Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 2x2e_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): VAL 7.A N LEU 3.A O no hydrogen 2.813 N/A ASN 8.A N ILE 4.A O no hydrogen 2.801 N/A ARG 9.A N PRO 5.A O no hydrogen 2.971 N/A LEU 10.A N LEU 6.A O no hydrogen 3.094 N/A GLN 11.A N VAL 7.A O no hydrogen 2.817 N/A ASP 12.A N ASN 8.A O no hydrogen 2.980 N/A ALA 13.A N ARG 9.A O no hydrogen 3.047 N/A PHE 14.A N LEU 10.A O no hydrogen 3.254 N/A SER 15.A N GLN 11.A O no hydrogen 2.742 N/A SER 15.A OG GLN 11.A O no hydrogen 2.932 N/A SER 15.A OG ASN 20.A OD1 no hydrogen 2.859 N/A SER 15.A OG ASN 115.A OD1 no hydrogen 3.500 N/A ALA 16.A N ASP 12.A O no hydrogen 2.920 N/A ILE 17.A N PHE 14.A O no hydrogen 3.117 N/A GLY 18.A N SER 15.A O no hydrogen 3.065 N/A GLN 19.A N PHE 14.A O no hydrogen 2.998 N/A GLN 19.A NE2 ASP 22.A OD1 no hydrogen 3.051 N/A ASP 22.A N GLN 19.A O no hydrogen 3.062 N/A LEU 23.A N ASN 20.A O no hydrogen 2.999 N/A GLN 27.A N ASN 159.A O no hydrogen 3.267 N/A ILE 28.A N THR 127.A O no hydrogen 2.883 N/A ALA 29.A N LEU 161.A O no hydrogen 2.845 N/A VAL 30.A N VAL 129.A O no hydrogen 3.113 N/A VAL 31.A N LEU 163.A O no hydrogen 2.990 N/A SER 35.A OG GLY 54.A O no hydrogen 3.436 N/A ALA 36.A N GLY 33.A O no hydrogen 3.236 N/A LYS 38.A NZ GLY 33.A O no hydrogen 2.950 N/A SER 39.A OG THR 59.A OG1 no hydrogen 2.856 N/A SER 39.A OG ASP 130.A OD1 no hydrogen 3.313 N/A SER 39.A OG ASP 130.A OD2 no hydrogen 2.619 N/A VAL 41.A N GLY 37.A O no hydrogen 3.037 N/A LEU 42.A N LYS 38.A O no hydrogen 3.026 N/A GLU 43.A N SER 39.A O no hydrogen 2.858 N/A ASN 44.A N SER 40.A O no hydrogen 3.293 N/A ASN 44.A ND2 ASN 226.A OD1 no hydrogen 3.160 N/A PHE 45.A N LEU 42.A O no hydrogen 2.855 N/A VAL 46.A N GLU 43.A O no hydrogen 2.996 N/A GLY 47.A N GLU 43.A O no hydrogen 3.184 N/A PHE 50.A N GLU 43.A OE2 no hydrogen 2.857 N/A LEU 51.A N GLU 43.A OE2 no hydrogen 3.039 N/A ARG 53.A NE SER 40.A OG no hydrogen 2.929 N/A THR 59.A OG1 SER 39.A OG no hydrogen 2.856 N/A ARG 60.A NH1 GLY 104.A O no hydrogen 2.813 N/A ARG 60.A NH1 GLY 108.A O no hydrogen 2.958 N/A ARG 60.A NH2 GLY 104.A O no hydrogen 2.581 N/A ARG 61.A NE VAL 112.A O no hydrogen 2.804 N/A ARG 61.A NH1 GLU 98.A O no hydrogen 2.852 N/A ARG 61.A NH1 GLU 98.A OE1 no hydrogen 2.970 N/A ARG 61.A NH2 VAL 112.A O no hydrogen 2.961 N/A LEU 63.A N ASP 130.A O no hydrogen 2.846 N/A VAL 64.A N ILE 114.A O no hydrogen 2.817 N/A LEU 65.A N LEU 128.A O no hydrogen 2.732 N/A GLN 66.A N LEU 116.A O no hydrogen 2.796 N/A GLN 66.A NE2 ASN 8.A O no hydrogen 3.478 N/A GLN 66.A NE2 GLN 11.A OE1 no hydrogen 2.898 N/A GLN 66.A NE2 ASP 12.A OD2 no hydrogen 3.196 N/A LEU 67.A N LEU 126.A O no hydrogen 2.814 N/A VAL 68.A N VAL 118.A O no hydrogen 2.980 N/A ALA 