Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 1frn_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): SER 2.A OG GLU 289.A OE1 no hydrogen 3.375 N/A SER 2.A OG GLU 289.A OE2 no hydrogen 2.936 N/A LYS 3.A N GLU 289.A OE1 no hydrogen 2.872 N/A LYS 3.A NZ ALA 288.A O no hydrogen 2.799 N/A LYS 4.A N SER 2.A OG no hydrogen 2.965 N/A LYS 4.A NZ GLU 136.A O no hydrogen 3.179 N/A LYS 4.A NZ ASN 292.A OD1 no hydrogen 2.832 N/A MET 5.A N MET 139.A O no hydrogen 2.816 N/A GLU 6.A N LYS 4.A O no hydrogen 2.849 N/A ASN 12.A N PRO 132.A O no hydrogen 2.915 N/A ASN 12.A ND2 PHE 14.A O no hydrogen 3.649 N/A LYS 13.A NZ GLU 49.A O no hydrogen 2.573 N/A PHE 14.A N GLY 131.A O no hydrogen 3.099 N/A LYS 15.A N THR 18.A O no hydrogen 3.351 N/A LYS 15.A NZ ASN 12.A O no hydrogen 3.027 N/A THR 18.A N LYS 15.A O no hydrogen 2.688 N/A TYR 20.A N LEU 129.A O no hydrogen 2.847 N/A GLY 22.A N VAL 127.A O no hydrogen 2.830 N/A CYS 24.A N ALA 125.A O no hydrogen 2.767 N/A CYS 24.A SG LEU 26.A O no hydrogen 3.706 N/A LEU 25.A N VAL 43.A O no hydrogen 2.952 N/A LEU 26.A N VAL 43.A O no hydrogen 3.444 N/A ASN 27.A ND2 LEU 118.A O no hydrogen 3.054 N/A ASN 27.A ND2 LEU 121.A O no hydrogen 3.049 N/A THR 28.A N HIS 41.A O no hydrogen 2.914 N/A LYS 29.A NZ ASP 33.A OD1 no hydrogen 3.034 N/A ILE 30.A N THR 39.A O no hydrogen 2.719 N/A GLY 32.A N SER 190.A O no hydrogen 3.035 N/A THR 39.A N THR 31.A OG1 no hydrogen 3.343 N/A TRP 40.A N VAL 97.A O no hydrogen 2.742 N/A TRP 40.A NE1 GLU 38.A OE1 no hydrogen 2.804 N/A HIS 41.A N THR 28.A O no hydrogen 2.885 N/A HIS 41.A ND1 TYR 194.A OH no hydrogen 2.490 N/A HIS 41.A NE2 ASP 86.A OD2 no hydrogen 2.976 N/A MET 42.A N LEU 95.A O no hydrogen 2.990 N/A VAL 43.A N LEU 26.A O no hydrogen 2.833 N/A PHE 44.A N VAL 93.A O no hydrogen 2.712 N/A SER 45.A N ARG 23.A O no hydrogen 2.880 N/A SER 45.A OG GLU 47.A OE2 no hydrogen 3.392 N/A HIS 46.A N LYS 91.A O no hydrogen 2.788 N/A GLU 47.A N LYS 91.A O no hydrogen 3.128 N/A GLU 49.A N HIS 46.A O no hydrogen 2.694 N/A ILE 50.A N HIS 46.A ND1 no hydrogen 3.087 N/A TYR 52.A N ILE 50.A O no hydrogen 2.895 N/A TYR 52.A OH SER 81.A OG no hydrogen 2.687 N/A TYR 52.A OH SER 82.A O no hydrogen 2.771 N/A TYR 52.A OH SER 92.A O no hydrogen 3.100 N/A ARG 53.A N GLN 56.A OE1 no hydrogen 2.872 N/A ARG 53.A NH1 MET 5.A O no hydrogen 3.125 N/A ARG 53.A NH1 GLU 7.A O no hydrogen 2.559 N/A ARG 53.A NH2 GLU 7.A O no hydrogen 3.095 N/A GLU 54.A N GLU 54.A OE1 no hydrogen 2.684 N/A GLN 56.A N ARG 53.A O no hydrogen 3.095 N/A GLN 56.A NE2 THR 10.A O no hydrogen 