Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 2gx8_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ASN 3.A N GLU 6.A OE2 no hydrogen 2.998 N/A ASN 3.A ND2 LYS 35.A O no hydrogen 3.561 N/A GLY 4.A N LEU 33.A O no hydrogen 2.876 N/A HIS 5.A N LEU 33.A O no hydrogen 3.327 N/A ILE 7.A N ASN 3.A O no hydrogen 3.338 N/A ILE 8.A N GLY 4.A O no hydrogen 2.684 N/A SER 9.A N HIS 5.A O no hydrogen 2.890 N/A LEU 10.A N GLU 6.A O no hydrogen 3.219 N/A PHE 11.A N ILE 7.A O no hydrogen 3.133 N/A GLU 12.A N ILE 8.A O no hydrogen 2.909 N/A SER 13.A N SER 9.A O no hydrogen 3.104 N/A SER 13.A OG LEU 10.A O no hydrogen 2.764 N/A MET 14.A N PHE 11.A O no hydrogen 3.129 N/A TYR 15.A N PHE 11.A O no hydrogen 2.856 N/A TYR 15.A OH GLY 108.A O no hydrogen 3.313 N/A TYR 15.A OH GLN 332.A OE1 no hydrogen 2.438 N/A LEU 19.A N PRO 16.A O no hydrogen 3.392 N/A ALA 20.A N LYS 17.A O no hydrogen 3.334 N/A MET 21.A N THR 101.A OG1 no hydrogen 2.885 N/A ASP 24.A N MET 21.A O no hydrogen 3.297 N/A LYS 25.A N ASP 24.A OD1 no hydrogen 2.959 N/A GLY 27.A N ALA 98.A O no hydrogen 2.912 N/A GLN 29.A N ILE 96.A O no hydrogen 2.660 N/A GLN 29.A NE2 ILE 69.A O no hydrogen 2.739 N/A ILE 30.A N ILE 96.A O no hydrogen 3.275 N/A LYS 35.A NZ ASN 60.A O no hydrogen 3.277 N/A LYS 35.A NZ ASP 93.A O no hydrogen 2.418 N/A VAL 37.A N PRO 2.A O no hydrogen 2.783 N/A HIS 39.A ND1 HIS 347.A NE2 no hydrogen 3.142 N/A VAL 40.A N HIS 345.A O no hydrogen 2.870 N/A LEU 41.A N VAL 61.A O no hydrogen 2.948 N/A ILE 42.A N HIS 347.A O no hydrogen 2.710 N/A ALA 43.A N ILE 63.A O no hydrogen 2.841 N/A GLU 49.A N GLU 49.A OE1 no hydrogen 2.684 N/A VAL 50.A N THR 47.A OG1 no hydrogen 3.209 N/A VAL 51.A N THR 47.A O no hydrogen 3.048 N/A ASP 52.A N GLU 48.A O no hydrogen 3.041 N/A GLU 53.A N GLU 49.A O no hydrogen 2.991 N/A ALA 54.A N VAL 50.A O no hydrogen 3.083 N/A ILE 55.A N VAL 51.A O no hydrogen 3.008 N/A GLN 56.A N ASP 52.A O no hydrogen 2.908 N/A LEU 57.A N GLU 53.A O no hydrogen 2.757 N/A GLY 58.A N ALA 54.A O no hydrogen 2.804 N/A GLY 58.A N ILE 55.A O no hydrogen 3.281 N/A ALA 59.A N ALA 54.A O no hydrogen 2.875 N/A ASN 60.A N HIS 39.A O no hydrogen 3.334 N/A ASN 60.A ND2 PRO 36.A O no hydrogen 3.060 N/A ILE 62.A N ALA 95.A O no hydrogen 2.848 N/A ILE 63.A N LEU 41.A O no hydrogen 2.914 N/A ALA 64.A N TYR 97.A O no hydrogen 2.934 N/A HIS 65.A N ALA 43.A O no hydrogen 2.958 N/A HIS 65.A ND1 ALA 99.A O no hydrogen 3.020 N/A HIS 66.A N LEU 44.A O no hydrogen 2.776 N/A HIS 66.A ND1 ASP 45.A OD2 no hydrogen 2.618 N/A ILE 69.A N GLN 29.A OE1 no hydrogen 3.012 N/A LYS 80.A N HIS 77.A O no hydrogen 3.168 N/A TYR 82.A OH LEU 68.A O no hydrogen 2.596 N/A LYS 84.A N LYS 80.A O no hydrogen 3.053 N/A LYS 84.A NZ THR 78.A O no hydrogen 