5TVCA

Crystal structure of a chimeric acetylcholine binding protein from aplysia californica (ac-achbp) containing loop c from the human alpha 3 nicotinic acetylcholine receptor in complex with (e,2s)-n-methyl-5-(5-phenoxy-3-pyridyl)pent-4-en-2-amine (ti-5312)
Total Genus 47
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
47
sequence length
216
structure length
211
Chain Sequence
DKLHSQANLMRLKSDLFYPGPTKDDPLTVTLGFTLQDIVKADSSTNEVDLVYWEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQYKHDIKYNCCEEIYPDVVLVVKFRERRAGNGF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Acetylcholine-binding protein
molecule keywords Soluble acetylcholine receptor,Neuronal acetylcholine recept
publication title Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with (E,2S)-N-methyl-5-(5-phenoxy-3-pyridyl)pent-4-en-2-amine (TI-5312)
rcsb
source organism Aplysia californica
total genus 47
structure length 211
sequence length 216
chains with identical sequence B, C, D, E
ec nomenclature
pdb deposition date 2016-11-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 5tvcA00
2BJ0A 4UXUA 5HEUA 3UU4A 3PEOA 5SYOA 5AFNA 2XNTA 4LMKA 5AFJA 4QH4A 4IL9A 4TWFA 5AFLA 2XQ3A 4UY2A 3UQ7A 2WNLA 4AFHA 5HCMA 2XQ8A 5JMEA 3RQWA 2XZ6A 2Y54A 4LMLA 2BYQA 2XQAA 2XYTA 3JAFA 4AFTA 3RQUA 5TVCA 4QABA 3EI0A 4UM1A 5BW2A 3UU8A 3RHWA 3ZDHA 5L47A 4XK9A 3WTHA 2X00D 2YKSA 4HFEA 3U8NA 3UUBA 5J5HA 5CO5A 3C79A 2BYSA 2XQ6A 3TLTA 1I9BA 4NZBA 4B5DA 4Z90A 5IUXA 3T4MA 2WNJA 5AINA 4PIRA 2W8GA 5HCJA 4QAAA 3RIFA 4F8HA 2BG9B 3RIAA 3SQ9A 2Y57A 2YMEA 4FRRA 4IREA 1UW6A 2YN6A 4D01A 4LMJA 4Z91A 4WV9A 2XYSA 4HFCA 2C9TA 2Y58A 3P50A 4ZJTA 5J5FA 3U8MA 3WTIA 4X5TA 5HEHA 3WTJA 5AFMB 2XQ4A 5HEOA 4ZK1A 4QH1A 2UZ6A 3WTOA 5KE4A 4ILBA 5J0ZA 3WTNA 4ZK4A 2X00A 4TWHA 3TLVA 3P4WA 4ZZBA 3U8JA 4ZZCA 3U8LA 2XQ5A 3RI5A 3ZDGA 5L4HA 4TNVA 2Y56A 2BG9E 5LG3A 3PMZA 5BP0A 3EHZA 3SH1A 4HFDA 3JAEA 2XNVA 2BG9C 5J5IA 