 5EDGA 2OUSA 2PW3A 2HD1A 2QYNA 3G45A 5K1IA 1XONA 3WI2A 3UI7A 4QGEA
chains in the Genus database with same CATH superfamily
1XORA 3DYQA 4LM0A 4PHLA 1XOTA 3TGEA 2YY2A 1XM4A 4MVHA 1TB7A 4Y87A 4OEWA 3HQWA 1Y2DA 4MRWA 4ZO5A 2OUUA 5DH5A 3FRGA 4W1OA 3SL6A 5EDIA 4WCUA 4D09A 3WYKA 2OUQA 3LXGA 3I8VA 4NPWA 5C29A 1XLZA 3SN7A 3GWTA 1TB5A 3HQYA 4NW7A 4AJDA 3HDZA 4C1IA 3ECNA 4G2LA 4LM1A 4OEXA 4YQHA 4YS7A 5AXPA 3IBJA 3TGGA 1XLXA 3O57A 4MSCA 2Y0JA 4MYQA 3DYLA 4MSHA 2OVVA 4FCDA 5EDHA 4LM4A 5EDEA 4MD6A 1PTWA 3JSIA 3ECMA 2OUVA 3WS8A 3V93A 3TVXA 4PM0A 5I2RA 3ITUA 1RO6A 3G58A 3HR1A 3D3PA 5DH4A 2OUNA 3WYLA 3UUOA 5B4KA 5K9RA 5B4LA 1Y2JA 3QI4A 4JIBA 4MSNA 4BBXA 4XY2A 3K3EA 5C1WA 3QPOA 3G4GA 1Y2EA 5C2HA 4HTXA 1SO2A 4LLPA 1RKPA 3JWQA 3O56A 3QPNA 4HF4A 4DDLA 4GH6A 2H40A 3G4IA 4LKQA 3SL4A 4HTZA 3WS9A 5B25A 3SL5A 1ZKLA 4PHWA 3HC8A 3IAKA 4AELA 3G3NA 2H44A 2OUPA 1MKDA 1RORA 3JWRA 4I9ZA 4Y8CA 1T9SA 4E90A 4TPPA 2CHMA 2QYKA 4P0NA 3SL8A 4WZIA 4Y86A 4G2YA 1SOJA 1XOQA 3G4LA 5C2AA 4G2WA 4TPMA 1XMUB 3DYNA 1TBBA 1XN0A 1Y2HA 3IADA 4OGBA 2WEYA 4MS0A 1XOSA 3DY8A 4AJFA 1T9RA 2OURA 3DYSA 5C2EA 3SHZA 1UDTA 1OYNA 4LLXA 3SL3A 3ITMA 1Q9MA 3KKTA 3WD9A 4IA0A 1UDUA 5EDGB 3W5EA 4KP6A 3SNLA 3SHYA 2OUYA 4MUWA 2O8HA 2R8QA 2QYMA 1TAZA 2H42A 3QI3A 2OVYA 4HEUA 3G4KA 3SNIA 3JSWA 4AJGA 1XM4B 3V9BA 4MSEA 1XMYB 2QYLA 1Y2BA 3HMVA 4MRZA 1Y2CA 3HQZA 5AXQA 3B2RA 3BJCA 4P1RA 5EDIB 5K32A 3V94A 1XMYA 1Y2KA 4X0FA 3SIEA 4D08A 3K4SA 3N3ZA 4MSAA 4WN1A 3LY2A 4G2JA 4LM3A 1UHOA 2FM5A 4NPVA 1ZKNA 2FM0A 1XP0A 4I15A 1XMUA 4LM2A 4LLJA 4LLKA 1F0JA 3K3HA 4AJMA 5C28A 1TBFA 1XOZA 4DFFA 4Y2BA 1RO9A 3QPPA 3WYMA 4FCBA 3O0JA 5EDEB 1XM6A 1XOMA 1Z1LA 5EDGA 2OUSA 2PW3A 2HD1A 2QYNA 3G45A 5K1IA 1XONA 3WI2A 3UI7A 4QGEA
chains in the Genus database with same CATH topology
1XORA 3DYQA 4LM0A 4PHLA 1XOTA 3TGEA 2YY2A 1XM4A 4MVHA 1TB7A 4Y87A 4OEWA 3HQWA 1Y2DA 4MRWA 4ZO5A 2OUUA 5DH5A 3FRGA 4W1OA 3SL6A 5EDIA 4WCUA 4D09A 3WYKA 2OUQA 3LXGA 3I8VA 4NPWA 5C29A 1XLZA 3SN7A 3GWTA 1TB5A 3HQYA 4NW7A 4AJDA 3HDZA 4C1IA 3ECNA 4G2LA 4LM1A 4OEXA 4YQHA 4YS7A 5AXPA 3IBJA 3TGGA 1XLXA 3O57A 4MSCA 2Y0JA 4MYQA 3DYLA 4MSHA 2OVVA 4FCDA 5EDHA 4LM4A 5EDEA 4MD6A 1PTWA 