3.491 N/A ILE 85.A N ALA 81.A O no hydrogen 3.288 N/A ILE 86.A N TYR 82.A O no hydrogen 3.279 N/A GLU 87.A N GLY 83.A O no hydrogen 2.640 N/A LYS 88.A N LYS 84.A O no hydrogen 3.055 N/A LYS 88.A NZ GLU 48.A OE1 no hydrogen 3.542 N/A LYS 88.A NZ ASP 52.A OD1 no hydrogen 2.881 N/A CYS 89.A N ILE 85.A O no hydrogen 3.231 N/A CYS 89.A SG ILE 85.A O no hydrogen 3.349 N/A ILE 90.A N ILE 86.A O no hydrogen 3.162 N/A LYS 91.A N GLU 87.A O no hydrogen 2.978 N/A LYS 91.A NZ GLU 87.A OE2 no hydrogen 3.159 N/A ASN 92.A N LYS 88.A O no hydrogen 3.114 N/A ASN 92.A ND2 LYS 88.A O no hydrogen 2.549 N/A ASP 93.A N ILE 90.A O no hydrogen 3.215 N/A ILE 94.A N CYS 89.A O no hydrogen 2.835 N/A ALA 95.A N ASN 60.A O no hydrogen 2.845 N/A ILE 96.A N ILE 30.A O no hydrogen 2.899 N/A TYR 97.A N ILE 62.A O no hydrogen 2.812 N/A TYR 97.A OH GLU 12.A OE1 no hydrogen 2.437 N/A ALA 98.A N GLY 27.A O no hydrogen 2.723 N/A ALA 99.A N ALA 64.A O no hydrogen 2.881 N/A HIS 100.A ND1 ASP 24.A OD1 no hydrogen 2.912 N/A THR 101.A N ASP 24.A OD2 no hydrogen 2.759 N/A THR 101.A OG1 ASP 24.A OD2 no hydrogen 2.665 N/A VAL 103.A N HIS 100.A O no hydrogen 2.974 N/A ASP 104.A N THR 101.A O no hydrogen 3.192 N/A VAL 105.A N THR 101.A O no hydrogen 3.091 N/A ALA 106.A N ASN 102.A O no hydrogen 2.953 N/A GLY 108.A N ASP 112.A OD2 no hydrogen 2.792 N/A GLY 109.A N ALA 106.A O no hydrogen 2.929 N/A VAL 110.A N VAL 103.A O no hydrogen 2.825 N/A ASN 111.A ND2 ASP 104.A O no hydrogen 2.950 N/A LEU 113.A N GLY 109.A O no hydrogen 2.971 N/A LEU 114.A N VAL 110.A O no hydrogen 3.035 N/A ALA 115.A N ASN 111.A O no hydrogen 3.161 N/A GLU 116.A N ASP 112.A O no hydrogen 2.933 N/A ALA 117.A N LEU 113.A O no hydrogen 2.980 N/A LEU 118.A N LEU 114.A O no hydrogen 2.896 N/A GLY 119.A N GLU 116.A O no hydrogen 3.133 N/A LEU 120.A N ALA 115.A O no hydrogen 3.044 N/A GLN 121.A N TYR 236.A O no hydrogen 2.638 N/A GLN 121.A NE2 GLY 119.A O no hydrogen 3.593 N/A GLU 124.A N ILE 234.A O no hydrogen 2.843 N/A LEU 126.A N GLY 232.A O no hydrogen 3.099 N/A ALA 127.A N LEU 231.A O no hydrogen 2.965 N/A THR 129.A N LEU 229.A O no hydrogen 2.894 N/A TYR 130.A N LEU 229.A O no hydrogen 3.131 N/A LYS 135.A N ILE 194.A O no hydrogen 2.750 N/A LYS 135.A NZ GLU 133.A OE1 no hydrogen 3.311 N/A LYS 136.A N TYR 220.A O no hydrogen 2.861 N/A LYS 136.A NZ GLU 191.A OE2 no hydrogen 3.491 N/A VAL 137.A N THR 192.A O no hydrogen 2.692 N/A VAL 138.A N ASP 218.A O no hydrogen 2.914 N/A VAL 139.A N ILE 190.A O no hydrogen 2.853 N/A PHE 140.A N ALA 216.A O no hydrogen 3.159 N/A VAL 141.A N VAL 188.A O no hydrogen 2.870 N/A THR 144.A OG1 HIS 145.A ND1 no hydrogen 2.809 N/A HIS 145.A N PRO 142.A O no hydrogen 2.973 N/A HIS 145.A ND1 THR 144.A OG1 no hydrogen 2.809 N/A