Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 2wwu_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): THR 3.A N ASN 210.A O no hydrogen 2.701 N/A THR 3.A OG1 ASN 210.A O no hydrogen 2.936 N/A SER 5.A N LYS 2.A O no hydrogen 3.298 N/A SER 5.A OG LYS 2.A O no hydrogen 2.615 N/A VAL 9.A N SER 5.A O no hydrogen 3.063 N/A ARG 10.A N PRO 6.A O no hydrogen 3.042 N/A GLU 11.A N THR 7.A O no hydrogen 2.943 N/A LEU 12.A N PHE 8.A O no hydrogen 2.857 N/A ARG 13.A N VAL 9.A O no hydrogen 2.916 N/A ARG 13.A NH1 PRO 245.A O no hydrogen 3.123 N/A ARG 13.A NH2 PRO 245.A O no hydrogen 3.542 N/A SER 14.A N GLU 11.A O no hydrogen 3.215 N/A SER 14.A OG GLU 11.A O no hydrogen 3.000 N/A ARG 15.A N LEU 12.A O no hydrogen 3.053 N/A THR 16.A OG1 PHE 17.A O no hydrogen 2.968 N/A ASP 18.A N CYS 221.A O no hydrogen 3.038 N/A SER 20.A N LYS 223.A O no hydrogen 3.270 N/A SER 20.A OG ASP 21.A OD1 no hydrogen 3.566 N/A SER 20.A OG LYS 223.A O no hydrogen 3.151 N/A ASP 21.A N SER 19.A OG no hydrogen 3.232 N/A GLU 22.A N SER 19.A O no hydrogen 3.130 N/A VAL 23.A N SER 20.A O no hydrogen 3.011 N/A ILE 24.A N SER 20.A O no hydrogen 3.003 N/A LEU 25.A N PRO 45.A O no hydrogen 3.093 N/A THR 28.A N GLN 31.A OE1 no hydrogen 2.996 N/A GLN 31.A N THR 28.A O no hydrogen 2.994 N/A LEU 32.A N THR 28.A O no hydrogen 3.150 N/A LEU 32.A N GLY 29.A O no hydrogen 3.234 N/A PHE 36.A N THR 33.A OG1 no hydrogen 2.970 N/A LEU 37.A N THR 33.A O no hydrogen 3.061 N/A GLU 38.A N VAL 34.A O no hydrogen 2.805 N/A GLU 39.A N GLU 35.A O no hydrogen 2.792 N/A ASN 40.A N PHE 36.A O no hydrogen 2.769 N/A ASN 40.A ND2 PHE 36.A O no hydrogen 2.953 N/A SER 41.A OG.A ASN 40.A O no hydrogen 2.476 N/A SER 41.A OG.A SER 43.A OG no hydrogen 2.779 N/A SER 43.A OG SER 41.A OG.A no hydrogen 2.779 N/A ILE 46.A N PHE 233.A O no hydrogen 2.951 N/A LEU 47.A N LEU 25.A O no hydrogen 2.933 N/A VAL 48.A N THR 231.A O no hydrogen 2.807 N/A LEU 54.A N LYS 51.A O no hydrogen 2.914 N/A THR 57.A N GLU 126.A O no hydrogen 2.964 N/A SER 62.A N SER 60.A OG no hydrogen 3.157 N/A SER 62.A OG SER 60.A OG no hydrogen 2.596 N/A PHE 63.A N SER 60.A O no hydrogen 3.033 N/A THR 64.A N ASP 67.A OD2 no hydrogen 3.067 N/A ARG 66.A N TYR 101.A OH no hydrogen 3.066 N/A ARG 66.A NH1 ARG 66.A O no hydrogen 3.062 N/A ASP 67.A N THR 64.A OG1 no hydrogen 3.076 N/A VAL 68.A N THR 64.A O no hydrogen 2.954 N/A GLU 69.A N VAL 65.A O no hydrogen 3.033 N/A HIS 70.A N ARG 66.A O no hydrogen 2.982 N/A TYR 71.A N ASP 67.A O no hydrogen 2.963 N/A VAL 