Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 1xcg_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): TRP 3.A N GLU 24.A OE1 no hydrogen 3.178 N/A GLN 4.A N GLU 24.A OE2 no hydrogen 2.960 N/A GLN 4.A NE2 GLU 24.A OE2 no hydrogen 2.921 N/A THR 6.A N TRP 3.A O no hydrogen 3.306 N/A THR 6.A OG1 ASN 2.A O no hydrogen 2.665 N/A THR 6.A OG1 TRP 3.A O no hydrogen 3.568 N/A LEU 15.A N VAL 12.A O no hydrogen 3.362 N/A ARG 18.A N THR 16.A OG1 no hydrogen 3.303 N/A ARG 18.A NH1 LYS 181.A O no hydrogen 2.875 N/A ILE 20.A N THR 16.A O no hydrogen 2.976 N/A ASP 21.A N GLN 17.A O no hydrogen 2.950 N/A ARG 22.A N ARG 18.A O no hydrogen 2.959 N/A ARG 22.A NH1 GLU 19.A OE1 no hydrogen 3.380 N/A ARG 22.A NH1 GLU 19.A OE2 no hydrogen 2.806 N/A ARG 22.A NH1 ILE 93.A O no hydrogen 3.292 N/A ARG 22.A NH2 LYS 94.A O no hydrogen 2.368 N/A GLN 23.A N GLU 19.A O no hydrogen 3.132 N/A GLN 23.A NE2 GLU 19.A OE2 no hydrogen 2.983 N/A GLN 23.A NE2 ILE 93.A O no hydrogen 2.868 N/A GLU 24.A N ILE 20.A O no hydrogen 2.830 N/A VAL 25.A N ASP 21.A O no hydrogen 3.125 N/A ILE 26.A N ARG 22.A O no hydrogen 3.159 N/A ASN 27.A N GLN 23.A O no hydrogen 3.050 N/A GLU 28.A N GLU 24.A O no hydrogen 2.929 N/A LEU 29.A N VAL 25.A O no hydrogen 3.082 N/A PHE 30.A N ILE 26.A O no hydrogen 2.826 N/A VAL 31.A N ASN 27.A O no hydrogen 2.764 N/A THR 32.A N GLU 28.A O no hydrogen 2.858 N/A THR 32.A OG1 GLU 28.A O no hydrogen 2.899 N/A THR 32.A OG1 LEU 29.A O no hydrogen 3.272 N/A GLU 33.A N LEU 29.A O no hydrogen 2.970 N/A ALA 34.A N PHE 30.A O no hydrogen 3.166 N/A SER 35.A N VAL 31.A O no hydrogen 3.030 N/A HIS 36.A N THR 32.A O no hydrogen 2.884 N/A LEU 37.A N GLU 33.A O no hydrogen 3.055 N/A ARG 38.A N ALA 34.A O no hydrogen 3.065 N/A ARG 38.A NH1 SER 35.A O no hydrogen 3.237 N/A THR 39.A N SER 35.A O no hydrogen 3.125 N/A THR 39.A OG1 SER 35.A O no hydrogen 3.504 N/A LEU 40.A N HIS 36.A O no hydrogen 2.884 N/A ARG 41.A N LEU 37.A O no hydrogen 2.916 N/A VAL 42.A N ARG 38.A O no hydrogen 2.966 N/A LEU 43.A N THR 39.A O no hydrogen 3.005 N/A ASP 44.A N LEU 40.A O no hydrogen 3.052 N/A LEU 45.A N ARG 41.A O no hydrogen 2.957 N/A ILE 46.A N VAL 42.A O no hydrogen 2.829 N/A PHE 47.A N LEU 43.A O no hydrogen 3.330 N/A TYR 48.A N LEU 43.A O no hydrogen 2.793 N/A GLN 49.A N ASP 44.A O no hydrogen 2.870 N/A GLN 49.A NE2 ASP 44.A OD1 no hydrogen 2.977 N/A ARG 50.A NH2 GLU 146.A OE1 no hydrogen 3.124 N/A MET 51.A N PHE 47.A O no hydrogen 2.838 N/A LYS 52.A N TYR 48.A O no hydrogen 2.993 N/A LYS 52.A NZ TYR 48.A OH no hydrogen 2.757 N/A LYS 53.A N