Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 1e25_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): LEU 4.A N SER 1.A OG no hydrogen 3.410 N/A LYS 5.A N SER 1.A O no hydrogen 3.216 N/A GLU 6.A N PRO 2.A O no hydrogen 3.068 N/A GLN 7.A N LEU 3.A O no hydrogen 3.048 N/A ILE 8.A N LEU 4.A O no hydrogen 2.964 N/A GLU 9.A N LYS 5.A O no hydrogen 2.928 N/A SER 10.A N.A GLU 6.A O no hydrogen 3.156 N/A SER 10.A N.B GLU 6.A O no hydrogen 3.172 N/A SER 10.A OG.A GLN 7.A O no hydrogen 2.575 N/A SER 10.A OG.B GLU 6.A O no hydrogen 3.185 N/A ILE 11.A N ILE 8.A O no hydrogen 2.901 N/A VAL 12.A N ILE 8.A O no hydrogen 3.368 N/A ILE 13.A N GLU 9.A O no hydrogen 2.987 N/A LYS 15.A N VAL 12.A O no hydrogen 3.225 N/A LYS 15.A NZ ILE 11.A O no hydrogen 2.768 N/A LYS 16.A N GLU 251.A OE2 no hydrogen 2.699 N/A LYS 16.A NZ GLU 251.A OE2 no hydrogen 3.370 N/A ALA 17.A N LYS 15.A O no hydrogen 2.762 N/A THR 18.A N LYS 247.A O no hydrogen 2.969 N/A GLY 20.A N PHE 245.A O no hydrogen 2.847 N/A VAL 21.A N ILE 34.A O no hydrogen 3.199 N/A ALA 22.A N ALA 243.A O no hydrogen 3.008 N/A VAL 23.A N LEU 32.A O no hydrogen 2.910 N/A TRP 24.A N LEU 241.A O no hydrogen 2.904 N/A TRP 24.A NE1 ASP 28.A O no hydrogen 3.026 N/A GLY 25.A N ASP 28.A OD2 no hydrogen 2.826 N/A ASP 28.A N GLY 25.A O no hydrogen 3.233 N/A LEU 32.A N VAL 23.A O no hydrogen 2.785 N/A ILE 34.A N VAL 21.A O no hydrogen 2.851 N/A ASN 35.A ND2 VAL 19.A O no hydrogen 2.989 N/A PHE 40.A N THR 159.A O no hydrogen 2.922 N/A MET 42.A N ASN 157.A O no hydrogen 2.962 N/A SER 44.A OG SER 108.A OG no hydrogen 3.166 N/A VAL 45.A N MET 42.A O no hydrogen 3.061 N/A PHE 46.A N GLN 43.A O no hydrogen 3.516 N/A LYS 47.A N SER 44.A O no hydrogen 3.042 N/A LYS 47.A NZ SER 44.A OG no hydrogen 2.753 N/A LYS 47.A NZ SER 108.A O no hydrogen 2.923 N/A LYS 47.A NZ ASN 110.A OD1 no hydrogen 2.681 N/A LYS 47.A NZ GLU 144.A OE2 no hydrogen 3.553 N/A LEU 48.A N VAL 45.A O no hydrogen 2.994 N/A LEU 50.A N PHE 46.A O no hydrogen 3.020 N/A ALA 51.A N LYS 47.A O no hydrogen 3.076 N/A MET 52.A N LEU 48.A O no hydrogen 3.099 N/A LEU 53.A N HIS 49.A O no hydrogen 3.068 N/A VAL 54.A N LEU 50.A O no hydrogen 2.936 N/A LEU 55.A N ALA 51.A O no hydrogen 2.874 N/A HIS 56.A N MET 52.A O no hydrogen 2.844 N/A GLN 57.A N.A LEU 53.A O no hydrogen 3.045 N/A GLN 57.A N.B LEU 53.A O no hydrogen 3.043 N/A GLN 57.A N.B VAL 54.A O no hydrogen 3.100 N/A VAL 58.A N VAL 54.A O no hydrogen 3.031 N/A ASP 59.A N LEU 55.A O no hydrogen 2.834 N/A GLN 60.A N HIS 56.A O no hydrogen 3.077 N/A GLY 61.A N VAL 58.A O no hydrogen 2.829 N/A LYS 62.A N GLN 57.A O.A no hydrogen 2.805 N/A LYS 62.A N GLN 57.A O.B no hydrogen 2.915 N/A LEU 63.A N GLN 57.A O.A