3WTKA 4ILAA 4ZR6A 2QC1B 4UM3S 2BR7A 2PGZA 5AFKA 4XHEA 4HFHA 3JADA 4ZJSA 2BYPA 3TLSA 4IL4A 3UU3A 2BR8A 3SIOA 4BFQA 5KZUA 2W8FA 2BYNA 2XQ9A 2YMDA 4TNWA 3C84A 5HEGA 2YOEA 4QACA 3U8KA 3UU5A 5AFMA 2XNUA 4A97A 4TWDA 4EZ1A 4A98A 3IGQA 3GUAA 3WTLA 3EAMA 4DBMA 4HFBA 4HQPA 2XQ7A 2PH9A 5CFBA 3UQ4A 4ALXA 4BQTA 4COFA 3SQ6A 4QH5A 5AFHA 2ZJVA 2BYRA 2VL0A 5FJVA 3WTMA 5LXBA 2WN9A 3TLUA 4ZRUA 2XZ5A 1UX2A 3UU6A 4UM3P 5HEJA 3TLWA 4AFGA 5J5GA 2BG9A 2Y7YA 3LSVA 2WZYA 4NPPA 3WIPA 3ZKRA 4HFIA 2WNCA 4UM3A 5L4EA 5BRXA 1UV6A 2ZJUA 4ILCA
chains in the Genus database with same CATH superfamily
2BJ0A 4UXUA 5HEUA 3UU4A 3PEOA 5SYOA 5AFNA 2XNTA 4LMKA 5AFJA 4QH4A 4IL9A 4TWFA 5AFLA 2XQ3A 4UY2A 3UQ7A 2WNLA 4AFHA 5HCMA 2XQ8A 5JMEA 3RQWA 2XZ6A 2Y54A 4LMLA 2BYQA 2XQAA 2XYTA 3JAFA 4AFTA 3RQUA 5TVCA 4QABA 3EI0A 4UM1A 5BW2A 3UU8A 3RHWA 3ZDHA 5L47A 4XK9A 3WTHA 2X00D 2YKSA 4HFEA 3U8NA 3UUBA 5J5HA 5CO5A 3C79A 2BYSA 2XQ6A 3TLTA 1I9BA 4NZBA 4B5DA 4Z90A 5IUXA 3T4MA 2WNJA 5AINA 4PIRA 2W8GA 5HCJA 4QAAA 3RIFA 4F8HA 2BG9B 3RIAA 3SQ9A 2Y57A 2YMEA 4FRRA 4IREA 1UW6A 2YN6A 4D01A 4LMJA 4Z91A 4WV9A 2XYSA 4HFCA 2C9TA 2Y58A 3P50A 4ZJTA 5J5FA 3U8MA 3WTIA 4X5TA 5HEHA 3WTJA 5AFMB 2XQ4A 5HEOA 4ZK1A 4QH1A 2UZ6A 3WTOA 5KE4A 4ILBA 5J0ZA 3WTNA 4ZK4A 2X00A 4TWHA 3TLVA 3P4WA 4ZZBA 3U8JA 4ZZCA 3U8LA 2XQ5A 3RI5A 3ZDGA 5L4HA 4TNVA 2Y56A 2BG9E 5LG3A 3PMZA 5BP0A 3EHZA 3SH1A 4HFDA 3JAEA 2XNVA 2BG9C 5J5IA 3WTKA 4ILAA 4ZR6A 2QC1B 4UM3S 2BR7A 2PGZA 5AFKA 4XHEA 4HFHA 3JADA 4ZJSA 2BYPA 3TLSA 4IL4A 3UU3A 2BR8A 3SIOA 4BFQA 5KZUA 2W8FA 2BYNA 2XQ9A 2YMDA 4TNWA 3C84A 5HEGA 2YOEA 4QACA 3U8KA 3UU5A 5AFMA 2XNUA 4A97A 4TWDA 4EZ1A 4A98A 3IGQA 3GUAA 3WTLA 3EAMA 4DBMA 4HFBA 4HQPA 2XQ7A 2PH9A 5CFBA 3UQ4A 4ALXA 4BQTA 4COFA 3SQ6A 4QH5A 5AFHA 2ZJVA 2BYRA 2VL0A 5FJVA 3WTMA 5LXBA 2WN9A 3TLUA 4ZRUA 2XZ5A 1UX2A 3UU6A 4UM3P 5HEJA 3TLWA 4AFGA 5J5GA 2BG9A 2Y7YA 3LSVA 2WZYA 4NPPA 3WIPA 3ZKRA 4HFIA 2WNCA 4UM3A 5L4EA 5BRXA 1UV6A 2ZJUA 4ILCA