GLN 49.A O no hydrogen 2.978 N/A GLU 54.A N ARG 50.A O no hydrogen 2.963 N/A ASN 55.A N LYS 52.A O no hydrogen 3.363 N/A LEU 56.A N MET 51.A O no hydrogen 3.078 N/A ARG 59.A NH2 LYS 52.A O no hydrogen 3.243 N/A GLU 60.A N GLU 60.A OE1 no hydrogen 2.687 N/A LEU 62.A N PRO 58.A O no hydrogen 2.924 N/A ALA 63.A N ARG 59.A O no hydrogen 2.703 N/A ARG 64.A N GLU 60.A O no hydrogen 3.292 N/A ARG 64.A N GLU 61.A O no hydrogen 3.114 N/A ARG 64.A NE GLU 60.A O no hydrogen 3.381 N/A LEU 65.A N GLU 61.A O no hydrogen 3.169 N/A LEU 65.A N LEU 62.A O no hydrogen 3.062 N/A PHE 66.A N LEU 62.A O no hydrogen 2.894 N/A ASN 68.A ND2 VAL 115.A O no hydrogen 3.014 N/A GLU 71.A N GLU 71.A OE1 no hydrogen 2.697 N/A LEU 72.A N ASN 68.A O no hydrogen 2.996 N/A ILE 73.A N LEU 69.A O no hydrogen 2.814 N/A GLU 74.A N PRO 70.A O no hydrogen 3.062 N/A ILE 75.A N GLU 71.A O no hydrogen 2.953 N/A HIS 76.A N LEU 72.A O no hydrogen 3.356 N/A HIS 76.A N ILE 73.A O no hydrogen 3.109 N/A HIS 76.A ND1 GLU 33.A OE2 no hydrogen 2.602 N/A HIS 76.A NE2 GLU 165.A OE2 no hydrogen 2.681 N/A ASN 77.A N ILE 73.A O no hydrogen 2.701 N/A SER 78.A N GLU 74.A O no hydrogen 3.034 N/A SER 78.A OG GLU 74.A O no hydrogen 2.957 N/A TRP 79.A NE1 LEU 99.A O no hydrogen 3.141 N/A CYS 80.A N HIS 76.A O no hydrogen 2.793 N/A GLU 81.A N ASN 77.A O no hydrogen 2.810 N/A ALA 82.A N SER 78.A O no hydrogen 3.107 N/A MET 83.A N TRP 79.A O no hydrogen 3.009 N/A LYS 84.A N CYS 80.A O no hydrogen 2.990 N/A LYS 84.A NZ GLU 81.A OE2 no hydrogen 2.941 N/A LYS 85.A N GLU 81.A O no hydrogen 2.851 N/A LEU 86.A N ALA 82.A O no hydrogen 3.106 N/A ARG 87.A N MET 83.A O no hydrogen 3.089 N/A GLU 88.A N LYS 84.A O no hydrogen 3.158 N/A GLU 89.A N LEU 86.A O no hydrogen 3.197 N/A GLY 90.A N ARG 87.A O no hydrogen 3.398 N/A ILE 93.A N GLN 23.A OE1 no hydrogen 2.887 N/A ILE 96.A N GLU 189.A OE1 no hydrogen 3.285 N/A ILE 96.A N GLU 189.A OE2 no hydrogen 2.771 N/A SER 97.A N GLU 189.A OE1 no hydrogen 3.032 N/A SER 97.A OG GLU 189.A OE1 no hydrogen 2.548 N/A MET 100.A N ILE 96.A O no hydrogen 3.038 N/A LEU 101.A N SER 97.A O no hydrogen 2.752 N/A ALA 102.A N ASP 98.A O no hydrogen 2.762 N/A ARG 103.A N MET 100.A O no hydrogen 2.927 N/A ARG 103.A NH1 ARG 103.A O no hydrogen 3.555 N/A ARG 103.A NH2 ILE 75.A O no hydrogen 3.349 N/A PHE 104.A N MET 100.A O no hydrogen 2.967 N/A ASP 105.A N LEU 101.A O no hydrogen 3.152 N/A ARG 109.A N ASP 105.A O no hydrogen 3.226 N/A GLU 110.A N GLY 106.A O no hydrogen 3.088 N/A GLU 111.A N PRO 107.A O no hydrogen 2.930 N/A LEU 112.A N ALA 108.A O no