8R4UB

Structure of salt-inducible kinase 3 with inhibitors
Total Genus 54
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
54
sequence length
255
structure length
236
Chain Sequence
EVQLVQSGAGVKKPGSSVKVSCKSSGGSGSSAVSWIRQAPGQGVEWMGGITSIFGPANYAQKFQDRLKITADKATNTVYMELSGLTFEDTAVYYCARVGDYNFWNGHYRSGYYFDLWGRGTLVTVSSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNWYQQLPGTAPKLLIYSNTQRPSGVPDRFSGSKSATSASLAISGLQSEDEADYYCAAWDDSLNGHVVFGGGTKVTVL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Ligase
molecule keywords Serine/threonine-protein kinase SIK3
publication title The structures of salt inducible kinase 3 in complex with pharmacological inhibitors reveal determinants for binding and selectivity
doi rcsb
source organism Homo sapiens
total genus 54
structure length 236
sequence length 255
chains with identical sequence D, F, H
ec nomenclature
pdb deposition date 2023-11-14
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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