Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 2hc2_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): SER 5.A OG ASP 246.A OD2 no hydrogen 2.594 N/A CYS 6.A N ASP 246.A OD1 no hydrogen 2.853 N/A CYS 6.A SG.A SER 5.A O no hydrogen 3.311 N/A CYS 6.A SG.A GLU 31.A OE1 no hydrogen 3.918 N/A CYS 6.A SG.B GLU 31.A OE1 no hydrogen 3.823 N/A ILE 8.A N VAL 245.A O no hydrogen 2.817 N/A ILE 10.A N ASP 243.A O no hydrogen 3.016 N/A GLN 12.A N LYS 9.A O no hydrogen 2.852 N/A PHE 13.A N ILE 10.A O no hydrogen 3.178 N/A HIS 16.A N GLN 12.A O no hydrogen 2.910 N/A PHE 17.A N PHE 13.A O no hydrogen 2.835 N/A MET 18.A N GLU 14.A O no hydrogen 2.981 N/A LYS 19.A N GLY 15.A O no hydrogen 2.883 N/A LEU 20.A N HIS 16.A O no hydrogen 2.947 N/A GLN 21.A N PHE 17.A O no hydrogen 2.905 N/A ALA 22.A N MET 18.A O no hydrogen 2.938 N/A ASN 25.A N GLN 21.A O no hydrogen 2.986 N/A ASN 25.A ND2 GLU 265.A OE2 no hydrogen 2.890 N/A TYR 26.A N ALA 22.A O no hydrogen 3.182 N/A LEU 28.A N LEU 20.A O no hydrogen 2.978 N/A SER 29.A N ASN 25.A O no hydrogen 2.902 N/A SER 29.A OG ASN 25.A O no hydrogen 3.030 N/A SER 29.A OG GLU 265.A OE1 no hydrogen 2.707 N/A SER 29.A OG GLU 265.A OE2 no hydrogen 3.282 N/A LYS 30.A N TYR 26.A O no hydrogen 3.319 N/A GLU 31.A N LEU 27.A O no hydrogen 2.892 N/A TYR 32.A N LEU 28.A O no hydrogen 2.847 N/A GLU 33.A N SER 29.A O no hydrogen 2.858 N/A GLU 34.A N LYS 30.A O no hydrogen 3.249 N/A GLU 34.A N GLU 31.A O no hydrogen 3.083 N/A LEU 35.A N TYR 32.A O no hydrogen 3.018 N/A LYS 36.A N GLU 33.A O no hydrogen 3.049 N/A VAL 38.A N LEU 35.A O no hydrogen 3.139 N/A ARG 40.A N ASP 37.A O no hydrogen 3.068 N/A GLN 42.A N GLY 39.A O no hydrogen 3.316 N/A GLN 42.A NE2 GLY 39.A O no hydrogen 2.991 N/A GLN 42.A NE2 LEU 256.A O no hydrogen 2.903 N/A CYS 44.A SG.A LEU 62.A O no hydrogen 3.641 N/A CYS 44.A SG.A PRO 63.A O no hydrogen 3.234 N/A ASP 45.A N ASP 65.A OD2 no hydrogen 2.867 N/A ILE 46.A N ASP 65.A OD1 no hydrogen 2.920 N/A LEU 48.A N CYS 44.A O no hydrogen 3.273 N/A LEU 48.A N ASP 45.A O no hydrogen 3.275 N/A LEU 49.A N ILE 46.A O no hydrogen 3.088 N/A GLU 51.A N GLU 51.A OE2.A no hydrogen 2.989 N/A ASN 52.A N LEU 49.A O no hydrogen 2.859 N/A ASN 52.A ND2 ILE 46.A O no hydrogen 2.935 N/A ARG 53.A N PRO 50.A O no hydrogen 3.273 N/A LYS 55.A N ASN 52.A O no hydrogen 2.948 N/A LYS 55.A NZ ASN 52.A OD1 no hydrogen 2.986 N/A ASN 56.A N ARG 53.A O no hydrogen 3.238 N/A ASN 56.A ND2 ALA 47.A O no hydrogen 3.108 N/A ARG 57.A N GLN 96.A OE1 no hydrogen 2.828 N/A ARG 57.A NE GLY 97.A O no hydrogen 2.950 N/A ARG 57.A NH2 GLY 97.A O no hydrogen 3.159 N/A ARG 57.A NH2 PRO 98.A O no hydrogen 2.762 N/A TYR 58.A OH SER 220.A OG no hydrogen 2.684 N/A ASN 59.A ND2 ARG 53.A O no hydrogen 3.517 N/A ILE 61.A N TYR 