hydrogen 3.098 N/A GLN 113.A N ARG 109.A O no hydrogen 2.873 N/A GLN 114.A N GLU 110.A O no hydrogen 2.985 N/A VAL 115.A N GLU 111.A O no hydrogen 2.932 N/A ALA 116.A N LEU 112.A O no hydrogen 2.859 N/A ALA 117.A N GLN 113.A O no hydrogen 3.000 N/A GLN 118.A N GLN 114.A O no hydrogen 2.959 N/A PHE 119.A N VAL 115.A O no hydrogen 3.040 N/A CYS 120.A N ALA 116.A O no hydrogen 2.994 N/A CYS 120.A SG ALA 116.A O no hydrogen 3.258 N/A SER 121.A N ALA 117.A O no hydrogen 2.958 N/A SER 121.A OG ALA 117.A O no hydrogen 3.061 N/A GLN 123.A N CYS 120.A O no hydrogen 2.900 N/A GLN 123.A NE2 ILE 162.A O no hydrogen 3.024 N/A SER 124.A OG GLU 215.A OE2 no hydrogen 2.734 N/A ALA 126.A N TYR 122.A O no hydrogen 3.157 N/A LEU 127.A N GLN 123.A O no hydrogen 2.865 N/A GLU 128.A N SER 124.A O no hydrogen 3.287 N/A LEU 129.A N ILE 125.A O no hydrogen 3.142 N/A ILE 130.A N ALA 126.A O no hydrogen 2.995 N/A LYS 131.A N LEU 127.A O no hydrogen 3.035 N/A THR 132.A N GLU 128.A O no hydrogen 3.009 N/A THR 132.A OG1 GLU 128.A O no hydrogen 3.245 N/A LYS 133.A N LEU 129.A O no hydrogen 2.914 N/A LYS 133.A NZ GLU 61.A OE1 no hydrogen 2.816 N/A GLN 134.A N ILE 130.A O no hydrogen 2.894 N/A ARG 135.A N LYS 131.A O no hydrogen 3.122 N/A LYS 136.A N THR 132.A O no hydrogen 2.918 N/A LYS 136.A N LYS 133.A O no hydrogen 3.076 N/A GLU 137.A N LYS 133.A O no hydrogen 2.859 N/A ARG 139.A NH1 GLU 54.A O no hydrogen 3.463 N/A ARG 139.A NH1 ASN 55.A O no hydrogen 3.355 N/A ARG 139.A NH2 GLU 54.A O no hydrogen 2.963 N/A PHE 140.A N GLU 137.A O no hydrogen 3.112 N/A GLN 141.A N GLU 137.A O no hydrogen 3.094 N/A LEU 142.A N SER 138.A O no hydrogen 2.980 N/A PHE 143.A N ARG 139.A O no hydrogen 3.057 N/A MET 144.A N PHE 140.A O no hydrogen 2.953 N/A GLN 145.A N GLN 141.A O no hydrogen 2.936 N/A GLU 146.A N LEU 142.A O no hydrogen 2.875 N/A ALA 147.A N PHE 143.A O no hydrogen 2.839 N/A GLU 148.A N MET 144.A O no hydrogen 2.959 N/A SER 149.A N GLU 146.A O no hydrogen 3.307 N/A SER 149.A OG GLU 146.A O no hydrogen 2.817 N/A HIS 150.A N ALA 147.A O no hydrogen 3.067 N/A HIS 150.A NE2 GLN 152.A OE1 no hydrogen 2.665 N/A CYS 153.A N HIS 150.A O no hydrogen 2.888 N/A CYS 153.A SG ALA 147.A O no hydrogen 3.530 N/A ARG 154.A N PRO 151.A O no hydrogen 2.926 N/A LEU 156.A N CYS 153.A O no hydrogen 2.889 N/A GLN 157.A N ASP 160.A OD2 no hydrogen 2.787 N/A LEU 158.A N GLU 148.A OE2 no hydrogen 2.935 N/A ASP 160.A N GLN 157.A O no hydrogen 2.771 N/A LEU 161.A N GLN 157.A O no hydrogen 3.104 N/A LEU 161.A N LEU 158.A O no hydrogen 2.888 N/A ILE 162.A N LEU 158.A