7LOOA

S-adenosyl methionine transferase cocrystallized with atp
Total Genus 140
50100150200250300350020406080100120140
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
140
sequence length
379
structure length
379
Chain Sequence
HLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDINQGVDRADPLEQGAGDQGLMFGYATNETDVLMPAPITYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVGIDAVVLSTQHSEEIDQKSLQEAVMEEIIKPILPAEWLTSATKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSIMVETFGTEKVPSEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGREHFPWEKTDKAQLLRDAAG
5010015020025030035035030025020015010050
020406080100120140Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
S1 (4-10)TI13 (247-250)AH1 (15-33)TIV11 (355-358)TI1 (11-14)EMPTYTII2 (241-244)TI12 (245-248)3H5 (352-354)TII3 (262-265)AH6 (270-288)TI2 (34-37)S3 (49-57)AH3 (100-106)TI14 (266-269)S2 (38-46)S11 (240-241)TII1 (46-49)3H4 (234-236)TI3 (85-88)S6 (90-96)AH2 (64-75)O2 (348-350)AH4 (136-154)S9 (176-189)S4 (78-79)3H1 (80-82)S5 (84-85)3H2 (111-113)TII4 (301-304)TVIII1 (108-111)TIV1 (116-119)S12 (293-300)S7 (120-127)TIV7 (246-249)TVIII4 (291-294)TIV2 (128-131)S8 (160-173)TI5 (130-133)AH5 (195-207)TI6 (157-160)TVIII2 (155-158)TIV5 (230-233)TIV3 (172-175)3H3 (213-215)TI7 (190-193)S10 (221-224)TI8 (207-210)TI9 (208-211)TIV4 (223-226)TI11 (225-228)TIV6 (243-246)TI'2 (251-254)TIV9 (253-256)AH9 (372-380)TI'3 (314-317)S13 (309-313)AH7 (322-332)AH8 (337-344)TI15 (362-365)TI10 (217-220)3H6 (366-368)TIV10 (318-321)Updating...
connected with : NaN
molecule tags Transferase
source organism Escherichia coli 908573
publication title Protein and substrate flexibility contribute to enzymatic specificity in human and bacterial methionine adenosyltransferase
rcsb
molecule keywords S-adenosylmethionine synthase
total genus 140
structure length 379
sequence length 379
chains with identical sequence B, Q, R
ec nomenclature ec 2.5.1.6: Methionine adenosyltransferase.
pdb deposition date 2021-02-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00438 S-AdoMet_synt_N S-adenosylmethionine synthetase, N-terminal domain
A PF02772 S-AdoMet_synt_M S-adenosylmethionine synthetase, central domain
A PF02773 S-AdoMet_synt_C S-adenosylmethionine synthetase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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