7APIA

The s variant of human alpha1-antitrypsin, structure and implications for function and metabolism
Total Genus 89
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
89
sequence length
339
structure length
339
Chain Sequence
HPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Proteinase inhibitor
molecule keywords ALPHA 1-ANTITRYPSIN
publication title The S variant of human alpha 1-antitrypsin, structure and implications for function and metabolism.
pubmed doi rcsb
source organism Homo sapiens
total genus 89
structure length 339
sequence length 339
ec nomenclature
pdb deposition date 1988-09-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 7apiA01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 7apiA02
3NE4A 1QLPA 2WXWA 4GA7A 7APIA 3Q03A 1C8OA 1AZXI 2PEEA 4Y3KA 2WY0C 4R9IA 1JMOA 2HI9A 4Y40A 2B4XI 3NDFA 4AJUA 1LJ5A 1LK6I 2WY1A 1JMJA 1HLEA 1XQGA 3UT3A 1ATUA 1DB2A 1DZGL 3DRMA 4AQHA 4DY0A 2XN5A 1ATHA 2VH4A 1NQ9I 5CDZA 2WXZA 2WXYC 4G8RA 1PSIA 4AJTA 4X30A 1UHGA 2ZV6A 3NDDA 4YIAA 2PEFA 4RO9A 3LW2A 2ACHA 3F02A 1DZGI 2H4PA 2QUGA 2VDYA 1E03I 1MTPA 2CEOA 3EVJI 4AU3A 9APIA 1T1FA 2BEHL 4IF8A 1TB6I 2WXZC 1DZHL 4AU3B 2OL2A 4CAAA 1DVMA 1F0CA 4P0FA 1JVQI 2H4QA 2HIJL 1OVAB 1OYHL 1R1LI 3B9FI 3PB1I 1BR8I 3DRUA 1YXAA 4RSQA 1SEKA 1JTIA 1OPHA 3CVMA 4AU4A 1DVNA 5IO1A 2BEHI 1QMBA 1QMNA 1EZXA 3KCGI 4PYWA 2ZNHA 9PAIA 1D5SA 1DZHI 4DTEA 3OZQA 4ZK0A 1K9OI 1ATTA 3STOA 4C41A 2HIJI 5CE0A 1OYHI 1WZ9A 4EB1L 2RIWA 1A7CA 3FGQA 2ARQA 1IMVA 3R4LA 2H4RA 3F5NA 2WXXA 1HP7A 3H5CA 1OO8A 1OVAA 4ZK3A 4G8OA 5HGCA 5EI0A 4BB2A 5INWA 1XU8A 1SNGA 3CWMA 2XN7A 3PZFA 4AFXA 1JRRA 1E05I 2D26A 2RIVA 1KCTA 1LQ8A 3T1PA 4EB1I 2XN6A 1BY7A 1JJOC 2DUTA 4KDSA 5BRRI 4AU2A 3DY0A 1OVAC 3F1SA 1B3KA 1SR5A 2ARRA 3DLWA 5CDXA 2B5TI 2ANTI 3ZHAA 3VVJA 1E04I 4DY7C 1M93B 1XQJA 2GD4C 4ROBA 2VDXA 3CAAA 4ROAA 1IZ2A 1OC0A 2V95A 1ANTI 4IC0A 2XN3A 1C5GA 3EOXA 4P0OA 4C49A 3LE2A 3NDAA 2OAYA 3Q02A 2B4XL 2R9YA 5C98A 8APIA 3CWLA 1AS4A
chains in the Genus database with same CATH superfamily