O no hydrogen 2.984 N/A SER 164.A N LEU 161.A O no hydrogen 3.069 N/A SER 164.A OG LEU 161.A O no hydrogen 2.681 N/A GLN 167.A N ILE 163.A O no hydrogen 3.047 N/A ARG 168.A N SER 164.A O no hydrogen 2.683 N/A ARG 168.A NE GLU 33.A OE1 no hydrogen 3.142 N/A ARG 168.A NE TYR 172.A OH no hydrogen 3.336 N/A ARG 168.A NH1 THR 32.A OG1 no hydrogen 2.682 N/A ARG 168.A NH2 LEU 29.A O no hydrogen 3.464 N/A ARG 168.A NH2 THR 32.A OG1 no hydrogen 3.089 N/A ARG 168.A NH2 GLU 33.A OE1 no hydrogen 2.754 N/A LEU 169.A N GLU 165.A O no hydrogen 2.993 N/A THR 170.A N MET 166.A O no hydrogen 3.262 N/A THR 170.A OG1 GLN 167.A O no hydrogen 2.702 N/A LYS 171.A N ARG 168.A O no hydrogen 3.010 N/A TYR 172.A OH GLU 33.A OE1 no hydrogen 2.505 N/A LEU 175.A N LYS 171.A O no hydrogen 2.805 N/A LEU 176.A N TYR 172.A O no hydrogen 2.825 N/A GLU 177.A N PRO 173.A O no hydrogen 2.893 N/A SER 178.A N LEU 174.A O no hydrogen 3.132 N/A ILE 179.A N LEU 175.A O no hydrogen 2.967 N/A ILE 180.A N LEU 176.A O no hydrogen 2.745 N/A LYS 181.A N GLU 177.A O no hydrogen 3.101 N/A HIS 182.A N ILE 179.A O no hydrogen 3.237 N/A THR 183.A N ILE 180.A O no hydrogen 2.906 N/A THR 183.A OG1 ILE 179.A O no hydrogen 2.812 N/A THR 187.A OG1 GLU 184.A O no hydrogen 3.247 N/A GLU 191.A N THR 187.A O no hydrogen 3.114 N/A LYS 192.A N SER 188.A O no hydrogen 2.794 N/A LYS 192.A NZ SER 97.A OG no hydrogen 3.081 N/A LYS 192.A NZ ASP 98.A OD1 no hydrogen 2.801 N/A LEU 193.A N GLU 189.A O no hydrogen 3.079 N/A CYS 194.A N HIS 190.A O no hydrogen 3.036 N/A CYS 194.A SG HIS 190.A O no hydrogen 3.381 N/A ARG 195.A N GLU 191.A O no hydrogen 3.032 N/A ARG 195.A NE ASP 105.A OD1 no hydrogen 2.999 N/A ARG 195.A NH2 ASP 105.A OD1 no hydrogen 3.133 N/A ALA 196.A N LYS 192.A O no hydrogen 2.984 N/A ARG 197.A N LEU 193.A O no hydrogen 2.869 N/A ARG 197.A NE ASP 198.A OD1 no hydrogen 2.812 N/A ARG 197.A NH2 ASP 198.A OD1 no hydrogen 2.705 N/A ARG 197.A NH2 ASP 198.A OD2 no hydrogen 3.374 N/A ASP 198.A N CYS 194.A O no hydrogen 3.077 N/A GLN 199.A N ARG 195.A O no hydrogen 2.907 N/A CYS 200.A N ALA 196.A O no hydrogen 2.977 N/A CYS 200.A SG ALA 196.A O no hydrogen 3.582 N/A ARG 201.A N ARG 197.A O no hydrogen 3.227 N/A GLU 202.A N ASP 198.A O no hydrogen 3.276 N/A ILE 203.A N GLN 199.A O no hydrogen 2.894 N/A LEU 204.A N CYS 200.A O no hydrogen 2.896 N/A LYS 205.A N ARG 201.A O no hydrogen 2.817 N/A TYR 206.A N GLU 202.A O no hydrogen 2.874 N/A VAL 207.A N ILE 203.A O no hydrogen 2.847 N/A ASN 208.A N LEU 204.A O no hydrogen 2.814 N/A GLU 209.A N LYS 205.A O no hydrogen 2.972 