70.A N SER 120.A O no hydrogen 3.056 N/A TYR 74.A N TYR 119.A O no hydrogen 3.136 N/A ALA 75.A N PHE 85.A O no hydrogen 2.823 N/A GLU 76.A N ARG 117.A O no hydrogen 2.935 N/A LEU 78.A N ASN 115.A O no hydrogen 3.069 N/A HIS 79.A NE2 GLU 94.A OE2 no hydrogen 2.775 N/A CYS 80.A N PHE 77.A O no hydrogen 3.048 N/A CYS 80.A SG HIS 79.A NE2 no hydrogen 3.239 N/A LYS 83.A N CYS 80.A O no hydrogen 3.178 N/A LYS 84.A NZ TYR 74.A OH no hydrogen 3.259 N/A LYS 84.A NZ GLU 76.A OE2 no hydrogen 2.798 N/A PHE 85.A N ALA 75.A O no hydrogen 2.897 N/A GLU 89.A N ASP 87.A OD2 no hydrogen 2.876 N/A GLU 90.A N ASP 87.A O no hydrogen 2.958 N/A VAL 91.A N ASP 87.A O no hydrogen 3.214 N/A ARG 92.A N PHE 88.A O no hydrogen 2.956 N/A ARG 92.A NE GLU 89.A OE1 no hydrogen 2.868 N/A ARG 92.A NH2 GLU 89.A OE2 no hydrogen 2.921 N/A LEU 93.A N GLU 89.A O no hydrogen 2.964 N/A GLU 94.A N GLU 90.A O no hydrogen 2.976 N/A ILE 95.A N VAL 91.A O no hydrogen 3.038 N/A GLU 96.A N ARG 92.A O no hydrogen 3.032 N/A ALA 97.A N LEU 93.A O no hydrogen 2.807 N/A GLU 98.A N GLU 94.A O no hydrogen 2.777 N/A THR 99.A N ILE 95.A O no hydrogen 2.864 N/A THR 99.A OG1 ILE 95.A O no hydrogen 2.817 N/A ASP 100.A N GLU 96.A O no hydrogen 2.865 N/A ARG 101.A N ALA 97.A O no hydrogen 2.792 N/A ARG 101.A NE GLU 98.A OE1 no hydrogen 3.407 N/A ARG 101.A NE GLU 98.A OE2 no hydrogen 2.916 N/A ARG 101.A NH2 GLU 98.A OE1 no hydrogen 2.891 N/A VAL 102.A N THR 99.A O no hydrogen 3.164 N/A THR 103.A N THR 99.A O no hydrogen 2.826 N/A THR 103.A OG1 THR 99.A O no hydrogen 2.822 N/A THR 103.A OG1 GLY 104.A O no hydrogen 3.211 N/A GLY 104.A N ASP 100.A O no hydrogen 2.744 N/A ASN 106.A ND2 ASP 140.A OD1 no hydrogen 3.346 N/A SER 110.A N ARG 60.A O no hydrogen 3.057 N/A VAL 112.A N SER 110.A OG no hydrogen 3.120 N/A ILE 114.A N PRO 62.A O no hydrogen 2.926 N/A LEU 116.A N VAL 64.A O no hydrogen 2.895 N/A ARG 117.A N GLU 76.A O no hydrogen 2.950 N/A ARG 117.A NE TYR 119.A OH no hydrogen 3.036 N/A ARG 117.A NH1 ASP 12.A OD1 no hydrogen 2.800 N/A ARG 117.A NH1 GLN 66.A OE1 no hydrogen 2.587 N/A ARG 117.A NH2 ASP 12.A OD1 no hydrogen 3.489 N/A ARG 117.A NH2 GLU 76.A OE1 no hydrogen 3.145 N/A VAL 118.A N GLN 66.A O no hydrogen 2.908 N/A TYR 119.A N TYR 74.A O no hydrogen 2.834 N/A SER 120.A N VAL 68.A O no hydrogen 2.999 N/A SER 120.A OG GLU 73.A OE2 no hydrogen 2.692 N/A HIS 122.A N SER 120.A OG no hydrogen 3.042 N/A VAL 123.A N SER 120.A O no hydrogen 3.462 N/A LEU 126.A N LEU 67.A O no hydrogen 3.197 N/A LEU 128.A N LEU 65.A O no hydrogen 2.841 N/A VAL 129.A N ILE 28.A O no hydrogen 2.754 N/A ASP 130.A N LEU 63.A O no hydrogen 2.851 N/A LYS 135.A NZ GLU 146.A OE2 no hydrogen 2.907 N/A VAL 138.A N GLN 141.A OE1 no hydrogen 2.927 N/A ASP 140.A N ASN 106.A O no hydrogen 