Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 2hoe_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ARG 7.A NE GLU 20.A OE1 no hydrogen 3.283 N/A ARG 7.A NH1 ARG 7.A O no hydrogen 3.013 N/A ARG 7.A NH1 SER 10.A OG no hydrogen 3.040 N/A ILE 8.A N ILE 4.A O no hydrogen 2.717 N/A SER 10.A N ARG 7.A O no hydrogen 3.164 N/A SER 10.A OG PRO 11.A O no hydrogen 3.423 N/A VAL 12.A N LEU 54.A O no hydrogen 3.094 N/A SER 13.A N GLU 16.A OE1 no hydrogen 2.735 N/A GLU 16.A N SER 13.A OG no hydrogen 3.310 N/A LEU 17.A N SER 13.A O no hydrogen 2.974 N/A ALA 18.A N ARG 14.A O no hydrogen 2.987 N/A GLU 19.A N VAL 15.A O no hydrogen 3.015 N/A GLU 20.A N GLU 16.A O no hydrogen 2.737 N/A LEU 21.A N LEU 17.A O no hydrogen 2.769 N/A THR 27.A N THR 24.A O no hydrogen 3.146 N/A THR 27.A N THR 24.A OG1 no hydrogen 2.813 N/A VAL 28.A N THR 24.A O no hydrogen 3.106 N/A GLY 29.A N LYS 25.A O no hydrogen 2.917 N/A GLU 30.A N THR 26.A O no hydrogen 3.252 N/A ILE 31.A N THR 27.A O no hydrogen 3.141 N/A ALA 32.A N VAL 28.A O no hydrogen 2.729 N/A LYS 33.A N GLY 29.A O no hydrogen 3.296 N/A ILE 34.A N GLU 30.A O no hydrogen 3.122 N/A PHE 35.A N ILE 31.A O no hydrogen 2.929 N/A LEU 36.A N ALA 32.A O no hydrogen 2.751 N/A GLU 37.A N LYS 33.A O no hydrogen 3.042 N/A LYS 38.A N ILE 34.A O no hydrogen 2.822 N/A LYS 38.A NZ VAL 343.A O no hydrogen 3.177 N/A LYS 38.A NZ SER 346.A O no hydrogen 3.317 N/A ILE 40.A N PHE 35.A O no hydrogen 3.222 N/A VAL 42.A N LYS 55.A O no hydrogen 2.891 N/A GLU 44.A N SER 53.A O no hydrogen 3.276 N/A ASP 46.A N THR 51.A O no hydrogen 3.272 N/A THR 51.A OG1 ASP 46.A OD2 no hydrogen 2.755 N/A SER 53.A N GLU 44.A O no hydrogen 3.041 N/A SER 53.A OG ASP 46.A OD1 no hydrogen 2.543 N/A SER 53.A OG ASP 46.A OD2 no hydrogen 3.238 N/A LEU 54.A N VAL 12.A O no hydrogen 2.781 N/A LYS 55.A N VAL 42.A O no hydrogen 3.039 N/A SER 57.A N ILE 40.A O no hydrogen 2.730 N/A CYS 60.A N SER 57.A O no hydrogen 3.231 N/A CYS 60.A SG SER 57.A O no hydrogen 3.264 N/A TYR 62.A OH ASN 59.A OD1 no hydrogen 3.065 N/A VAL 63.A N ILE 78.A O no hydrogen 3.144 N/A LEU 64.A N ALA 121.A O no hydrogen 3.150 N/A GLY 65.A N CYS 76.A O no hydrogen 2.796 N/A ILE 66.A N THR 123.A O no hydrogen 2.972 N/A GLU 67.A N ALA 74.A O no hydrogen 2.926 N/A VAL 68.A N ALA 125.A O no hydrogen 2.930 N/A THR 69.A N GLU 72.A O no hydrogen 2.938 N/A THR 69.A OG1 GLU 72.A O no hydrogen 2.856 N/A ILE 73.A N HIS 89.A O no hydrogen 3.048 N/A ALA 