N/A ALA 210.A N TYR 206.A O no hydrogen 2.954 N/A VAL 211.A N VAL 207.A O no hydrogen 3.013 N/A LYS 212.A N ASN 208.A O no hydrogen 3.040 N/A GLN 213.A N GLU 209.A O no hydrogen 2.972 N/A GLN 213.A NE2 GLU 209.A OE2 no hydrogen 3.365 N/A THR 214.A N ALA 210.A O no hydrogen 3.088 N/A THR 214.A OG1 ALA 210.A O no hydrogen 3.054 N/A GLU 215.A N VAL 211.A O no hydrogen 2.874 N/A ASN 216.A N LYS 212.A O no hydrogen 2.883 N/A ASN 216.A ND2 MET 253.A O no hydrogen 3.212 N/A ARG 217.A N GLN 213.A O no hydrogen 2.903 N/A HIS 218.A N THR 214.A O no hydrogen 3.224 N/A ARG 219.A N GLU 215.A O no hydrogen 2.921 N/A LEU 220.A N ASN 216.A O no hydrogen 2.972 N/A GLU 221.A N ARG 217.A O no hydrogen 2.857 N/A GLY 222.A N HIS 218.A O no hydrogen 3.223 N/A TYR 223.A N ARG 219.A O no hydrogen 2.977 N/A TYR 223.A OH GLU 256.A OE1 no hydrogen 2.704 N/A GLN 224.A N LEU 220.A O no hydrogen 2.972 N/A LYS 225.A N GLU 221.A O no hydrogen 3.436 N/A ARG 226.A N GLY 222.A O no hydrogen 3.418 N/A LEU 227.A N GLN 224.A O no hydrogen 3.295 N/A ASP 228.A N LEU 290.A O no hydrogen 2.811 N/A THR 230.A OG1 ASP 228.A OD1 no hydrogen 3.090 N/A THR 230.A OG1 ASP 228.A OD2 no hydrogen 3.202 N/A GLU 233.A N THR 230.A O no hydrogen 3.288 N/A SER 236.A OG ASN 237.A OD1 no hydrogen 3.330 N/A ALA 240.A N ASN 237.A O no hydrogen 2.967 N/A PHE 243.A N ALA 240.A O no hydrogen 3.166 N/A LYS 244.A N ALA 241.A O no hydrogen 3.253 N/A LEU 248.A N GLN 224.A OE1 no hydrogen 2.607 N/A THR 249.A N ASP 247.A OD1 no hydrogen 3.258 N/A THR 250.A N ASP 247.A O no hydrogen 3.506 N/A THR 250.A OG1 ASP 247.A O no hydrogen 3.082 N/A ARG 251.A N LEU 248.A O no hydrogen 3.330 N/A LYS 252.A NZ GLU 277.A OE2 no hydrogen 3.517 N/A ILE 254.A N LEU 275.A O no hydrogen 2.780 N/A HIS 255.A N LEU 275.A O no hydrogen 3.196 N/A GLY 257.A N VAL 273.A O no hydrogen 3.205 N/A LEU 259.A N LEU 271.A O no hydrogen 3.000 N/A THR 260.A N VAL 334.A O no hydrogen 2.924 N/A THR 260.A OG1 ASP 270.A OD1 no hydrogen 3.040 N/A TRP 261.A N LEU 269.A O no hydrogen 2.649 N/A ARG 262.A NE GLU 332.A OE2 no hydrogen 3.218 N/A ARG 262.A NH1 ASP 313.A OD2 no hydrogen 3.337 N/A ARG 262.A NH2 ASP 313.A OD2 no hydrogen 2.610 N/A ARG 262.A NH2 GLU 332.A OE2 no hydrogen 3.075 N/A ILE 263.A N LYS 267.A O no hydrogen 3.102 N/A SER 264.A N LYS 267.A O no hydrogen 3.232 N/A LEU 271.A N LEU 259.A O no hydrogen 2.675 N/A HIS 272.A N LEU 283.A O no hydrogen 2.849 N/A VAL 273.A N GLY 257.A O no hydrogen 3.083 N/A LEU 274.A N VAL 281.A O no hydrogen 2.936 N/A LEU 275.A N HIS 255.A O no hydrogen 2.901 N/A LEU 