3.295 N/A GLN 141.A N VAL 138.A O no hydrogen 2.998 N/A GLN 141.A NE2 LYS 107.A O no hydrogen 3.016 N/A ILE 145.A N PRO 142.A O no hydrogen 2.957 N/A GLN 148.A N ASP 144.A O no hydrogen 2.992 N/A ILE 149.A N ILE 145.A O no hydrogen 2.973 N/A ARG 150.A N GLU 146.A O no hydrogen 3.047 N/A ARG 150.A NH2 GLU 183.A OE1 no hydrogen 2.957 N/A ASP 151.A N PHE 147.A O no hydrogen 2.816 N/A GLN 153.A NE2 ASP 151.A O no hydrogen 3.014 N/A PHE 154.A N LEU 152.A O no hydrogen 2.963 N/A VAL 155.A N LEU 152.A O no hydrogen 2.962 N/A LYS 157.A N PHE 154.A O no hydrogen 3.351 N/A LYS 157.A NZ ASN 20.A O no hydrogen 2.846 N/A LYS 157.A NZ LEU 23.A O no hydrogen 2.930 N/A ASN 159.A N ASP 24.A OD1 no hydrogen 2.896 N/A ASN 159.A ND2 ASP 24.A O no hydrogen 2.765 N/A CYS 160.A N LYS 157.A O no hydrogen 3.250 N/A CYS 160.A SG LEU 161.A O no hydrogen 3.492 N/A LEU 161.A N GLN 27.A O no hydrogen 2.725 N/A ILE 162.A N ARG 190.A O no hydrogen 2.804 N/A LEU 163.A N ALA 29.A O no hydrogen 2.848 N/A ALA 164.A N ILE 192.A O no hydrogen 2.817 N/A VAL 165.A N VAL 31.A O no hydrogen 2.965 N/A SER 166.A N VAL 194.A O no hydrogen 2.872 N/A SER 166.A OG SER 175.A OG no hydrogen 2.590 N/A ALA 168.A N THR 196.A O no hydrogen 2.692 N/A SER 170.A N PRO 167.A O no hydrogen 3.364 N/A ASN 174.A N ASP 171.A O no hydrogen 2.892 N/A ASN 174.A ND2 SER 170.A OG no hydrogen 3.179 N/A SER 175.A N LEU 172.A O no hydrogen 2.879 N/A SER 175.A OG SER 166.A OG no hydrogen 2.590 N/A LEU 178.A N SER 175.A OG no hydrogen 2.990 N/A LYS 179.A N SER 175.A O no hydrogen 3.218 N/A VAL 180.A N ASP 176.A O no hydrogen 3.121 N/A ALA 181.A N ALA 177.A O no hydrogen 2.902 N/A LYS 182.A N LEU 178.A O no hydrogen 2.889 N/A GLU 183.A N LYS 179.A O no hydrogen 2.997 N/A VAL 184.A N VAL 180.A O no hydrogen 3.103 N/A ASP 185.A N ALA 181.A O no hydrogen 2.782 N/A GLY 188.A N ASP 185.A O no hydrogen 2.837 N/A ARG 190.A N ASP 185.A OD2 no hydrogen 2.845 N/A ARG 190.A NH1 VAL 155.A O no hydrogen 2.836 N/A ARG 190.A NH1 CYS 160.A O no hydrogen 2.863 N/A ARG 190.A NH2 VAL 155.A O no hydrogen 3.010 N/A THR 191.A OG1 ASP 185.A OD2 no hydrogen 2.730 N/A ILE 192.A N ILE 162.A O no hydrogen 2.835 N/A GLY 193.A N GLY 220.A O no hydrogen 3.233 N/A VAL 194.A N ALA 164.A O no hydrogen 2.899 N/A ILE 195.A N ILE 222.A O no hydrogen 2.972 N/A THR 196.A N SER 166.A O no hydrogen 2.937 N/A THR 196.A OG1 ALA 36.A O no hydrogen 2.654 N/A LYS 197.A NZ SER 35.A O no hydrogen 2.848 N/A LEU 200.A N LYS 197.A O no hydrogen 2.957 N/A THR 204.A N ASP 201.A O no hydrogen 3.142 N/A THR 204.A OG1 ASP 201.A O no hydrogen 2.733 N/A ALA 206.A N TYR 255.A OH no hydrogen 2.805 N/A ARG 207.A N ASP 205.A OD1 no hydrogen 2.803 N/A ARG 207.A NH1 GLU 211.A OE2 no hydrogen 3.277 N/A LEU 210.A N ALA 206.A