no hydrogen 3.142 N/A ASP 64.A N.A GLN 67.A OE1 no hydrogen 3.282 N/A ASP 64.A N.B GLN 67.A OE1 no hydrogen 3.278 N/A ASN 66.A N ASP 64.A OD2.B no hydrogen 2.773 N/A ASN 66.A ND2 ASP 64.A OD2.B no hydrogen 3.224 N/A GLN 67.A N ASP 64.A O.A no hydrogen 2.958 N/A GLN 67.A N ASP 64.A O.B no hydrogen 3.166 N/A VAL 69.A N VAL 95.A O no hydrogen 2.829 N/A VAL 71.A N PHE 93.A O no hydrogen 2.654 N/A ARG 73.A N ASP 91.A O no hydrogen 2.799 N/A ARG 73.A NE GLY 90B.A O no hydrogen 2.839 N/A ARG 73.A NH1 MET 85.A O no hydrogen 2.960 N/A ARG 73.A NH2 MET 85.A O no hydrogen 3.181 N/A ARG 73.A NH2 TYR 88.A O no hydrogen 2.861 N/A ARG 73.A NH2 GLY 90B.A O no hydrogen 3.136 N/A ALA 74.A N ASN 72.A OD1 no hydrogen 2.908 N/A LYS 75.A N ASN 72.A O no hydrogen 2.893 N/A VAL 76.A N ASN 72.A O no hydrogen 3.314 N/A TRP 81.A NE1 HIS 107.A O no hydrogen 2.833 N/A ILE 84.A N ASP 109.A OD2 no hydrogen 2.751 N/A MET 85.A N ALA 82.A O no hydrogen 2.980 N/A LYS 86.A N PRO 83.A O no hydrogen 2.916 N/A ALA 87.A N ILE 84.A O no hydrogen 3.111 N/A TYR 88.A OH GLN 99.A OE1 no hydrogen 2.504 N/A PHE 93.A N VAL 71.A O no hydrogen 3.163 N/A VAL 95.A N VAL 69.A O no hydrogen 2.956 N/A VAL 97.A N GLN 67.A O no hydrogen 2.821 N/A GLN 98.A N.A LEU 65.A O no hydrogen 2.915 N/A GLN 98.A N.B LEU 65.A O no hydrogen 2.943 N/A GLN 98.A NE2.A GLN 102.A OE1 no hydrogen 3.535 N/A LEU 100.A N PRO 96.A O no hydrogen 3.111 N/A LEU 101.A N VAL 97.A O no hydrogen 2.888 N/A GLN 102.A N GLN 98.A O.A no hydrogen 3.246 N/A GLN 102.A N GLN 98.A O.B no hydrogen 2.944 N/A TYR 103.A N GLN 99.A O no hydrogen 2.931 N/A SER 104.A N.A LEU 100.A O no hydrogen 2.890 N/A SER 104.A N.B LEU 100.A O no hydrogen 2.874 N/A SER 104.A OG.A LEU 100.A O no hydrogen 2.834 N/A VAL 105.A N LEU 101.A O no hydrogen 2.958 N/A SER 106.A N GLN 102.A O no hydrogen 2.859 N/A SER 106.A OG TRP 188.A O no hydrogen 2.770 N/A HIS 107.A N TYR 103.A O no hydrogen 3.139 N/A ASP 109.A N TYR 103.A O no hydrogen 2.939 N/A ASN 110.A N TRP 81.A O no hydrogen 2.958 N/A ASN 110.A ND2 THR 80.A OG1 no hydrogen 2.885 N/A ALA 112.A N ASP 109.A OD1 no hydrogen 2.876 N/A CYS 113.A N ASP 109.A O no hydrogen 3.257 N/A ASP 114.A N ASN 110.A O no hydrogen 3.314 N/A LEU 115.A N VAL 111.A O no hydrogen 3.016 N/A LEU 116.A N ALA 112.A O no hydrogen 3.067 N/A PHE 117.A N CYS 113.A O no hydrogen 3.021 N/A GLU 118.A N ASP 114.A O no hydrogen 3.113 N/A LEU 119.A N LEU 116.A O no hydrogen 2.974 N/A VAL 120.A N PHE 117.A O no hydrogen 3.240 N/A GLY 122.A N PHE 117.A O no hydrogen 2.934 N/A ALA 125.A N GLY 122.A O no hydrogen 2.874 N/A LEU 126.A N GLY 122.A O no hydrogen 3.293 N/A HIS 127.A N PRO 123.A O no hydrogen 2.834 N/A ASP 128.A N ALA 124.A O no