Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 2e49_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ARG 2.A NH1 GLY 174.A O no hydrogen 2.670 N/A VAL 3.A N ASP 31.A O no hydrogen 2.638 N/A VAL 4.A N VAL 177.A O no hydrogen 3.088 N/A VAL 5.A N LYS 33.A O no hydrogen 2.794 N/A ILE 6.A N VAL 179.A O no hydrogen 3.223 N/A GLY 7.A N TYR 35.A O no hydrogen 2.678 N/A LEU 13.A N GLY 9.A O no hydrogen 2.869 N/A SER 14.A N VAL 10.A O no hydrogen 2.988 N/A SER 14.A OG VAL 10.A O no hydrogen 2.816 N/A SER 14.A OG ILE 11.A O no hydrogen 3.067 N/A THR 15.A N ILE 11.A O no hydrogen 2.929 N/A THR 15.A OG1 ILE 11.A O no hydrogen 2.982 N/A ALA 16.A N GLY 12.A O no hydrogen 2.816 N/A LEU 17.A N SER 14.A O no hydrogen 3.128 N/A CYS 18.A N SER 14.A O no hydrogen 3.165 N/A CYS 18.A N THR 15.A O no hydrogen 2.845 N/A CYS 18.A SG SER 14.A O no hydrogen 3.429 N/A ILE 19.A N THR 15.A O no hydrogen 3.141 N/A GLU 21.A N LEU 17.A O no hydrogen 3.197 N/A ARG 22.A N CYS 18.A O no hydrogen 2.926 N/A TYR 23.A N HIS 20.A O no hydrogen 2.741 N/A HIS 24.A N HIS 20.A O no hydrogen 2.854 N/A VAL 26.A N TYR 23.A O no hydrogen 2.865 N/A LYS 33.A N VAL 3.A O no hydrogen 3.034 N/A LYS 33.A NZ TYR 35.A OH no hydrogen 3.346 N/A VAL 34.A N LYS 158.A O no hydrogen 2.887 N/A TYR 35.A N VAL 5.A O no hydrogen 2.654 N/A ALA 36.A N PHE 160.A O no hydrogen 2.994 N/A ARG 38.A NH1 GLU 249.A OE2 no hydrogen 3.130 N/A ARG 38.A NH2 GLU 249.A OE2 no hydrogen 2.760 N/A LEU 42.A N PHE 39.A O no hydrogen 2.937 N/A THR 43.A N ASP 46.A OD1 no hydrogen 2.822 N/A THR 43.A OG1 THR 45.A OG1 no hydrogen 2.905 N/A THR 43.A OG1 ASP 46.A OD1 no hydrogen 2.649 N/A THR 45.A OG1 THR 43.A OG1 no hydrogen 2.905 N/A ASP 46.A N THR 43.A O no hydrogen 3.160 N/A VAL 47.A N THR 44.A O no hydrogen 2.836 N/A ALA 48.A N THR 44.A O no hydrogen 3.281 N/A ALA 48.A N THR 45.A O no hydrogen 2.817 N/A TRP 52.A N LEU 137.A O no hydrogen 2.714 N/A GLN 53.A N THR 317.A OG1 no hydrogen 3.329 N/A GLN 53.A NE2 ASN 96.A OD1 no hydrogen 2.528 N/A GLU 64.A N ASN 61.A O no hydrogen 2.819 N/A TRP 67.A N GLN 63.A O no hydrogen 3.038 N/A TRP 67.A NE1 GLU 325.A OE1 no hydrogen 3.260 N/A SER 68.A N GLU 64.A O no hydrogen 2.888 N/A SER 68.A OG GLU 64.A O no hydrogen 3.334 N/A GLN 69.A N ALA 65.A O no hydrogen 3.232 N/A GLN 70.A N ASP 66.A O no hydrogen 3.145 N/A THR 71.A N TRP 67.A O no hydrogen 3.001 N/A THR 71.A OG1 TRP 67.A O no hydrogen 2.993 N/A THR 