Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 2nzx_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): MET 1.A N LEU 299.A O no hydrogen 2.799 N/A GLN 3.A NE2 ASP 7.A OD1 no hydrogen 3.024 N/A GLN 3.A NE2 LYS 135.A O no hydrogen 3.014 N/A LEU 6.A N PHE 2.A O no hydrogen 2.967 N/A ASP 7.A N GLN 3.A O no hydrogen 2.941 N/A ALA 8.A N PRO 4.A O no hydrogen 2.901 N/A TYR 9.A N LEU 5.A O no hydrogen 2.798 N/A TYR 9.A OH TYR 142.A OH no hydrogen 2.601 N/A VAL 10.A N LEU 6.A O no hydrogen 2.912 N/A GLU 11.A N ASP 7.A O no hydrogen 3.105 N/A SER 12.A N ALA 8.A O no hydrogen 2.843 N/A SER 12.A OG TYR 9.A O no hydrogen 2.681 N/A SER 12.A OG TYR 117.A OH no hydrogen 2.611 N/A ALA 13.A N VAL 10.A O no hydrogen 3.104 N/A SER 14.A N GLU 11.A O no hydrogen 2.918 N/A SER 22.A OG SER 20.A O no hydrogen 3.437 N/A LEU 26.A N THR 56.A O no hydrogen 2.859 N/A LYS 27.A N ASP 68.A OD2 no hydrogen 2.883 N/A ILE 28.A N THR 58.A O no hydrogen 2.975 N/A ALA 29.A N LEU 69.A O no hydrogen 2.835 N/A VAL 30.A N HIS 60.A O no hydrogen 2.974 N/A TRP 34.A N ALA 31.A O no hydrogen 3.388 N/A GLY 35.A N GLU 38.A OE1 no hydrogen 2.775 N/A GLU 38.A N GLU 38.A OE1 no hydrogen 2.643 N/A ILE 39.A N GLY 35.A O no hydrogen 3.079 N/A LYS 40.A N ASP 36.A O no hydrogen 2.852 N/A GLU 41.A N GLU 37.A O no hydrogen 3.059 N/A PHE 42.A N GLU 38.A O no hydrogen 2.814 N/A LYS 43.A N ILE 39.A O no hydrogen 2.834 N/A ASN 44.A N GLU 41.A O no hydrogen 2.881 N/A SER 45.A N PHE 42.A O no hydrogen 2.961 N/A SER 45.A OG PHE 42.A O no hydrogen 2.753 N/A VAL 46.A N ASP 118.A OD1 no hydrogen 2.831 N/A PHE 49.A N SER 45.A O no hydrogen 2.973 N/A ILE 50.A N VAL 46.A O no hydrogen 2.674 N/A LEU 51.A N LEU 47.A O no hydrogen 2.996 N/A SER 52.A N TYR 48.A O no hydrogen 2.834 N/A SER 52.A OG TYR 48.A O no hydrogen 3.470 N/A SER 52.A OG PHE 49.A O no hydrogen 2.865 N/A GLN 53.A N ILE 50.A O no hydrogen 3.102 N/A GLN 53.A NE2 PHE 49.A O no hydrogen 3.212 N/A ARG 54.A N LEU 51.A O no hydrogen 2.793 N/A ARG 54.A NH1 GLU 16.A O no hydrogen 2.734 N/A ARG 54.A NH1 GLN 53.A O no hydrogen 3.428 N/A ARG 54.A NH2 GLU 16.A O no hydrogen 2.755 N/A THR 56.A N PRO 24.A O no hydrogen 2.804 N/A THR 56.A OG1 PRO 23.A O no hydrogen 2.414 N/A THR 58.A N LEU 26.A O no hydrogen 2.981 N/A HIS 60.A N ILE 28.A O no hydrogen 2.708 N/A GLN 61.A NE2 ALA 31.A O no hydrogen 2.958 N/A GLN 