hydrogen 3.074 N/A TYR 129.A N ALA 125.A O no hydrogen 3.102 N/A ILE 130.A N LEU 126.A O no hydrogen 2.960 N/A GLN 131.A N HIS 127.A O no hydrogen 3.049 N/A GLN 131.A NE2 HIS 127.A NE2 no hydrogen 3.473 N/A SER 132.A N ASP 128.A O no hydrogen 2.839 N/A SER 132.A OG TYR 129.A O no hydrogen 2.645 N/A MET 133.A N ILE 130.A O no hydrogen 2.994 N/A GLY 134.A N GLN 131.A O no hydrogen 2.773 N/A ILE 135.A N ILE 130.A O no hydrogen 3.393 N/A LYS 136.A NZ GLN 131.A O no hydrogen 3.527 N/A LYS 136.A NZ GLN 131.A OE1 no hydrogen 3.012 N/A THR 138.A OG1 THR 159.A OG1 no hydrogen 3.051 N/A ALA 139.A N TRP 158.A O no hydrogen 2.765 N/A VAL 141.A N ASN 157.A OD1 no hydrogen 2.848 N/A ALA 142.A N ASN 157.A OD1 no hydrogen 3.068 N/A ASN 143.A N GLN 146.A OE1 no hydrogen 3.092 N/A GLU 144.A N ASP 114.A OD1 no hydrogen 3.019 N/A ALA 145.A N ASP 114.A OD2 no hydrogen 2.976 N/A GLN 146.A N ASN 143.A OD1 no hydrogen 2.890 N/A MET 147.A N ASN 143.A O no hydrogen 3.026 N/A HIS 148.A N GLU 144.A O no hydrogen 2.803 N/A HIS 148.A N ALA 145.A O no hydrogen 3.035 N/A ALA 149.A N ALA 145.A O no hydrogen 2.942 N/A ALA 149.A N GLN 146.A O no hydrogen 3.286 N/A ASP 150.A N GLN 146.A O no hydrogen 3.324 N/A GLN 152.A N ASP 150.A OD1 no hydrogen 3.234 N/A VAL 153.A N ASP 150.A O no hydrogen 3.153 N/A GLN 154.A NE2 ASP 151.A O no hydrogen 3.037 N/A TYR 155.A N GLN 152.A O no hydrogen 3.035 N/A TYR 155.A OH ASP 248.A OD1 no hydrogen 2.688 N/A GLN 156.A N VAL 153.A O no hydrogen 2.714 N/A ASN 157.A N GLN 154.A O no hydrogen 3.387 N/A ASN 157.A ND2 ALA 142.A O no hydrogen 2.822 N/A THR 159.A N PHE 40.A O no hydrogen 2.938 N/A THR 159.A OG1 GLU 137.A O no hydrogen 3.436 N/A THR 159.A OG1 THR 138.A OG1 no hydrogen 3.051 N/A THR 159.A OG1 SER 160.A O no hydrogen 2.864 N/A SER 160.A N GLU 137.A O no hydrogen 2.952 N/A SER 160.A OG GLU 137.A O no hydrogen 3.518 N/A SER 160.A OG GLU 137.A OE1 no hydrogen 2.754 N/A GLY 163.A N SER 160.A OG no hydrogen 3.035 N/A ALA 164.A N SER 160.A O no hydrogen 3.033 N/A ALA 165.A N MET 161.A O.A no hydrogen 3.064 N/A ALA 165.A N MET 161.A O.B no hydrogen 2.843 N/A GLU 166.A N LYS 162.A O no hydrogen 2.944 N/A ILE 167.A N GLY 163.A O no hydrogen 3.170 N/A LEU 168.A N ALA 164.A O no hydrogen 3.322 N/A LYS 169.A N ALA 165.A O no hydrogen 2.930 N/A LYS 169.A NZ GLU 172.A OE2.A no hydrogen 3.215 N/A LYS 170.A N GLU 166.A O no hydrogen 2.899 N/A LYS 170.A NZ MET 133.A O no hydrogen 3.049 N/A PHE 171.A N ILE 167.A O no hydrogen 3.069 N/A GLU 172.A N.A LEU 168.A O no hydrogen 2.853 N/A GLU 172.A N.B LEU 168.A O no hydrogen 2.872 N/A GLN 173.A N LYS 169.A O no hydrogen 2.905 N/A LYS 174.A N PHE 171.A O no hydrogen 3.033 N/A GLN 176.A NE2 THR 175.A OG1 no