O no hydrogen 2.987 N/A GLU 211.A N ARG 207.A O no hydrogen 2.972 N/A ASN 212.A N VAL 209.A O no hydrogen 2.872 N/A ASN 212.A ND2 LEU 217.A O no hydrogen 2.987 N/A LYS 213.A N ASP 208.A O no hydrogen 3.054 N/A LYS 213.A NZ GLU 211.A OE1 no hydrogen 2.684 N/A LEU 214.A N ASP 208.A O no hydrogen 3.211 N/A LEU 217.A N ASN 212.A OD1 no hydrogen 2.857 N/A ARG 218.A NE GLN 187.A O no hydrogen 3.219 N/A ARG 219.A NE GLN 189.A O no hydrogen 3.417 N/A ARG 219.A NH2 GLN 189.A O no hydrogen 3.040 N/A GLY 220.A N LEU 217.A O no hydrogen 2.948 N/A TYR 221.A OH LEU 215.A O no hydrogen 2.782 N/A ILE 222.A N GLY 193.A O no hydrogen 2.982 N/A VAL 224.A N ILE 195.A O no hydrogen 2.905 N/A VAL 225.A N GLU 245.A OE2 no hydrogen 3.028 N/A ARG 227.A NH1 ASP 49.A OD1 no hydrogen 2.971 N/A ARG 227.A NH1 ASP 49.A OD2 no hydrogen 3.081 N/A ARG 227.A NH1 LYS 236.A O no hydrogen 2.932 N/A ARG 227.A NH2 ASP 49.A OD1 no hydrogen 2.870 N/A SER 228.A N ASP 231.A OD2 no hydrogen 3.046 N/A GLN 229.A NE2 ASP 233.A OD2 no hydrogen 3.078 N/A ASP 231.A N SER 228.A OG no hydrogen 2.896 N/A ILE 232.A N SER 228.A O no hydrogen 3.047 N/A ASP 233.A N GLN 229.A O no hydrogen 2.828 N/A GLY 234.A N LYS 230.A O no hydrogen 2.865 N/A LYS 235.A N ILE 232.A O no hydrogen 2.890 N/A LYS 236.A N ASP 231.A O no hydrogen 3.063 N/A ALA 240.A N ASP 237.A OD1 no hydrogen 2.933 N/A ALA 241.A N ASP 237.A O no hydrogen 3.064 N/A LEU 242.A N ILE 238.A O no hydrogen 2.891 N/A ALA 243.A N THR 239.A O no hydrogen 3.159 N/A ALA 244.A N ALA 240.A O no hydrogen 2.977 N/A GLU 245.A N ALA 241.A O no hydrogen 2.860 N/A ARG 246.A N LEU 242.A O no hydrogen 2.979 N/A LYS 247.A N ALA 243.A O no hydrogen 3.049 N/A PHE 248.A N ALA 244.A O no hydrogen 2.941 N/A PHE 249.A N GLU 245.A O no hydrogen 3.277 N/A LEU 250.A N ARG 246.A O no hydrogen 3.179 N/A SER 251.A N LYS 247.A O no hydrogen 2.854 N/A SER 251.A OG LYS 247.A O no hydrogen 3.325 N/A HIS 252.A N PHE 248.A O no hydrogen 3.023 N/A SER 254.A N HIS 252.A ND1 no hydrogen 2.977 N/A TYR 255.A N HIS 252.A O no hydrogen 2.972 N/A ARG 256.A N HIS 252.A O no hydrogen 2.952 N/A HIS 257.A NE2 GLU 211.A OE2 no hydrogen 2.818 N/A LEU 258.A N TYR 255.A O no hydrogen 2.727 N/A ALA 259.A N ARG 256.A O no hydrogen 3.201 N/A ARG 261.A N LEU 258.A O no hydrogen 2.866 N/A GLY 262.A N GLY 223.A O no hydrogen 2.826 N/A THR 263.A N GLU 245.A OE1 no hydrogen 2.879 N/A THR 263.A N GLU 245.A OE2 no hydrogen 3.271 N/A THR 263.A OG1 GLU 245.A OE1 no hydrogen 3.445 N/A THR 263.A OG1 GLU 245.A OE2 no hydrogen 2.784 N/A LEU 266.A N GLY 262.A O no hydrogen 2.922 N/A GLN 267.A N THR 263.A O no hydrogen 2.986 N/A LYS 268.A N PRO 264.A O no hydrogen 2.953 N/A VAL 269.A N TYR 265.A O no hydrogen 2.930 N/A LEU 270.A N LEU 266.A O no hydrogen 2.899 