74.A N GLU 67.A O no hydrogen 2.978 N/A ALA 75.A N GLU 87.A O no hydrogen 2.925 N/A CYS 76.A N GLY 65.A O no hydrogen 2.867 N/A LEU 77.A N ALA 85.A O no hydrogen 2.925 N/A ILE 78.A N VAL 63.A O no hydrogen 2.972 N/A ASP 79.A N ASN 82.A O no hydrogen 3.169 N/A ALA 80.A N PRO 58.A O no hydrogen 3.170 N/A SER 81.A N ASP 79.A OD1 no hydrogen 2.889 N/A ASN 82.A ND2 ASP 79.A OD2 no hydrogen 3.563 N/A LEU 84.A N LEU 77.A O no hydrogen 2.810 N/A GLU 87.A N ALA 75.A O no hydrogen 3.097 N/A HIS 89.A N ILE 73.A O no hydrogen 2.831 N/A HIS 89.A NE2 GLU 87.A OE1 no hydrogen 2.440 N/A LEU 91.A N ASP 71.A O no hydrogen 2.906 N/A SER 95.A OG PRO 92.A O no hydrogen 2.801 N/A ASP 96.A N GLU 99.A OE1 no hydrogen 2.958 N/A THR 100.A N ASP 96.A O no hydrogen 2.905 N/A THR 100.A OG1 ASP 96.A O no hydrogen 2.816 N/A LEU 101.A N ARG 97.A O no hydrogen 2.936 N/A ASN 102.A N GLU 98.A O no hydrogen 3.064 N/A VAL 103.A N GLU 99.A O no hydrogen 3.409 N/A ARG 105.A N ASN 102.A O no hydrogen 2.950 N/A ILE 106.A N VAL 103.A O no hydrogen 3.045 N/A ASP 108.A N TYR 104.A O no hydrogen 2.801 N/A ARG 109.A N ARG 105.A O no hydrogen 2.940 N/A ARG 109.A NH1 GLU 87.A OE1 no hydrogen 2.927 N/A ALA 110.A N ILE 106.A O no hydrogen 3.155 N/A LYS 111.A N ILE 107.A O no hydrogen 2.824 N/A LYS 111.A NZ TYR 158.A O no hydrogen 3.550 N/A ASP 112.A N ASP 108.A O no hydrogen 2.945 N/A LYS 114.A N ASP 112.A O no hydrogen 2.985 N/A GLY 116.A N GLU 113.A O no hydrogen 3.174 N/A SER 120.A N TYR 62.A O no hydrogen 2.878 N/A LEU 122.A N GLU 161.A O no hydrogen 2.728 N/A THR 123.A N LEU 64.A O no hydrogen 3.179 N/A THR 123.A OG1 HIS 334.A ND1 no hydrogen 2.953 N/A VAL 124.A N TRP 163.A O no hydrogen 2.825 N/A ALA 125.A N ILE 66.A O no hydrogen 2.529 N/A ALA 126.A N GLU 165.A O no hydrogen 2.973 N/A ILE 130.A N GLY 209.A O no hydrogen 2.890 N/A ASP 131.A N ILE 136.A O no hydrogen 2.857 N/A ARG 134.A N ASP 131.A OD1 no hydrogen 2.936 N/A ARG 134.A NE ASP 131.A OD2 no hydrogen 3.243 N/A GLY 135.A N ASP 131.A O no hydrogen 2.740 N/A ILE 136.A N ASP 131.A O no hydrogen 3.180 N/A ILE 138.A N PRO 129.A O no hydrogen 3.211 N/A ARG 141.A N ASP 139.A OD1 no hydrogen 3.138 N/A SER 146.A N PHE 143.A O no hydrogen 3.112 N/A SER 146.A OG ASP 139.A O no hydrogen 2.704 N/A SER 146.A OG PHE 143.A O no hydrogen 3.314 N/A GLN 147.A N ILE 137.A O no hydrogen 2.866 N/A ALA 151.A N GLY 135.A O no hydrogen 3.175 N/A LEU 153.A N PRO 149.A O no hydrogen 3.036 N/A LEU 154.A