Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 2x0n_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ILE 2.A N GLU 29.A O no hydrogen 2.674 N/A LYS 3.A NZ ASP 31.A OD2 no hydrogen 3.247 N/A VAL 4.A N ASP 31.A O no hydrogen 2.902 N/A GLY 5.A N TYR 105.A O no hydrogen 2.903 N/A ASN 7.A N ILE 107.A O no hydrogen 2.780 N/A GLY 8.A N VAL 36.A O no hydrogen 2.868 N/A PHE 9.A N ASP 37.A OD1 no hydrogen 3.115 N/A ARG 11.A NE GLU 335.A OE2 no hydrogen 2.649 N/A ARG 11.A NH2 ASP 52.A OD2 no hydrogen 2.572 N/A ARG 11.A NH2 GLU 335.A OE1 no hydrogen 3.540 N/A MET 15.A N ARG 11.A O no hydrogen 2.912 N/A VAL 16.A N ILE 12.A O no hydrogen 2.504 N/A PHE 17.A N GLY 13.A O no hydrogen 3.276 N/A GLN 18.A N ARG 14.A O no hydrogen 3.037 N/A GLN 18.A NE2 ASP 22.A OD2 no hydrogen 3.344 N/A ALA 19.A N MET 15.A O no hydrogen 2.923 N/A LEU 20.A N VAL 16.A O no hydrogen 3.298 N/A CYS 21.A N PHE 17.A O no hydrogen 3.093 N/A CYS 21.A N GLN 18.A O no hydrogen 2.946 N/A ASP 22.A N GLN 18.A O no hydrogen 2.726 N/A ASP 23.A N ALA 19.A O no hydrogen 2.670 N/A GLY 24.A N CYS 21.A O no hydrogen 2.870 N/A GLY 27.A N ILE 30.A O no hydrogen 2.821 N/A ASN 28.A N LEU 25.A O no hydrogen 3.495 N/A GLU 29.A N LEU 25.A O no hydrogen 3.222 N/A ILE 30.A N LEU 25.A O no hydrogen 2.804 N/A ASP 31.A N ILE 2.A O no hydrogen 2.512 N/A VAL 33.A N VAL 4.A O no hydrogen 3.027 N/A VAL 35.A N LEU 85.A O no hydrogen 2.785 N/A VAL 36.A N ILE 6.A O no hydrogen 3.160 N/A ASN 39.A N ASP 37.A O no hydrogen 2.565 N/A ALA 42.A N ASP 74.A O no hydrogen 3.355 N/A TYR 44.A N ASP 41.A O no hydrogen 3.129 N/A ALA 46.A N ALA 42.A O no hydrogen 3.143 N/A TYR 47.A N ARG 43.A O no hydrogen 2.996 N/A GLN 48.A N TYR 44.A O no hydrogen 2.745 N/A MET 49.A N ALA 46.A O no hydrogen 3.288 N/A LYS 50.A N ALA 46.A O no hydrogen 3.152 N/A LYS 50.A N TYR 47.A O no hydrogen 3.253 N/A TYR 51.A N TYR 47.A O no hydrogen 3.312 N/A VAL 54.A N ASP 52.A OD1 no hydrogen 2.684 N/A HIS 55.A N ASP 52.A OD1 no hydrogen 2.629 N/A HIS 55.A ND1 SER 302.A OG no hydrogen 2.843 N/A HIS 55.A NE2 GLU 335.A OE1 no hydrogen 2.914 N/A GLY 56.A N ASP 52.A O no hydrogen 3.217 N/A PHE 58.A N LYS 50.A O no hydrogen 2.824 N/A LYS 59.A NZ LYS 57.A O no hydrogen 3.194 N/A HIS 60.A NE2 ASP 22.A OD1 no hydrogen 3.225 N/A THR 64.A OG1 ASP 74.A OD2 no hydrogen 3.107 N/A THR 65.A N THR 76.A O no hydrogen 3.221 N/A THR 65.A OG1 THR 64.A O no hydrogen 2.692 N/A SER 67.A N ASP 75.A