72.A N VAL 68.A O no hydrogen 2.832 N/A GLY 73.A N GLU 69.A O no hydrogen 2.770 N/A SER 74.A OG GLU 69.A OE2 no hydrogen 3.274 N/A LYS 76.A N GLY 73.A O no hydrogen 3.264 N/A ILE 78.A N MET 91.A O no hydrogen 2.697 N/A VAL 80.A N CYS 89.A O no hydrogen 2.871 N/A ILE 81.A N ASN 110.A O no hydrogen 2.958 N/A ASP 82.A N ALA 87.A O no hydrogen 3.108 N/A VAL 83.A N VAL 108.A O no hydrogen 2.520 N/A THR 84.A N ASP 82.A OD1 no hydrogen 3.164 N/A THR 84.A OG1 ASP 82.A OD1 no hydrogen 3.242 N/A ARG 85.A NE TYR 164.A O no hydrogen 2.852 N/A GLN 86.A N ASP 82.A O no hydrogen 3.298 N/A CYS 89.A N VAL 80.A O no hydrogen 3.187 N/A CYS 89.A SG LYS 90.A O no hydrogen 3.990 N/A LYS 90.A NZ ASP 79.A OD1 no hydrogen 3.162 N/A MET 91.A N ILE 78.A O no hydrogen 2.982 N/A LEU 93.A N LYS 76.A O no hydrogen 2.777 N/A GLY 94.A N SER 74.A O no hydrogen 3.015 N/A PHE 96.A N LYS 92.A O no hydrogen 3.138 N/A VAL 97.A N LEU 93.A O no hydrogen 2.824 N/A LYS 98.A N GLY 94.A O no hydrogen 2.952 N/A TYR 99.A N ASP 95.A O no hydrogen 2.991 N/A TYR 99.A OH LYS 107.A O no hydrogen 2.600 N/A TYR 100.A N PHE 96.A O no hydrogen 2.684 N/A TYR 101.A N VAL 97.A O no hydrogen 2.965 N/A SER 102.A N LYS 98.A O no hydrogen 2.894 N/A SER 102.A OG TYR 99.A O no hydrogen 2.597 N/A GLY 103.A N TYR 100.A O no hydrogen 3.126 N/A LYS 104.A N SER 102.A OG no hydrogen 3.086 N/A ARG 105.A NE LYS 104.A O no hydrogen 3.400 N/A ARG 105.A NH1 TYR 100.A O no hydrogen 3.347 N/A ARG 105.A NH2 TYR 100.A O no hydrogen 3.107 N/A LEU 109.A N TYR 99.A OH no hydrogen 2.865 N/A ASN 110.A N ILE 81.A O no hydrogen 2.845 N/A VAL 111.A N MET 158.A O no hydrogen 3.086 N/A PHE 116.A N LYS 154.A O no hydrogen 3.078 N/A SER 117.A N GLU 115.A OE2 no hydrogen 2.752 N/A SER 117.A OG GLU 115.A OE1 no hydrogen 2.646 N/A SER 117.A OG GLU 115.A OE2 no hydrogen 3.149 N/A THR 119.A N PHE 116.A O no hydrogen 2.988 N/A THR 119.A OG1 PHE 116.A O no hydrogen 2.733 N/A LEU 121.A N TYR 71.A O no hydrogen 3.356 N/A SER 122.A N THR 119.A O no hydrogen 2.901 N/A SER 122.A OG SER 117.A O no hydrogen 3.317 N/A ASN 123.A N ARG 120.A O no hydrogen 3.073 N/A LEU 124.A N LEU 121.A O no hydrogen 2.948 N/A VAL 125.A N SER 122.A O no hydrogen 3.370 N/A GLU 126.A N THR 57.A O no hydrogen 2.772 N/A THR 127.A N GLU 126.A OE1 no hydrogen 2.881 N/A LYS 129.A N LEU 54.A O no hydrogen 2.915 N/A ARG 132.A N PRO 128.A O no hydrogen 3.192 N/A ARG 132.A NE THR 127.A O no hydrogen 2.818 N/A ARG 132.A NE THR 127.A OG1 no hydrogen 3.314 N/A ARG 132.A NH2 THR 127.A O no