2.981 N/A GLN 56.A NE2 GLY 134.A O no hydrogen 3.129 N/A SER 57.A N VAL 133.A O no hydrogen 2.907 N/A VAL 58.A N TYR 77.A O no hydrogen 3.078 N/A GLY 59.A N THR 130.A O no hydrogen 2.799 N/A VAL 60.A N ARG 75.A O no hydrogen 2.867 N/A ILE 61.A N LYS 128.A O no hydrogen 3.228 N/A ASP 66.A N LYS 70.A O no hydrogen 2.424 N/A ASN 68.A N ASP 66.A OD1 no hydrogen 2.924 N/A GLY 69.A N ASP 66.A O no hydrogen 2.769 N/A LYS 70.A N ASP 66.A OD1 no hydrogen 2.602 N/A ARG 75.A N VAL 60.A O no hydrogen 2.975 N/A ARG 75.A NH1 LYS 73.A O no hydrogen 2.652 N/A TYR 77.A N VAL 58.A O no hydrogen 3.087 N/A ILE 79.A N GLN 56.A O no hydrogen 2.890 N/A ALA 80.A N SER 94.A O no hydrogen 2.871 N/A SER 81.A OG TYR 52.A OH no hydrogen 2.687 N/A SER 82.A OG GLU 169.A OE2 no hydrogen 2.703 N/A ALA 83.A N GLU 54.A OE2 no hydrogen 2.775 N/A GLY 85.A N SER 82.A OG no hydrogen 3.408 N/A GLY 88.A N GLY 85.A O no hydrogen 3.101 N/A ALA 90.A N LEU 84.A O no hydrogen 2.637 N/A LYS 91.A N ASP 89.A OD1 no hydrogen 2.880 N/A VAL 93.A N PHE 44.A O no hydrogen 2.751 N/A SER 94.A N SER 81.A OG no hydrogen 3.053 N/A SER 94.A OG ASP 86.A OD2 no hydrogen 2.645 N/A LEU 95.A N MET 42.A O no hydrogen 2.853 N/A VAL 97.A N TRP 40.A O no hydrogen 2.799 N/A ARG 99.A N GLU 38.A O no hydrogen 2.702 N/A ARG 99.A NE GLU 38.A OE1 no hydrogen 2.801 N/A ARG 99.A NH1 ASN 116.A OD1 no hydrogen 2.916 N/A ARG 99.A NH1 ASP 120.A OD1 no hydrogen 3.123 N/A ARG 99.A NH2 GLU 38.A OE1 no hydrogen 3.420 N/A ARG 99.A NH2 ASP 120.A OD1 no hydrogen 3.047 N/A LEU 100.A N SER 115.A OG no hydrogen 3.035 N/A TYR 102.A N ILE 110.A O no hydrogen 2.623 N/A ASN 104.A N GLU 108.A O no hydrogen 2.751 N/A ASN 104.A ND2 GLU 108.A OE1 no hydrogen 3.266 N/A GLY 107.A N ASN 104.A O no hydrogen 3.041 N/A ILE 110.A N TYR 102.A O no hydrogen 2.327 N/A GLY 112.A N LEU 100.A O no hydrogen 2.420 N/A CYS 114.A SG TYR 77.A OH no hydrogen 3.708 N/A ASN 116.A N GLY 112.A O no hydrogen 3.140 N/A ASN 116.A ND2 LEU 100.A O no hydrogen 2.791 N/A ASN 116.A ND2 GLY 112.A O no hydrogen 2.632 N/A PHE 117.A N VAL 113.A O no hydrogen 3.165 N/A LEU 118.A N CYS 114.A O no hydrogen 2.983 N/A CYS 119.A N SER 115.A O no hydrogen 2.840 N/A CYS 119.A SG VAL 97.A O no hydrogen 3.850 N/A CYS 119.A SG SER 115.A O no hydrogen 3.363 N/A ASP 120.A N ASN 116.A O no hydrogen 2.922 N/A ASP 120.A N PHE 117.A O no hydrogen 3.301 N/A LEU 121.A N LEU 118.A O no hydrogen 3.002 N/A GLY 124.A N CYS 24.A O no hydrogen 2.570 N/A ALA 125.A N LYS 122.A O no hydrogen 2.792 N/A VAL 127.A N GLY 22.A O no hydrogen 2.732 N/A LEU 