OD1 no hydrogen 2.543 N/A SER 67.A OG ASP 75.A OD1 no hydrogen 3.333 N/A SER 67.A OG ASP 75.A OD2 no hydrogen 2.466 N/A ASP 75.A N THR 65.A O no hydrogen 2.765 N/A THR 76.A N THR 65.A O no hydrogen 2.843 N/A THR 76.A OG1 THR 65.A O no hydrogen 3.264 N/A LEU 77.A N ILE 84.A O no hydrogen 2.833 N/A VAL 78.A N SER 63.A O no hydrogen 2.837 N/A ASN 80.A N SER 61.A O no hydrogen 3.091 N/A HIS 82.A N VAL 79.A O no hydrogen 2.943 N/A HIS 82.A ND1 ASN 80.A O no hydrogen 3.244 N/A ILE 84.A N LEU 77.A O no hydrogen 2.719 N/A LEU 85.A N VAL 33.A O no hydrogen 2.803 N/A CYS 86.A N ASP 75.A O no hydrogen 3.037 N/A VAL 87.A N VAL 35.A O no hydrogen 2.881 N/A ALA 89.A N ASP 37.A O no hydrogen 3.101 N/A GLN 90.A NE2 ASP 95.A O no hydrogen 3.571 N/A ALA 94.A N ASN 92.A OD1 no hydrogen 2.926 N/A ASP 95.A N ASN 92.A O no hydrogen 3.122 N/A LEU 96.A N PRO 93.A O no hydrogen 3.028 N/A TRP 98.A N LEU 96.A O no hydrogen 2.728 N/A TRP 98.A NE1 HIS 122.A ND1 no hydrogen 2.644 N/A GLY 99.A N GLY 125.A O no hydrogen 2.752 N/A LEU 101.A N PRO 97.A O no hydrogen 2.986 N/A GLY 102.A N TRP 98.A O no hydrogen 3.197 N/A VAL 103.A N TRP 98.A O no hydrogen 3.125 N/A GLU 104.A N LYS 3.A O no hydrogen 3.364 N/A TYR 105.A N LYS 3.A O no hydrogen 3.198 N/A TYR 105.A OH ASP 353.A OD2 no hydrogen 2.583 N/A VAL 106.A N LYS 129.A O no hydrogen 3.041 N/A ILE 107.A N GLY 5.A O no hydrogen 2.909 N/A GLU 108.A N VAL 131.A O no hydrogen 3.133 N/A SER 109.A N ASN 7.A O no hydrogen 2.653 N/A THR 110.A OG1 GLU 108.A OE1 no hydrogen 2.891 N/A LEU 112.A N THR 110.A OG1 no hydrogen 3.154 N/A LYS 116.A N SER 137.A O no hydrogen 2.829 N/A ALA 119.A N VAL 115.A O no hydrogen 3.279 N/A GLU 120.A N SER 117.A O no hydrogen 3.205 N/A GLY 121.A N ALA 118.A O no hydrogen 3.174 N/A HIS 122.A N ALA 119.A O no hydrogen 3.214 N/A HIS 122.A NE2 GLU 108.A OE2 no hydrogen 2.620 N/A ARG 124.A N GLU 120.A O no hydrogen 3.475 N/A GLY 125.A N HIS 122.A O no hydrogen 3.019 N/A GLY 126.A N LEU 123.A O no hydrogen 3.031 N/A ALA 127.A N HIS 122.A O no hydrogen 2.822 N/A ARG 128.A N GLU 104.A O no hydrogen 2.979 N/A ARG 128.A NH2 GLU 104.A OE1 no hydrogen 3.521 N/A LYS 129.A N GLU 104.A O no hydrogen 2.758 N/A LYS 129.A NZ TYR 152.A OH no hydrogen 3.260 N/A LYS 129.A NZ PRO 154.A O no hydrogen 2.941 N/A LYS 129.A NZ GLN 157.A O no hydrogen 2.565 N/A VAL 130.A N HIS 158.A O no hydrogen 2.901 N/A VAL 131.A N VAL 106.A O no hydrogen 3.344 N/A ILE 