61.A NE2 ASN 32.A O no hydrogen 3.567 N/A GLN 61.A NE2 TRP 34.A O no hydrogen 2.804 N/A ASN 64.A N ASN 62.A OD1 no hydrogen 2.722 N/A ASP 68.A N LYS 27.A O no hydrogen 2.864 N/A LEU 69.A N LYS 27.A O no hydrogen 3.181 N/A VAL 70.A N LYS 79.A O no hydrogen 3.040 N/A PHE 71.A N ALA 29.A O no hydrogen 2.865 N/A ASN 73.A ND2 GLU 88.A OE2 no hydrogen 3.369 N/A ASN 77.A ND2 HIS 337.A NE2 no hydrogen 2.589 N/A ASN 77.A ND2 ASN 339.A OD1 no hydrogen 2.568 N/A ALA 78.A N TYR 75.A O no hydrogen 3.269 N/A LYS 79.A NZ ILE 329.A O no hydrogen 2.994 N/A LYS 79.A NZ ASN 332.A O no hydrogen 2.943 N/A ARG 80.A N ASP 96.A OD1 no hydrogen 3.011 N/A VAL 81.A N VAL 70.A O no hydrogen 2.800 N/A PHE 82.A N TYR 97.A O no hydrogen 2.803 N/A TYR 83.A N GLY 72.A O no hydrogen 3.055 N/A GLU 86.A N THR 84.A OG1 no hydrogen 3.140 N/A ASN 87.A ND2 THR 232.A OG1 no hydrogen 2.871 N/A ASN 87.A ND2 GLN 233.A O no hydrogen 3.009 N/A SER 89.A OG ASP 102.A OD2 no hydrogen 2.816 N/A PHE 95.A N ASN 91.A O no hydrogen 3.061 N/A TYR 97.A N ARG 80.A O no hydrogen 2.991 N/A ALA 98.A N ARG 109.A O no hydrogen 2.888 N/A ILE 99.A N PHE 82.A O no hydrogen 2.835 N/A GLY 100.A N LEU 111.A O no hydrogen 3.105 N/A ASN 107.A N ASP 105.A OD1 no hydrogen 2.917 N/A ARG 109.A N PHE 106.A O no hydrogen 2.870 N/A ARG 109.A NE ASP 96.A O no hydrogen 2.682 N/A ARG 109.A NH2 PHE 92.A O no hydrogen 2.747 N/A ARG 109.A NH2 PHE 95.A O no hydrogen 2.691 N/A ARG 109.A NH2 ASP 96.A O no hydrogen 3.432 N/A TYR 110.A OH ASP 102.A O no hydrogen 2.692 N/A LEU 111.A N ALA 98.A O no hydrogen 3.009 N/A ARG 112.A NE PHE 101.A O no hydrogen 2.822 N/A ARG 112.A NH1 ASP 263.A OD1 no hydrogen 2.827 N/A ARG 112.A NH2 GLY 236.A O no hydrogen 2.934 N/A ARG 112.A NH2 ASP 263.A OD1 no hydrogen 3.442 N/A ARG 112.A NH2 ASP 263.A OD2 no hydrogen 2.767 N/A MET 113.A N GLY 100.A O no hydrogen 2.938 N/A TYR 116.A OH ASP 263.A OD1 no hydrogen 2.902 N/A TYR 117.A N PRO 114.A O no hydrogen 3.005 N/A TYR 117.A OH SER 12.A OG no hydrogen 2.611 N/A ARG 119.A N LEU 115.A O no hydrogen 2.927 N/A ARG 119.A NE ASP 244.A OD1 no hydrogen 3.009 N/A ARG 119.A NH2 ASP 244.A OD1 no hydrogen 3.509 N/A ARG 119.A NH2 ASP 244.A OD2 no hydrogen 3.025 N/A LEU 120.A N TYR 116.A O no hydrogen 3.031 N/A HIS 121.A N TYR 117.A O no hydrogen 3.145 N/A HIS 121.A ND1 TYR 142.A OH no hydrogen 2.663 N/A HIS 121.A NE2 