129.A N TYR 20.A O no hydrogen 2.746 N/A THR 130.A N GLY 59.A O no hydrogen 2.736 N/A GLY 131.A N PHE 14.A O no hydrogen 2.867 N/A VAL 133.A N SER 57.A O no hydrogen 2.700 N/A LEU 138.A N LYS 135.A O no hydrogen 3.225 N/A LYS 141.A N LYS 3.A O no hydrogen 2.796 N/A LYS 141.A NZ SER 2.A O no hydrogen 2.437 N/A LYS 141.A NZ LYS 4.A O no hydrogen 3.509 N/A LYS 141.A NZ GLU 7.A OE2 no hydrogen 2.738 N/A ASN 144.A N ASP 142.A OD1 no hydrogen 2.826 N/A ALA 145.A N ASP 142.A O no hydrogen 3.161 N/A THR 146.A N ASN 248.A O no hydrogen 2.830 N/A ILE 147.A N LEU 179.A O no hydrogen 2.816 N/A ILE 148.A N TYR 250.A O no hydrogen 3.013 N/A MET 149.A N TRP 181.A O no hydrogen 2.851 N/A LEU 150.A N TYR 252.A O no hydrogen 2.975 N/A GLY 151.A N PHE 183.A O no hydrogen 3.022 N/A THR 152.A N CYS 254.A O no hydrogen 3.094 N/A GLY 153.A N GLY 185.A O no hydrogen 3.236 N/A THR 154.A OG1 TYR 296.A OH no hydrogen 2.594 N/A GLY 155.A N THR 152.A O no hydrogen 2.796 N/A ILE 156.A N GLY 153.A O no hydrogen 3.062 N/A ALA 157.A N THR 154.A O no hydrogen 2.939 N/A PHE 159.A N ILE 156.A O no hydrogen 2.906 N/A ARG 160.A N ILE 156.A O no hydrogen 2.963 N/A ARG 160.A NE GLU 197.A OE1 no hydrogen 2.695 N/A ARG 160.A NH1 ALA 80.A O no hydrogen 2.810 N/A ARG 160.A NH1 ASP 86.A OD1 no hydrogen 2.834 N/A ARG 160.A NH2 ASP 86.A OD1 no hydrogen 3.058 N/A ARG 160.A NH2 GLU 197.A OE2 no hydrogen 2.985 N/A SER 161.A N ALA 157.A O no hydrogen 3.211 N/A SER 161.A OG SER 81.A O no hydrogen 2.892 N/A PHE 162.A N PRO 158.A O no hydrogen 3.027 N/A LEU 163.A N PHE 159.A O no hydrogen 2.913 N/A TRP 164.A N ARG 160.A O no hydrogen 3.033 N/A TRP 164.A NE1 GLU 197.A OE1 no hydrogen 2.981 N/A LYS 165.A N SER 161.A O no hydrogen 3.373 N/A MET 166.A N PHE 162.A O no hydrogen 2.917 N/A PHE 167.A N LEU 163.A O no hydrogen 2.629 N/A PHE 168.A N TRP 164.A O no hydrogen 2.824 N/A HIS 171.A NE2 GLU 169.A OE1 no hydrogen 2.549 N/A ASN 177.A N PRO 143.A O no hydrogen 2.737 N/A ASN 177.A ND2 PHE 176.A O no hydrogen 3.536 N/A LEU 179.A N ALA 145.A O no hydrogen 3.327 N/A ALA 180.A N ASN 208.A O no hydrogen 2.757 N/A TRP 181.A N ILE 147.A O no hydrogen 2.700 N/A TRP 181.A NE1 ASP 212.A OD2 no hydrogen 3.063 N/A LEU 182.A N ARG 210.A O no hydrogen 2.869 N/A PHE 183.A N MET 149.A O no hydrogen 2.695 N/A LEU 184.A N ASP 212.A O no hydrogen 2.793 N/A GLY 185.A N GLY 151.A O no hydrogen 3.057 N/A VAL 186.A N ALA 214.A O no hydrogen 2.857 N/A THR 188.A OG1 SER 190.A OG no hydrogen 2.582 N/A THR 188.A OG1 SER 191.A OG no hydrogen 3.144 N/A SER 189.A N GLU 218.A OE2 