58.A O no hydrogen 3.078 N/A ASP 65.A N SER 43.A O no hydrogen 2.888 N/A THR 67.A N TYR 64.A O no hydrogen 3.314 N/A THR 67.A OG1 HIS 257.A O no hydrogen 2.740 N/A ARG 68.A NH1 ASP 76.A OD1 no hydrogen 2.912 N/A ARG 68.A NH2 ASP 76.A OD1 no hydrogen 3.352 N/A ARG 68.A NH2 ASP 76.A OD2 no hydrogen 2.986 N/A VAL 69.A N ALA 80.A O no hydrogen 2.980 N/A LEU 71.A N ASP 76.A O no hydrogen 2.758 N/A SER 72.A N GLU 112.A OE1 no hydrogen 2.977 N/A SER 72.A OG GLU 112.A OE2 no hydrogen 2.457 N/A TYR 77.A OH ASN 56.A OD1 no hydrogen 2.691 N/A ASN 79.A ND2 ASN 56.A OD1 no hydrogen 2.987 N/A ASN 79.A ND2 ILE 61.A O no hydrogen 2.913 N/A SER 81.A N VAL 94.A O no hydrogen 2.809 N/A TYR 82.A N THR 67.A O no hydrogen 2.899 N/A TYR 82.A OH GLN 113.A OE1 no hydrogen 2.682 N/A ILE 83.A N TYR 92.A O no hydrogen 2.866 N/A GLY 85.A N PHE 88.A O no hydrogen 2.980 N/A ASN 86.A ND2 ARG 234.A O no hydrogen 2.801 N/A ASN 87.A N GLU 91.A OE2 no hydrogen 2.856 N/A ASN 87.A ND2 GLU 91.A OE1 no hydrogen 2.731 N/A ASN 87.A ND2 GLN 237.A OE1 no hydrogen 2.953 N/A PHE 88.A N GLU 91.A OE2 no hydrogen 2.894 N/A TYR 92.A N ILE 83.A O no hydrogen 3.000 N/A TYR 92.A OH ASP 233.A OD2 no hydrogen 2.530 N/A ILE 93.A N THR 215.A O no hydrogen 2.877 N/A VAL 94.A N SER 81.A O no hydrogen 2.900 N/A THR 95.A N VAL 217.A O no hydrogen 3.182 N/A THR 95.A OG1 ASN 79.A O no hydrogen 2.612 N/A GLN 96.A N ASN 79.A O no hydrogen 3.400 N/A GLN 96.A NE2 LYS 55.A O no hydrogen 2.894 N/A GLY 97.A N SER 220.A O no hydrogen 2.806 N/A LEU 99.A N THR 102.A OG1 no hydrogen 2.904 N/A THR 102.A N LEU 99.A O no hydrogen 2.934 N/A THR 102.A OG1 LEU 99.A O no hydrogen 3.556 N/A LYS 103.A NZ.A PRO 100.A O no hydrogen 3.230 N/A PHE 106.A N THR 102.A O no hydrogen 2.938 N/A TRP 107.A N LYS 103.A O no hydrogen 3.007 N/A TRP 107.A NE1 TYR 135.A O no hydrogen 2.858 N/A LYS 108.A N ASP 104.A O no hydrogen 2.834 N/A LYS 108.A NZ SER 72.A O no hydrogen 2.727 N/A MET 109.A N ASP 105.A O no hydrogen 2.936 N/A VAL 110.A N PHE 106.A O no hydrogen 2.974 N/A TRP 111.A N TRP 107.A O no hydrogen 2.903 N/A GLU 112.A N LYS 108.A O no hydrogen 2.842 N/A GLN 113.A N MET 109.A O no hydrogen 2.875 N/A ASN 114.A N TRP 111.A O no hydrogen 3.208 N/A VAL 115.A N VAL 110.A O no hydrogen 3.052 N/A HIS 116.A ND1 ASN 114.A O no hydrogen 3.090 N/A ILE 118.A N ARG 176.A O no hydrogen 2.859 N/A VAL 119.A N VAL 216.A O no hydrogen 2.736 N/A MET 120.A N PHE 178.A O no hydrogen 2.839 N/A VAL 121.A N HIS 218.A O no hydrogen 2.908 N/A THR 122.A OG1 GLN 123.A O no hydrogen 2.824 N/A THR 122.A OG1 GLU 126.A OE2.A no hydrogen 3.273 N/A GLN 123.A N GLU 126.A OE2.A no hydrogen 2.968 N/A GLU 126.A N ARG 129.A O no hydrogen 2.933 N/A LYS 127.A NZ ASP 185.A OD2 no hydrogen 2.766 N/A ARG 129.A N GLU 126.A O no