ASN 44.A O no hydrogen 2.978 N/A HIS 122.A N ASP 118.A O no hydrogen 3.194 N/A LYS 123.A N ARG 119.A O no hydrogen 2.994 N/A LYS 123.A NZ ASP 244.A OD1 no hydrogen 2.586 N/A ALA 124.A N LEU 120.A O no hydrogen 2.843 N/A GLU 125.A N HIS 121.A O no hydrogen 3.094 N/A SER 126.A N HIS 122.A O no hydrogen 2.974 N/A SER 126.A OG LYS 123.A O no hydrogen 2.855 N/A VAL 127.A N LYS 123.A O no hydrogen 3.049 N/A VAL 127.A N ALA 124.A O no hydrogen 3.230 N/A ASN 128.A N GLU 125.A O no hydrogen 3.077 N/A ASN 128.A ND2 LYS 145.A O no hydrogen 3.319 N/A THR 130.A N SER 148.A O no hydrogen 2.991 N/A THR 130.A OG1 HIS 149.A ND1 no hydrogen 2.794 N/A THR 131.A N ASP 129.A OD2 no hydrogen 2.704 N/A THR 131.A OG1 ASP 129.A OD2 no hydrogen 2.864 N/A ALA 132.A N ASP 129.A O no hydrogen 3.248 N/A TYR 134.A OH PHE 247.A O no hydrogen 2.720 N/A LYS 135.A N GLN 3.A OE1 no hydrogen 3.034 N/A SER 140.A N LYS 137.A O no hydrogen 3.473 N/A SER 140.A OG LYS 137.A O no hydrogen 2.818 N/A TYR 142.A OH TYR 9.A OH no hydrogen 2.601 N/A TYR 142.A OH HIS 121.A ND1 no hydrogen 2.663 N/A ALA 143.A N SER 140.A O no hydrogen 2.855 N/A LEU 144.A N LEU 141.A O no hydrogen 3.350 N/A LYS 145.A NZ GLU 125.A OE2 no hydrogen 3.126 N/A SER 148.A N ASN 128.A O no hydrogen 3.223 N/A SER 148.A OG ASP 129.A OD1 no hydrogen 2.686 N/A HIS 149.A ND1 THR 130.A OG1 no hydrogen 2.794 N/A PHE 151.A N ASP 129.A OD1 no hydrogen 3.073 N/A LYS 152.A N THR 131.A OG1 no hydrogen 2.584 N/A LYS 154.A N CYS 150.A O no hydrogen 3.016 N/A HIS 155.A N PHE 151.A O no hydrogen 2.632 N/A HIS 155.A ND1 PHE 151.A O no hydrogen 2.878 N/A ASN 157.A N GLU 218.A OE2 no hydrogen 2.796 N/A LEU 158.A N GLU 218.A OE1 no hydrogen 3.050 N/A CYS 159.A N HIS 155.A O no hydrogen 2.968 N/A CYS 159.A SG HIS 155.A O no hydrogen 3.020 N/A ALA 160.A N PRO 156.A O no hydrogen 2.940 N/A VAL 161.A N ASN 157.A O no hydrogen 3.122 N/A VAL 162.A N LEU 158.A O no hydrogen 3.181 N/A ASN 163.A N CYS 159.A O no hydrogen 2.611 N/A ASP 164.A N VAL 161.A O no hydrogen 3.439 N/A GLU 165.A N ALA 160.A O no hydrogen 2.905 N/A LEU 169.A N ASP 167.A OD1 no hydrogen 3.278 N/A LYS 170.A N ASP 167.A O no hydrogen 3.064 N/A LYS 170.A NZ ASP 167.A OD2 no hydrogen 2.798 N/A ARG 171.A NE PRO 168.A O no hydrogen 2.884 N/A ARG 171.A NH1 SER 221.A O no hydrogen 2.940 N/A ARG 171.A NH1 HIS 249.A O no hydrogen 2.861 N/A