71.A OG1 THR 317.A O no hydrogen 3.314 N/A PHE 72.A N SER 68.A O no hydrogen 2.972 N/A ASP 73.A N GLN 69.A O no hydrogen 3.235 N/A ASP 73.A N GLN 70.A O no hydrogen 3.324 N/A TYR 74.A N GLN 70.A O no hydrogen 2.989 N/A LEU 75.A N THR 71.A O no hydrogen 2.685 N/A LEU 76.A N PHE 72.A O no hydrogen 3.046 N/A SER 77.A N ASP 73.A O no hydrogen 3.229 N/A SER 77.A OG ASP 73.A O no hydrogen 2.991 N/A SER 77.A OG TYR 74.A O no hydrogen 3.063 N/A SER 77.A OG HIS 78.A ND1 no hydrogen 3.028 N/A HIS 78.A N LEU 75.A O no hydrogen 2.897 N/A HIS 78.A ND1 TYR 74.A O no hydrogen 2.821 N/A HIS 78.A ND1 SER 77.A OG no hydrogen 3.028 N/A SER 81.A N HIS 78.A O no hydrogen 2.931 N/A ALA 84.A N SER 81.A O no hydrogen 3.028 N/A ASN 86.A N ASN 83.A O no hydrogen 2.671 N/A LEU 87.A N ASN 83.A O no hydrogen 3.054 N/A LEU 89.A N ALA 84.A O no hydrogen 2.849 N/A PHE 90.A N ILE 138.A O no hydrogen 3.405 N/A ILE 92.A N SER 136.A O no hydrogen 2.987 N/A SER 93.A OG THR 135.A OG1 no hydrogen 3.166 N/A GLY 94.A N HIS 134.A O no hydrogen 3.283 N/A TYR 95.A N PHE 213.A O no hydrogen 2.644 N/A ASN 96.A N TRP 132.A O no hydrogen 3.121 N/A LEU 97.A N LEU 215.A O no hydrogen 3.111 N/A PHE 98.A N TYR 130.A O no hydrogen 2.563 N/A TRP 107.A NE1 TYR 55.A O no hydrogen 2.959 N/A LYS 108.A NZ ASP 109.A OD1 no hydrogen 2.811 N/A THR 110.A N TRP 107.A O no hydrogen 2.632 N/A THR 110.A OG1 TRP 107.A O no hydrogen 2.498 N/A VAL 111.A N TRP 107.A O no hydrogen 3.278 N/A LEU 112.A N THR 135.A O no hydrogen 2.988 N/A ARG 115.A NE LYS 116.A O no hydrogen 3.071 N/A ARG 115.A NH2 GLU 121.A OE1 no hydrogen 2.813 N/A THR 118.A N GLU 121.A OE2 no hydrogen 2.932 N/A THR 118.A OG1 GLU 121.A OE2 no hydrogen 2.941 N/A GLU 121.A N THR 118.A O no hydrogen 3.101 N/A LEU 122.A N THR 118.A O no hydrogen 3.314 N/A ASP 123.A N ARG 120.A O no hydrogen 3.347 N/A MET 124.A N GLU 121.A O no hydrogen 3.027 N/A PHE 125.A N LEU 122.A O no hydrogen 3.303 N/A TYR 128.A N PHE 125.A O no hydrogen 3.111 N/A GLY 129.A N PHE 98.A O no hydrogen 3.312 N/A TYR 130.A N PHE 98.A O no hydrogen 2.971 N/A TRP 132.A N ASN 96.A O no hydrogen 3.120 N/A PHE 133.A N ARG 115.A O no hydrogen 3.020 N/A THR 135.A N LEU 112.A O no hydrogen 2.970 N/A THR 135.A OG1 SER 93.A OG no hydrogen 3.166 N/A THR 135.A OG1 LEU 112.A O no hydrogen 3.216 N/A SER 136.A N ILE 92.A O no hydrogen 2.926 N/A SER 136.A OG TRP 52.A O no hydrogen 2.654 N/A SER 136.A OG LEU 137.A O no