N/A ASN 271.A N GLN 267.A O no hydrogen 3.102 N/A GLN 272.A N LYS 268.A O no hydrogen 2.999 N/A GLN 272.A NE2 GLN 272.A O no hydrogen 3.219 N/A GLN 273.A N VAL 269.A O no hydrogen 2.847 N/A LEU 274.A N LEU 270.A O no hydrogen 2.806 N/A THR 275.A N ASN 271.A O no hydrogen 2.930 N/A THR 275.A OG1 ASN 271.A O no hydrogen 2.805 N/A ASN 276.A N GLN 272.A O no hydrogen 2.918 N/A HIS 277.A N GLN 273.A O no hydrogen 2.881 N/A HIS 277.A NE2 GLU 158.A O no hydrogen 3.033 N/A ILE 278.A N LEU 274.A O no hydrogen 2.827 N/A ARG 279.A N THR 275.A O no hydrogen 2.969 N/A ASP 280.A N ASN 276.A O no hydrogen 3.230 N/A THR 281.A N HIS 277.A O no hydrogen 2.950 N/A THR 281.A OG1 ASN 159.A OD1 no hydrogen 3.445 N/A THR 281.A OG1 HIS 277.A O no hydrogen 2.921 N/A THR 281.A OG1 ILE 278.A O no hydrogen 3.468 N/A LEU 282.A N ILE 278.A O no hydrogen 2.884 N/A LEU 285.A N THR 281.A O no hydrogen 2.912 N/A ARG 286.A N LEU 282.A O no hydrogen 2.837 N/A ASN 287.A N PRO 283.A O no hydrogen 3.060 N/A ASN 287.A ND2 GLN 290.A OE1 no hydrogen 3.477 N/A LYS 288.A N GLY 284.A O no hydrogen 2.944 N/A LEU 289.A N LEU 285.A O no hydrogen 2.902 N/A GLN 290.A N ARG 286.A O no hydrogen 2.918 N/A SER 291.A N ASN 287.A O no hydrogen 3.133 N/A GLN 292.A N LYS 288.A O no hydrogen 2.890 N/A LEU 293.A N LEU 289.A O no hydrogen 2.854 N/A LEU 294.A N GLN 290.A O no hydrogen 3.189 N/A SER 295.A N SER 291.A O no hydrogen 2.924 N/A ILE 296.A N GLN 292.A O no hydrogen 2.823 N/A GLU 297.A N LEU 293.A O no hydrogen 2.938 N/A LYS 298.A N LEU 294.A O no hydrogen 3.144 N/A GLU 299.A N SER 295.A O no hydrogen 2.995 N/A VAL 300.A N ILE 296.A O no hydrogen 2.936 N/A GLU 301.A N GLU 297.A O no hydrogen 3.087 N/A GLU 302.A N LYS 298.A O no hydrogen 2.839 N/A TYR 303.A N GLU 299.A O no hydrogen 2.816 N/A TYR 303.A OH ASP 314.A OD2 no hydrogen 2.516 N/A LYS 304.A N VAL 300.A O no hydrogen 3.328 N/A ASN 305.A N GLU 302.A O no hydrogen 3.039 N/A PHE 306.A N GLU 302.A O no hydrogen 3.091 N/A ARG 307.A N TYR 303.A O no hydrogen 2.813 N/A ARG 307.A NH1 PHE 306.A O no hydrogen 2.891 N/A VAL 317.A N ASP 314.A O no hydrogen 3.084 N/A GLU 319.A N SER 315.A O no hydrogen 2.856 N/A ARG 321.A N ASP 318.A O no hydrogen 2.888 N/A HIS 323.A N LEU 320.A O no hydrogen 2.870 N/A ALA 324.A N ARG 321.A O no hydrogen 3.066 N/A LYS 326.A N TYR 322.A O no hydrogen 3.002 N/A GLU 327.A N HIS 323.A O no hydrogen 2.868 N/A ALA 328.A N ALA 324.A O no hydrogen 2.911 N/A LEU 329.A N LEU 325.A O no hydrogen 2.900 N/A SER 330.A N LYS 326.A O no hydrogen 3.034 N/A SER 330.A N GLU 327.A O no hydrogen 3.183 N/A SER 330.A OG LYS 326.A O no hydrogen 2.903 N/A ILE 331.A N GLU 327.A O no hydrogen 3.417 N/A ILE 331.A N ALA 328.A O no hydrogen 3.119 N/A ILE 332.A N ALA 328.A O no hydrogen 3.089 N/A