3JSIA 3ECMA 2OUVA 3WS8A 3V93A 3TVXA 4PM0A 5I2RA 3ITUA 1RO6A 3G58A 3HR1A 3D3PA 5DH4A 2OUNA 3WYLA 3UUOA 5B4KA 5K9RA 5B4LA 1Y2JA 3QI4A 4JIBA 4MSNA 4BBXA 4XY2A 3K3EA 5C1WA 3QPOA 3G4GA 1Y2EA 5C2HA 4HTXA 1SO2A 4LLPA 1RKPA 3JWQA 3O56A 3QPNA 4HF4A 4DDLA 4GH6A 2H40A 3G4IA 4LKQA 3SL4A 4HTZA 3WS9A 5B25A 3SL5A 1ZKLA 4PHWA 3HC8A 3IAKA 4AELA 3G3NA 2H44A 2OUPA 1MKDA 1RORA 3JWRA 4I9ZA 4Y8CA 1T9SA 4E90A 4TPPA 2CHMA 2QYKA 4P0NA 3SL8A 4WZIA 4Y86A 4G2YA 1SOJA 1XOQA 3G4LA 5C2AA 4G2WA 4TPMA 1XMUB 3DYNA 1TBBA 1XN0A 1Y2HA 3IADA 4OGBA 2WEYA 4MS0A 1XOSA 3DY8A 4AJFA 1T9RA 2OURA 3DYSA 5C2EA 3SHZA 1UDTA 1OYNA 4LLXA 3SL3A 3ITMA 1Q9MA 3KKTA 3WD9A 4IA0A 1UDUA 5EDGB 3W5EA 4KP6A 3SNLA 3SHYA 2OUYA 4MUWA 2O8HA 2R8QA 2QYMA 1TAZA 2H42A 3QI3A 2OVYA 4HEUA 3G4KA 3SNIA 3JSWA 4AJGA 1XM4B 3V9BA 4MSEA 1XMYB 2QYLA 1Y2BA 3HMVA 4MRZA 1Y2CA 3HQZA 5AXQA 3B2RA 3BJCA 4P1RA 5EDIB 5K32A 3V94A 1XMYA 1Y2KA 4X0FA 3SIEA 4D08A 3K4SA 3N3ZA 4MSAA 4WN1A 3LY2A 4G2JA 4LM3A 1UHOA 2FM5A 4NPVA 1ZKNA 2FM0A 1XP0A 4I15A 1XMUA 4LM2A 4LLJA 4LLKA 1F0JA 3K3HA 4AJMA 5C28A 1TBFA 1XOZA 4DFFA 4Y2BA 1RO9A 3QPPA 3WYMA 4FCBA 3O0JA 5EDEB 1XM6A 1XOMA 1Z1LA 5EDGA 2OUSA 2PW3A 2HD1A 2QYNA 3G45A 5K1IA 1XONA 3WI2A 3UI7A 4QGEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XOR A;  3DYQ A;  4LM0 A;  4PHL A;  1XOT A;  3TGE A;  2YY2 A;  1XM4 A;  4MVH A;  1TB7 A;  4Y87 A;  4OEW A;  3HQW A;  1Y2D A;  4MRW A;  4ZO5 A;  2OUU A;  5DH5 A;  3FRG A;  4W1O A;  3SL6 A;  5EDI A;  4WCU A;  4D09 A;  3WYK A;  2OUQ A;  3LXG A;  3I8V A;  4NPW A;  5C29 A;  1XLZ A;  3SN7 A;  3GWT A;  1TB5 A;  3HQY A;  4NW7 A;  4AJD A;  3HDZ A;  4C1I A;  3ECN A;  4G2L A;  4LM1 A;  4OEX A;  4YQH A;  4YS7 A;  5AXP A;  3IBJ A;  3TGG A;  1XLX A;  3O57 A;  4MSC A;  2Y0J A;  4MYQ A;  3DYL A;  4MSH A;  2OVV A;  4FCD A;  5EDH A;  4LM4 A;  5EDE A;  4MD6 A;  1PTW A;  3JSI A;  3ECM A;  2OUV A;  3WS8 A;  3V93 A;  3TVX A;  4PM0 A;  5I2R A;  3ITU A;  1RO6 A;  3G58 A;  3HR1 A;  3D3P A;  5DH4 A;  2OUN A;  3WYL A;  3UUO A;  5B4K A;  5K9R A;  5B4L A;  1Y2J A;  3QI4 A;  4JIB A;  4MSN A;  4BBX A;  4XY2 A;  3K3E A;  5C1W A;  3QPO A;  3G4G A;  1Y2E A;  5C2H A;  4HTX A;  1SO2 A;  4LLP