ALA 146.A N VAL 143.A O no hydrogen 3.257 N/A VAL 149.A N HIS 145.A O no hydrogen 3.107 N/A ARG 150.A N ALA 146.A O no hydrogen 2.976 N/A ARG 150.A NE GLU 147.A OE1 no hydrogen 3.124 N/A ARG 150.A NH2 GLU 147.A OE1 no hydrogen 2.692 N/A LYS 151.A N GLU 147.A O no hydrogen 3.028 N/A ALA 152.A N GLU 148.A O no hydrogen 3.030 N/A LEU 153.A N VAL 149.A O no hydrogen 2.934 N/A GLY 154.A N ARG 150.A O no hydrogen 3.034 N/A ASP 155.A N LYS 151.A O no hydrogen 2.935 N/A ALA 156.A N ALA 152.A O no hydrogen 3.086 N/A GLY 157.A N GLY 154.A O no hydrogen 2.886 N/A ALA 158.A N LEU 153.A O no hydrogen 3.017 N/A GLY 159.A N ILE 193.A O no hydrogen 2.769 N/A ILE 161.A N TYR 164.A O no hydrogen 2.966 N/A TYR 164.A N ILE 161.A O no hydrogen 3.106 N/A SER 165.A OG HIS 166.A ND1 no hydrogen 2.786 N/A HIS 166.A ND1 SER 165.A OG no hydrogen 2.786 N/A HIS 166.A NE2 ASP 155.A OD1 no hydrogen 2.993 N/A CYS 167.A N GLY 159.A O no hydrogen 3.159 N/A CYS 167.A SG GLY 159.A O no hydrogen 3.280 N/A CYS 167.A SG SER 165.A O no hydrogen 3.876 N/A PHE 169.A N GLU 191.A O no hydrogen 2.938 N/A SER 171.A N ARG 189.A O no hydrogen 2.920 N/A GLY 173.A N GLU 187.A O no hydrogen 2.968 N/A GLY 175.A N VAL 185.A O no hydrogen 2.887 N/A PHE 177.A N GLU 183.A O no hydrogen 3.005 N/A GLU 183.A N PHE 177.A O no hydrogen 2.854 N/A VAL 185.A N GLY 175.A O no hydrogen 2.926 N/A GLU 187.A N GLY 173.A O no hydrogen 2.781 N/A VAL 188.A N VAL 141.A O no hydrogen 2.828 N/A ARG 189.A N SER 171.A O no hydrogen 2.832 N/A ARG 189.A NH2 GLU 191.A OE1 no hydrogen 2.581 N/A ILE 190.A N VAL 139.A O no hydrogen 2.905 N/A GLU 191.A N PHE 169.A O no hydrogen 2.775 N/A THR 192.A N VAL 137.A O no hydrogen 2.901 N/A THR 192.A OG1 CYS 167.A O no hydrogen 2.601 N/A ILE 194.A N LYS 135.A O no hydrogen 2.860 N/A ALA 196.A N GLU 133.A O no hydrogen 2.781 N/A SER 197.A N GLU 132.A OE2 no hydrogen 3.052 N/A SER 197.A OG GLU 132.A OE2 no hydrogen 2.900 N/A LEU 198.A N PRO 195.A O no hydrogen 2.736 N/A GLN 199.A N ALA 196.A O no hydrogen 3.201 N/A VAL 202.A N LEU 198.A O no hydrogen 2.932 N/A ILE 203.A N GLN 199.A O no hydrogen 2.898 N/A LYS 204.A N ARG 200.A O no hydrogen 2.899 N/A ALA 205.A N LYS 201.A O no hydrogen 3.089 N/A MET 206.A N VAL 202.A O no hydrogen 2.893 N/A VAL 207.A N ILE 203.A O no hydrogen 2.901 N/A THR 208.A N LYS 204.A O no hydrogen 3.229 N/A THR 208.A OG1 LYS 204.A O no hydrogen 3.085 N/A ALA 209.A N ALA 205.A O no hydrogen 3.248 N/A HIS 210.A N VAL 207.A O no hydrogen 3.016 N/A HIS 210.A NE2 PHE 140.A O no hydrogen 2.644 N/A TYR 212.A N HIS 210.A ND1 no hydrogen 3.244 N/A ASP 218.A N VAL 138.A O no hydrogen 2.737 N/A TYR 220.A N LYS 136.A O no hydrogen 2.756 N/A LEU 222.A N MET 134.A O no hydrogen 3.237 N/A GLY 226.A N GLU 132.A