3NE4A 1QLPA 2WXWA 4GA7A 7APIA 3Q03A 1C8OA 1AZXI 2PEEA 4Y3KA 2WY0C 4R9IA 1JMOA 2HI9A 4Y40A 2B4XI 3NDFA 4AJUA 1LJ5A 1LK6I 2WY1A 1JMJA 1HLEA 1XQGA 3UT3A 1ATUA 1DB2A 1DZGL 3DRMA 4AQHA 4DY0A 2XN5A 1ATHA 2VH4A 1NQ9I 5CDZA 2WXZA 2WXYC 4G8RA 1PSIA 4AJTA 4X30A 1UHGA 2ZV6A 3NDDA 4YIAA 2PEFA 4RO9A 3LW2A 2ACHA 3F02A 1DZGI 2H4PA 2QUGA 2VDYA 1E03I 1MTPA 2CEOA 3EVJI 4AU3A 9APIA 1T1FA 2BEHL 4IF8A 1TB6I 2WXZC 1DZHL 4AU3B 2OL2A 4CAAA 1DVMA 1F0CA 4P0FA 1JVQI 2H4QA 2HIJL 1OVAB 1OYHL 1R1LI 3B9FI 3PB1I 1BR8I 3DRUA 1YXAA 4RSQA 1SEKA 1JTIA 1OPHA 3CVMA 4AU4A 1DVNA 5IO1A 2BEHI 1QMBA 1QMNA 1EZXA 3KCGI 4PYWA 2ZNHA 9PAIA 1D5SA 1DZHI 4DTEA 3OZQA 4ZK0A 1K9OI 1ATTA 3STOA 4C41A 2HIJI 5CE0A 1OYHI 1WZ9A 4EB1L 2RIWA 1A7CA 3FGQA 2ARQA 1IMVA 3R4LA 2H4RA 3F5NA 2WXXA 1HP7A 3H5CA 1OO8A 1OVAA 4ZK3A 4G8OA 5HGCA 5EI0A 4BB2A 5INWA 1XU8A 1SNGA 3CWMA 2XN7A 3PZFA 4AFXA 1JRRA 1E05I 2D26A 2RIVA 1KCTA 1LQ8A 3T1PA 4EB1I 2XN6A 1BY7A 1JJOC 2DUTA 4KDSA 5BRRI 4AU2A 3DY0A 1OVAC 3F1SA 1B3KA 1SR5A 2ARRA 3DLWA 5CDXA 2B5TI 2ANTI 3ZHAA 3VVJA 1E04I 4DY7C 1M93B 1XQJA 2GD4C 4ROBA 2VDXA 3CAAA 4ROAA 1IZ2A 1OC0A 2V95A 1ANTI 4IC0A 2XN3A 1C5GA 3EOXA 4P0OA 4C49A 3LE2A 3NDAA 2OAYA 3Q02A 2B4XL 2R9YA 5C98A 8APIA 3CWLA 1AS4A
chains in the Genus database with same CATH topology
3NE4A 1QLPA 2WXWA 4GA7A 7APIA 3Q03A 1C8OA 1AZXI 2PEEA 4Y3KA 2WY0C 4R9IA 1JMOA 2HI9A 4Y40A 2B4XI 3NDFA 4AJUA 1LJ5A 1LK6I 2WY1A 1JMJA 1HLEA 1XQGA 3UT3A 1ATUA 1DB2A 1DZGL 3DRMA 4AQHA 4DY0A 2XN5A 1ATHA 2VH4A 1NQ9I 5CDZA 2WXZA 2WXYC 4G8RA 1PSIA 4AJTA 4X30A 1UHGA 2ZV6A 3NDDA 4YIAA 2PEFA 4RO9A 3LW2A 2ACHA 3F02A 1DZGI 2H4PA 2QUGA 2VDYA 1E03I 1MTPA 2CEOA 3EVJI 4AU3A 9APIA 1T1FA 2BEHL 4IF8A 1TB6I 2WXZC 1DZHL 4AU3B 2OL2A 4CAAA 1DVMA 1F0CA 4P0FA 1JVQI 2H4QA 2HIJL 1OVAB 1OYHL 1R1LI 3B9FI 3PB1I 1BR8I 3DRUA 1YXAA 4RSQA 1SEKA 1JTIA 1OPHA 3CVMA 4AU4A 1DVNA 5IO1A 2BEHI 1QMBA 1QMNA 1EZXA 3KCGI 4PYWA 2ZNHA 9PAIA 1D5SA 1DZHI 4DTEA 3OZQA 4ZK0A 1K9OI 1ATTA 3STOA 4C41A 2HIJI 5CE0A 1OYHI 1WZ9A 4EB1L 2RIWA 1A7CA 3FGQA 2ARQA 1IMVA 3R4LA 2H4RA 3F5NA 2WXXA 1HP7A 3H5CA 1OO8A 1OVAA 4ZK3A 