Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 2hc1_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ARG 2.A NH1 GLU 33.A OE1.C no hydrogen 3.305 N/A SER 5.A OG ASP 251.A OD2 no hydrogen 2.410 N/A CYS 6.A N ASP 251.A OD1 no hydrogen 2.804 N/A CYS 6.A SG.A SER 5.A O no hydrogen 3.259 N/A CYS 6.A SG.B GLU 31.A OE1 no hydrogen 3.863 N/A ILE 8.A N VAL 250.A O no hydrogen 2.845 N/A ILE 10.A N ASP 248.A O no hydrogen 3.039 N/A GLN 12.A N LYS 9.A O no hydrogen 2.884 N/A PHE 13.A N ILE 10.A O no hydrogen 3.183 N/A HIS 16.A N GLN 12.A O no hydrogen 2.962 N/A PHE 17.A N PHE 13.A O no hydrogen 2.904 N/A MET 18.A N GLU 14.A O no hydrogen 3.084 N/A LYS 19.A N GLY 15.A O no hydrogen 2.887 N/A LEU 20.A N HIS 16.A O no hydrogen 2.896 N/A GLN 21.A N PHE 17.A O no hydrogen 3.074 N/A GLN 21.A N MET 18.A O no hydrogen 3.186 N/A GLN 21.A NE2 PHE 17.A O no hydrogen 3.131 N/A ALA 22.A N LYS 19.A O no hydrogen 3.409 N/A ASN 25.A N GLN 21.A O no hydrogen 2.946 N/A ASN 25.A ND2 GLN 21.A O no hydrogen 3.349 N/A TYR 26.A N ALA 22.A O no hydrogen 3.167 N/A LEU 28.A N LEU 20.A O no hydrogen 3.000 N/A SER 29.A N ASN 25.A O no hydrogen 2.851 N/A SER 29.A OG ASN 25.A O no hydrogen 3.016 N/A SER 29.A OG GLU 270.A OE1 no hydrogen 2.709 N/A SER 29.A OG GLU 270.A OE2 no hydrogen 3.486 N/A LYS 30.A N TYR 26.A O no hydrogen 3.196 N/A GLU 31.A N LEU 27.A O no hydrogen 2.907 N/A TYR 32.A N LEU 28.A O no hydrogen 2.879 N/A GLU 33.A N SER 29.A O no hydrogen 2.895 N/A GLU 34.A N LYS 30.A O no hydrogen 3.297 N/A GLU 34.A N GLU 31.A O no hydrogen 3.021 N/A LEU 35.A N TYR 32.A O no hydrogen 3.021 N/A LYS 36.A N GLU 33.A O no hydrogen 3.038 N/A VAL 38.A N LEU 35.A O no hydrogen 3.129 N/A ARG 40.A N ASP 37.A O no hydrogen 3.006 N/A GLN 42.A N GLY 39.A O no hydrogen 3.255 N/A GLN 42.A NE2 GLY 39.A O no hydrogen 2.986 N/A GLN 42.A NE2 LEU 261.A O no hydrogen 2.928 N/A CYS 44.A SG.A LEU 62.A O no hydrogen 3.670 N/A CYS 44.A SG.A PRO 63.A O no hydrogen 3.277 N/A ASP 45.A N ASP 65.A OD2 no hydrogen 2.907 N/A ILE 46.A N ASP 65.A OD1 no hydrogen 2.929 N/A LEU 48.A N CYS 44.A O no hydrogen 3.198 N/A LEU 48.A N ASP 45.A O no hydrogen 3.272 N/A LEU 49.A N.A ILE 46.A O no hydrogen 3.065 N/A LEU 49.A N.B ILE 46.A O no hydrogen 3.035 N/A ASN 52.A N LEU 49.A O.A no hydrogen 2.896 N/A ASN 52.A N LEU 49.A O.B no hydrogen 2.400 N/A ASN 52.A ND2 ILE 46.A O no hydrogen 2.866 N/A ARG 53.A N PRO 50.A O.B no