N LEU 150.A O no hydrogen 3.042 N/A LYS 155.A N ALA 151.A O no hydrogen 2.726 N/A GLU 156.A N ASN 152.A O no hydrogen 2.882 N/A LYS 157.A N LEU 153.A O no hydrogen 3.054 N/A TYR 158.A N LEU 154.A O no hydrogen 2.838 N/A TYR 158.A OH ASP 108.A OD1 no hydrogen 2.795 N/A GLY 159.A N LYS 155.A O no hydrogen 2.731 N/A TRP 163.A N LEU 122.A O no hydrogen 2.946 N/A GLU 165.A N VAL 124.A O no hydrogen 2.897 N/A ASN 166.A ND2 GLY 128.A O no hydrogen 2.691 N/A ASP 167.A N ALA 126.A O no hydrogen 2.828 N/A ALA 168.A N ASP 167.A OD1 no hydrogen 2.656 N/A ALA 171.A N ALA 168.A O no hydrogen 3.016 N/A VAL 172.A N ASP 169.A O no hydrogen 2.950 N/A GLU 174.A N GLY 170.A O no hydrogen 3.016 N/A LYS 175.A N ALA 171.A O no hydrogen 3.061 N/A LYS 175.A NZ GLY 201.A O no hydrogen 2.803 N/A TRP 176.A N VAL 172.A O no hydrogen 3.199 N/A TYR 177.A N GLY 173.A O no hydrogen 2.977 N/A THR 178.A N GLU 174.A O no hydrogen 2.924 N/A THR 178.A OG1 GLU 174.A O no hydrogen 2.641 N/A LYS 179.A N TRP 176.A O no hydrogen 3.254 N/A ARG 180.A N LYS 175.A O no hydrogen 2.919 N/A ARG 180.A NE ASP 182.A OD1 no hydrogen 2.921 N/A ARG 180.A NH2 ASP 182.A OD1 no hydrogen 3.375 N/A ARG 180.A NH2 ASP 182.A OD2 no hydrogen 2.930 N/A PHE 184.A N ILE 198.A O no hydrogen 3.032 N/A ALA 185.A N LYS 284.A O no hydrogen 3.146 N/A TRP 186.A N GLY 196.A O no hydrogen 2.782 N/A ILE 187.A N VAL 286.A O no hydrogen 2.746 N/A LEU 188.A N GLY 194.A O no hydrogen 2.881 N/A THR 189.A OG1 GLY 288.A O no hydrogen 2.411 N/A ILE 193.A N GLU 229.A OE2 no hydrogen 3.118 N/A GLY 194.A N LEU 188.A O no hydrogen 3.369 N/A GLY 196.A N TRP 186.A O no hydrogen 2.808 N/A ILE 198.A N PHE 184.A O no hydrogen 3.008 N/A ILE 199.A N GLU 202.A O no hydrogen 2.885 N/A ASP 200.A N SER 183.A OG no hydrogen 2.985 N/A GLY 201.A N ASP 182.A O no hydrogen 3.183 N/A GLU 202.A N ILE 199.A O no hydrogen 3.088 N/A TYR 204.A N ILE 197.A O no hydrogen 2.763 N/A ARG 205.A NH1 GLU 165.A OE2 no hydrogen 2.994 N/A ARG 205.A NH2 GLU 165.A OE1 no hydrogen 3.549 N/A ARG 205.A NH2 GLU 165.A OE2 no hydrogen 3.071 N/A ILE 214.A N GLY 212.A O no hydrogen 2.797 N/A THR 217.A N ILE 214.A O no hydrogen 3.235 N/A THR 217.A OG1 ILE 214.A O no hydrogen 2.565 N/A VAL 219.A N VAL 226.A O no hydrogen 2.831 N/A ASN 221.A N GLU 224.A O no hydrogen 3.204 N/A ASN 223.A N ASN 221.A OD1 no hydrogen 2.751 N/A GLU 224.A N ASN 221.A OD1 no hydrogen 2.973 N/A VAL 226.A N VAL 219.A O no hydrogen 2.778 N/A LEU 