4G8OA 5HGCA 5EI0A 4BB2A 5INWA 1XU8A 1SNGA 3CWMA 2XN7A 3PZFA 4AFXA 1JRRA 1E05I 2D26A 2RIVA 1KCTA 1LQ8A 3T1PA 4EB1I 2XN6A 1BY7A 1JJOC 2DUTA 4KDSA 5BRRI 4AU2A 3DY0A 1OVAC 3F1SA 1B3KA 1SR5A 2ARRA 3DLWA 5CDXA 2B5TI 2ANTI 3ZHAA 3VVJA 1E04I 4DY7C 1M93B 1XQJA 2GD4C 4ROBA 2VDXA 3CAAA 4ROAA 1IZ2A 1OC0A 2V95A 1ANTI 4IC0A 2XN3A 1C5GA 3EOXA 4P0OA 4C49A 3LE2A 3NDAA 2OAYA 3Q02A 2B4XL 2R9YA 5C98A 8APIA 3CWLA 1AS4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NE4 A;  1QLP A;  2WXW A;  4GA7 A;  7API A;  3Q03 A;  1C8O A;  1AZX I;  2PEE A;  4Y3K A;  2WY0 C;  4R9I A;  1JMO A;  2HI9 A;  4Y40 A;  2B4X I;  3NDF A;  4AJU A;  1LJ5 A;  1LK6 I;  2WY1 A;  1JMJ A;  1HLE A;  1XQG A;  3UT3 A;  1ATU A;  1DB2 A;  1DZG L;  3DRM A;  4AQH A;  4DY0 A;  2XN5 A;  1ATH A;  2VH4 A;  1NQ9 I;  5CDZ A;  2WXZ A;  2WXY C;  4G8R A;  1PSI A;  4AJT A;  4X30 A;  1UHG A;  2ZV6 A;  3NDD A;  4YIA A;  2PEF A;  4RO9 A;  3LW2 A;  2ACH A;  3F02 A;  1DZG I;  2H4P A;  2QUG A;  2VDY A;  1E03 I;  1MTP A;  2CEO A;  3EVJ I;  4AU3 A;  9API A;  1T1F A;  2BEH L;  4IF8 A;  1TB6 I;  2WXZ C;  1DZH L;  4AU3 B;  2OL2 A;  4CAA A;  1DVM A;  1F0C A;  4P0F A;  1JVQ I;  2H4Q A;  2HIJ L;  1OVA B;  1OYH L;  1R1L I;  3B9F I;  3PB1 I;  1BR8 I;  3DRU A;  1YXA A;  4RSQ A;  1SEK A;  1JTI A;  1OPH A;  3CVM A;  4AU4 A;  1DVN A;  5IO1 A;  2BEH I;  1QMB A;  1QMN A;  1EZX A;  3KCG I;  4PYW A;  2ZNH A;  9PAI A;  1D5S A;  1DZH I;  4DTE A;  3OZQ A;  4ZK0 A;  1K9O I;  1ATT A;  3STO A;  4C41 A;  2HIJ I;  5CE0 A;  1OYH I;  1WZ9 A;  4EB1 L;  2RIW A;  1A7C A;  3FGQ A;  2ARQ A;  1IMV A;  3R4L A;  2H4R A;  3F5N A;  2WXX A;  1HP7 A;  3H5C A;  1OO8 A;  1OVA A;  4ZK3 A;  4G8O A;  5HGC A;  5EI0 A;  4BB2 A;  5INW A;  1XU8 A;  1SNG A;  3CWM A;  2XN7 A;  3PZF A;  4AFX A;  1JRR A;  1E05 I;  2D26 A;  2RIV A;  1KCT A;  1LQ8 A;  3T1P A;  4EB1 I;  2XN6 A;  1BY7 A;  1JJO C;  2DUT A;  4KDS A;  5BRR I;  4AU2 A;  3DY0 A;  1OVA C;  3F1S A;  1B3K A;  1SR5 A;  2ARR A;  3DLW A;  5CDX A;  2B5T I;  2ANT I;  3ZHA A;  3VVJ A;  1E04 I;  4DY7 C;  1M93 B;  1XQJ A;  2GD4 C;  4ROB A;  2VDX A;  3CAA A;  4ROA A;  1IZ2 A;  1OC0 A;  2V95 A;  1ANT I;  4IC0 A;  2XN3 A;  1C5G A;  3EOX A;  4P0O A;  4C49 A;  3LE2 A;  3NDA A;  2OAY A;  3Q02 A;  2B4X L;  2R9Y A;  5C98 A;  8API A;  3CWL A;  1AS4 A; 