hydrogen 2.972 N/A LYS 131.A N CYS 124.A O no hydrogen 2.754 N/A CYS 132.A N CYS 124.A O no hydrogen 3.043 N/A CYS 132.A SG ASP 133.A O no hydrogen 3.419 N/A ASP 133.A N PRO 98.A O no hydrogen 3.010 N/A HIS 134.A ND1 TRP 136.A O no hydrogen 2.914 N/A TYR 135.A OH HIS 218.A NE2 no hydrogen 2.685 N/A GLN 140.A NE2 LEU 153.A O no hydrogen 3.101 N/A ASP 141.A N ASP 139.A OD1 no hydrogen 2.920 N/A LEU 143.A N LEU 150.A O no hydrogen 3.017 N/A TYR 145.A N LEU 148.A O no hydrogen 2.905 N/A LEU 148.A N TYR 145.A O no hydrogen 3.159 N/A ILE 149.A N CYS 169.A O no hydrogen 2.946 N/A LEU 150.A N LEU 143.A O no hydrogen 2.916 N/A GLN 151.A N LYS 167.A O no hydrogen 2.900 N/A LEU 153.A N GLU 165.A O no hydrogen 2.775 N/A SER 156.A N ILE 163.A O no hydrogen 2.848 N/A LEU 158.A N TRP 161.A O no hydrogen 2.818 N/A THR 162.A N HIS 179.A O no hydrogen 2.799 N/A ILE 163.A N SER 156.A O no hydrogen 2.918 N/A ARG 164.A N HIS 177.A O no hydrogen 2.905 N/A ARG 164.A NE GLU 155.A OE2 no hydrogen 2.700 N/A ARG 164.A NH2 GLU 155.A OE2 no hydrogen 3.217 N/A GLU 165.A N SER 154.A O no hydrogen 3.123 N/A PHE 166.A N ILE 175.A O no hydrogen 2.824 N/A LYS 167.A N GLN 151.A O no hydrogen 2.769 N/A ILE 168.A N ARG 173.A O no hydrogen 2.896 N/A CYS 169.A N ILE 149.A O no hydrogen 2.923 N/A CYS 169.A SG.A ILE 149.A O no hydrogen 4.038 N/A CYS 169.A SG.B GLY 170.A O no hydrogen 3.985 N/A ARG 173.A N ILE 168.A O no hydrogen 2.957 N/A ARG 173.A NH1.A TRP 111.A O no hydrogen 2.837 N/A ARG 173.A NH1.B TRP 111.A O no hydrogen 2.917 N/A ARG 173.A NH2.B VAL 110.A O no hydrogen 2.946 N/A ARG 173.A NH2.B VAL 115.A O no hydrogen 2.817 N/A ILE 175.A N PHE 166.A O no hydrogen 2.847 N/A ARG 176.A N HIS 116.A O no hydrogen 2.877 N/A HIS 177.A N ARG 164.A O no hydrogen 2.852 N/A HIS 177.A NE2 TYR 135.A OH no hydrogen 2.800 N/A PHE 178.A N ILE 118.A O no hydrogen 2.766 N/A HIS 179.A N THR 162.A O no hydrogen 2.840 N/A HIS 179.A NE2 THR 122.A O no hydrogen 2.777 N/A TYR 180.A N MET 120.A O no hydrogen 2.949 N/A TYR 180.A OH SER 194.A OG.A no hydrogen 3.164 N/A TYR 180.A OH SER 194.A OG.B no hydrogen 2.600 N/A THR 181.A N GLU 160.A O no hydrogen 2.973 N/A TRP 183.A NE1 GLY 187.A O no hydrogen 3.089 N/A THR 192.A OG1 ASP 277.A OD2 no hydrogen 2.591 N/A GLN 193.A NE2.A GLU 160.A OE2 no hydrogen 2.932 N/A GLN 193.A NE2.A THR 191.A OG1 no hydrogen 3.147 N/A SER 194.A N THR 191.A OG1 no hydrogen 3.383 N/A SER 194.A OG.A TYR 180.A OH no hydrogen 3.164 N/A SER 194.A OG.B TYR 180.A OH no hydrogen 2.600 N/A ILE 196.A N THR 192.A O no hydrogen 3.012 N/A GLN 197.A N GLN 193.A O no hydrogen 2.877 N/A PHE 198.A N SER 194.A O no hydrogen 3.032 N/A VAL 199.A N LEU 195.A O no hydrogen 2.855 N/A ARG 200.A N ILE 196.A O no hydrogen 2.894 N/A THR 201.A N GLN 197.A O no