132.A N VAL 160.A O no hydrogen 2.812 N/A SER 133.A N GLU 108.A O no hydrogen 3.292 N/A SER 133.A OG GLU 108.A O no hydrogen 2.560 N/A ALA 134.A N ILE 132.A O no hydrogen 2.608 N/A SER 137.A N THR 114.A O no hydrogen 3.427 N/A PHE 143.A N SER 161.A O no hydrogen 2.901 N/A VAL 144.A N ASN 148.A OD1 no hydrogen 2.801 N/A VAL 147.A N VAL 144.A O no hydrogen 2.724 N/A ASN 148.A N VAL 144.A O no hydrogen 3.213 N/A ASN 148.A ND2 THR 142.A O no hydrogen 3.592 N/A ASN 151.A N ASN 148.A O no hydrogen 3.190 N/A TYR 152.A OH ASP 353.A OD1 no hydrogen 2.666 N/A ARG 155.A N ASN 153.A OD1 no hydrogen 3.183 N/A GLU 156.A N ASN 153.A O no hydrogen 2.748 N/A GLN 157.A N ASN 153.A O no hydrogen 2.967 N/A GLN 157.A NE2 ASN 151.A O no hydrogen 3.157 N/A HIS 158.A ND1 GLU 156.A O no hydrogen 3.153 N/A VAL 160.A N VAL 130.A O no hydrogen 2.780 N/A SER 161.A N LYS 141.A O no hydrogen 2.765 N/A SER 161.A OG ALA 134.A O no hydrogen 2.540 N/A ASN 162.A N ILE 132.A O no hydrogen 3.240 N/A ALA 163.A N SER 161.A OG no hydrogen 2.992 N/A SER 164.A OG THR 167.A OG1 no hydrogen 2.853 N/A THR 166.A OG1 TYR 332.A OH no hydrogen 2.753 N/A THR 167.A N SER 164.A OG no hydrogen 2.885 N/A THR 167.A OG1 SER 164.A OG no hydrogen 2.853 N/A THR 167.A OG1 ALA 227.A O no hydrogen 3.312 N/A ASN 168.A N SER 164.A O no hydrogen 3.201 N/A ASN 168.A ND2 ASN 162.A O no hydrogen 3.091 N/A ASN 168.A ND2 SER 164.A O no hydrogen 2.416 N/A CYS 169.A N CYS 165.A O no hydrogen 3.203 N/A CYS 169.A SG SER 307.A OG no hydrogen 3.596 N/A CYS 169.A SG SER 330.A O no hydrogen 4.043 N/A CYS 169.A SG TRP 331.A O no hydrogen 3.881 N/A LEU 170.A N THR 166.A O no hydrogen 2.889 N/A ALA 171.A N THR 167.A O no hydrogen 2.993 N/A LEU 173.A N LEU 170.A O no hydrogen 3.058 N/A VAL 174.A N LEU 170.A O no hydrogen 3.293 N/A HIS 175.A N ALA 171.A O no hydrogen 2.948 N/A LEU 177.A N LEU 173.A O no hydrogen 3.288 N/A VAL 178.A N VAL 174.A O no hydrogen 2.964 N/A VAL 178.A N HIS 175.A O no hydrogen 3.187 N/A LYS 179.A N HIS 175.A O no hydrogen 2.906 N/A GLU 180.A N VAL 176.A O no hydrogen 3.205 N/A GLY 181.A N VAL 178.A O no hydrogen 3.189 N/A PHE 182.A N LEU 177.A O no hydrogen 2.880 N/A GLY 183.A N LEU 177.A O no hydrogen 2.908 N/A SER 185.A N ILE 262.A O no hydrogen 3.095 N/A GLY 187.A N LYS 241.A O no hydrogen 2.687 N/A LEU 188.A N THR 260.A O no hydrogen 2.842 N/A MET 189.A N THR 243.A O no hydrogen 2.949 N/A THR 190.A N ASP 258.A O no hydrogen 