hydrogen 3.009 N/A SER 178.A N ASP 59.A OD2 no hydrogen 2.875 N/A SER 178.A OG ASP 59.A OD1 no hydrogen 2.644 N/A SER 178.A OG SER 181.A OG no hydrogen 3.283 N/A SER 181.A N SER 178.A OG no hydrogen 3.209 N/A SER 181.A OG ASP 59.A OD1 no hydrogen 2.626 N/A SER 181.A OG SER 178.A OG no hydrogen 3.283 N/A GLN 182.A N SER 178.A O no hydrogen 2.999 N/A ALA 183.A N GLU 179.A O no hydrogen 3.052 N/A LEU 184.A N THR 180.A O no hydrogen 3.075 N/A LEU 185.A N SER 181.A O no hydrogen 3.016 N/A TRP 186.A N GLN 182.A O no hydrogen 2.979 N/A LYS 187.A N ALA 183.A O no hydrogen 3.014 N/A LYS 187.A NZ GLU 191.A OE2 no hydrogen 2.692 N/A TRP 188.A N LEU 184.A O no hydrogen 3.057 N/A MET 189.A N LEU 185.A O no hydrogen 2.978 N/A VAL 190.A N TRP 186.A O no hydrogen 2.937 N/A GLU 191.A N LYS 187.A O no hydrogen 2.978 N/A THR 192.A OG1 TRP 188.A O no hydrogen 3.415 N/A THR 192.A OG1 MET 189.A O no hydrogen 3.022 N/A THR 192.A OG1 HIS 211.A O no hydrogen 2.939 N/A THR 193.A N SER 106.A O no hydrogen 3.374 N/A THR 193.A OG1 SER 106.A O no hydrogen 3.559 N/A THR 193.A OG1 HIS 107.A ND1 no hydrogen 3.402 N/A THR 194.A OG1 THR 213.A OG1 no hydrogen 2.698 N/A ARG 198.A N GLY 195.A O no hydrogen 3.172 N/A ARG 198.A NE GLU 257.A OE2 no hydrogen 2.838 N/A ARG 198.A NH1 GLY 214.A O no hydrogen 3.234 N/A ARG 198.A NH1 THR 215.A OG1 no hydrogen 3.065 N/A ARG 198.A NH1 ASN 227.A O no hydrogen 3.008 N/A ARG 198.A NH2 THR 215.A OG1 no hydrogen 2.789 N/A ARG 198.A NH2 GLU 257.A OE2 no hydrogen 3.497 N/A LEU 199.A N ASP 228.A OD2 no hydrogen 3.021 N/A GLY 201.A N ARG 198.A O no hydrogen 2.867 N/A LEU 203.A N LYS 200.A O no hydrogen 3.416 N/A THR 207.A N PRO 204.A O no hydrogen 3.072 N/A THR 207.A OG1 PRO 204.A O no hydrogen 2.655 N/A ALA 210.A N ILE 231.A O no hydrogen 2.974 N/A HIS 211.A N MET 189.A O no hydrogen 3.068 N/A HIS 211.A ND1 ASP 228.A OD1 no hydrogen 2.644 N/A LYS 212.A N LEU 229.A O no hydrogen 3.000 N/A LYS 212.A NZ SER 108.A OG no hydrogen 2.862 N/A LYS 212.A NZ THR 213.A O no hydrogen 2.782 N/A THR 213.A OG1 THR 194.A OG1 no hydrogen 2.698 N/A GLY 214.A N ASN 227.A O no hydrogen 3.028 N/A SER 216.A N ALA 225.A O no hydrogen 3.041 N/A SER 216.A OG GLN 217.A O no hydrogen 3.398 N/A SER 216.A OG ALA 225.A O no hydrogen 3.532 N/A THR 223.A N SER 249.A O no hydrogen 3.056 N/A ALA 225.A N SER 216.A OG no hydrogen 3.083 N/A THR 226.A N VAL 246.A O no hydrogen 2.916 N/A ASN 227.A N GLY 214.A O no hydrogen 2.806 N/A ASN 227.A ND2 PRO 41.A O no hydrogen 3.018 N/A ASN 227.A ND2 MET 42.A O no hydrogen 3.156 N/A ASP 228.A N VAL 244.A O no hydrogen 3.086 N/A LEU 229.A N LYS 212.A O no hydrogen 3.198 N/A GLY 230.A N VAL 242.A O no hydrogen 2.888 N/A ILE 231.A N ALA 210.A