A;  1RKP A;  3JWQ A;  3O56 A;  3QPN A;  4HF4 A;  4DDL A;  4GH6 A;  2H40 A;  3G4I A;  4LKQ A;  3SL4 A;  4HTZ A;  3WS9 A;  5B25 A;  3SL5 A;  1ZKL A;  4PHW A;  3HC8 A;  3IAK A;  4AEL A;  3G3N A;  2H44 A;  2OUP A;  1MKD A;  1ROR A;  3JWR A;  4I9Z A;  4Y8C A;  1T9S A;  4E90 A;  4TPP A;  2CHM A;  2QYK A;  4P0N A;  3SL8 A;  4WZI A;  4Y86 A;  4G2Y A;  1SOJ A;  1XOQ A;  3G4L A;  5C2A A;  4G2W A;  4TPM A;  1XMU B;  3DYN A;  1TBB A;  1XN0 A;  1Y2H A;  3IAD A;  4OGB A;  2WEY A;  4MS0 A;  1XOS A;  3DY8 A;  4AJF A;  1T9R A;  2OUR A;  3DYS A;  5C2E A;  3SHZ A;  1UDT A;  1OYN A;  4LLX A;  3SL3 A;  3ITM A;  1Q9M A;  3KKT A;  3WD9 A;  4IA0 A;  1UDU A;  5EDG B;  3W5E A;  4KP6 A;  3SNL A;  3SHY A;  2OUY A;  4MUW A;  2O8H A;  2R8Q A;  2QYM A;  1TAZ A;  2H42 A;  3QI3 A;  2OVY A;  4HEU A;  3G4K A;  3SNI A;  3JSW A;  4AJG A;  1XM4 B;  3V9B A;  4MSE A;  1XMY B;  2QYL A;  1Y2B A;  3HMV A;  4MRZ A;  1Y2C A;  3HQZ A;  5AXQ A;  3B2R A;  3BJC A;  4P1R A;  5EDI B;  5K32 A;  3V94 A;  1XMY A;  1Y2K A;  4X0F A;  3SIE A;  4D08 A;  3K4S A;  3N3Z A;  4MSA A;  4WN1 A;  3LY2 A;  4G2J A;  4LM3 A;  1UHO A;  2FM5 A;  4NPV A;  1ZKN A;  2FM0 A;  1XP0 A;  4I15 A;  1XMU A;  4LM2 A;  4LLJ A;  4LLK A;  1F0J A;  3K3H A;  4AJM A;  5C28 A;  1TBF A;  1XOZ A;  4DFF A;  4Y2B A;  1RO9 A;  3QPP A;  3WYM A;  4FCB A;  3O0J A;  5EDE B;  1XM6 A;  1XOM A;  1Z1L A;  5EDG A;  2OUS A;  2PW3 A;  2HD1 A;  2QYN A;  3G45 A;  5K1I A;  1XON A;  3WI2 A;  3UI7 A;  4QGE A; 
#chains in the Genus database with same CATH topology
 1XOR A;  3DYQ A;  4LM0 A;  4PHL A;  1XOT A;  3TGE A;  2YY2 A;  1XM4 A;  4MVH A;  1TB7 A;  4Y87 A;  4OEW A;  3HQW A;  1Y2D A;  4MRW A;  4ZO5 A;  2OUU A;  5DH5 A;  3FRG A;  4W1O A;  3SL6 A;  5EDI A;  4WCU A;  4D09 A;  3WYK A;  2OUQ A;  3LXG A;  3I8V A;  4NPW A;  5C29 A;  1XLZ A;  3SN7 A;  3GWT A;  1TB5 A;  3HQY A;  4NW7 A;  4AJD A;  3HDZ A;  4C1I A;  3ECN A;  4G2L A;  4LM1 A;  4OEX A;  4YQH A;  4YS7 A;  5AXP A;  3IBJ A;  3TGG A;  1XLX A;  3O57 A;  4MSC A;  2Y0J A;  4MYQ A;  3DYL A;  4MSH A;  2OVV A;  4FCD A;  5EDH A;  4LM4 A;  5EDE A;  4MD6 A;  1PTW A;  3JSI A;  3ECM A;  2OUV A;  3WS8 A;  