ARG 171.A NH2 HIS 249.A O no hydrogen 3.087 N/A GLY 172.A N GLN 222.A O no hydrogen 3.043 N/A SER 175.A N PHE 225.A O no hydrogen 3.095 N/A SER 175.A OG PHE 225.A O no hydrogen 3.531 N/A SER 175.A OG ASN 226.A OD1 no hydrogen 3.176 N/A PHE 176.A N THR 200.A O no hydrogen 2.817 N/A SER 179.A OG SER 204.A OG no hydrogen 3.267 N/A ALA 183.A N PRO 181.A O no hydrogen 2.505 N/A ARG 186.A NH1 PHE 229.A O no hydrogen 2.839 N/A ARG 186.A NH2 ASN 180.A O no hydrogen 3.289 N/A ASN 187.A N ALA 183.A O no hydrogen 3.038 N/A ALA 188.A N PRO 184.A O no hydrogen 2.921 N/A PHE 189.A N ILE 185.A O no hydrogen 3.090 N/A TYR 190.A N ARG 186.A O no hydrogen 3.036 N/A TYR 190.A OH VAL 199.A O no hydrogen 2.941 N/A ASP 191.A N ASN 187.A O no hydrogen 3.288 N/A ALA 192.A N ALA 188.A O no hydrogen 2.927 N/A LEU 193.A N PHE 189.A O no hydrogen 2.900 N/A ASN 194.A N TYR 190.A O no hydrogen 2.604 N/A SER 195.A N ASP 191.A O no hydrogen 3.075 N/A SER 195.A OG ALA 192.A O no hydrogen 2.814 N/A ILE 196.A N LEU 193.A O no hydrogen 3.012 N/A GLU 197.A N LEU 193.A O no hydrogen 3.017 N/A VAL 199.A N ASN 194.A OD1 no hydrogen 2.641 N/A THR 200.A N ALA 174.A O no hydrogen 2.747 N/A GLY 202.A N PHE 176.A O no hydrogen 2.826 N/A SER 204.A N SER 179.A OG no hydrogen 3.090 N/A VAL 205.A N ALA 178.A O no hydrogen 2.790 N/A ARG 206.A NH1 ASN 187.A O no hydrogen 3.224 N/A ARG 206.A NH1 ASP 191.A OD2 no hydrogen 2.881 N/A ARG 206.A NH2 ASP 191.A OD2 no hydrogen 3.390 N/A ASN 207.A ND2 GLY 203.A O no hydrogen 3.297 N/A ASN 207.A ND2 TYR 211.A O no hydrogen 3.060 N/A THR 208.A N GLY 201.A O no hydrogen 3.039 N/A GLY 210.A N ASN 207.A OD1 no hydrogen 2.867 N/A ASN 212.A ND2 GLY 202.A O no hydrogen 3.656 N/A VAL 213.A N GLY 202.A O no hydrogen 3.003 N/A LYS 216.A NZ ASP 244.A OD2 no hydrogen 2.906 N/A GLU 218.A N ASN 215.A OD1 no hydrogen 2.301 N/A PHE 219.A N ASN 215.A O no hydrogen 3.174 N/A LEU 220.A N LYS 216.A O no hydrogen 2.925 N/A SER 221.A N ASN 217.A O no hydrogen 3.205 N/A SER 221.A OG ASN 157.A OD1 no hydrogen 3.254 N/A SER 221.A OG GLU 218.A O no hydrogen 2.614 N/A GLN 222.A N PHE 219.A O no hydrogen 2.952 N/A TYR 223.A N LEU 220.A O no hydrogen 3.236 N/A LYS 224.A N GLY 172.A O no hydrogen 2.904 N/A PHE 225.A N PHE 173.A O no hydrogen 2.947 N/A ASN 226.A N ILE 251.A O no hydrogen 2.766 N/A LEU 227.A N SER 175.A O no hydrogen 2.951 N/A