chains in the Genus database with same CATH topology
2BJ0A 4UXUA 5HEUA 3UU4A 3PEOA 5SYOA 5AFNA 2XNTA 4LMKA 5AFJA 4QH4A 4IL9A 4TWFA 5AFLA 2XQ3A 4UY2A 3UQ7A 2WNLA 4AFHA 5HCMA 2XQ8A 5JMEA 3RQWA 2XZ6A 2Y54A 4LMLA 2BYQA 2XQAA 2XYTA 3JAFA 4AFTA 3RQUA 5TVCA 4QABA 3EI0A 4UM1A 5BW2A 3UU8A 3RHWA 3ZDHA 5L47A 4XK9A 3WTHA 2X00D 2YKSA 4HFEA 3U8NA 3UUBA 5J5HA 5CO5A 3C79A 2BYSA 2XQ6A 3TLTA 1I9BA 4NZBA 4B5DA 4Z90A 5IUXA 3T4MA 2WNJA 5AINA 4PIRA 2W8GA 5HCJA 4QAAA 3RIFA 4F8HA 2BG9B 3RIAA 3SQ9A 2Y57A 2YMEA 4FRRA 4IREA 1UW6A 2YN6A 4D01A 4LMJA 4Z91A 4WV9A 2XYSA 4HFCA 2C9TA 2Y58A 3P50A 4ZJTA 5J5FA 3U8MA 3WTIA 4X5TA 5HEHA 3WTJA 5AFMB 2XQ4A 5HEOA 4ZK1A 4QH1A 2UZ6A 3WTOA 5KE4A 4ILBA 5J0ZA 3WTNA 4ZK4A 2X00A 4TWHA 3TLVA 3P4WA 4ZZBA 3U8JA 4ZZCA 3U8LA 2XQ5A 3RI5A 3ZDGA 5L4HA 4TNVA 2Y56A 2BG9E 5LG3A 3PMZA 5BP0A 3EHZA 3SH1A 4HFDA 3JAEA 2XNVA 2BG9C 5J5IA 3WTKA 4ILAA 4ZR6A 2QC1B 4UM3S 2BR7A 2PGZA 5AFKA 4XHEA 4HFHA 3JADA 4ZJSA 2BYPA 3TLSA 4IL4A 3UU3A 2BR8A 3SIOA 4BFQA 5KZUA 2W8FA 2BYNA 2XQ9A 2YMDA 4TNWA 3C84A 5HEGA 2YOEA 4QACA 3U8KA 3UU5A 5AFMA 2XNUA 4A97A 4TWDA 4EZ1A 4A98A 3IGQA 3GUAA 3WTLA 3EAMA 4DBMA 4HFBA 4HQPA 2XQ7A 2PH9A 5CFBA 3UQ4A 4ALXA 4BQTA 4COFA 3SQ6A 4QH5A 5AFHA 2ZJVA 2BYRA 2VL0A 5FJVA 3WTMA 5LXBA 2WN9A 3TLUA 4ZRUA 2XZ5A 1UX2A 3UU6A 4UM3P 5HEJA 3TLWA 4AFGA 5J5GA 2BG9A 2Y7YA 3LSVA 2WZYA 4NPPA 3WIPA 3ZKRA 4HFIA 2WNCA 4UM3A 5L4EA 5BRXA 1UV6A 2ZJUA 4ILCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BJ0 A;  4UXU A;  5HEU A;  3UU4 A;  3PEO A;  5SYO A;  5AFN A;  2XNT A;  4LMK A;  5AFJ A;  4QH4 A;  4IL9 A;  4TWF A;  5AFL A;  2XQ3 A;  4UY2 A;  3UQ7 A;  2WNL A;  4AFH A;  5HCM A;  2XQ8 A;  5JME A;  3RQW A;  2XZ6 A;  2Y54 A;  4LML A;  2BYQ A;  2XQA A;  2XYT A;  3JAF A;  4AFT A;  3RQU A;  5TVC A;  4QAB A;  3EI0 A;  4UM1 A;  5BW2 A;  3UU8 A;  3RHW A;  3ZDH A;  5L47 A;  4XK9 A;  3WTH A;  2X00 D;  2YKS A;  4HFE A;  3U8N A;  3UUB A;  5J5H A;  5CO5 A;  3C79 A;  