hydrogen 3.518 N/A LEU 137.A N SER 136.A OG no hydrogen 2.571 N/A ILE 138.A N PHE 90.A O no hydrogen 3.139 N/A LEU 139.A N GLY 50.A O no hydrogen 2.700 N/A GLU 140.A N GLY 88.A O no hydrogen 3.111 N/A TYR 144.A N GLU 140.A O no hydrogen 2.937 N/A LEU 145.A N GLY 141.A O no hydrogen 2.985 N/A GLN 146.A NE2 GLN 146.A O no hydrogen 3.007 N/A TRP 147.A N ASN 143.A O no hydrogen 2.994 N/A LEU 148.A N TYR 144.A O no hydrogen 3.248 N/A THR 149.A N LEU 145.A O no hydrogen 2.658 N/A THR 149.A OG1 LEU 145.A O no hydrogen 2.657 N/A GLU 150.A N GLN 146.A O no hydrogen 3.341 N/A ARG 151.A N TRP 147.A O no hydrogen 3.014 N/A LEU 152.A N LEU 148.A O no hydrogen 2.972 N/A THR 153.A N THR 149.A O no hydrogen 2.937 N/A THR 153.A OG1 THR 149.A O no hydrogen 2.829 N/A GLU 154.A N GLU 150.A O no hydrogen 3.026 N/A ARG 155.A N ARG 151.A O no hydrogen 3.179 N/A ARG 155.A NH1 ARG 151.A O no hydrogen 3.389 N/A GLY 156.A N THR 153.A O no hydrogen 3.331 N/A PHE 160.A N VAL 34.A O no hydrogen 2.867 N/A ARG 162.A NH1 GLU 173.A OE2 no hydrogen 3.261 N/A LYS 163.A NZ GLU 165.A OE2 no hydrogen 3.203 N/A GLU 165.A N GLU 169.A OE2 no hydrogen 2.694 N/A GLU 169.A N SER 166.A OG no hydrogen 3.008 N/A VAL 170.A N PHE 167.A O no hydrogen 3.129 N/A ALA 171.A N PHE 167.A O no hydrogen 3.050 N/A ARG 172.A N GLU 168.A O no hydrogen 2.668 N/A GLU 173.A N VAL 170.A O no hydrogen 3.264 N/A GLY 174.A N ALA 171.A O no hydrogen 2.670 N/A ALA 175.A N ALA 171.A O no hydrogen 3.408 N/A VAL 177.A N ARG 2.A O no hydrogen 3.022 N/A ILE 178.A N GLU 304.A O no hydrogen 2.540 N/A VAL 179.A N VAL 4.A O no hydrogen 3.054 N/A ASN 180.A N ILE 306.A O no hydrogen 2.637 N/A CYS 181.A N ILE 6.A O no hydrogen 3.219 N/A CYS 181.A SG VAL 179.A O no hydrogen 3.730 N/A THR 182.A OG1 ASN 180.A OD1 no hydrogen 2.853 N/A LEU 189.A N GLY 187.A O no hydrogen 2.666 N/A GLN 190.A N GLY 187.A O no hydrogen 3.018 N/A LEU 194.A N ASP 192.A OD1 no hydrogen 2.635 N/A LEU 195.A N ASP 192.A OD1 no hydrogen 3.307 N/A GLN 196.A N VAL 285.A O no hydrogen 2.670 N/A GLY 198.A N ARG 283.A O no hydrogen 2.980 N/A ARG 199.A N GLN 243.A O no hydrogen 2.997 N/A ARG 199.A NE SER 248.A O no hydrogen 2.820 N/A ARG 199.A NH1 ASP 255.A OD2 no hydrogen 2.541 N/A GLY 200.A N GLY 281.A O no hydrogen 2.745 N/A ILE 202.A N ARG 279.A O no hydrogen 3.174 N/A MET 203.A N LEU 238.A O no hydrogen 3.439 N/A LYS 204.A N GLY 277.A O no hydrogen 2.759 N/A VAL 205.A N VAL 236.A