O no hydrogen 2.854 N/A ILE 232.A N LEU 240.A O no hydrogen 2.846 N/A LEU 233.A N VAL 208.A O no hydrogen 3.011 N/A LEU 234.A N ARG 238.A O no hydrogen 2.787 N/A GLY 237.A N LEU 234.A O no hydrogen 2.740 N/A ARG 238.A N ASP 236.A OD1 no hydrogen 3.120 N/A ARG 238.A NE ASP 236.A OD2 no hydrogen 2.876 N/A ARG 238.A NH1 ASP 27.A OD1 no hydrogen 2.978 N/A ARG 238.A NH2 ASP 27.A OD2 no hydrogen 3.021 N/A LEU 240.A N ILE 232.A O no hydrogen 2.783 N/A LEU 241.A N TRP 24.A O no hydrogen 3.023 N/A VAL 242.A N GLY 230.A O no hydrogen 3.049 N/A ALA 243.A N ALA 22.A O no hydrogen 2.989 N/A VAL 244.A N ASP 228.A O no hydrogen 2.963 N/A PHE 245.A N GLY 20.A O no hydrogen 2.960 N/A VAL 246.A N THR 226.A O no hydrogen 2.859 N/A LYS 247.A N THR 18.A O no hydrogen 2.770 N/A LYS 247.A NZ GLU 38.A OE2 no hydrogen 2.664 N/A LYS 247.A NZ LYS 39.A O no hydrogen 2.728 N/A ASP 248.A N ALA 224.A O no hydrogen 3.003 N/A SER 249.A N THR 223.A O no hydrogen 3.008 N/A SER 249.A OG ASN 256.A OD1 no hydrogen 2.600 N/A ALA 250.A N LYS 16.A O no hydrogen 2.751 N/A GLU 251.A N SER 249.A OG no hydrogen 2.967 N/A SER 252.A OG THR 255.A OG1 no hydrogen 3.087 N/A THR 255.A N SER 252.A OG no hydrogen 3.048 N/A THR 255.A OG1 SER 252.A OG no hydrogen 3.087 N/A ASN 256.A N SER 252.A O no hydrogen 3.004 N/A GLU 257.A N SER 253.A O no hydrogen 3.089 N/A ALA 258.A N ARG 254.A O no hydrogen 2.951 N/A ILE 259.A N THR 255.A O no hydrogen 2.975 N/A ALA 261.A N GLU 257.A O no hydrogen 2.941 N/A GLN 262.A N ALA 258.A O no hydrogen 2.819 N/A VAL 263.A N ILE 259.A O no hydrogen 2.975 N/A ALA 264.A N ILE 260.A O no hydrogen 2.965 N/A GLN 265.A N ALA 261.A O no hydrogen 2.917 N/A THR 266.A N GLN 262.A O no hydrogen 2.944 N/A THR 266.A OG1 GLN 262.A O no hydrogen 2.789 N/A ALA 267.A N VAL 263.A O no hydrogen 2.962 N/A TYR 268.A N ALA 264.A O no hydrogen 2.935 N/A GLN 269.A N GLN 265.A O no hydrogen 2.902 N/A PHE 270.A N THR 266.A O no hydrogen 3.027 N/A GLU 271.A N ALA 267.A O no hydrogen 3.108 N/A LEU 272.A N TYR 268.A O no hydrogen 3.054 N/A LYS 273.A N GLN 269.A O no hydrogen 2.909 N/A LYS 274.A N PHE 270.A O no hydrogen 3.165 N/A LYS 274.A NZ ASP 28.A OD1 no hydrogen 3.042 N/A LYS 274.A NZ GLU 271.A OE2 no hydrogen 3.226 N/A LEU 275.A N GLU 271.A O no hydrogen 3.025 N/A SER 276.A N.A LEU 272.A O no hydrogen 2.733 N/A SER 276.A N.B LEU 272.A O no hydrogen 2.740 N/A SER 276.A OG.B LEU 272.A O no hydrogen 3.099 N/A ALA 277.A N LYS 273.A O no hydrogen 3.068 N/A LEU 278.A N LYS 274.A O no hydrogen 2.842 N/A GLN 78A.A NE2 ARG 73.A O no hydrogen 2.914 N/A GLN 78A.A NE2 VAL 76.A O no hydrogen 2.581 N/A LYS 219A.A N LYS 222D.A O no hydrogen 2.923 N/A LYS 222D.A N LYS 219A.A O no hydrogen 3.199 N/A