hydrogen 3.018 N/A THR 201.A OG1 GLN 197.A O no hydrogen 2.778 N/A VAL 202.A N PHE 198.A O no hydrogen 2.934 N/A ARG 203.A N VAL 199.A O no hydrogen 2.826 N/A ARG 203.A NE ASP 233.A OD1 no hydrogen 2.995 N/A ARG 203.A NH1 ASN 207.A OD1 no hydrogen 2.956 N/A ARG 203.A NH2 ASP 233.A OD2 no hydrogen 2.850 N/A ASP 204.A N ARG 200.A O no hydrogen 2.966 N/A TYR 205.A N THR 201.A O no hydrogen 3.233 N/A ILE 206.A N VAL 202.A O no hydrogen 2.826 N/A ASN 207.A N ARG 203.A O no hydrogen 2.891 N/A ARG 208.A N ASP 204.A O no hydrogen 3.277 N/A ARG 208.A N TYR 205.A O no hydrogen 3.114 N/A ARG 208.A NE ASP 204.A OD2.A no hydrogen 2.957 N/A SER 209.A N ILE 206.A O no hydrogen 2.891 N/A SER 209.A OG ASN 117.A OD1 no hydrogen 3.179 N/A SER 209.A OG TYR 205.A O no hydrogen 3.070 N/A ALA 212.A N SER 209.A O no hydrogen 2.997 N/A GLY 213.A N ASN 114.A O no hydrogen 2.772 N/A THR 215.A N GLU 91.A O no hydrogen 2.989 N/A VAL 216.A N ASN 117.A O no hydrogen 3.084 N/A VAL 217.A N ILE 93.A O no hydrogen 2.842 N/A HIS 218.A N VAL 119.A O no hydrogen 2.893 N/A HIS 218.A ND1 CYS 219.A O no hydrogen 2.953 N/A HIS 218.A NE2 TYR 135.A OH no hydrogen 2.685 N/A CYS 219.A SG THR 226.A OG1.A no hydrogen 3.606 N/A SER 220.A OG TYR 58.A OH no hydrogen 2.684 N/A SER 220.A OG LYS 131.A O no hydrogen 2.696 N/A GLY 224.A N GLN 263.A OE1 no hydrogen 3.022 N/A ARG 225.A NH1 VAL 121.A O no hydrogen 3.026 N/A ARG 225.A NH1 GLU 126.A OE2.A no hydrogen 3.229 N/A ARG 225.A NH2 GLU 126.A OE1.A no hydrogen 3.345 N/A ARG 225.A NH2 GLU 126.A OE1.B no hydrogen 2.772 N/A ARG 225.A NH2 ASP 185.A O no hydrogen 3.356 N/A THR 226.A OG1.B VAL 223.A O no hydrogen 2.751 N/A GLY 227.A N VAL 223.A O no hydrogen 2.991 N/A THR 228.A N GLY 224.A O no hydrogen 2.846 N/A THR 228.A OG1 GLY 224.A O no hydrogen 2.809 N/A PHE 229.A N ARG 225.A O no hydrogen 2.926 N/A ILE 230.A N THR 226.A O no hydrogen 2.953 N/A ALA 231.A N GLY 227.A O no hydrogen 2.832 N/A LEU 232.A N THR 228.A O no hydrogen 2.924 N/A ASP 233.A N PHE 229.A O no hydrogen 2.899 N/A ARG 234.A N ILE 230.A O no hydrogen 2.877 N/A ARG 234.A NE ASN 86.A OD1 no hydrogen 3.151 N/A ARG 234.A NH1 PRO 84.A O no hydrogen 3.045 N/A ARG 234.A NH1 ASP 253.A OD2 no hydrogen 2.883 N/A ARG 234.A NH2 ASP 253.A OD2 no hydrogen 3.364 N/A ILE 235.A N ALA 231.A O no hydrogen 2.891 N/A LEU 236.A N LEU 232.A O no hydrogen 2.876 N/A GLN 237.A N ASP 233.A O no hydrogen 3.211 N/A GLN 237.A NE2 ASP 233.A O no hydrogen 3.015 N/A GLN 238.A N ARG 234.A O no hydrogen 3.156 N/A GLN 238.A NE2.A ASN 86.A OD1 no hydrogen 3.586 N/A LEU 239.A N ILE 235.A O no hydrogen 2.956 N/A ASP 240.A N LEU 236.A O no hydrogen 3.196 N/A ASP 240.A N GLN 237.A O no hydrogen 3.088 N/A SER 241.A N GLN 238.A O no hydrogen 3.122 N/A SER 241.A OG GLN 237.A