O no hydrogen 2.768 N/A ASP 206.A N ARG 274.A O no hydrogen 2.712 N/A TRP 209.A NE1 THR 269.A OG1 no hydrogen 2.885 N/A MET 210.A N ALA 207.A O no hydrogen 3.210 N/A PHE 213.A N SER 93.A O no hydrogen 2.952 N/A ILE 214.A N ILE 229.A O no hydrogen 2.988 N/A LEU 215.A N TYR 95.A O no hydrogen 2.665 N/A THR 216.A N PRO 227.A O no hydrogen 3.093 N/A THR 216.A OG1 SER 226.A OG no hydrogen 2.905 N/A THR 216.A OG1 PRO 227.A O no hydrogen 2.234 N/A HIS 217.A N LEU 97.A O no hydrogen 3.085 N/A HIS 217.A NE2 ASN 96.A OD1 no hydrogen 3.063 N/A ARG 221.A N ASP 218.A O no hydrogen 2.933 N/A GLY 222.A N PRO 219.A O no hydrogen 3.412 N/A ASN 225.A ND2 PHE 242.A O no hydrogen 2.993 N/A SER 226.A OG THR 216.A OG1 no hydrogen 2.905 N/A TYR 228.A N GLY 239.A O no hydrogen 2.860 N/A ILE 229.A N ILE 214.A O no hydrogen 3.129 N/A ILE 230.A N THR 237.A O no hydrogen 2.778 N/A GLY 232.A N THR 235.A O no hydrogen 2.745 N/A THR 233.A N GLU 140.A OE2 no hydrogen 2.791 N/A THR 235.A OG1 VAL 205.A O no hydrogen 2.517 N/A VAL 236.A N VAL 205.A O no hydrogen 2.851 N/A THR 237.A N ILE 230.A O no hydrogen 2.773 N/A THR 237.A OG1 ILE 230.A O no hydrogen 3.201 N/A LEU 238.A N MET 203.A O no hydrogen 2.694 N/A GLN 243.A N ARG 199.A O no hydrogen 3.243 N/A GLN 243.A NE2 ASP 255.A OD2 no hydrogen 3.467 N/A GLY 245.A N PRO 197.A O no hydrogen 2.878 N/A ASN 246.A N GLN 243.A O no hydrogen 3.431 N/A SER 248.A N ASN 246.A OD1 no hydrogen 3.229 N/A ASN 251.A ND2 GLU 278.A O no hydrogen 2.990 N/A HIS 256.A N ASN 252.A O no hydrogen 2.820 N/A HIS 256.A ND1 GLU 278.A OE2 no hydrogen 2.618 N/A ASN 257.A N ILE 253.A O no hydrogen 3.358 N/A THR 258.A N GLN 254.A O no hydrogen 3.093 N/A THR 258.A OG1 GLN 254.A O no hydrogen 2.743 N/A ILE 259.A N ASP 255.A O no hydrogen 2.759 N/A TRP 260.A N HIS 256.A O no hydrogen 2.952 N/A GLU 261.A N ASN 257.A O no hydrogen 2.747 N/A GLY 262.A N THR 258.A O no hydrogen 3.121 N/A CYS 263.A N ILE 259.A O no hydrogen 3.207 N/A CYS 263.A SG TYR 228.A O no hydrogen 3.389 N/A CYS 263.A SG GLY 239.A O no hydrogen 3.933 N/A CYS 264.A N TRP 260.A O no hydrogen 2.944 N/A CYS 264.A SG TRP 260.A O no hydrogen 3.735 N/A LEU 266.A N CYS 263.A O no hydrogen 3.163 N/A GLU 267.A N CYS 263.A O no hydrogen 3.185 N/A LEU 270.A N GLU 267.A O no hydrogen 2.892 N/A LYS 271.A N PRO 268.A O no hydrogen 2.711 N/A ALA 273.A N LEU 270.A O no hydrogen 2.843 N/A ARG 274.A NE ILE 275.A O no hydrogen 3.539 N/A