hydrogen 2.782 N/A LYS 133.A N LYS 129.A O no hydrogen 2.887 N/A LEU 134.A N ILE 130.A O no hydrogen 2.946 N/A SER 135.A N VAL 131.A O no hydrogen 2.786 N/A TRP 136.A N LEU 256.A O no hydrogen 2.832 N/A TRP 136.A NE1 SER 258.A OG no hydrogen 2.805 N/A GLU 138.A N SER 135.A OG no hydrogen 3.180 N/A ASN 139.A N SER 135.A O no hydrogen 3.083 N/A ASN 139.A ND2 ARG 132.A O no hydrogen 2.827 N/A ASN 139.A ND2 SER 135.A O no hydrogen 2.926 N/A LEU 140.A N TRP 136.A O no hydrogen 2.741 N/A CYS 145.A N PRO 142.A O no hydrogen 3.304 N/A CYS 145.A SG TYR 291.A OH no hydrogen 3.583 N/A ARG 149.A NH2 GLN 153.A OE1 no hydrogen 3.084 N/A LYS 154.A N GLU 115.A OE1 no hydrogen 2.953 N/A LYS 154.A NZ SER 122.A O no hydrogen 2.959 N/A LYS 154.A NZ SER 122.A OG no hydrogen 2.977 N/A LYS 154.A NZ VAL 125.A O no hydrogen 2.843 N/A TYR 155.A N GLY 252.A O no hydrogen 2.700 N/A CYS 156.A N LEU 114.A O no hydrogen 2.904 N/A LEU 157.A N ALA 250.A O no hydrogen 2.723 N/A MET 158.A N VAL 111.A O no hydrogen 2.818 N/A SER 159.A N CYS 248.A O no hydrogen 2.847 N/A SER 159.A OG ASN 110.A OD1 no hydrogen 2.742 N/A ARG 161.A N ASP 247.A OD1 no hydrogen 2.874 N/A ASP 162.A N THR 244.A O no hydrogen 2.652 N/A SER 163.A N VAL 160.A O no hydrogen 3.044 N/A SER 163.A OG VAL 160.A O no hydrogen 3.025 N/A TYR 164.A OH ASP 166.A OD1 no hydrogen 2.832 N/A THR 165.A N VAL 242.A O no hydrogen 2.851 N/A HIS 168.A N HIS 240.A O no hydrogen 2.942 N/A HIS 168.A ND1 ASP 166.A O no hydrogen 3.011 N/A GLY 172.A N GLU 271.A OE1 no hydrogen 3.332 N/A GLY 173.A N ASP 170.A O no hydrogen 3.232 N/A THR 174.A N PHE 171.A O no hydrogen 3.083 N/A THR 174.A OG1 PHE 171.A O no hydrogen 2.823 N/A SER 175.A N PHE 255.A O no hydrogen 2.810 N/A SER 175.A OG THR 236.A OG1 no hydrogen 3.317 N/A SER 175.A OG HIS 257.A NE2 no hydrogen 3.022 N/A VAL 176.A N ILE 234.A O no hydrogen 3.099 N/A TRP 177.A N GLY 253.A O no hydrogen 3.117 N/A TYR 178.A N LEU 232.A O no hydrogen 2.803 N/A HIS 179.A N PHE 251.A O no hydrogen 2.627 N/A HIS 179.A ND1 THR 231.A OG1 no hydrogen 2.895 N/A VAL 180.A N GLN 230.A O no hydrogen 3.224 N/A LEU 181.A N LEU 249.A O no hydrogen 2.993 N/A LYS 182.A N LEU 249.A O no hydrogen 3.209 N/A LYS 182.A NZ PHE 63.A O no hydrogen 2.834 N/A LYS 185.A N VAL 226.A O no hydrogen 2.868 N/A LYS 185.A NZ SER 159.A OG no hydrogen 2.946 N/A LYS 185.A NZ THR 244.A OG1 no hydrogen 2.714 N/A ILE 186.A N LEU 243.A O no hydrogen 2.809 N/A PHE 187.A N CYS 224.A O no hydrogen 2.849 N/A TYR 188.A N ALA 241.A O no hydrogen 