O no hydrogen 2.960 N/A LYS 242.A N GLN 238.A O no hydrogen 2.776 N/A LYS 242.A NZ SER 241.A OG no hydrogen 3.385 N/A SER 244.A OG.A ILE 8.A O no hydrogen 3.036 N/A VAL 245.A N ILE 8.A O no hydrogen 2.889 N/A ASP 246.A N GLN 238.A OE1.A no hydrogen 3.005 N/A ASP 246.A N GLN 238.A OE1.B no hydrogen 2.918 N/A TYR 248.A OH LYS 3.A O no hydrogen 2.846 N/A GLY 249.A N ASP 246.A OD1 no hydrogen 2.883 N/A ALA 250.A N ASP 246.A O no hydrogen 3.069 N/A VAL 251.A N ILE 247.A O no hydrogen 3.029 N/A HIS 252.A N TYR 248.A O no hydrogen 2.844 N/A ASP 253.A N GLY 249.A O no hydrogen 2.926 N/A LEU 254.A N ALA 250.A O no hydrogen 3.028 N/A ARG 255.A N VAL 251.A O no hydrogen 2.946 N/A ARG 255.A NE MET 261.A O no hydrogen 3.071 N/A ARG 255.A NE VAL 262.A O no hydrogen 3.083 N/A ARG 255.A NH1 LEU 35.A O no hydrogen 2.893 N/A ARG 255.A NH2 VAL 262.A O no hydrogen 2.659 N/A LEU 256.A N HIS 252.A O no hydrogen 3.086 N/A HIS 257.A N LEU 254.A O no hydrogen 2.996 N/A HIS 257.A ND1 ASP 253.A O no hydrogen 2.942 N/A ARG 258.A N LEU 254.A O no hydrogen 3.276 N/A ARG 258.A NE GLY 222.A O no hydrogen 2.825 N/A ARG 258.A NH1 ASN 79.A OD1 no hydrogen 3.123 N/A ARG 258.A NH1 SER 81.A OG no hydrogen 2.928 N/A ARG 258.A NH2 ASN 79.A OD1 no hydrogen 2.880 N/A ARG 258.A NH2 ALA 221.A O no hydrogen 2.941 N/A GLN 263.A N GLN 267.A OE1 no hydrogen 2.767 N/A THR 264.A N GLN 267.A OE1 no hydrogen 3.411 N/A GLN 267.A N THR 264.A O no hydrogen 3.130 N/A GLN 267.A N THR 264.A OG1 no hydrogen 2.983 N/A TYR 268.A N THR 264.A O no hydrogen 3.162 N/A TYR 268.A OH GLU 31.A OE2 no hydrogen 2.598 N/A VAL 269.A N GLU 265.A O no hydrogen 2.825 N/A TYR 270.A N CYS 266.A O no hydrogen 2.901 N/A TYR 270.A OH THR 191.A O no hydrogen 2.759 N/A LEU 271.A N GLN 267.A O no hydrogen 2.978 N/A HIS 272.A N TYR 268.A O no hydrogen 3.313 N/A HIS 272.A ND1 TYR 268.A O no hydrogen 2.863 N/A GLN 273.A N VAL 269.A O no hydrogen 2.830 N/A CYS 274.A N TYR 270.A O no hydrogen 2.876 N/A CYS 274.A SG TYR 270.A O no hydrogen 3.374 N/A VAL 275.A N LEU 271.A O no hydrogen 3.160 N/A ARG 276.A N HIS 272.A O no hydrogen 2.914 N/A ARG 276.A NE ASP 277.A OD1 no hydrogen 3.039 N/A ARG 276.A NH2 ASP 277.A OD1 no hydrogen 3.061 N/A ASP 277.A N GLN 273.A O no hydrogen 2.932 N/A VAL 278.A N CYS 274.A O no hydrogen 2.971 N/A LEU 279.A N VAL 275.A O no hydrogen 2.979 N/A ARG 280.A N ARG 276.A O no hydrogen 2.870 N/A ARG 280.A NE GLU 14.A OE1 no hydrogen 3.075 N/A ARG 280.A NE GLU 14.A OE2 no hydrogen 3.372 N/A ARG 280.A NH2 GLU 14.A OE2 no hydrogen 2.884 N/A ALA 281.A N ASP 277.A O no hydrogen 3.012 N/A ARG 282.A N VAL 278.A O no hydrogen 3.045 N/A ARG 282.A NH2 LEU 239.A O no hydrogen 2.489 N/A LYS 283.A N ARG 280.A O no hydrogen 3.215 N/A LEU 284.A N ARG 280.A O no hydrogen 3.430 N/A