3V93 A;  3TVX A;  4PM0 A;  5I2R A;  3ITU A;  1RO6 A;  3G58 A;  3HR1 A;  3D3P A;  5DH4 A;  2OUN A;  3WYL A;  3UUO A;  5B4K A;  5K9R A;  5B4L A;  1Y2J A;  3QI4 A;  4JIB A;  4MSN A;  4BBX A;  4XY2 A;  3K3E A;  5C1W A;  3QPO A;  3G4G A;  1Y2E A;  5C2H A;  4HTX A;  1SO2 A;  4LLP A;  1RKP A;  3JWQ A;  3O56 A;  3QPN A;  4HF4 A;  4DDL A;  4GH6 A;  2H40 A;  3G4I A;  4LKQ A;  3SL4 A;  4HTZ A;  3WS9 A;  5B25 A;  3SL5 A;  1ZKL A;  4PHW A;  3HC8 A;  3IAK A;  4AEL A;  3G3N A;  2H44 A;  2OUP A;  1MKD A;  1ROR A;  3JWR A;  4I9Z A;  4Y8C A;  1T9S A;  4E90 A;  4TPP A;  2CHM A;  2QYK A;  4P0N A;  3SL8 A;  4WZI A;  4Y86 A;  4G2Y A;  1SOJ A;  1XOQ A;  3G4L A;  5C2A A;  4G2W A;  4TPM A;  1XMU B;  3DYN A;  1TBB A;  1XN0 A;  1Y2H A;  3IAD A;  4OGB A;  2WEY A;  4MS0 A;  1XOS A;  3DY8 A;  4AJF A;  1T9R A;  2OUR A;  3DYS A;  5C2E A;  3SHZ A;  1UDT A;  1OYN A;  4LLX A;  3SL3 A;  3ITM A;  1Q9M A;  3KKT A;  3WD9 A;  4IA0 A;  1UDU A;  5EDG B;  3W5E A;  4KP6 A;  3SNL A;  3SHY A;  2OUY A;  4MUW A;  2O8H A;  2R8Q A;  2QYM A;  1TAZ A;  2H42 A;  3QI3 A;  2OVY A;  4HEU A;  3G4K A;  3SNI A;  3JSW A;  4AJG A;  1XM4 B;  3V9B A;  4MSE A;  1XMY B;  2QYL A;  1Y2B A;  3HMV A;  4MRZ A;  1Y2C A;  3HQZ A;  5AXQ A;  3B2R A;  3BJC A;  4P1R A;  5EDI B;  5K32 A;  3V94 A;  1XMY A;  1Y2K A;  4X0F A;  3SIE A;  4D08 A;  3K4S A;  3N3Z A;  4MSA A;  4WN1 A;  3LY2 A;  4G2J A;  4LM3 A;  1UHO A;  2FM5 A;  4NPV A;  1ZKN A;  2FM0 A;  1XP0 A;  4I15 A;  1XMU A;  4LM2 A;  4LLJ A;  4LLK A;  1F0J A;  3K3H A;  4AJM A;  5C28 A;  1TBF A;  1XOZ A;  4DFF A;  4Y2B A;  1RO9 A;  3QPP A;  3WYM A;  4FCB A;  3O0J A;  5EDE B;  1XM6 A;  1XOM A;  1Z1L A;  5EDG A;  2OUS A;  2PW3 A;  2HD1 A;  2QYN A;  3G45 A;  5K1I A;  1XON A;  3WI2 A;  3UI7 A;  4QGE A; 
#chains in the Genus database with same CATH homology
 1XOR A;  3DYQ A;  4LM0 A;  4PHL A;  1XOT A;  3TGE A;  2YY2 A;  1XM4 A;  4MVH A;  1TB7 A;  4Y87 A;  4OEW A;  3HQW A;  1Y2D A;  4MRW A;  4ZO5 A;  2OUU A;  5DH5 A;  3FRG A;  4W1O A;  3SL6 A;  5EDI A;  4WCU A;  4D09 A;  3WYK A;  2OUQ A;  3LXG A;  3I8V A;  4NPW A;  5C29 A;  1XLZ A;  3SN7 A;  3GWT A;  1TB5 A;  3HQY A;  4NW7 