2.856 N/A LEU 189.A N TYR 222.A O no hydrogen 2.777 N/A ILE 190.A N ILE 239.A O no hydrogen 2.780 N/A ASN 196.A N THR 193.A OG1 no hydrogen 2.927 N/A ASN 196.A ND2 ARG 191.A O no hydrogen 2.863 N/A LEU 197.A N THR 193.A O no hydrogen 2.854 N/A THR 198.A N ASN 194.A O no hydrogen 3.071 N/A THR 198.A OG1 ASN 194.A O no hydrogen 3.155 N/A LEU 199.A N ALA 195.A O no hydrogen 3.232 N/A PHE 200.A N ASN 196.A O no hydrogen 2.887 N/A GLU 201.A N LEU 197.A O no hydrogen 2.890 N/A CYS 202.A N THR 198.A O no hydrogen 3.082 N/A TRP 203.A N LEU 199.A O no hydrogen 2.830 N/A TRP 203.A NE1 MET 212.A O no hydrogen 3.009 N/A SER 204.A N PHE 200.A O no hydrogen 2.777 N/A SER 204.A OG PHE 200.A O no hydrogen 2.851 N/A SER 205.A N GLU 201.A O no hydrogen 3.233 N/A SER 205.A N CYS 202.A O no hydrogen 3.248 N/A SER 205.A OG GLU 201.A O no hydrogen 2.879 N/A SER 206.A N CYS 202.A O no hydrogen 2.946 N/A SER 206.A N TRP 203.A O no hydrogen 3.346 N/A SER 206.A OG TRP 203.A O no hydrogen 2.968 N/A GLU 211.A N ASN 208.A O no hydrogen 2.984 N/A MET 212.A N GLN 209.A O no hydrogen 3.243 N/A ASP 216.A N PHE 213.A O no hydrogen 3.050 N/A GLN 217.A N PHE 214.A O no hydrogen 2.912 N/A LYS 220.A NZ GLU 22.A OE1 no hydrogen 3.562 N/A CYS 221.A N ASP 18.A OD2 no hydrogen 3.154 N/A TYR 222.A N LEU 189.A O no hydrogen 2.880 N/A LYS 223.A N ASP 18.A O no hydrogen 2.884 N/A LYS 223.A NZ ARG 15.A O no hydrogen 3.059 N/A CYS 224.A N PHE 187.A O no hydrogen 2.750 N/A SER 225.A OG GLU 184.A OE2 no hydrogen 3.550 N/A VAL 226.A N LYS 185.A O no hydrogen 2.682 N/A LYS 227.A N GLN 230.A OE1 no hydrogen 2.755 N/A GLY 229.A N VAL 180.A O no hydrogen 2.696 N/A GLN 230.A N LYS 227.A O no hydrogen 2.928 N/A THR 231.A N VAL 48.A O no hydrogen 2.979 N/A THR 231.A OG1 HIS 179.A ND1 no hydrogen 2.895 N/A LEU 232.A N TYR 178.A O no hydrogen 2.802 N/A PHE 233.A N ILE 46.A O no hydrogen 2.749 N/A ILE 234.A N VAL 176.A O no hydrogen 2.789 N/A THR 236.A OG1 SER 175.A OG no hydrogen 3.317 N/A TRP 238.A N PRO 235.A O no hydrogen 3.399 N/A TRP 238.A NE1 SER 43.A O no hydrogen 3.078 N/A ILE 239.A N ILE 190.A O no hydrogen 2.997 N/A HIS 240.A N HIS 168.A O no hydrogen 2.980 N/A HIS 240.A ND1 TRP 238.A O no hydrogen 2.939 N/A ALA 241.A N TYR 188.A O no hydrogen 3.106 N/A VAL 242.A N THR 165.A O no hydrogen 2.905 N/A LEU 243.A N ILE 186.A O no hydrogen 2.886 N/A THR 244.A N SER 163.A O no hydrogen 2.880 N/A CYS 248.A N SER 159.A O no hydrogen 2.725 N/A CYS 248.A SG LYS 182.A O no hydrogen 3.355 N/A CYS 248.A SG GLU 