hydrogen 3.151 N/A LYS 55.A N ASN 52.A O no hydrogen 2.896 N/A ASN 56.A N ARG 53.A O no hydrogen 3.159 N/A ASN 56.A ND2 ALA 47.A O no hydrogen 3.068 N/A ARG 57.A N GLN 96.A OE1 no hydrogen 2.867 N/A ARG 57.A NE GLY 97.A O no hydrogen 2.889 N/A ARG 57.A NH2 GLY 97.A O no hydrogen 3.162 N/A ARG 57.A NH2 PRO 98.A O no hydrogen 2.799 N/A TYR 58.A OH SER 225.A OG no hydrogen 2.667 N/A ILE 61.A N TYR 58.A O no hydrogen 3.092 N/A ASP 65.A N SER 43.A O no hydrogen 2.876 N/A THR 67.A N TYR 64.A O no hydrogen 3.268 N/A THR 67.A OG1 HIS 262.A O no hydrogen 2.723 N/A ARG 68.A NH1 ASP 76.A OD1 no hydrogen 2.862 N/A ARG 68.A NH2 ASP 76.A OD1 no hydrogen 3.312 N/A ARG 68.A NH2 ASP 76.A OD2 no hydrogen 2.947 N/A VAL 69.A N ALA 80.A O no hydrogen 2.999 N/A LEU 71.A N ASP 76.A O no hydrogen 2.841 N/A SER 72.A N GLU 112.A OE1 no hydrogen 3.012 N/A SER 72.A OG GLU 112.A OE2 no hydrogen 2.514 N/A TYR 77.A OH ASN 56.A OD1 no hydrogen 2.614 N/A ASN 79.A ND2 ASN 56.A OD1 no hydrogen 2.946 N/A ASN 79.A ND2 ILE 61.A O no hydrogen 2.866 N/A SER 81.A N VAL 94.A O no hydrogen 2.783 N/A TYR 82.A N THR 67.A O no hydrogen 2.861 N/A TYR 82.A OH GLN 113.A OE1 no hydrogen 2.659 N/A ILE 83.A N TYR 92.A O no hydrogen 2.877 N/A GLY 85.A N PHE 88.A O no hydrogen 2.823 N/A TYR 92.A N ILE 83.A O no hydrogen 3.160 N/A TYR 92.A OH.A ASP 238.A OD2.A no hydrogen 2.407 N/A ILE 93.A N THR 220.A O no hydrogen 2.887 N/A VAL 94.A N SER 81.A O no hydrogen 2.835 N/A THR 95.A N VAL 222.A O no hydrogen 3.170 N/A THR 95.A OG1 ASN 79.A O no hydrogen 2.588 N/A GLN 96.A N ASN 79.A O no hydrogen 3.433 N/A GLN 96.A NE2 LYS 55.A O no hydrogen 2.890 N/A GLY 97.A N SER 225.A O no hydrogen 2.802 N/A LEU 99.A N THR 102.A OG1 no hydrogen 2.895 N/A THR 102.A N LEU 99.A O no hydrogen 2.909 N/A LYS 103.A NZ.A PRO 100.A O no hydrogen 2.953 N/A PHE 106.A N THR 102.A O no hydrogen 2.897 N/A TRP 107.A N LYS 103.A O no hydrogen 3.089 N/A TRP 107.A NE1 TYR 135.A O no hydrogen 2.889 N/A LYS 108.A N ASP 104.A O no hydrogen 2.937 N/A LYS 108.A NZ SER 72.A O no hydrogen 2.855 N/A MET 109.A N ASP 105.A O no hydrogen 2.908 N/A VAL 110.A N PHE 106.A O no hydrogen 2.961 N/A TRP 111.A N TRP 107.A O no hydrogen 2.905 N/A TRP 111.A NE1 GLU 171.A O no hydrogen 2.818 N/A GLU 112.A N LYS 108.A O no hydrogen 2.844 N/A GLN 113.A N MET 109.A O no hydrogen 2.866 N/A ASN 114.A N TRP 111.A O no hydrogen 3.295 N/A VAL 115.A N VAL 110.A O no