ILE 276.A N LYS 204.A O no hydrogen 2.918 N/A GLY 277.A N LYS 204.A O no hydrogen 2.996 N/A ARG 279.A NH2 PRO 41.A O no hydrogen 3.352 N/A THR 280.A OG1 ASN 251.A OD1 no hydrogen 2.696 N/A GLY 281.A N GLY 200.A O no hydrogen 2.815 N/A ARG 283.A N GLY 198.A O no hydrogen 2.884 N/A ARG 283.A NH1 ARG 199.A O no hydrogen 3.550 N/A ARG 283.A NH1 ILE 241.A O no hydrogen 2.755 N/A ARG 283.A NH2 ILE 241.A O no hydrogen 2.623 N/A VAL 285.A N ARG 283.A O no hydrogen 2.685 N/A ARG 286.A NE GLN 288.A O no hydrogen 2.731 N/A ILE 289.A N GLU 64.A OE2 no hydrogen 3.252 N/A ARG 290.A NE GLU 292.A OE2 no hydrogen 2.785 N/A ARG 290.A NH1 GLN 190.A OE1 no hydrogen 3.394 N/A ARG 290.A NH1 TYR 309.A OH no hydrogen 3.091 N/A ARG 290.A NH2 GLU 294.A OE1 no hydrogen 3.153 N/A LEU 291.A N ILE 289.A O no hydrogen 2.960 N/A GLU 292.A N HIS 307.A O no hydrogen 2.827 N/A ARG 293.A NE GLU 304.A OE2 no hydrogen 3.413 N/A ARG 293.A NH1 GLU 336.A OE2 no hydrogen 3.074 N/A ARG 293.A NH2 GLU 304.A OE2 no hydrogen 3.051 N/A ARG 293.A NH2 GLU 336.A OE1 no hydrogen 2.692 N/A ARG 293.A NH2 GLU 336.A OE2 no hydrogen 3.131 N/A GLU 294.A N VAL 305.A O no hydrogen 3.080 N/A GLU 304.A N ASP 176.A O no hydrogen 2.927 N/A ILE 306.A N ILE 178.A O no hydrogen 2.747 N/A HIS 307.A N GLU 292.A O no hydrogen 2.864 N/A ASN 308.A N ASN 180.A O no hydrogen 3.067 N/A TYR 309.A N ARG 290.A O no hydrogen 2.900 N/A TYR 309.A OH ASP 192.A OD2 no hydrogen 3.205 N/A GLY 312.A N PRO 284.A O no hydrogen 3.086 N/A TYR 314.A N HIS 311.A O no hydrogen 3.137 N/A TYR 314.A OH GLU 64.A OE1 no hydrogen 3.071 N/A THR 317.A OG1 LEU 51.A O no hydrogen 3.313 N/A ILE 318.A N TYR 314.A O no hydrogen 3.312 N/A ILE 318.A N GLY 315.A O no hydrogen 3.211 N/A HIS 319.A N LEU 316.A O no hydrogen 3.136 N/A GLY 321.A N THR 71.A OG1 no hydrogen 3.379 N/A CYS 322.A SG HIS 311.A NE2 no hydrogen 3.407 N/A CYS 322.A SG ILE 318.A O no hydrogen 3.613 N/A ALA 323.A N HIS 319.A O no hydrogen 3.330 N/A LEU 324.A N TRP 320.A O no hydrogen 3.139 N/A ALA 326.A N CYS 322.A O no hydrogen 2.745 N/A LYS 328.A N LEU 324.A O no hydrogen 3.333 N/A LYS 328.A NZ GLU 325.A OE2 no hydrogen 3.535 N/A LEU 329.A N GLU 325.A O no hydrogen 2.770 N/A PHE 330.A N ALA 326.A O no hydrogen 2.935 N/A GLY 331.A N LYS 328.A O no hydrogen 2.702 N/A ARG 332.A N LYS 328.A O no hydrogen 3.156 N/A ILE 333.A N LEU 329.A O no hydrogen 3.490 N/A GLU 336.A N ILE 333.A O no hydrogen 2.884 N/A