#chains in the Genus database with same CATH topology
 3NE4 A;  1QLP A;  2WXW A;  4GA7 A;  7API A;  3Q03 A;  1C8O A;  1AZX I;  2PEE A;  4Y3K A;  2WY0 C;  4R9I A;  1JMO A;  2HI9 A;  4Y40 A;  2B4X I;  3NDF A;  4AJU A;  1LJ5 A;  1LK6 I;  2WY1 A;  1JMJ A;  1HLE A;  1XQG A;  3UT3 A;  1ATU A;  1DB2 A;  1DZG L;  3DRM A;  4AQH A;  4DY0 A;  2XN5 A;  1ATH A;  2VH4 A;  1NQ9 I;  5CDZ A;  2WXZ A;  2WXY C;  4G8R A;  1PSI A;  4AJT A;  4X30 A;  1UHG A;  2ZV6 A;  3NDD A;  4YIA A;  2PEF A;  4RO9 A;  3LW2 A;  2ACH A;  3F02 A;  1DZG I;  2H4P A;  2QUG A;  2VDY A;  1E03 I;  1MTP A;  2CEO A;  3EVJ I;  4AU3 A;  9API A;  1T1F A;  2BEH L;  4IF8 A;  1TB6 I;  2WXZ C;  1DZH L;  4AU3 B;  2OL2 A;  4CAA A;  1DVM A;  1F0C A;  4P0F A;  1JVQ I;  2H4Q A;  2HIJ L;  1OVA B;  1OYH L;  1R1L I;  3B9F I;  3PB1 I;  1BR8 I;  3DRU A;  1YXA A;  4RSQ A;  1SEK A;  1JTI A;  1OPH A;  3CVM A;  4AU4 A;  1DVN A;  5IO1 A;  2BEH I;  1QMB A;  1QMN A;  1EZX A;  3KCG I;  4PYW A;  2ZNH A;  9PAI A;  1D5S A;  1DZH I;  4DTE A;  3OZQ A;  4ZK0 A;  1K9O I;  1ATT A;  3STO A;  4C41 A;  2HIJ I;  5CE0 A;  1OYH I;  1WZ9 A;  4EB1 L;  2RIW A;  1A7C A;  3FGQ A;  2ARQ A;  1IMV A;  3R4L A;  2H4R A;  3F5N A;  2WXX A;  1HP7 A;  3H5C A;  1OO8 A;  1OVA A;  4ZK3 A;  4G8O A;  5HGC A;  5EI0 A;  4BB2 A;  5INW A;  1XU8 A;  1SNG A;  3CWM A;  2XN7 A;  3PZF A;  4AFX A;  1JRR A;  1E05 I;  2D26 A;  2RIV A;  1KCT A;  1LQ8 A;  3T1P A;  4EB1 I;  2XN6 A;  1BY7 A;  1JJO C;  2DUT A;  4KDS A;  5BRR I;  4AU2 A;  3DY0 A;  1OVA C;  3F1S A;  1B3K A;  1SR5 A;  2ARR A;  3DLW A;  5CDX A;  2B5T I;  2ANT I;  3ZHA A;  3VVJ A;  1E04 I;  4DY7 C;  1M93 B;  1XQJ A;  2GD4 C;  4ROB A;  2VDX A;  3CAA A;  4ROA A;  1IZ2 A;  1OC0 A;  2V95 A;  1ANT I;  4IC0 A;  2XN3 A;  1C5G A;  3EOX A;  4P0O A;  4C49 A;  3LE2 A;  3NDA A;  2OAY A;  3Q02 A;  2B4X L;  2R9Y A;  5C98 A;  8API A;  3CWL A;  1AS4 A; 