228.A N THR 217.A O no hydrogen 2.996 N/A GLU 229.A N GLY 215.A O no hydrogen 3.062 N/A ASP 230.A N PHE 227.A O no hydrogen 3.153 N/A VAL 231.A N LEU 228.A O no hydrogen 3.284 N/A CYS 232.A N LEU 228.A O no hydrogen 3.202 N/A CYS 232.A SG LEU 228.A O no hydrogen 3.564 N/A ASN 233.A N GLU 229.A O no hydrogen 3.286 N/A ASN 235.A N ASN 233.A OD1 no hydrogen 2.739 N/A VAL 237.A N ASN 233.A O no hydrogen 3.056 N/A LEU 238.A N GLU 234.A O no hydrogen 3.203 N/A LYS 239.A N ASN 235.A O no hydrogen 2.826 N/A HIS 240.A N VAL 236.A O no hydrogen 3.149 N/A VAL 241.A N VAL 237.A O no hydrogen 3.051 N/A LEU 242.A N LEU 238.A O no hydrogen 2.953 N/A LEU 242.A N LYS 239.A O no hydrogen 3.224 N/A SER 246.A N GLU 249.A OE1 no hydrogen 2.969 N/A GLU 249.A N SER 246.A OG no hydrogen 2.833 N/A ARG 251.A N ALA 248.A O no hydrogen 3.054 N/A ARG 251.A NE ALA 248.A O no hydrogen 3.591 N/A SER 253.A N GLU 249.A O no hydrogen 2.680 N/A SER 253.A N ALA 250.A O no hydrogen 2.978 N/A GLY 254.A N ARG 251.A O no hydrogen 3.037 N/A VAL 258.A N ASP 255.A O no hydrogen 2.998 N/A LYS 259.A N ASP 255.A O no hydrogen 3.183 N/A GLU 260.A N VAL 256.A O no hydrogen 2.801 N/A TYR 261.A N ARG 257.A O no hydrogen 3.223 N/A PHE 262.A N VAL 258.A O no hydrogen 2.880 N/A ASP 263.A N LYS 259.A O no hydrogen 2.749 N/A ASP 264.A N GLU 260.A O no hydrogen 3.068 N/A ILE 265.A N TYR 261.A O no hydrogen 3.175 N/A ALA 266.A N PHE 262.A O no hydrogen 2.940 N/A ARG 267.A N ASP 263.A O no hydrogen 2.897 N/A ARG 267.A NH1 ASP 264.A OD1 no hydrogen 3.175 N/A TYR 268.A N ASP 264.A O no hydrogen 3.109 N/A PHE 269.A N ILE 265.A O no hydrogen 2.776 N/A SER 270.A N ALA 266.A O no hydrogen 2.835 N/A SER 270.A OG ALA 266.A O no hydrogen 3.040 N/A ILE 271.A N ARG 267.A O no hydrogen 3.223 N/A LEU 273.A N PHE 269.A O no hydrogen 3.085 N/A LEU 274.A N SER 270.A O no hydrogen 2.654 N/A ASN 275.A N ILE 271.A O no hydrogen 3.212 N/A LEU 276.A N GLY 272.A O no hydrogen 3.263 N/A ILE 277.A N LEU 273.A O no hydrogen 2.931 N/A HIS 278.A N LEU 274.A O no hydrogen 2.791 N/A LEU 279.A N ASN 275.A O no hydrogen 2.780 N/A PHE 280.A N LEU 276.A O no hydrogen 2.809 N/A GLY 281.A N ILE 277.A O no hydrogen 2.935 N/A LYS 284.A NZ ASP 182.A OD2 no hydrogen 2.971 N/A ILE 285.A N ASP 317.A O no hydrogen 2.861 N/A VAL 286.A N ALA 185.A O no hydrogen 2.807 N/A ILE 287.A N SER 318.A O no hydrogen 2.774 N/A GLY 288.A N ILE 187.A O no hydrogen 2.891 N/A PHE 290.A N THR 189.A O no hydrogen 