Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 2x4m_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ASN 7.A N PRO 236.A O no hydrogen 2.891 N/A SER 9.A OG SER 12.A OG no hydrogen 3.116 N/A ASP 11.A N ASP 59.A O no hydrogen 3.102 N/A SER 12.A OG SER 9.A O no hydrogen 2.585 N/A THR 14.A OG1 TYR 289.A O no hydrogen 3.208 N/A VAL 15.A N TYR 289.A O no hydrogen 2.846 N/A ALA 16.A N ASP 55.A O no hydrogen 2.826 N/A ALA 17.A N LEU 287.A O no hydrogen 3.059 N/A SER 18.A N LYS 53.A O no hydrogen 2.851 N/A SER 18.A OG THR 284.A OG1 no hydrogen 3.424 N/A THR 19.A N ALA 285.A O no hydrogen 2.676 N/A THR 19.A OG1 ILE 51.A O no hydrogen 2.735 N/A GLY 20.A N ILE 51.A O no hydrogen 3.100 N/A MET 21.A N VAL 283.A O no hydrogen 2.758 N/A LEU 22.A N VAL 49.A O no hydrogen 2.761 N/A SER 23.A N TYR 281.A O no hydrogen 3.064 N/A SER 23.A OG ILE 46.A O no hydrogen 3.419 N/A GLY 24.A N ILE 46.A O no hydrogen 3.478 N/A LYS 25.A N LYS 279.A O no hydrogen 3.074 N/A SER 26.A N TRP 44.A O no hydrogen 3.233 N/A SER 26.A OG GLN 169.A OE1 no hydrogen 2.728 N/A HIS 27.A N SER 277.A O no hydrogen 3.021 N/A GLU 28.A N LEU 42.A O no hydrogen 3.055 N/A MET 29.A N GLY 275.A O no hydrogen 3.237 N/A LEU 30.A N SER 40.A O no hydrogen 3.137 N/A TYR 31.A N ALA 273.A O no hydrogen 3.122 N/A TYR 31.A OH GLU 251.A OE1 no hydrogen 3.127 N/A TYR 31.A OH GLU 251.A OE2 no hydrogen 2.491 N/A ASP 32.A N ARG 37.A O no hydrogen 2.817 N/A ARG 37.A N THR 35.A OG1 no hydrogen 3.345 N/A LYS 38.A NZ GLN 41.A OE1 no hydrogen 2.957 N/A ILE 39.A N LEU 30.A O no hydrogen 3.023 N/A SER 40.A N LEU 30.A O no hydrogen 3.128 N/A SER 40.A OG TYR 84.A O no hydrogen 3.213 N/A GLN 41.A N TYR 84.A O no hydrogen 2.814 N/A GLN 41.A NE2 ASP 43.A OD2 no hydrogen 2.526 N/A LEU 42.A N GLU 28.A O no hydrogen 3.010 N/A ASP 43.A N ASP 82.A O no hydrogen 2.747 N/A TRP 44.A N SER 26.A O no hydrogen 3.162 N/A TRP 44.A NE1 GLU 28.A OE2 no hydrogen 3.216 N/A ILE 46.A N GLY 24.A O no hydrogen 2.796 N/A LYS 47.A N SER 78.A O no hydrogen 2.998 N/A VAL 49.A N LEU 22.A O no hydrogen 2.978 N/A ILE 51.A N GLY 20.A O no hydrogen 2.804 N/A LEU 52.A N THR 72.A O no hydrogen 3.042 N/A GLY 54.A N GLY 70.A O no hydrogen 2.862 N/A ASP 55.A N ALA 16.A O no hydrogen 2.468 N/A SER 57.A N THR 14.A O no hydrogen 2.766 N/A TRP 58.A NE1 ASP 11.A OD1 no hydrogen 2.776 N/A ASP 59.A N SER 12.A O no hydrogen 3.023 N/A LEU 64.A N TYR 61.A O no hydrogen 3.304 N/A THR 65.A N LYS 116.A O no hydrogen 3.126 N/A LEU 66.A N TRP 58.A O no