CYS 228.A N ILE 253.A O no hydrogen 2.646 N/A GLU 230.A N TRP 255.A O no hydrogen 2.825 N/A THR 232.A OG1 ASN 231.A OD1 no hydrogen 2.620 N/A GLY 236.A N SER 257.A OG no hydrogen 2.933 N/A TYR 237.A N GLY 234.A O no hydrogen 2.917 N/A TYR 237.A OH GLY 85.A O no hydrogen 3.264 N/A VAL 238.A N GLY 236.A O no hydrogen 2.873 N/A THR 239.A N GLU 230.A OE2 no hydrogen 3.027 N/A THR 239.A OG1 GLU 230.A OE1 no hydrogen 2.538 N/A THR 239.A OG1 GLU 240.A OE1 no hydrogen 3.401 N/A GLU 240.A N GLU 240.A OE1 no hydrogen 2.679 N/A LYS 241.A NZ THR 239.A OG1 no hydrogen 3.087 N/A LYS 241.A NZ GLU 240.A OE2 no hydrogen 3.080 N/A ILE 243.A N GLU 240.A O no hydrogen 3.037 N/A ASP 244.A N GLU 240.A O no hydrogen 3.111 N/A ALA 245.A N LYS 241.A O no hydrogen 3.261 N/A TYR 246.A N ILE 242.A O no hydrogen 3.138 N/A TYR 246.A OH SER 268.A OG no hydrogen 2.798 N/A PHE 247.A N ILE 243.A O no hydrogen 2.816 N/A SER 248.A N ASP 244.A O no hydrogen 3.055 N/A SER 248.A N ALA 245.A O no hydrogen 2.905 N/A SER 248.A OG ASN 217.A O no hydrogen 3.054 N/A SER 248.A OG ASN 217.A OD1 no hydrogen 3.236 N/A SER 248.A OG ASP 244.A O no hydrogen 2.877 N/A HIS 249.A N TYR 246.A O no hydrogen 3.124 N/A THR 250.A N ALA 245.A O no hydrogen 3.405 N/A THR 250.A OG1 TYR 223.A O no hydrogen 2.921 N/A ILE 251.A N LYS 224.A O no hydrogen 3.059 N/A ILE 253.A N ASN 226.A O no hydrogen 2.740 N/A TYR 254.A N VAL 270.A O no hydrogen 2.939 N/A TYR 254.A OH GLU 230.A OE2 no hydrogen 2.811 N/A GLY 256.A N HIS 273.A NE2 no hydrogen 2.873 N/A SER 257.A N TYR 254.A OH no hydrogen 3.005 N/A SER 259.A N SER 257.A OG no hydrogen 3.237 N/A SER 259.A OG GLU 103.A OE2 no hydrogen 2.637 N/A SER 259.A OG SER 257.A OG no hydrogen 3.033 N/A VAL 260.A N SER 257.A O no hydrogen 2.909 N/A LYS 262.A N SER 259.A O no hydrogen 2.834 N/A LYS 262.A NZ GLU 103.A OE1 no hydrogen 2.717 N/A ASP 263.A N VAL 260.A O no hydrogen 2.963 N/A PHE 264.A N VAL 260.A O no hydrogen 2.932 N/A ASN 265.A N PRO 303.A O no hydrogen 2.914 N/A SER 268.A N ASN 265.A O no hydrogen 2.900 N/A SER 268.A OG TYR 246.A OH no hydrogen 2.798 N/A SER 268.A OG ASN 265.A O no hydrogen 2.480 N/A VAL 270.A N PRO 252.A O no hydrogen 3.022 N/A VAL 272.A N TYR 254.A O no hydrogen 2.821 N/A HIS 273.A N ASN 271.A OD1 no hydrogen 3.024 N/A ASP 274.A N ASN 271.A O no hydrogen 2.853 N/A PHE 275.A N VAL 272.A O no hydrogen 