2BYS A;  2XQ6 A;  3TLT A;  1I9B A;  4NZB A;  4B5D A;  4Z90 A;  5IUX A;  3T4M A;  2WNJ A;  5AIN A;  4PIR A;  2W8G A;  5HCJ A;  4QAA A;  3RIF A;  4F8H A;  2BG9 B;  3RIA A;  3SQ9 A;  2Y57 A;  2YME A;  4FRR A;  4IRE A;  1UW6 A;  2YN6 A;  4D01 A;  4LMJ A;  4Z91 A;  4WV9 A;  2XYS A;  4HFC A;  2C9T A;  2Y58 A;  3P50 A;  4ZJT A;  5J5F A;  3U8M A;  3WTI A;  4X5T A;  5HEH A;  3WTJ A;  5AFM B;  2XQ4 A;  5HEO A;  4ZK1 A;  4QH1 A;  2UZ6 A;  3WTO A;  5KE4 A;  4ILB A;  5J0Z A;  3WTN A;  4ZK4 A;  2X00 A;  4TWH A;  3TLV A;  3P4W A;  4ZZB A;  3U8J A;  4ZZC A;  3U8L A;  2XQ5 A;  3RI5 A;  3ZDG A;  5L4H A;  4TNV A;  2Y56 A;  2BG9 E;  5LG3 A;  3PMZ A;  5BP0 A;  3EHZ A;  3SH1 A;  4HFD A;  3JAE A;  2XNV A;  2BG9 C;  5J5I A;  3WTK A;  4ILA A;  4ZR6 A;  2QC1 B;  4UM3 S;  2BR7 A;  2PGZ A;  5AFK A;  4XHE A;  4HFH A;  3JAD A;  4ZJS A;  2BYP A;  3TLS A;  4IL4 A;  3UU3 A;  2BR8 A;  3SIO A;  4BFQ A;  5KZU A;  2W8F A;  2BYN A;  2XQ9 A;  2YMD A;  4TNW A;  3C84 A;  5HEG A;  2YOE A;  4QAC A;  3U8K A;  3UU5 A;  5AFM A;  2XNU A;  4A97 A;  4TWD A;  4EZ1 A;  4A98 A;  3IGQ A;  3GUA A;  3WTL A;  3EAM A;  4DBM A;  4HFB A;  4HQP A;  2XQ7 A;  2PH9 A;  5CFB A;  3UQ4 A;  4ALX A;  4BQT A;  4COF A;  3SQ6 A;  4QH5 A;  5AFH A;  2ZJV A;  2BYR A;  2VL0 A;  5FJV A;  3WTM A;  5LXB A;  2WN9 A;  3TLU A;  4ZRU A;  2XZ5 A;  1UX2 A;  3UU6 A;  4UM3 P;  5HEJ A;  3TLW A;  4AFG A;  5J5G A;  2BG9 A;  2Y7Y A;  3LSV A;  2WZY A;  4NPP A;  3WIP A;  3ZKR A;  4HFI A;  2WNC A;  4UM3 A;  5L4E A;  5BRX A;  1UV6 A;  2ZJU A;  4ILC A; 
#chains in the Genus database with same CATH topology
 2BJ0 A;  4UXU A;  5HEU A;  3UU4 A;  3PEO A;  5SYO A;  5AFN A;  2XNT A;  4LMK A;  5AFJ A;  4QH4 A;  4IL9 A;  4TWF A;  5AFL A;  2XQ3 A;  4UY2 A;  3UQ7 A;  2WNL A;  4AFH A;  5HCM A;  2XQ8 A;  5JME A;  3RQW A;  2XZ6 A;  2Y54 A;  4LML A;  2BYQ A;  2XQA A;  2XYT A;  3JAF A;  4AFT A;  3RQU A;  5TVC A;  4QAB A;  3EI0 A;  4UM1 