hydrogen 2.754 N/A ASN 67.A ND2 LEU 66.A O no hydrogen 3.112 N/A ALA 68.A N ILE 56.A O no hydrogen 3.002 N/A ARG 69.A N ASP 112.A O no hydrogen 3.019 N/A ARG 69.A NH2 GLU 243.A OE1 no hydrogen 3.356 N/A TRP 71.A N GLU 110.A O no hydrogen 2.919 N/A THR 72.A N LEU 52.A O no hydrogen 3.104 N/A THR 72.A OG1 SER 73.A O no hydrogen 3.164 N/A SER 73.A N ALA 108.A O no hydrogen 2.542 N/A LEU 74.A N ALA 50.A O no hydrogen 2.925 N/A SER 76.A OG ASN 104.A OD1 no hydrogen 3.288 N/A GLY 77.A N VAL 105.A O no hydrogen 2.904 N/A GLY 79.A N THR 103.A O no hydrogen 2.867 N/A MET 81.A N ASN 80.A OD1 no hydrogen 2.466 N/A ASP 82.A N ASP 43.A O no hydrogen 3.134 N/A ASP 83.A N SER 98.A O no hydrogen 2.796 N/A TYR 84.A N GLN 41.A O no hydrogen 2.778 N/A ALA 85.A N ASP 96.A O no hydrogen 2.953 N/A TRP 86.A N ILE 39.A O no hydrogen 3.096 N/A MET 87.A N THR 95.A OG1 no hydrogen 3.025 N/A GLN 91.A NE2 ASN 151.A OD1 no hydrogen 3.589 N/A THR 95.A N ALA 85.A O no hydrogen 2.837 N/A THR 95.A OG1 ALA 85.A O no hydrogen 3.087 N/A THR 95.A OG1 ASP 96.A OD1 no hydrogen 2.984 N/A ASP 96.A N ALA 85.A O no hydrogen 2.927 N/A HIS 97.A N SER 148.A O no hydrogen 3.070 N/A HIS 97.A NE2 ASP 82.A OD1 no hydrogen 3.272 N/A SER 98.A N ASP 83.A O no hydrogen 2.915 N/A SER 98.A OG HIS 100.A NE2 no hydrogen 3.383 N/A SER 99.A N SER 146.A O no hydrogen 3.048 N/A SER 99.A OG ASP 82.A OD1 no hydrogen 3.088 N/A HIS 100.A N MET 81.A O no hydrogen 2.778 N/A HIS 100.A ND1 GLY 144.A O no hydrogen 2.898 N/A THR 103.A OG1 HIS 100.A O no hydrogen 2.559 N/A ASN 104.A N THR 141.A O no hydrogen 2.728 N/A VAL 105.A N GLY 77.A O no hydrogen 2.808 N/A ASN 109.A N ARG 137.A O no hydrogen 3.161 N/A GLU 110.A N TRP 71.A O no hydrogen 2.928 N/A TYR 111.A N GLU 135.A O no hydrogen 3.205 N/A ASP 112.A N ARG 69.A O no hydrogen 2.869 N/A LEU 113.A N TYR 133.A O no hydrogen 2.907 N/A ASN 114.A N ASN 67.A O no hydrogen 2.948 N/A ASN 114.A ND2 TYR 175.A OH no hydrogen 3.114 N/A VAL 115.A N ALA 131.A O no hydrogen 2.806 N/A LYS 116.A N THR 65.A O no hydrogen 2.879 N/A GLY 117.A N ILE 129.A O no hydrogen 2.696 N/A TRP 118.A N PHE 63.A O no hydrogen 2.985 N/A LEU 119.A N ALA 127.A O no hydrogen 2.871 N/A LEU 120.A N ALA 127.A O no hydrogen 3.095 N/A ASP 122.A N TYR 125.A O no hydrogen 3.139 N/A LYS 126.A N GLN 181.A O no hydrogen 2.826 N/A LYS 126.A NZ GLN 181.A OE1 no hydrogen 2.805 N/A ALA 127.A N LEU 120.A O no hydrogen 2.890 N/A GLY 128.A N ALA 179.A O no hydrogen 2.916 N/A ILE 129.A N GLY 117.A O no