3.223 N/A GLU 280.A N ASN 277.A OD1 no hydrogen 2.754 N/A ILE 282.A N PHE 278.A O no hydrogen 2.803 N/A ASP 283.A N ASP 279.A O no hydrogen 2.737 N/A TYR 284.A N GLU 280.A O no hydrogen 3.072 N/A ILE 285.A N ALA 281.A O no hydrogen 2.934 N/A LYS 286.A N ILE 282.A O no hydrogen 2.673 N/A LYS 286.A NZ ASP 283.A OD1 no hydrogen 3.401 N/A TYR 287.A N ASP 283.A O no hydrogen 3.116 N/A LEU 288.A N TYR 284.A O no hydrogen 3.082 N/A HIS 289.A N ILE 285.A O no hydrogen 2.980 N/A THR 290.A N TYR 287.A O no hydrogen 2.957 N/A THR 290.A OG1 LYS 286.A O no hydrogen 3.084 N/A THR 290.A OG1 TYR 287.A O no hydrogen 3.179 N/A TYR 295.A N HIS 291.A O no hydrogen 3.174 N/A TYR 295.A OH LYS 224.A O no hydrogen 2.718 N/A LEU 296.A N LYS 292.A O no hydrogen 2.934 N/A ASP 297.A N ASN 293.A O no hydrogen 2.831 N/A MET 298.A N ALA 294.A O no hydrogen 3.066 N/A LEU 299.A N TYR 295.A O no hydrogen 2.996 N/A TYR 300.A N LEU 296.A O no hydrogen 3.181 N/A GLU 301.A N MET 298.A O no hydrogen 3.149 N/A LEU 307.A N LYS 310.A O no hydrogen 2.765 N/A LYS 310.A N LEU 307.A O no hydrogen 3.107 N/A TYR 312.A N ASN 305.A O no hydrogen 3.117 N/A ASN 316.A N PHE 313.A O no hydrogen 2.901 N/A LEU 317.A N TYR 314.A O no hydrogen 3.435 N/A PHE 319.A N SER 12.A O no hydrogen 2.846 N/A LYS 321.A N SER 318.A OG no hydrogen 2.995 N/A LYS 321.A NZ GLN 315.A O no hydrogen 2.869 N/A ILE 322.A N SER 318.A O no hydrogen 3.098 N/A LEU 323.A N PHE 319.A O no hydrogen 2.811 N/A ALA 324.A N LYS 320.A O no hydrogen 2.881 N/A PHE 325.A N LYS 321.A O no hydrogen 3.023 N/A PHE 326.A N ILE 322.A O no hydrogen 3.127 N/A LYS 327.A N LEU 323.A O no hydrogen 2.864 N/A THR 328.A N ALA 324.A O no hydrogen 2.957 N/A THR 328.A OG1 ALA 324.A O no hydrogen 2.878 N/A ILE 329.A N PHE 325.A O no hydrogen 3.068 N/A LEU 330.A N PHE 326.A O no hydrogen 2.895 N/A GLU 331.A N LYS 327.A O no hydrogen 3.016 N/A ASN 332.A N THR 328.A O no hydrogen 2.999 N/A ASN 332.A N ILE 329.A O no hydrogen 3.289 N/A ASN 332.A ND2 TYR 336.A OH no hydrogen 2.987 N/A THR 334.A N ASN 332.A OD1 no hydrogen 2.948 N/A THR 334.A OG1 ASN 332.A OD1 no hydrogen 3.108 N/A TYR 336.A N ASP 96.A OD2 no hydrogen 2.791 N/A TYR 336.A OH ASP 108.A OD2 no hydrogen 2.682 N/A HIS 337.A N ASP 96.A OD2 no hydrogen 2.860 N/A HIS 337.A ND1 ASP 96.A OD1 no hydrogen 2.602 N/A ASP 338.A N ASN 93.A O no hydrogen 2.782 N/A