A;  5BW2 A;  3UU8 A;  3RHW A;  3ZDH A;  5L47 A;  4XK9 A;  3WTH A;  2X00 D;  2YKS A;  4HFE A;  3U8N A;  3UUB A;  5J5H A;  5CO5 A;  3C79 A;  2BYS A;  2XQ6 A;  3TLT A;  1I9B A;  4NZB A;  4B5D A;  4Z90 A;  5IUX A;  3T4M A;  2WNJ A;  5AIN A;  4PIR A;  2W8G A;  5HCJ A;  4QAA A;  3RIF A;  4F8H A;  2BG9 B;  3RIA A;  3SQ9 A;  2Y57 A;  2YME A;  4FRR A;  4IRE A;  1UW6 A;  2YN6 A;  4D01 A;  4LMJ A;  4Z91 A;  4WV9 A;  2XYS A;  4HFC A;  2C9T A;  2Y58 A;  3P50 A;  4ZJT A;  5J5F A;  3U8M A;  3WTI A;  4X5T A;  5HEH A;  3WTJ A;  5AFM B;  2XQ4 A;  5HEO A;  4ZK1 A;  4QH1 A;  2UZ6 A;  3WTO A;  5KE4 A;  4ILB A;  5J0Z A;  3WTN A;  4ZK4 A;  2X00 A;  4TWH A;  3TLV A;  3P4W A;  4ZZB A;  3U8J A;  4ZZC A;  3U8L A;  2XQ5 A;  3RI5 A;  3ZDG A;  5L4H A;  4TNV A;  2Y56 A;  2BG9 E;  5LG3 A;  3PMZ A;  5BP0 A;  3EHZ A;  3SH1 A;  4HFD A;  3JAE A;  2XNV A;  2BG9 C;  5J5I A;  3WTK A;  4ILA A;  4ZR6 A;  2QC1 B;  4UM3 S;  2BR7 A;  2PGZ A;  5AFK A;  4XHE A;  4HFH A;  3JAD A;  4ZJS A;  2BYP A;  3TLS A;  4IL4 A;  3UU3 A;  2BR8 A;  3SIO A;  4BFQ A;  5KZU A;  2W8F A;  2BYN A;  2XQ9 A;  2YMD A;  4TNW A;  3C84 A;  5HEG A;  2YOE A;  4QAC A;  3U8K A;  3UU5 A;  5AFM A;  2XNU A;  4A97 A;  4TWD A;  4EZ1 A;  4A98 A;  3IGQ A;  3GUA A;  3WTL A;  3EAM A;  4DBM A;  4HFB A;  4HQP A;  2XQ7 A;  2PH9 A;  5CFB A;  3UQ4 A;  4ALX A;  4BQT A;  4COF A;  3SQ6 A;  4QH5 A;  5AFH A;  2ZJV A;  2BYR A;  2VL0 A;  5FJV A;  3WTM A;  5LXB A;  2WN9 A;  3TLU A;  4ZRU A;  2XZ5 A;  1UX2 A;  3UU6 A;  4UM3 P;  5HEJ A;  3TLW A;  4AFG A;  5J5G A;  2BG9 A;  2Y7Y A;  3LSV A;  2WZY A;  4NPP A;  3WIP A;  3ZKR A;  4HFI A;  2WNC A;  4UM3 A;  5L4E A;  5BRX A;  1UV6 A;  2ZJU A;  4ILC A; 
#chains in the Genus database with same CATH homology