hydrogen 2.742 N/A THR 130.A N GLY 177.A O no hydrogen 2.725 N/A ALA 131.A N VAL 115.A O no hydrogen 3.083 N/A GLY 132.A N TYR 175.A O no hydrogen 3.017 N/A TYR 133.A N LEU 113.A O no hydrogen 2.777 N/A GLN 134.A N MET 173.A O no hydrogen 2.870 N/A GLU 135.A N TYR 111.A O no hydrogen 3.273 N/A THR 136.A N PHE 171.A O no hydrogen 3.052 N/A THR 136.A OG1 TYR 249.A OH no hydrogen 3.323 N/A ARG 137.A N ASN 109.A O no hydrogen 2.928 N/A PHE 138.A N GLN 169.A O no hydrogen 3.103 N/A SER 139.A N HIS 107.A O no hydrogen 3.037 N/A SER 139.A OG ASN 106.A OD1 no hydrogen 3.274 N/A TRP 140.A N TYR 167.A O no hydrogen 2.839 N/A TRP 140.A NE1 LYS 45.A O no hydrogen 3.022 N/A THR 141.A N ASN 104.A O no hydrogen 2.761 N/A THR 141.A OG1 ASN 106.A OD1 no hydrogen 2.942 N/A ALA 142.A N ILE 165.A O no hydrogen 3.018 N/A THR 143.A OG1 ALA 102.A O no hydrogen 2.729 N/A GLY 144.A N VAL 162.A O no hydrogen 3.348 N/A SER 146.A N SER 99.A O no hydrogen 2.841 N/A TYR 147.A N GLY 156.A O no hydrogen 2.916 N/A TYR 147.A OH THR 155.A O no hydrogen 3.352 N/A SER 148.A N HIS 97.A O no hydrogen 3.029 N/A TYR 149.A N TYR 154.A O no hydrogen 3.446 N/A ASN 150.A N ASP 96.A OD1 no hydrogen 3.268 N/A ASN 151.A N THR 95.A O no hydrogen 3.047 N/A GLY 152.A N TYR 149.A O no hydrogen 2.920 N/A ALA 153.A N TYR 149.A O no hydrogen 3.066 N/A ALA 153.A N ASN 150.A O no hydrogen 3.235 N/A TYR 154.A N TYR 149.A O no hydrogen 3.413 N/A GLY 156.A N TYR 147.A O no hydrogen 3.083 N/A PHE 158.A N GLY 145.A O no hydrogen 2.831 N/A VAL 162.A N PRO 159.A O no hydrogen 3.026 N/A VAL 164.A N ALA 142.A O no hydrogen 3.045 N/A GLY 166.A N GLU 206.A O no hydrogen 2.748 N/A TYR 167.A N TRP 140.A O no hydrogen 3.228 N/A TYR 167.A OH ASP 203.A OD2 no hydrogen 2.755 N/A ASN 168.A N ASN 204.A O no hydrogen 2.990 N/A GLN 169.A N PHE 138.A O no hydrogen 2.977 N/A GLN 169.A NE2 TYR 167.A OH no hydrogen 2.881 N/A GLN 169.A NE2 SER 277.A O no hydrogen 3.347 N/A ARG 170.A N HIS 202.A O no hydrogen 2.881 N/A PHE 171.A N THR 136.A O no hydrogen 2.893 N/A SER 172.A N ARG 200.A O no hydrogen 2.844 N/A SER 172.A OG GLU 135.A OE2 no hydrogen 3.455 N/A MET 173.A N GLN 134.A O no hydrogen 2.938 N/A TYR 175.A N GLY 132.A O no hydrogen 2.767 N/A TYR 175.A OH ASP 112.A OD1 no hydrogen 3.238 N/A TYR 175.A OH ASP 112.A OD2 no hydrogen 2.812 N/A ILE 176.A N PHE 195.A O no hydrogen 3.130 N/A GLY 177.A N THR 130.A O no hydrogen 2.744 N/A LEU 178.A N PHE 193.A O no hydrogen 2.941 N/A ALA 179.A N GLY 128.A O no hydrogen 2.693 