184.A O no hydrogen 3.830 N/A LEU 249.A N LYS 182.A O no hydrogen 3.059 N/A ALA 250.A N LEU 157.A O no hydrogen 2.878 N/A PHE 251.A N HIS 179.A O no hydrogen 2.844 N/A GLY 252.A N TYR 155.A O no hydrogen 3.026 N/A GLY 253.A N TRP 177.A O no hydrogen 3.157 N/A ASN 254.A N VAL 152.A O no hydrogen 2.942 N/A ASN 254.A ND2 THR 174.A OG1 no hydrogen 2.894 N/A PHE 255.A N SER 175.A O no hydrogen 2.913 N/A HIS 257.A N GLN 264.A OE1 no hydrogen 3.064 N/A HIS 257.A NE2 SER 175.A OG no hydrogen 3.022 N/A LEU 259.A N HIS 257.A ND1 no hydrogen 3.132 N/A ASN 260.A ND2 THR 236.A OG1 no hydrogen 2.848 N/A ASN 260.A ND2 ASN 260.A O no hydrogen 2.634 N/A GLN 264.A N ASN 260.A O no hydrogen 3.039 N/A GLN 264.A NE2 HIS 257.A O no hydrogen 3.132 N/A LEU 265.A N ILE 261.A O no hydrogen 2.898 N/A LYS 266.A N GLU 262.A O no hydrogen 3.016 N/A LYS 266.A NZ ASN 194.A OD1 no hydrogen 3.128 N/A ALA 267.A N MET 263.A O no hydrogen 2.789 N/A TYR 268.A N GLN 264.A O no hydrogen 2.817 N/A TYR 268.A OH GLU 286.A OE2 no hydrogen 3.245 N/A GLU 269.A N LEU 265.A O no hydrogen 2.902 N/A ILE 270.A N LYS 266.A O no hydrogen 2.972 N/A GLU 271.A N ALA 267.A O no hydrogen 2.912 N/A LYS 272.A N TYR 268.A O no hydrogen 2.937 N/A LYS 272.A NZ TYR 268.A OH no hydrogen 3.567 N/A ARG 273.A N GLU 269.A O no hydrogen 3.259 N/A ARG 273.A NH1 GLU 201.A OE1 no hydrogen 3.082 N/A LEU 274.A N ILE 270.A O no hydrogen 2.968 N/A SER 275.A N GLU 271.A O no hydrogen 2.782 N/A ALA 277.A N SER 275.A OG no hydrogen 2.978 N/A ARG 281.A NH2 TYR 155.A OH no hydrogen 3.194 N/A ASN 284.A ND2 GLU 340.A OE1 no hydrogen 2.615 N/A THR 287.A OG1 GLU 340.A O no hydrogen 2.869 N/A ILE 288.A N ASN 284.A O no hydrogen 3.212 N/A CYS 289.A N PHE 285.A O no hydrogen 3.070 N/A CYS 289.A SG PHE 285.A O no hydrogen 3.496 N/A TRP 290.A N GLU 286.A O no hydrogen 2.930 N/A TYR 291.A N THR 287.A O no hydrogen 3.161 N/A VAL 292.A N ILE 288.A O no hydrogen 2.841 N/A GLY 293.A N CYS 289.A O no hydrogen 2.788 N/A LYS 294.A N TRP 290.A O no hydrogen 3.236 N/A LYS 294.A NZ ASP 298.A OD1 no hydrogen 3.199 N/A HIS 295.A N TYR 291.A O no hydrogen 3.141 N/A ILE 296.A N VAL 292.A O no hydrogen 2.827 N/A LEU 297.A N GLY 293.A O no hydrogen 2.953 N/A ASP 298.A N LYS 294.A O no hydrogen 2.894 N/A ILE 299.A N HIS 295.A O no hydrogen 2.902 N/A PHE 300.A N ILE 296.A O no hydrogen 2.921 N/A ARG 301.A N LEU 297.A O no hydrogen 2.891 N/A GLY 302.A N ASP 298.A O no hydrogen 2.938 N/A LEU 303.A N ILE 299.A O no hydrogen 2.917 N/A ARG 304.A N PHE 300.A O no