 2BJ0 A;  4UXU A;  5HEU A;  3UU4 A;  3PEO A;  5SYO A;  5AFN A;  2XNT A;  4LMK A;  5AFJ A;  4QH4 A;  4IL9 A;  4TWF A;  5AFL A;  2XQ3 A;  4UY2 A;  3UQ7 A;  2WNL A;  4AFH A;  5HCM A;  2XQ8 A;  5JME A;  3RQW A;  2XZ6 A;  2Y54 A;  4LML A;  2BYQ A;  2XQA A;  2XYT A;  3JAF A;  4AFT A;  3RQU A;  5TVC A;  4QAB A;  3EI0 A;  4UM1 A;  5BW2 A;  3UU8 A;  3RHW A;  3ZDH A;  5L47 A;  4XK9 A;  3WTH A;  2X00 D;  2YKS A;  4HFE A;  3U8N A;  3UUB A;  5J5H A;  5CO5 A;  3C79 A;  2BYS A;  2XQ6 A;  3TLT A;  1I9B A;  4NZB A;  4B5D A;  4Z90 A;  5IUX A;  3T4M A;  2WNJ A;  5AIN A;  4PIR A;  2W8G A;  5HCJ A;  4QAA A;  3RIF A;  4F8H A;  2BG9 B;  3RIA A;  3SQ9 A;  2Y57 A;  2YME A;  4FRR A;  4IRE A;  1UW6 A;  2YN6 A;  4D01 A;  4LMJ A;  4Z91 A;  4WV9 A;  2XYS A;  4HFC A;  2C9T A;  2Y58 A;  3P50 A;  4ZJT A;  5J5F A;  3U8M A;  3WTI A;  4X5T A;  5HEH A;  3WTJ A;  5AFM B;  2XQ4 A;  5HEO A;  4ZK1 A;  4QH1 A;  2UZ6 A;  3WTO A;  5KE4 A;  4ILB A;  5J0Z A;  3WTN A;  4ZK4 A;  2X00 A;  4TWH A;  3TLV A;  3P4W A;  4ZZB A;  3U8J A;  4ZZC A;  3U8L A;  2XQ5 A;  3RI5 A;  3ZDG A;  5L4H A;  4TNV A;  2Y56 A;  2BG9 E;  5LG3 A;  3PMZ A;  5BP0 A;  3EHZ A;  3SH1 A;  4HFD A;  3JAE A;  2XNV A;  2BG9 C;  5J5I A;  3WTK A;  4ILA A;  4ZR6 A;  2QC1 B;  4UM3 S;  2BR7 A;  2PGZ A;  5AFK A;  4XHE A;  4HFH A;  3JAD A;  4ZJS A;  2BYP A;  3TLS A;  4IL4 A;  3UU3 A;  2BR8 A;  3SIO A;  4BFQ A;  5KZU A;  2W8F A;  2BYN A;  2XQ9 A;  2YMD A;  4TNW A;  3C84 A;  5HEG A;  2YOE A;  4QAC A;  3U8K A;  3UU5 A;  5AFM A;  2XNU A;  4A97 A;  4TWD A;  4EZ1 A;  4A98 A;  3IGQ A;  3GUA A;  3WTL A;  3EAM A;  4DBM A;  4HFB A;  4HQP A;  2XQ7 A;  2PH9 A;  5CFB A;  3UQ4 A;  4ALX A;  4BQT A;  4COF A;  3SQ6 A;  4QH5 A;  5AFH A;  2ZJV A;  2BYR A;  2VL0 A;  5FJV A;  3WTM A;  5LXB A;  2WN9 A;  3TLU A;  4ZRU A;  2XZ5 A;  1UX2 A;  3UU6 A;  4UM3 P;  5HEJ A;  3TLW A;  4AFG A;  5J5G A;  2BG9 A;  2Y7Y A;  3LSV A;  2WZY A;  4NPP A;  3WIP A;  3ZKR A;  4HFI A;  2WNC A;  4UM3 A;  5L4E A;  5BRX A;  1UV6 A;  2ZJU A;  4ILC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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