N/A GLY 180.A N ALA 191.A O no hydrogen 2.981 N/A GLN 181.A N LYS 126.A O no hydrogen 2.721 N/A TYR 182.A N LEU 189.A O no hydrogen 2.954 N/A ARG 183.A N ASN 124.A O no hydrogen 2.584 N/A ARG 183.A NE GLU 188.A OE2 no hydrogen 2.643 N/A ARG 183.A NH2 GLU 188.A OE2 no hydrogen 2.622 N/A ILE 184.A N PHE 187.A O no hydrogen 3.061 N/A PHE 187.A N ILE 184.A O no hydrogen 3.225 N/A GLU 188.A N GLY 231.A O no hydrogen 3.125 N/A LEU 189.A N TYR 182.A O no hydrogen 2.706 N/A ASN 190.A N ASN 229.A O no hydrogen 2.873 N/A ASN 190.A ND2 GLU 188.A OE1 no hydrogen 2.712 N/A ALA 191.A N GLY 180.A O no hydrogen 3.276 N/A PHE 193.A N LEU 178.A O no hydrogen 2.934 N/A LYS 194.A N GLY 225.A O no hydrogen 2.867 N/A LYS 194.A NZ GLN 134.A OE1 no hydrogen 2.763 N/A PHE 195.A N ILE 176.A O no hydrogen 3.027 N/A SER 196.A N TYR 223.A O no hydrogen 3.066 N/A SER 196.A OG PRO 174.A O no hydrogen 2.781 N/A TRP 198.A N SER 196.A OG no hydrogen 3.081 N/A VAL 199.A N SER 221.A O no hydrogen 2.910 N/A ARG 200.A N SER 172.A O no hydrogen 2.758 N/A ALA 201.A N THR 218.A O no hydrogen 2.681 N/A HIS 202.A N ARG 170.A O no hydrogen 2.881 N/A ASP 203.A N GLU 216.A O no hydrogen 2.760 N/A ASN 204.A N ASN 168.A O no hydrogen 2.867 N/A ASP 205.A N PHE 214.A O no hydrogen 3.032 N/A GLU 206.A N GLY 166.A O no hydrogen 2.931 N/A HIS 207.A N LEU 212.A O no hydrogen 2.995 N/A HIS 207.A ND1 ASP 205.A OD1 no hydrogen 2.441 N/A TYR 208.A N VAL 164.A O no hydrogen 3.367 N/A ARG 210.A N HIS 207.A O no hydrogen 3.347 N/A LEU 212.A N HIS 207.A O no hydrogen 3.196 N/A THR 213.A N ILE 259.A O no hydrogen 3.002 N/A PHE 214.A N ASP 205.A O no hydrogen 2.607 N/A ARG 215.A N GLN 257.A O no hydrogen 2.772 N/A GLU 216.A N ASP 203.A O no hydrogen 3.173 N/A THR 218.A N ALA 201.A O no hydrogen 2.486 N/A GLY 220.A N VAL 199.A O no hydrogen 2.731 N/A SER 221.A N VAL 199.A O no hydrogen 3.226 N/A ARG 222.A NH1 ASP 197.A O no hydrogen 3.344 N/A TYR 223.A N SER 196.A O no hydrogen 2.851 N/A TYR 224.A N LYS 248.A O no hydrogen 3.022 N/A GLY 225.A N LYS 194.A O no hydrogen 2.986 N/A THR 226.A N TYR 246.A O no hydrogen 3.011 N/A THR 226.A OG1 LEU 192.A O no hydrogen 3.048 N/A VAL 227.A N LEU 192.A O no hydrogen 3.083 N/A ILE 228.A N PHE 244.A O no hydrogen 3.020 N/A ASN 229.A N ASN 190.A O no hydrogen 2.891 N/A ALA 230.A N ALA 242.A O no hydrogen 3.122 N/A GLY 231.A N GLU 188.A O no hydrogen 2.891 N/A TYR 232.A N VAL 240.A O no hydrogen 2.832 N/A TYR 233.A N ASP 186.A O no hydrogen 2.537 N/A TYR 233.A