276.A N LEU 279.A O no hydrogen 2.843 N/A GLU 277.A N LYS 252.A O no hydrogen 3.082 N/A LEU 280.A N LEU 300.A O no hydrogen 2.815 N/A VAL 281.A N LEU 274.A O no hydrogen 2.893 N/A LEU 282.A N PRO 298.A O no hydrogen 2.768 N/A LEU 283.A N HIS 272.A O no hydrogen 3.118 N/A GLN 284.A N LEU 291.A O no hydrogen 3.216 N/A GLN 286.A N LYS 289.A O no hydrogen 3.379 N/A LEU 290.A N ARG 226.A O no hydrogen 2.971 N/A LEU 291.A N GLN 284.A O no hydrogen 3.039 N/A LEU 292.A N ASP 228.A O no hydrogen 2.987 N/A CYS 294.A SG ASN 237.A OD1 no hydrogen 3.560 N/A CYS 294.A SG PHE 296.A O no hydrogen 3.533 N/A SER 297.A OG LEU 239.A O no hydrogen 3.534 N/A SER 297.A OG VAL 299.A O no hydrogen 2.728 N/A VAL 299.A N SER 297.A OG no hydrogen 3.244 N/A LEU 300.A N LEU 280.A O no hydrogen 2.950 N/A LEU 302.A N ASP 278.A O no hydrogen 2.832 N/A ALA 304.A N LYS 301.A O no hydrogen 3.226 N/A LEU 306.A N ILE 320.A O no hydrogen 2.835 N/A ARG 308.A N PHE 318.A O no hydrogen 3.095 N/A ARG 315.A N ASP 313.A OD1 no hydrogen 3.023 N/A ALA 316.A N ASP 313.A O no hydrogen 3.411 N/A PHE 317.A N LEU 333.A O no hydrogen 2.945 N/A PHE 318.A N ARG 308.A O no hydrogen 2.766 N/A ILE 319.A N TYR 331.A O no hydrogen 3.030 N/A ILE 320.A N LEU 306.A O no hydrogen 2.914 N/A CYS 321.A SG GLN 329.A O no hydrogen 3.763 N/A THR 322.A N ALA 304.A O no hydrogen 3.013 N/A TYR 331.A N ILE 319.A O no hydrogen 3.147 N/A TYR 331.A OH SER 297.A O no hydrogen 2.797 N/A LEU 333.A N PHE 317.A O no hydrogen 3.071 N/A VAL 334.A N THR 260.A O no hydrogen 2.736 N/A ALA 335.A N ARG 315.A O no hydrogen 2.972 N/A LEU 336.A N ASP 340.A OD2 no hydrogen 3.076 N/A ASP 340.A N THR 337.A OG1 no hydrogen 3.214 N/A LYS 341.A N THR 337.A O no hydrogen 3.139 N/A LYS 341.A NZ SER 309.A OG no hydrogen 3.369 N/A LYS 341.A NZ ASP 313.A O no hydrogen 3.546 N/A LYS 341.A NZ ALA 316.A O no hydrogen 3.036 N/A ASN 342.A N SER 338.A O no hydrogen 2.906 N/A THR 343.A N SER 339.A O no hydrogen 3.134 N/A TRP 344.A N ASP 340.A O no hydrogen 2.992 N/A MET 345.A N LYS 341.A O no hydrogen 2.827 N/A GLU 346.A N ASN 342.A O no hydrogen 2.966 N/A LEU 347.A N THR 343.A O no hydrogen 3.076 N/A LEU 348.A N TRP 344.A O no hydrogen 2.983 N/A GLU 349.A N MET 345.A O no hydrogen 2.776 N/A GLU 350.A N GLU 346.A O no hydrogen 3.101 N/A ALA 351.A N LEU 347.A O no hydrogen 3.007 N/A VAL 352.A N LEU 348.A O no hydrogen 3.030 N/A ARG 353.A N GLU 349.A O no hydrogen 2.985 N/A ARG 353.A NH2 GLU 350.A OE1 no hydrogen 2.814 N/A ASN 354.A N GLU 350.A O no hydrogen 3.043 N/A ALA 355.A N VAL 352.A O no hydrogen 3.288 N/A