hydrogen 2.997 N/A ARG 304.A NH2 GLU 357.A OE2 no hydrogen 3.286 N/A GLU 305.A N ARG 301.A O no hydrogen 2.839 N/A ASN 306.A N GLY 302.A O no hydrogen 2.969 N/A ARG 307.A N ARG 304.A O no hydrogen 2.984 N/A ARG 308.A N LEU 303.A O no hydrogen 2.694 N/A SER 312.A OG HIS 316.A NE2 no hydrogen 3.405 N/A TYR 313.A OH GLU 38.A OE2 no hydrogen 3.247 N/A LEU 314.A N ALA 311.A O no hydrogen 3.008 N/A VAL 315.A N ALA 311.A O no hydrogen 3.315 N/A HIS 316.A N SER 312.A O no hydrogen 3.063 N/A GLY 317.A N TYR 313.A O no hydrogen 2.924 N/A GLY 318.A N LEU 314.A O no hydrogen 2.845 N/A LYS 319.A N VAL 315.A O no hydrogen 3.027 N/A ALA 320.A N HIS 316.A O no hydrogen 3.020 N/A LEU 321.A N GLY 317.A O no hydrogen 2.910 N/A ASN 322.A N GLY 318.A O no hydrogen 2.956 N/A ASN 322.A ND2 ILE 351.A O no hydrogen 3.086 N/A LEU 323.A N LYS 319.A O no hydrogen 3.012 N/A ALA 324.A N ALA 320.A O no hydrogen 3.005 N/A PHE 325.A N LEU 321.A O no hydrogen 2.817 N/A ARG 326.A N ASN 322.A O no hydrogen 3.018 N/A ALA 327.A N LEU 323.A O no hydrogen 2.984 N/A TRP 328.A N ALA 324.A O no hydrogen 2.812 N/A THR 329.A N ARG 326.A O no hydrogen 3.190 N/A THR 329.A OG1 PHE 325.A O no hydrogen 2.859 N/A THR 329.A OG1 ARG 326.A O no hydrogen 3.355 N/A ARG 330.A NH1 GLU 332.A OE2 no hydrogen 3.147 N/A GLU 332.A N GLU 332.A OE1 no hydrogen 2.432 N/A ALA 333.A N ARG 330.A O no hydrogen 3.001 N/A LEU 334.A N ARG 330.A O no hydrogen 2.790 N/A ASP 336.A N ALA 333.A O no hydrogen 2.799 N/A HIS 337.A N LEU 334.A O no hydrogen 3.009 N/A HIS 337.A ND1 GLU 286.A OE1 no hydrogen 2.803 N/A HIS 337.A ND1 GLU 286.A OE2 no hydrogen 3.132 N/A GLU 338.A N LEU 334.A O no hydrogen 2.911 N/A GLU 340.A N HIS 337.A O no hydrogen 2.927 N/A ILE 341.A N GLU 338.A O no hydrogen 3.119 N/A VAL 345.A N PRO 342.A O no hydrogen 2.946 N/A GLN 349.A NE2 ASP 353.A OD1 no hydrogen 2.803 N/A GLN 349.A NE2 ASP 353.A OD2 no hydrogen 3.363 N/A LEU 350.A N ARG 346.A O no hydrogen 2.926 N/A ILE 351.A N THR 347.A O no hydrogen 2.919 N/A LYS 352.A N VAL 348.A O no hydrogen 3.065 N/A ASP 353.A N GLN 349.A O no hydrogen 2.871 N/A LEU 354.A N LEU 350.A O no hydrogen 2.875 N/A ALA 355.A N ILE 351.A O no hydrogen 2.997 N/A ARG 356.A N LYS 352.A O no hydrogen 3.009 N/A GLU 357.A N ASP 353.A O no hydrogen 2.948 N/A ILE 358.A N LEU 354.A O no hydrogen 2.901 N/A ARG 359.A N ALA 355.A O no hydrogen 2.930 N/A LEU 360.A N ARG 356.A O no hydrogen 3.099 N/A VAL 361.A N ILE 358.A O no hydrogen 3.162 N/A GLU 362.A N ILE 358.A O no hydrogen 3.281 N/A