A;  4AJD A;  3HDZ A;  4C1I A;  3ECN A;  4G2L A;  4LM1 A;  4OEX A;  4YQH A;  4YS7 A;  5AXP A;  3IBJ A;  3TGG A;  1XLX A;  3O57 A;  4MSC A;  2Y0J A;  4MYQ A;  3DYL A;  4MSH A;  2OVV A;  4FCD A;  5EDH A;  4LM4 A;  5EDE A;  4MD6 A;  1PTW A;  3JSI A;  3ECM A;  2OUV A;  3WS8 A;  3V93 A;  3TVX A;  4PM0 A;  5I2R A;  3ITU A;  1RO6 A;  3G58 A;  3HR1 A;  3D3P A;  5DH4 A;  2OUN A;  3WYL A;  3UUO A;  5B4K A;  5K9R A;  5B4L A;  1Y2J A;  3QI4 A;  4JIB A;  4MSN A;  4BBX A;  4XY2 A;  3K3E A;  5C1W A;  3QPO A;  3G4G A;  1Y2E A;  5C2H A;  4HTX A;  1SO2 A;  4LLP A;  1RKP A;  3JWQ A;  3O56 A;  3QPN A;  4HF4 A;  4DDL A;  4GH6 A;  2H40 A;  3G4I A;  4LKQ A;  3SL4 A;  4HTZ A;  3WS9 A;  5B25 A;  3SL5 A;  1ZKL A;  4PHW A;  3HC8 A;  3IAK A;  4AEL A;  3G3N A;  2H44 A;  2OUP A;  1MKD A;  1ROR A;  3JWR A;  4I9Z A;  4Y8C A;  1T9S A;  4E90 A;  4TPP A;  2CHM A;  2QYK A;  4P0N A;  3SL8 A;  4WZI A;  4Y86 A;  4G2Y A;  1SOJ A;  1XOQ A;  3G4L A;  5C2A A;  4G2W A;  4TPM A;  1XMU B;  3DYN A;  1TBB A;  1XN0 A;  1Y2H A;  3IAD A;  4OGB A;  2WEY A;  4MS0 A;  1XOS A;  3DY8 A;  4AJF A;  1T9R A;  2OUR A;  3DYS A;  5C2E A;  3SHZ A;  1UDT A;  1OYN A;  4LLX A;  3SL3 A;  3ITM A;  1Q9M A;  3KKT A;  3WD9 A;  4IA0 A;  1UDU A;  5EDG B;  3W5E A;  4KP6 A;  3SNL A;  3SHY A;  2OUY A;  4MUW A;  2O8H A;  2R8Q A;  2QYM A;  1TAZ A;  2H42 A;  3QI3 A;  2OVY A;  4HEU A;  3G4K A;  3SNI A;  3JSW A;  4AJG A;  1XM4 B;  3V9B A;  4MSE A;  1XMY B;  2QYL A;  1Y2B A;  3HMV A;  4MRZ A;  1Y2C A;  3HQZ A;  5AXQ A;  3B2R A;  3BJC A;  4P1R A;  5EDI B;  5K32 A;  3V94 A;  1XMY A;  1Y2K A;  4X0F A;  3SIE A;  4D08 A;  3K4S A;  3N3Z A;  4MSA A;  4WN1 A;  3LY2 A;  4G2J A;  4LM3 A;  1UHO A;  2FM5 A;  4NPV A;  1ZKN A;  2FM0 A;  1XP0 A;  4I15 A;  1XMU A;  4LM2 A;  4LLJ A;  4LLK A;  1F0J A;  3K3H A;  4AJM A;  5C28 A;  1TBF A;  1XOZ A;  4DFF A;  4Y2B A;  1RO9 A;  3QPP A;  3WYM A;  4FCB A;  3O0J A;  5EDE B;  1XM6 A;  1XOM A;  1Z1L A;  5EDG A;  2OUS A;  2PW3 A;  2HD1 A;  2QYN A;  3G45 A;  5K1I A;  1XON A;  3WI2 A;  3UI7 A;  4QGE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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