no hydrogen 3.058 N/A SER 189.A OG GLU 218.A OE1 no hydrogen 3.232 N/A SER 190.A N THR 188.A OG1 no hydrogen 3.065 N/A SER 190.A OG THR 188.A OG1 no hydrogen 2.582 N/A SER 191.A N THR 188.A O no hydrogen 2.744 N/A SER 191.A OG THR 188.A OG1 no hydrogen 3.144 N/A TYR 194.A OH HIS 41.A ND1 no hydrogen 2.490 N/A GLU 197.A N TYR 194.A O no hydrogen 2.926 N/A PHE 198.A N TYR 194.A O no hydrogen 3.066 N/A GLU 199.A N LYS 195.A O no hydrogen 2.799 N/A LYS 200.A N GLU 196.A O no hydrogen 3.199 N/A MET 201.A N GLU 197.A O no hydrogen 3.093 N/A LYS 202.A N PHE 198.A O no hydrogen 3.006 N/A LYS 202.A NZ PRO 206.A O no hydrogen 3.186 N/A LYS 202.A NZ PHE 209.A O no hydrogen 3.099 N/A GLU 203.A N GLU 199.A O no hydrogen 3.251 N/A LYS 204.A N LYS 200.A O no hydrogen 3.113 N/A ALA 205.A N MET 201.A O no hydrogen 2.904 N/A ASN 208.A N ALA 205.A O no hydrogen 2.964 N/A ASN 208.A ND2 GLY 178.A O no hydrogen 2.854 N/A ARG 210.A N ALA 180.A O no hydrogen 2.731 N/A ARG 210.A NH1 GLU 239.A OE2 no hydrogen 2.820 N/A ASP 212.A N LEU 182.A O no hydrogen 2.869 N/A ALA 214.A N LEU 184.A O no hydrogen 2.769 N/A VAL 215.A N GLN 219.A OE1 no hydrogen 2.634 N/A SER 216.A N VAL 186.A O no hydrogen 2.992 N/A ARG 217.A N PRO 187.A O no hydrogen 3.017 N/A GLU 218.A N VAL 215.A O no hydrogen 2.833 N/A GLN 219.A N VAL 215.A O no hydrogen 3.005 N/A ASN 221.A N GLU 225.A O no hydrogen 2.805 N/A ASN 221.A ND2 GLU 225.A OE1 no hydrogen 3.250 N/A LYS 223.A NZ GLU 225.A OE2 no hydrogen 2.593 N/A GLY 224.A N ASN 221.A O no hydrogen 2.771 N/A MET 227.A N GLN 219.A O no hydrogen 2.770 N/A TYR 228.A N LYS 226.A O no hydrogen 2.977 N/A TYR 228.A N THR 231.A OG1 no hydrogen 3.124 N/A THR 231.A OG1 LYS 226.A O no hydrogen 3.127 N/A ARG 232.A N TYR 228.A O no hydrogen 2.755 N/A ARG 232.A N ILE 229.A O no hydrogen 2.881 N/A ARG 232.A NE PHE 213.A O no hydrogen 2.926 N/A ARG 232.A NH1 GLN 235.A OE1 no hydrogen 3.535 N/A ARG 232.A NH2 PHE 213.A O no hydrogen 3.189 N/A MET 233.A N ILE 229.A O no hydrogen 2.867 N/A ALA 234.A N GLN 230.A O no hydrogen 2.774 N/A TYR 236.A N MET 233.A O no hydrogen 2.491 N/A TYR 236.A OH ASP 212.A OD1 no hydrogen 2.872 N/A ALA 237.A N ALA 234.A O no hydrogen 3.334 N/A LEU 240.A N TYR 236.A O no hydrogen 2.860 N/A TRP 241.A N ALA 237.A O no hydrogen 2.898 N/A TRP 241.A NE1 GLU 274.A OE2 no hydrogen 2.631 N/A GLU 242.A N VAL 238.A O no hydrogen 2.951 N/A MET 243.A N GLU 239.A O no hydrogen 2.807 N/A LEU 244.A N LEU 240.A O no hydrogen 2.880 N/A LYS 245.A N GLU 242.A O no hydrogen 3.200 N/A LYS 245.A NZ GLU 242.A OE1 no