hydrogen 3.095 N/A HIS 116.A N ALA 217.A O no hydrogen 2.991 N/A HIS 116.A ND1 ASN 114.A O no hydrogen 2.886 N/A HIS 116.A ND1 ALA 217.A O no hydrogen 2.993 N/A ILE 118.A N ARG 181.A O no hydrogen 2.884 N/A VAL 119.A N VAL 221.A O no hydrogen 2.741 N/A MET 120.A N PHE 183.A O no hydrogen 2.863 N/A VAL 121.A N HIS 223.A O no hydrogen 2.883 N/A THR 122.A OG1 GLN 123.A O no hydrogen 2.821 N/A THR 122.A OG1 GLU 126.A OE2 no hydrogen 3.206 N/A GLN 123.A N GLU 126.A OE2 no hydrogen 2.952 N/A GLU 126.A N ARG 129.A O no hydrogen 3.000 N/A ARG 129.A N GLU 126.A O no hydrogen 2.964 N/A LYS 131.A N CYS 124.A O no hydrogen 2.743 N/A CYS 132.A N CYS 124.A O no hydrogen 3.165 N/A CYS 132.A SG ASP 133.A O no hydrogen 3.420 N/A ASP 133.A N PRO 98.A O no hydrogen 3.020 N/A HIS 134.A ND1 TRP 136.A O no hydrogen 2.829 N/A TYR 135.A OH HIS 223.A NE2 no hydrogen 2.702 N/A ASP 141.A N ASP 139.A OD1 no hydrogen 3.062 N/A LEU 143.A N LEU 150.A O no hydrogen 3.012 N/A TYR 145.A N LEU 148.A O no hydrogen 2.800 N/A LEU 148.A N TYR 145.A O no hydrogen 3.017 N/A ILE 149.A N CYS 169.A O no hydrogen 2.992 N/A LEU 150.A N LEU 143.A O no hydrogen 2.929 N/A GLN 151.A N LYS 167.A O no hydrogen 2.900 N/A GLN 151.A NE2.A GLN 140.A O no hydrogen 3.028 N/A GLN 151.A NE2.B GLN 140.A O no hydrogen 3.509 N/A LEU 153.A N GLU 165.A O no hydrogen 2.791 N/A SER 154.A N GLU 165.A O no hydrogen 3.435 N/A SER 156.A N ILE 163.A O no hydrogen 2.840 N/A LEU 158.A N TRP 161.A O no hydrogen 2.842 N/A THR 162.A N HIS 184.A O no hydrogen 2.862 N/A ILE 163.A N SER 156.A O no hydrogen 2.879 N/A ARG 164.A N HIS 182.A O no hydrogen 2.886 N/A ARG 164.A NE GLU 155.A OE2 no hydrogen 2.764 N/A ARG 164.A NH1 HIS 184.A ND1 no hydrogen 3.392 N/A ARG 164.A NH2 GLU 155.A OE2 no hydrogen 3.385 N/A GLU 165.A N SER 154.A O no hydrogen 3.054 N/A PHE 166.A N ILE 180.A O no hydrogen 2.838 N/A LYS 167.A N GLN 151.A O no hydrogen 2.782 N/A LYS 167.A NZ.B HIS 177.A ND1 no hydrogen 2.893 N/A ILE 168.A N ARG 178.A O no hydrogen 2.925 N/A CYS 169.A N ILE 149.A O no hydrogen 3.015 N/A CYS 169.A SG.A ILE 149.A O no hydrogen 4.045 N/A CYS 169.A SG.B ALA 176.A O no hydrogen 3.094 N/A CYS 169.A SG.C ALA 176.A O no hydrogen 3.781 N/A GLN 173.A N ASP 175.A O no hydrogen 3.329 N/A ARG 178.A N ILE 168.A O no hydrogen 2.934 N/A ARG 178.A NE ASP 175.A OD2 no hydrogen 2.830 N/A ARG 178.A NH1 VAL 110.A O no hydrogen 2.886 N/A ARG 178.A NH1 