8QYUG

Beta-cardiac myosin s1 fragment in the pre-powerstroke state complexed to omecamtiv mecarbil
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
152
structure length
140
Chain Sequence
IEFTPEQIEEFKEAFTLFDRTPKCEMKITYGQCGDVLRALGQNPTQAEVLRVLGKPKQEELNSKMMDFDTFLPMLQHISKTYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGEKLTEDEVEKLMACINYEAFVKHIMAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Contractile protein
molecule keywords Myosin-7
publication title Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite antagonistic effects in heart contraction.
pubmed doi rcsb
total genus 43
structure length 140
sequence length 152
chains with identical sequence H
ec nomenclature
pdb deposition date 2023-10-26
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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