hydrogen 3.428 N/A LYS 245.A NZ GLU 274.A OE2 no hydrogen 2.508 N/A LYS 246.A N MET 243.A O no hydrogen 3.055 N/A THR 249.A N LYS 246.A O no hydrogen 3.216 N/A THR 249.A OG1 MET 243.A O no hydrogen 2.780 N/A TYR 250.A N THR 146.A O no hydrogen 2.725 N/A PHE 251.A N GLN 290.A O no hydrogen 2.749 N/A TYR 252.A N ILE 148.A O no hydrogen 2.797 N/A TYR 252.A OH LEU 138.A O no hydrogen 2.625 N/A MET 253.A N ASN 292.A O no hydrogen 2.739 N/A CYS 254.A N LEU 150.A O no hydrogen 2.859 N/A CYS 254.A SG GLU 294.A O no hydrogen 3.443 N/A GLY 255.A N GLU 294.A O no hydrogen 3.300 N/A LEU 256.A N THR 152.A OG1 no hydrogen 3.197 N/A LYS 257.A N TYR 296.A O no hydrogen 2.726 N/A MET 259.A N LEU 256.A O no hydrogen 2.793 N/A GLU 260.A N LYS 257.A O no hydrogen 3.183 N/A LYS 261.A N GLY 258.A O no hydrogen 3.329 N/A ILE 263.A N GLU 260.A O no hydrogen 3.153 N/A ASP 264.A N GLU 260.A O no hydrogen 3.092 N/A ASP 265.A N LYS 261.A O no hydrogen 2.862 N/A MET 267.A N ILE 263.A O no hydrogen 2.844 N/A VAL 268.A N ASP 264.A O no hydrogen 2.779 N/A SER 269.A N ILE 266.A O no hydrogen 3.134 N/A LEU 270.A N ILE 266.A O no hydrogen 3.181 N/A ALA 271.A N MET 267.A O no hydrogen 2.930 N/A ALA 272.A N VAL 268.A O no hydrogen 3.152 N/A ALA 273.A N SER 269.A O no hydrogen 3.142 N/A GLU 274.A N ALA 271.A O no hydrogen 2.732 N/A GLY 275.A N ALA 272.A O no hydrogen 2.679 N/A ILE 276.A N ALA 271.A O no hydrogen 2.883 N/A TRP 278.A NE1 ASP 264.A OD1 no hydrogen 2.618 N/A TYR 281.A N ASP 277.A O no hydrogen 2.861 N/A LYS 282.A N TRP 278.A O no hydrogen 2.832 N/A LYS 282.A NZ ASP 264.A OD1 no hydrogen 2.934 N/A ARG 283.A N ILE 279.A O no hydrogen 3.373 N/A ARG 283.A NE GLU 280.A OE1 no hydrogen 3.009 N/A ARG 283.A NH2 GLU 280.A OE1 no hydrogen 2.866 N/A GLN 284.A N GLU 280.A O no hydrogen 3.103 N/A GLN 284.A NE2 GLU 280.A O no hydrogen 2.734 N/A LEU 285.A N TYR 281.A O no hydrogen 2.775 N/A LYS 286.A N LYS 282.A O no hydrogen 2.692 N/A LYS 287.A N ARG 283.A O no hydrogen 3.056 N/A ALA 288.A N GLN 284.A O no hydrogen 3.002 N/A GLU 289.A N LYS 286.A O no hydrogen 3.015 N/A GLN 290.A N LEU 285.A O no hydrogen 2.866 N/A GLN 290.A NE2 LYS 246.A O no hydrogen 3.104 N/A GLN 290.A NE2 THR 249.A O no hydrogen 2.841 N/A ASN 292.A N PHE 251.A O no hydrogen 2.735 N/A ASN 292.A ND2 PHE 251.A O no hydrogen 3.235 N/A ASN 292.A ND2 GLU 289.A O no hydrogen 3.240 N/A VAL 293.A N GLU 136.A OE2 no hydrogen 3.184 N/A GLU 294.A N MET 253.A O no hydrogen 2.955 N/A TYR 296.A N GLY 255.A O no hydrogen 2.615 N/A TYR 296.A OH THR 154.A OG1 no hydrogen 2.594 N/A