#chains in the Genus database with same CATH homology
 3NE4 A;  1QLP A;  2WXW A;  4GA7 A;  7API A;  3Q03 A;  1C8O A;  1AZX I;  2PEE A;  4Y3K A;  2WY0 C;  4R9I A;  1JMO A;  2HI9 A;  4Y40 A;  2B4X I;  3NDF A;  4AJU A;  1LJ5 A;  1LK6 I;  2WY1 A;  1JMJ A;  1HLE A;  1XQG A;  3UT3 A;  1ATU A;  1DB2 A;  1DZG L;  3DRM A;  4AQH A;  4DY0 A;  2XN5 A;  1ATH A;  2VH4 A;  1NQ9 I;  5CDZ A;  2WXZ A;  2WXY C;  4G8R A;  1PSI A;  4AJT A;  4X30 A;  1UHG A;  2ZV6 A;  3NDD A;  4YIA A;  2PEF A;  4RO9 A;  3LW2 A;  2ACH A;  3F02 A;  1DZG I;  2H4P A;  2QUG A;  2VDY A;  1E03 I;  1MTP A;  2CEO A;  3EVJ I;  4AU3 A;  9API A;  1T1F A;  2BEH L;  4IF8 A;  1TB6 I;  2WXZ C;  1DZH L;  4AU3 B;  2OL2 A;  4CAA A;  1DVM A;  1F0C A;  4P0F A;  1JVQ I;  2H4Q A;  2HIJ L;  1OVA B;  1OYH L;  1R1L I;  3B9F I;  3PB1 I;  1BR8 I;  3DRU A;  1YXA A;  4RSQ A;  1SEK A;  1JTI A;  1OPH A;  3CVM A;  4AU4 A;  1DVN A;  5IO1 A;  2BEH I;  1QMB A;  1QMN A;  1EZX A;  3KCG I;  4PYW A;  2ZNH A;  9PAI A;  1D5S A;  1DZH I;  4DTE A;  3OZQ A;  4ZK0 A;  1K9O I;  1ATT A;  3STO A;  4C41 A;  2HIJ I;  5CE0 A;  1OYH I;  1WZ9 A;  4EB1 L;  2RIW A;  1A7C A;  3FGQ A;  2ARQ A;  1IMV A;  3R4L A;  2H4R A;  3F5N A;  2WXX A;  1HP7 A;  3H5C A;  1OO8 A;  1OVA A;  4ZK3 A;  4G8O A;  5HGC A;  5EI0 A;  4BB2 A;  5INW A;  1XU8 A;  1SNG A;  3CWM A;  2XN7 A;  3PZF A;  4AFX A;  1JRR A;  1E05 I;  2D26 A;  2RIV A;  1KCT A;  1LQ8 A;  3T1P A;  4EB1 I;  2XN6 A;  1BY7 A;  1JJO C;  2DUT A;  4KDS A;  5BRR I;  4AU2 A;  3DY0 A;  1OVA C;  3F1S A;  1B3K A;  1SR5 A;  2ARR A;  3DLW A;  5CDX A;  2B5T I;  2ANT I;  3ZHA A;  3VVJ A;  1E04 I;  4DY7 C;  1M93 B;  1XQJ A;  2GD4 C;  4ROB A;  2VDX A;  3CAA A;  4ROA A;  1IZ2 A;  1OC0 A;  2V95 A;  1ANT I;  4IC0 A;  2XN3 A;  1C5G A;  3EOX A;  4P0O A;  4C49 A;  3LE2 A;  3NDA A;  2OAY A;  3Q02 A;  2B4X L;  2R9Y A;  5C98 A;  8API A;  3CWL A;  1AS4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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