O no hydrogen 2.647 N/A LEU 229.A N TYR 130.A O no hydrogen 2.880 N/A LEU 231.A N ALA 127.A O no hydrogen 2.860 N/A LYS 233.A N VAL 274.A O no hydrogen 3.129 N/A ILE 234.A N GLU 124.A O no hydrogen 2.742 N/A GLY 235.A N VAL 272.A O no hydrogen 3.017 N/A TYR 236.A N GLN 121.A O no hydrogen 2.885 N/A LEU 237.A N ARG 270.A O no hydrogen 3.052 N/A MET 241.A N VAL 269.A O no hydrogen 3.068 N/A LEU 243.A N ASP 267.A O no hydrogen 2.845 N/A GLY 244.A N LEU 265.A O no hydrogen 2.827 N/A GLN 245.A N THR 242.A OG1 no hydrogen 2.875 N/A PHE 246.A N THR 242.A O no hydrogen 2.985 N/A ALA 247.A N LEU 243.A O no hydrogen 2.957 N/A GLU 248.A N GLY 244.A O no hydrogen 3.296 N/A HIS 249.A N GLN 245.A O no hydrogen 2.757 N/A VAL 250.A N PHE 246.A O no hydrogen 2.836 N/A LYS 251.A N ALA 247.A O no hydrogen 3.209 N/A GLN 252.A N GLU 248.A O no hydrogen 2.792 N/A SER 253.A N HIS 249.A O no hydrogen 2.823 N/A SER 253.A OG ALA 117.A O no hydrogen 3.341 N/A SER 253.A OG HIS 249.A O no hydrogen 2.676 N/A LEU 254.A N VAL 250.A O no hydrogen 2.865 N/A VAL 256.A N LYS 251.A O no hydrogen 3.065 N/A ARG 260.A N ASP 316.A O no hydrogen 2.978 N/A ARG 260.A NH2 MET 299.A O no hydrogen 3.057 N/A ARG 260.A NH2 ASP 316.A OD2 no hydrogen 2.769 N/A VAL 262.A N ILE 314.A O no hydrogen 2.909 N/A ASP 267.A N LYS 264.A O no hydrogen 3.124 N/A VAL 269.A N MET 241.A O no hydrogen 2.812 N/A ARG 270.A N ASP 292.A OD2 no hydrogen 3.015 N/A LYS 271.A N ASP 292.A OD2 no hydrogen 2.953 N/A LYS 271.A NZ TYR 236.A OH no hydrogen 3.457 N/A LYS 271.A NZ LYS 289.A O no hydrogen 2.761 N/A VAL 272.A N GLY 235.A O no hydrogen 2.791 N/A ALA 273.A N VAL 293.A O no hydrogen 2.809 N/A VAL 274.A N LYS 233.A O no hydrogen 3.005 N/A LEU 275.A N VAL 295.A O no hydrogen 2.924 N/A GLY 276.A N ASN 111.A OD1 no hydrogen 2.828 N/A ASN 280.A N ASP 278.A OD1 no hydrogen 3.389 N/A ASN 280.A ND2 ASP 278.A OD1 no hydrogen 2.699 N/A ASN 280.A ND2 ASP 298.A O no hydrogen 2.837 N/A TYR 282.A N GLY 279.A O no hydrogen 3.223 N/A GLN 285.A NE2 LEU 126.A O no hydrogen 2.805 N/A ALA 286.A N TYR 282.A O no hydrogen 2.968 N/A LYS 287.A N ILE 283.A O no hydrogen 2.974 N/A LYS 287.A NZ GLY 311.A O no hydrogen 2.589 N/A PHE 288.A N ASN 284.A O no hydrogen 3.016 N/A LYS 289.A N GLN 285.A O no hydrogen 2.939 N/A GLY 290.A N LYS 287.A O no hydrogen 2.984 N/A ALA 291.A N ALA 286.A O no hydrogen 3.117 N/A ASP 292.A N LYS 271.A O no hydrogen 2.744 N/A TYR 294.A N ASN 313.A O no hydrogen 2.916 N/A TYR 294.A OH GLY 279.A O no hydrogen 2.661 N/A VAL 295.A N ALA 273.A O no hydrogen 2.787 N/A THR 296.A N VAL 315.A O no hydrogen 3.333 N/A THR 296.A OG1 LEU 275.A O no hydrogen 2.992 N/A THR 296.A OG1 GLY 277.A O no hydrogen 3.525 N/A GLY 297.A N GLY 277.A O no hydrogen 2.905 