TRP 111.A O no hydrogen 3.515 N/A ARG 178.A NH1 VAL 115.A O no hydrogen 2.999 N/A ARG 178.A NH2 TRP 111.A O no hydrogen 2.902 N/A ARG 178.A NH2 ASP 175.A OD1 no hydrogen 2.988 N/A ARG 178.A NH2 ASP 175.A OD2 no hydrogen 3.523 N/A ILE 180.A N PHE 166.A O no hydrogen 2.810 N/A ARG 181.A N HIS 116.A O no hydrogen 2.913 N/A ARG 181.A NH1.B GLU 165.A OE1.B no hydrogen 2.988 N/A HIS 182.A N ARG 164.A O no hydrogen 2.804 N/A HIS 182.A NE2 TYR 135.A OH no hydrogen 2.817 N/A PHE 183.A N ILE 118.A O no hydrogen 2.798 N/A HIS 184.A N THR 162.A O no hydrogen 2.851 N/A HIS 184.A NE2 THR 122.A O no hydrogen 2.801 N/A TYR 185.A N MET 120.A O no hydrogen 2.840 N/A TYR 185.A OH SER 199.A OG.A no hydrogen 2.707 N/A TYR 185.A OH SER 199.A OG.B no hydrogen 3.129 N/A THR 186.A N GLU 160.A O no hydrogen 3.023 N/A THR 186.A OG1 GLU 160.A O no hydrogen 3.237 N/A TRP 188.A NE1 GLY 192.A O.A no hydrogen 3.026 N/A TRP 188.A NE1 GLY 192.A O.B no hydrogen 2.958 N/A THR 196.A OG1 SER 199.A OG.B no hydrogen 3.298 N/A THR 197.A OG1 ASP 282.A OD2 no hydrogen 2.717 N/A SER 199.A N THR 196.A OG1 no hydrogen 3.132 N/A SER 199.A OG.A GLU 160.A OE1 no hydrogen 2.731 N/A SER 199.A OG.A TYR 185.A OH no hydrogen 2.707 N/A SER 199.A OG.B TYR 185.A OH no hydrogen 3.129 N/A SER 199.A OG.B THR 196.A O no hydrogen 3.011 N/A SER 199.A OG.B THR 196.A OG1 no hydrogen 3.298 N/A ILE 201.A N THR 197.A O no hydrogen 3.015 N/A GLN 202.A N GLN 198.A O no hydrogen 2.934 N/A PHE 203.A N SER 199.A O no hydrogen 2.985 N/A VAL 204.A N LEU 200.A O no hydrogen 2.879 N/A ARG 205.A N ILE 201.A O no hydrogen 2.927 N/A ARG 205.A NH1 GLN 202.A OE1.A no hydrogen 3.060 N/A THR 206.A N GLN 202.A O no hydrogen 2.833 N/A THR 206.A OG1 GLN 202.A O no hydrogen 2.818 N/A VAL 207.A N PHE 203.A O no hydrogen 2.986 N/A ARG 208.A N VAL 204.A O no hydrogen 2.942 N/A ARG 208.A NE ASP 238.A OD1.A no hydrogen 3.136 N/A ARG 208.A NE ASP 238.A OD2.B no hydrogen 2.858 N/A ARG 208.A NH1 ASN 212.A OD1 no hydrogen 3.221 N/A ARG 208.A NH2 GLU 91.A OE1 no hydrogen 3.249 N/A ARG 208.A NH2 TYR 92.A OH.B no hydrogen 2.978 N/A ARG 208.A NH2 ASP 238.A OD1.B no hydrogen 3.188 N/A ARG 208.A NH2 ASP 238.A OD2.A no hydrogen 2.748 N/A ARG 208.A NH2 ASP 238.A OD2.B no hydrogen 3.330 N/A ASP 209.A N ARG 205.A O no hydrogen 2.892 N/A TYR 210.A N THR 206.A O no hydrogen 3.073 N/A ILE 211.A N VAL 207.A O no hydrogen 2.907 N/A ASN 212.A N ARG 208.A O no