2.996 N/A THR 191.A N MET 245.A O no hydrogen 3.025 N/A THR 191.A OG1 VAL 256.A O no hydrogen 3.096 N/A THR 191.A OG1 TYR 332.A OH no hydrogen 2.950 N/A VAL 192.A N VAL 256.A O no hydrogen 3.236 N/A HIS 193.A N PHE 247.A O no hydrogen 2.768 N/A HIS 193.A ND1 SER 194.A O no hydrogen 2.588 N/A SER 194.A N SER 255.A OG no hydrogen 3.242 N/A SER 194.A OG THR 251.A O no hydrogen 2.831 N/A SER 194.A OG THR 251.A OG1 no hydrogen 2.953 N/A SER 194.A OG VAL 254.A O no hydrogen 2.605 N/A TYR 195.A N THR 251.A O no hydrogen 2.990 N/A THR 196.A OG1 THR 198.A OG1 no hydrogen 3.304 N/A THR 198.A OG1 THR 196.A OG1 no hydrogen 3.304 N/A GLN 199.A N THR 196.A O no hydrogen 3.296 N/A LYS 200.A NZ VAL 205.A O no hydrogen 2.737 N/A GLY 204.A N GLY 213.A O no hydrogen 2.564 N/A SER 206.A OG ASP 209.A O no hydrogen 2.834 N/A GLY 212.A N ASP 209.A O no hydrogen 3.201 N/A GLY 213.A N TRP 210.A O no hydrogen 3.325 N/A ARG 214.A NE ASP 203.A OD1 no hydrogen 3.088 N/A ALA 215.A N ASP 203.A OD1 no hydrogen 3.001 N/A ALA 216.A N LYS 200.A O no hydrogen 3.005 N/A LEU 218.A N ALA 215.A O no hydrogen 3.200 N/A ASN 219.A ND2 ALA 215.A O no hydrogen 2.795 N/A ILE 221.A N ARG 248.A O no hydrogen 3.045 N/A SER 223.A N ALA 246.A O no hydrogen 2.595 N/A ALA 230.A N GLY 226.A O no hydrogen 3.107 N/A ALA 230.A N ALA 227.A O no hydrogen 3.245 N/A VAL 231.A N ALA 227.A O no hydrogen 3.295 N/A VAL 231.A N ALA 228.A O no hydrogen 2.677 N/A GLY 232.A N LYS 229.A O no hydrogen 3.188 N/A VAL 234.A N ALA 230.A O no hydrogen 3.230 N/A ILE 235.A N VAL 231.A O no hydrogen 2.613 N/A THR 238.A N ILE 235.A O no hydrogen 2.924 N/A THR 238.A OG1 ILE 235.A O no hydrogen 2.964 N/A GLN 239.A N PRO 236.A O no hydrogen 3.452 N/A GLN 239.A NE2 PRO 236.A O no hydrogen 3.238 N/A LYS 241.A N THR 238.A O no hydrogen 3.250 N/A LYS 241.A NZ ILE 184.A O no hydrogen 3.244 N/A THR 243.A N GLY 187.A O no hydrogen 3.382 N/A MET 245.A N MET 189.A O no hydrogen 3.064 N/A ALA 246.A N SER 223.A O no hydrogen 2.790 N/A PHE 247.A N THR 191.A O no hydrogen 3.002 N/A ARG 248.A N ILE 221.A O no hydrogen 3.130 N/A ARG 248.A NH1 THR 196.A OG1 no hydrogen 2.826 N/A VAL 249.A N HIS 193.A O no hydrogen 2.946 N/A THR 251.A N VAL 249.A O no hydrogen 2.783 N/A THR 251.A OG1 SER 194.A OG no hydrogen 2.953 N/A SER 255.A N TYR 332.A O no hydrogen 2.839 N/A SER 255.A OG ASN 334.A OD1 no hydrogen 2.652 N/A VAL 256.A N VAL 192.A O no hydrogen 3.229 N/A VAL 257.A