5Z79A

Crystal structure analysis of the hppk-dhps in complex with substrates
Total Genus 203
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
203
Knots found
sequence length
707
structure length
588
Chain Sequence
TPRNIAVLNFGTNDKKNCVTILETALYLTEKYLGKIINSSYIYETVPEYIVRDISWIGDLIPTVENSRYEESEDLIYECKELEVFLKNEKINESIIREVSVEDYENEARRIIKRNDEIMKKNLTSYFFNLTVVVRTFVEDPLAMLVILKYIEQIMKNRMIDIDILFFNNYTIFEKSISLKGEDIYKIITKYIHINHTSDQNRLDIIQNLGDKIEFLCIPHVYTKYRYSILLCLNDIIPEYKHSTFEEAIRSTYNSYVESFEEKYHINIRKNNKRLYVLKDKVSYLKERTHIVGILNVNYDSFSDGGLFVDPVKAVERMFEMASDGASVIDIGGESSAPYVVPNPSVTERDLVMPVLKLFKEEWHKLECEVGGGAVSSLQGKLQKVRDAKPIISIDTVNYDLFKECVEGELVDILNDISACTHNPEIIKLLRRKNKFYSVVLMHKRGNPHTMDKLTNYDDLISDIKRYLEDRLHFLVLNGVPRYRVLFDVGLGFAKKHDQSIKLLQHIHVYDEYPLFLGYSRKRFIVHCMWRFKMSHMRQDKDQLLYQKNICGGLAIASYSFYKKVDLIRVHDVLETKAVLDVLTRIHQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate
publication title Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase fromPlasmodium vivaxsheds light on drug resistance
pubmed doi rcsb
total genus 203
structure length 588
sequence length 707
chains with identical sequence B, C, D, E, F
other databases KnotProt 2.0: Artifct K -61 -31 -
ec nomenclature ec 2.5.1.15: Dihydropteroate synthase.
pdb deposition date 2018-01-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00809 Pterin_bind Pterin binding enzyme
A PF01288 HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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