hydrogen 2.893 N/A ARG 213.A N ASP 209.A O no hydrogen 3.108 N/A ARG 213.A N TYR 210.A O no hydrogen 3.312 N/A SER 214.A N ILE 211.A O no hydrogen 3.137 N/A GLY 216.A N SER 214.A OG no hydrogen 3.007 N/A THR 220.A N GLU 91.A O no hydrogen 2.989 N/A VAL 221.A N ASN 117.A O no hydrogen 3.066 N/A VAL 222.A N ILE 93.A O no hydrogen 2.882 N/A HIS 223.A N VAL 119.A O no hydrogen 2.898 N/A HIS 223.A ND1 CYS 224.A O no hydrogen 2.939 N/A HIS 223.A NE2 TYR 135.A OH no hydrogen 2.702 N/A CYS 224.A SG THR 231.A OG1.A no hydrogen 3.364 N/A SER 225.A OG TYR 58.A OH no hydrogen 2.667 N/A SER 225.A OG LYS 131.A O no hydrogen 2.684 N/A GLY 229.A N GLN 268.A OE1 no hydrogen 3.094 N/A ARG 230.A NH1 VAL 121.A O no hydrogen 3.183 N/A ARG 230.A NH1 GLU 126.A OE1 no hydrogen 3.331 N/A ARG 230.A NH1 GLU 126.A OE2 no hydrogen 2.889 N/A ARG 230.A NH2 GLU 126.A OE1 no hydrogen 2.866 N/A THR 231.A OG1.B VAL 228.A O no hydrogen 2.710 N/A GLY 232.A N VAL 228.A O no hydrogen 2.932 N/A THR 233.A N GLY 229.A O no hydrogen 2.882 N/A THR 233.A OG1 GLY 229.A O no hydrogen 2.768 N/A PHE 234.A N ARG 230.A O no hydrogen 2.954 N/A ILE 235.A N THR 231.A O no hydrogen 3.028 N/A ALA 236.A N GLY 232.A O no hydrogen 2.868 N/A LEU 237.A N THR 233.A O no hydrogen 2.935 N/A ASP 238.A N PHE 234.A O no hydrogen 2.976 N/A ARG 239.A N ILE 235.A O no hydrogen 2.966 N/A ARG 239.A NE.A GLU 91.A OE2 no hydrogen 3.236 N/A ARG 239.A NH2.A GLU 91.A OE2 no hydrogen 2.742 N/A ARG 239.A NH2.B PRO 84.A O no hydrogen 2.902 N/A ARG 239.A NH2.B GLU 91.A OE2 no hydrogen 2.904 N/A ILE 240.A N ALA 236.A O no hydrogen 2.835 N/A LEU 241.A N LEU 237.A O no hydrogen 2.864 N/A GLN 242.A N ASP 238.A O no hydrogen 3.147 N/A GLN 242.A NE2 ASP 238.A OD1.B no hydrogen 2.837 N/A GLN 243.A N ARG 239.A O no hydrogen 2.908 N/A GLN 243.A NE2 ASP 251.A O no hydrogen 3.656 N/A LEU 244.A N ILE 240.A O no hydrogen 2.955 N/A ASP 245.A N LEU 241.A O no hydrogen 3.295 N/A ASP 245.A N GLN 242.A O no hydrogen 3.077 N/A SER 246.A N GLN 243.A O no hydrogen 2.991 N/A SER 246.A OG.B GLN 242.A O no hydrogen 3.194 N/A SER 246.A OG.B GLN 243.A O no hydrogen 3.242 N/A LYS 247.A N GLN 243.A O no hydrogen 2.836 N/A SER 249.A N SER 249.A OG.C no hydrogen 3.041 N/A VAL 250.A N ILE 8.A O no hydrogen 2.868 N/A ASP 251.A N GLN 243.A OE1 no hydrogen 2.840 N/A TYR 253.A OH LYS 3.A O no hydrogen 2.898 N/A GLY 254.A N ASP 251.A OD1 no hydrogen 2.862 N/A ALA 