N/A MET 299.A N ASP 316.A OD2 no hydrogen 3.126 N/A TYR 300.A N.A ASN 280.A OD1 no hydrogen 3.070 N/A TYR 300.A N.B ASN 280.A OD1 no hydrogen 3.080 N/A ALA 304.A N TYR 300.A O.A no hydrogen 2.892 N/A ALA 304.A N TYR 300.A O.B no hydrogen 2.966 N/A HIS 305.A N TYR 301.A O no hydrogen 2.979 N/A ASP 306.A N HIS 302.A O no hydrogen 3.107 N/A ALA 307.A N VAL 303.A O no hydrogen 2.912 N/A MET 308.A N ALA 304.A O no hydrogen 2.830 N/A MET 309.A N HIS 305.A O no hydrogen 2.903 N/A LEU 310.A N ASP 306.A O no hydrogen 2.888 N/A GLY 311.A N MET 308.A O no hydrogen 2.862 N/A LEU 312.A N ALA 307.A O no hydrogen 2.959 N/A ASN 313.A ND2 ASP 292.A O no hydrogen 3.190 N/A ILE 314.A N VAL 262.A O no hydrogen 2.901 N/A VAL 315.A N TYR 294.A O no hydrogen 3.081 N/A ASP 316.A N ARG 260.A O no hydrogen 2.674 N/A GLY 318.A N ASP 316.A OD1 no hydrogen 2.837 N/A HIS 319.A ND1 ASP 298.A OD2 no hydrogen 2.549 N/A HIS 319.A NE2 HIS 66.A NE2 no hydrogen 3.075 N/A ASN 320.A ND2 THR 353.A OG1 no hydrogen 3.196 N/A VAL 321.A N GLY 318.A O no hydrogen 3.377 N/A GLU 322.A N HIS 319.A O no hydrogen 3.315 N/A LYS 323.A N ASN 320.A O no hydrogen 2.803 N/A LYS 323.A NZ LEU 254.A O no hydrogen 3.020 N/A LYS 323.A NZ ASP 255.A O no hydrogen 2.687 N/A MET 325.A N GLU 322.A O no hydrogen 2.989 N/A LYS 326.A N LYS 323.A O no hydrogen 2.772 N/A LYS 326.A NZ SER 349.A O no hydrogen 3.188 N/A LYS 326.A NZ LEU 351.A O no hydrogen 3.379 N/A GLY 328.A N VAL 324.A O no hydrogen 2.991 N/A VAL 329.A N MET 325.A O no hydrogen 2.948 N/A GLN 330.A N LYS 326.A O no hydrogen 3.177 N/A LYS 331.A N GLN 327.A O no hydrogen 3.198 N/A LYS 331.A NZ GLU 335.A OE2 no hydrogen 3.542 N/A GLN 332.A N GLY 328.A O no hydrogen 3.227 N/A GLN 332.A NE2 GLY 108.A O no hydrogen 2.917 N/A LEU 333.A N VAL 329.A O no hydrogen 2.661 N/A GLN 334.A N GLN 330.A O no hydrogen 2.776 N/A GLN 334.A NE2 ASP 338.A OD2 no hydrogen 3.497 N/A GLN 334.A NE2 VAL 344.A O no hydrogen 2.977 N/A GLU 335.A N LYS 331.A O no hydrogen 3.117 N/A LYS 336.A N GLN 332.A O no hydrogen 3.373 N/A VAL 337.A N LEU 333.A O no hydrogen 3.060 N/A ASP 338.A N GLN 334.A O no hydrogen 2.968 N/A ALA 339.A N GLU 335.A O no hydrogen 3.306 N/A LYS 340.A N LYS 336.A O no hydrogen 3.175 N/A LYS 341.A N ASP 338.A O no hydrogen 2.967 N/A LEU 342.A N VAL 337.A O no hydrogen 2.990 N/A HIS 345.A N ARG 38.A O no hydrogen 3.089 N/A ILE 346.A N GLN 334.A OE1 no hydrogen 2.959 N/A HIS 347.A N VAL 40.A O no hydrogen 2.678 N/A HIS 347.A NE2 HIS 39.A ND1 no hydrogen 3.142 N/A SER 349.A N ILE 42.A O no hydrogen 2.792 N/A SER 349.A OG GLU 53.A OE2 no hydrogen 2.655 N/A GLN 350.A N GLU 53.A OE1 no hydrogen 2.920 N/A THR 353.A OG1 ASP 45.A OD1 no hydrogen 2.739 N/A PHE 356.A N ASP 354.A OD2 no hydrogen 3.180 N/A