3.023 N/A PHE 291.A N THR 189.A OG1 no hydrogen 3.298 N/A LYS 292.A N GLY 289.A O no hydrogen 2.756 N/A LYS 292.A NZ SER 320.A O no hydrogen 2.709 N/A GLU 293.A N PHE 290.A O no hydrogen 3.047 N/A LEU 294.A N PHE 291.A O no hydrogen 3.114 N/A GLY 295.A N LYS 292.A O no hydrogen 2.983 N/A PHE 298.A N GLY 295.A O no hydrogen 3.081 N/A LEU 299.A N GLY 295.A O no hydrogen 3.228 N/A LYS 300.A N GLU 296.A O no hydrogen 2.737 N/A ILE 302.A N PHE 298.A O no hydrogen 3.256 N/A LYS 303.A N LEU 299.A O no hydrogen 2.923 N/A ILE 304.A N LYS 300.A O no hydrogen 3.096 N/A GLU 305.A N LYS 301.A O no hydrogen 2.852 N/A VAL 306.A N ILE 302.A O no hydrogen 2.946 N/A GLU 307.A N LYS 303.A O no hydrogen 2.838 N/A THR 308.A N ILE 304.A O no hydrogen 2.935 N/A THR 308.A OG1 ILE 304.A O no hydrogen 2.946 N/A HIS 309.A N GLU 305.A O no hydrogen 3.296 N/A HIS 309.A ND1 GLU 305.A O no hydrogen 3.093 N/A LEU 310.A N GLU 307.A O no hydrogen 3.287 N/A LEU 311.A N HIS 278.A NE2 no hydrogen 3.130 N/A HIS 314.A ND1 SER 315.A O no hydrogen 3.027 N/A ASP 317.A N SER 283.A O no hydrogen 2.888 N/A SER 318.A OG ILE 285.A O no hydrogen 3.407 N/A SER 320.A N ILE 287.A O no hydrogen 2.678 N/A SER 320.A OG GLU 174.A OE2 no hydrogen 2.323 N/A VAL 322.A N SER 320.A OG no hydrogen 3.337 N/A VAL 326.A N GLU 324.A OE1 no hydrogen 2.925 N/A PHE 329.A N PRO 325.A O no hydrogen 2.959 N/A GLY 330.A N VAL 326.A O no hydrogen 3.109 N/A ALA 331.A N ILE 327.A O no hydrogen 2.931 N/A ALA 332.A N ALA 328.A O no hydrogen 2.995 N/A VAL 333.A N PHE 329.A O no hydrogen 3.022 N/A HIS 334.A N GLY 330.A O no hydrogen 2.867 N/A HIS 334.A ND1 THR 123.A OG1 no hydrogen 2.953 N/A ALA 335.A N ALA 331.A O no hydrogen 3.029 N/A LEU 336.A N ALA 332.A O no hydrogen 2.994 N/A GLU 337.A N VAL 333.A O no hydrogen 3.021 N/A ASN 338.A N HIS 334.A O no hydrogen 3.128 N/A ASN 338.A ND2 HIS 334.A O no hydrogen 2.782 N/A TYR 339.A N ALA 335.A O no hydrogen 2.753 N/A LEU 340.A N LEU 336.A O no hydrogen 2.877 N/A GLU 341.A N GLU 337.A O no hydrogen 2.697 N/A ARG 342.A N ASN 338.A O no hydrogen 3.170 N/A VAL 343.A N TYR 339.A O no hydrogen 2.896 N/A THR 344.A N LEU 340.A O no hydrogen 3.060 N/A THR 344.A OG1 LEU 340.A O no hydrogen 3.115 N/A THR 344.A OG1 GLU 341.A O no hydrogen 3.079 N/A THR 345.A N GLU 341.A O no hydrogen 3.376 N/A THR 345.A OG1 GLU 341.A O no hydrogen 2.925 N/A SER 346.A N THR 344.A O no hydrogen 2.879 N/A SER 346.A OG VAL 343.A O no hydrogen 3.100 N/A