255.A N ASP 251.A O no hydrogen 3.041 N/A VAL 256.A N ILE 252.A O no hydrogen 3.056 N/A HIS 257.A N TYR 253.A O no hydrogen 2.846 N/A ASP 258.A N GLY 254.A O no hydrogen 2.878 N/A LEU 259.A N ALA 255.A O no hydrogen 3.319 N/A ARG 260.A N VAL 256.A O no hydrogen 2.957 N/A ARG 260.A NE MET 266.A O no hydrogen 2.914 N/A ARG 260.A NE VAL 267.A O no hydrogen 3.009 N/A ARG 260.A NH2 VAL 267.A O no hydrogen 2.723 N/A LEU 261.A N HIS 257.A O no hydrogen 3.241 N/A HIS 262.A N LEU 259.A O no hydrogen 2.905 N/A HIS 262.A ND1 ASP 258.A O no hydrogen 2.819 N/A ARG 263.A N LEU 259.A O no hydrogen 3.337 N/A ARG 263.A NE GLY 227.A O no hydrogen 2.762 N/A ARG 263.A NH1 ASN 79.A OD1 no hydrogen 3.111 N/A ARG 263.A NH1 SER 81.A OG no hydrogen 2.944 N/A ARG 263.A NH2 ASN 79.A OD1 no hydrogen 2.931 N/A ARG 263.A NH2 ALA 226.A O no hydrogen 2.871 N/A GLN 268.A N GLN 272.A OE1 no hydrogen 2.846 N/A THR 269.A N GLN 272.A OE1 no hydrogen 3.360 N/A GLN 272.A N THR 269.A O no hydrogen 3.143 N/A GLN 272.A N THR 269.A OG1 no hydrogen 2.946 N/A TYR 273.A N THR 269.A O no hydrogen 3.132 N/A TYR 273.A OH GLU 31.A OE2 no hydrogen 2.611 N/A VAL 274.A N GLU 270.A O no hydrogen 2.809 N/A TYR 275.A N CYS 271.A O no hydrogen 2.948 N/A TYR 275.A OH THR 196.A O no hydrogen 2.646 N/A LEU 276.A N GLN 272.A O no hydrogen 3.021 N/A HIS 277.A N TYR 273.A O no hydrogen 3.285 N/A HIS 277.A ND1 TYR 273.A O no hydrogen 2.885 N/A GLN 278.A N VAL 274.A O no hydrogen 2.874 N/A CYS 279.A N TYR 275.A O no hydrogen 2.903 N/A CYS 279.A SG TYR 275.A O no hydrogen 3.421 N/A VAL 280.A N LEU 276.A O no hydrogen 3.160 N/A ARG 281.A N HIS 277.A O no hydrogen 2.825 N/A ARG 281.A NE ASP 282.A OD1 no hydrogen 2.960 N/A ARG 281.A NH2 ASP 282.A OD1 no hydrogen 3.046 N/A ASP 282.A N GLN 278.A O no hydrogen 2.980 N/A VAL 283.A N CYS 279.A O no hydrogen 3.027 N/A LEU 284.A N VAL 280.A O no hydrogen 2.984 N/A ARG 285.A N ARG 281.A O no hydrogen 2.858 N/A ARG 285.A NE GLU 14.A OE1 no hydrogen 2.809 N/A ARG 285.A NH2 GLU 14.A OE2 no hydrogen 2.811 N/A ALA 286.A N ASP 282.A O no hydrogen 3.156 N/A ARG 287.A N VAL 283.A O no hydrogen 2.989 N/A ARG 287.A NH1 LEU 244.A O no hydrogen 3.118 N/A ARG 287.A NH1 ASP 245.A OD1 no hydrogen 3.066 N/A ARG 287.A NH2 ASP 245.A OD1 no hydrogen 2.773 N/A LYS 288.A N LEU 284.A O no hydrogen 2.966 N/A LEU 289.A N ALA 286.A O no hydrogen 3.291 N/A ARG 290.A N ARG 287.A O no hydrogen 3.046 N/A