N SER 330.A O no hydrogen 2.753 N/A ASP 258.A N THR 190.A O no hydrogen 2.929 N/A LEU 259.A N ILE 328.A O no hydrogen 3.042 N/A THR 260.A N LEU 188.A O no hydrogen 2.880 N/A PHE 261.A N PHE 326.A O no hydrogen 2.977 N/A ILE 262.A N THR 186.A O no hydrogen 3.050 N/A ALA 263.A N ARG 324.A O no hydrogen 2.925 N/A THR 264.A N PHE 182.A O no hydrogen 2.918 N/A THR 267.A N ARG 323.A O no hydrogen 2.898 N/A THR 267.A OG1 ARG 265.A O no hydrogen 3.433 N/A GLU 271.A N SER 268.A O no hydrogen 3.031 N/A ILE 272.A N SER 268.A O no hydrogen 3.388 N/A ASP 273.A N ILE 269.A O no hydrogen 2.802 N/A ALA 274.A N LYS 270.A O no hydrogen 3.285 N/A ALA 275.A N GLU 271.A O no hydrogen 3.031 N/A LEU 276.A N ILE 272.A O no hydrogen 3.011 N/A LYS 277.A N ASP 273.A O no hydrogen 3.234 N/A LYS 277.A NZ ASP 273.A OD2 no hydrogen 3.401 N/A ARG 278.A N ALA 274.A O no hydrogen 3.189 N/A ALA 279.A N ALA 275.A O no hydrogen 3.014 N/A SER 280.A N LEU 276.A O no hydrogen 3.099 N/A SER 280.A OG LEU 276.A O no hydrogen 3.246 N/A LYS 281.A N ARG 278.A O no hydrogen 3.062 N/A THR 282.A N ALA 279.A O no hydrogen 3.281 N/A THR 282.A OG1 ARG 278.A O no hydrogen 2.674 N/A TYR 283.A OH GLU 180.A OE2 no hydrogen 2.351 N/A MET 284.A N ALA 279.A O no hydrogen 3.094 N/A LYS 285.A N THR 282.A O no hydrogen 3.191 N/A ILE 287.A N MET 284.A O no hydrogen 3.165 N/A LEU 288.A N MET 284.A O no hydrogen 3.028 N/A GLY 289.A N SER 307.A O no hydrogen 2.821 N/A THR 291.A N TYR 309.A O no hydrogen 2.935 N/A GLU 293.A N THR 291.A OG1 no hydrogen 3.351 N/A VAL 296.A N ASP 299.A OD2 no hydrogen 2.985 N/A ASP 299.A N VAL 296.A O no hydrogen 2.698 N/A PHE 300.A N SER 297.A O no hydrogen 3.186 N/A ILE 301.A N ALA 298.A O no hydrogen 3.493 N/A SER 302.A N ASP 333.A OD2 no hydrogen 2.627 N/A SER 302.A OG HIS 55.A ND1 no hydrogen 2.843 N/A ASP 303.A N PHE 300.A O no hydrogen 2.809 N/A ARG 305.A N ASP 303.A OD1 no hydrogen 2.903 N/A ARG 305.A NE ASP 303.A OD1 no hydrogen 2.662 N/A ARG 305.A NE ASP 303.A OD2 no hydrogen 3.204 N/A ARG 305.A NH2 ASP 303.A OD2 no hydrogen 3.291 N/A SER 306.A N ILE 287.A O no hydrogen 3.107 N/A SER 307.A OG CYS 169.A O no hydrogen 3.096 N/A SER 307.A OG SER 330.A OG no hydrogen 2.876 N/A ILE 308.A N TRP 331.A O no hydrogen 2.947 N/A TYR 309.A N GLY 289.A O no hydrogen 2.873 N/A TYR 309.A OH ASP 273.A OD1 no hydrogen 2.867 N/A ASP 310.A N VAL 329.A O no hydrogen 2.941 N/A SER 311.A N THR 291.A O no hydrogen 2.979 N/A SER 311.A OG ASP 273.A OD1 no hydrogen 3.017 N/A LYS 312.A NZ ASP 292.A O no hydrogen 2.564 N/A ALA 313.A N ASP 310.A OD1 no hydrogen 3.139 N/A THR 314.A OG1 ASP 310.A O no hydrogen 3.122 N/A LEU 315.A N SER 311.A O no hydrogen 2.979 N/A GLN 316.A N LYS 312.A O no hydrogen 2.841 N/A ASN 317.A N THR 314.A O no hydrogen 2.810 N/A ASN 317.A ND2 ALA 313.A O no hydrogen 2.917 N/A ASN 318.A ND2 THR 314.A O no hydrogen 2.580 N/A ASN 318.A ND2 LYS 327.A O no hydrogen 3.602 N/A ARG 324.A N GLU 322.A OE2 no hydrogen 3.133 N/A ARG 324.A NE ASP 266.A OD1 no hydrogen 2.464 N/A PHE 325.A N GLU 322.A OE2 no hydrogen 2.843 N/A PHE 326.A N PHE 261.A O no hydrogen 3.236 N/A LYS 327.A N ASN 318.A OD1 no hydrogen 2.866 N/A ILE 328.A N LEU 259.A O no hydrogen 2.776 N/A VAL 329.A N THR 314.A OG1 no hydrogen 3.205 N/A SER 330.A N VAL 257.A O no hydrogen 3.338 N/A SER 330.A OG SER 307.A OG no hydrogen 2.876 N/A TRP 331.A N ILE 308.A O no hydrogen 2.812 N/A TRP 331.A NE1 ASP 310.A OD2 no hydrogen 3.030 N/A TYR 332.A N SER 255.A O no hydrogen 2.932 N/A TYR 332.A OH THR 166.A OG1 no hydrogen 2.753 N/A TYR 332.A OH THR 191.A OG1 no hydrogen 2.950 N/A GLU 335.A N ASP 333.A OD1 no hydrogen 3.129 N/A TRP 336.A N ASP 333.A OD1 no hydrogen 3.077 N/A TYR 338.A OH ALA 163.A O no hydrogen 2.944 N/A SER 339.A N GLU 335.A O no hydrogen 3.195 N/A SER 339.A OG GLU 335.A O no hydrogen 2.792 N/A HIS 340.A N TRP 336.A O no hydrogen 3.139 N/A ARG 341.A N GLY 337.A O no hydrogen 2.987 N/A ARG 341.A NE ASP 344.A OD2 no hydrogen 2.885 N/A ARG 341.A NH1 SER 304.A O no hydrogen 3.303 N/A ARG 341.A NH1 SER 306.A OG no hydrogen 2.728 N/A ARG 341.A NH2 SER 304.A O no hydrogen 3.183 N/A ARG 341.A NH2 ASP 344.A OD2 no hydrogen 3.380 N/A VAL 342.A N TYR 338.A O no hydrogen 3.081 N/A VAL 343.A N SER 339.A O no hydrogen 3.448 N/A ASP 344.A N HIS 340.A O no hydrogen 2.866 N/A LEU 345.A N ARG 341.A O no hydrogen 2.972 N/A VAL 346.A N VAL 342.A O no hydrogen 3.186 N/A ARG 347.A N VAL 343.A O no hydrogen 3.132 N/A HIS 348.A N ASP 344.A O no hydrogen 3.181 N/A MET 349.A N LEU 345.A O no hydrogen 2.879 N/A ALA 350.A N VAL 346.A O no hydrogen 3.190 N/A ALA 351.A N ARG 347.A O no hydrogen 3.011 N/A ARG 352.A N MET 349.A O no hydrogen 2.787 N/A ARG 352.A NH1 TYR 152.A O no hydrogen 2.672 N/A ASP 353.A N MET 349.A O no hydrogen 2.952 N/A ARG 354.A NH1 ARG 352.A O no hydrogen 3.471 N/A ALA 355.A N ALA 350.A O no hydrogen 2.919 N/A