OH GLU 188.A OE2 no hydrogen 2.773 N/A VAL 234.A N ALA 238.A O no hydrogen 2.992 N/A THR 235.A N ALA 238.A O no hydrogen 3.380 N/A ASN 237.A N THR 235.A OG1 no hydrogen 3.057 N/A ALA 238.A N THR 235.A O no hydrogen 3.380 N/A LYS 239.A N GLN 288.A O no hydrogen 2.871 N/A LYS 239.A NZ GLU 188.A OE1 no hydrogen 2.950 N/A LYS 239.A NZ GLN 288.A OE1 no hydrogen 3.423 N/A VAL 240.A N TYR 232.A O no hydrogen 2.943 N/A PHE 241.A N GLY 286.A O no hydrogen 3.167 N/A ALA 242.A N ALA 230.A O no hydrogen 2.968 N/A GLU 243.A N THR 284.A O no hydrogen 2.718 N/A PHE 244.A N ILE 228.A O no hydrogen 2.860 N/A THR 245.A N THR 282.A O no hydrogen 2.929 N/A TYR 246.A N THR 226.A O no hydrogen 2.872 N/A SER 247.A N ASN 280.A O no hydrogen 3.011 N/A LYS 248.A N TYR 224.A O no hydrogen 2.858 N/A LYS 248.A NZ TYR 249.A O no hydrogen 3.397 N/A TYR 249.A N ASN 278.A O no hydrogen 3.074 N/A ASP 250.A N ARG 222.A O no hydrogen 2.794 N/A GLY 252.A N ILE 276.A O no hydrogen 3.397 N/A GLY 254.A N ALA 274.A O no hydrogen 3.254 N/A GLN 257.A N ARG 215.A O no hydrogen 2.756 N/A THR 258.A N VAL 267.A O no hydrogen 2.874 N/A ILE 259.A N THR 213.A O no hydrogen 2.976 N/A ASP 260.A N ASP 265.A O no hydrogen 2.709 N/A LYS 261.A N ASP 211.A O no hydrogen 2.823 N/A LYS 261.A NZ GLU 206.A OE2 no hydrogen 3.365 N/A SER 263.A OG ASP 260.A O no hydrogen 3.430 N/A SER 263.A OG ASP 260.A OD2 no hydrogen 2.635 N/A GLY 264.A N ASP 260.A O no hydrogen 2.824 N/A SER 266.A OG THR 258.A O no hydrogen 3.074 N/A VAL 267.A N THR 258.A O no hydrogen 2.717 N/A ILE 269.A N THR 256.A O no hydrogen 2.999 N/A ALA 273.A N GLY 254.A O no hydrogen 2.892 N/A GLY 275.A N MET 29.A O no hydrogen 3.082 N/A ILE 276.A N GLY 252.A O no hydrogen 3.306 N/A SER 277.A N HIS 27.A O no hydrogen 3.330 N/A SER 277.A OG HIS 27.A ND1 no hydrogen 3.261 N/A ASN 278.A N TYR 249.A O no hydrogen 3.385 N/A ASN 278.A ND2 SER 26.A OG no hydrogen 2.900 N/A ASN 280.A N SER 247.A O no hydrogen 2.637 N/A TYR 281.A N SER 23.A O no hydrogen 2.946 N/A THR 282.A N THR 245.A O no hydrogen 2.994 N/A VAL 283.A N MET 21.A O no hydrogen 3.061 N/A THR 284.A N GLU 243.A O no hydrogen 3.001 N/A THR 284.A OG1 SER 18.A OG no hydrogen 3.424 N/A ALA 285.A N THR 19.A O no hydrogen 2.898 N/A GLY 286.A N PHE 241.A O no hydrogen 3.139 N/A LEU 287.A N ALA 17.A O no hydrogen 3.016 N/A GLN 288.A N LYS 239.A O no hydrogen 2.726 N/A TYR 289.A N VAL 15.A O no hydrogen 2.795 N/A ARG 290.A N ASN 237.A O no hydrogen 3.121 N/A PHE 291.A N PHE 13.A O no hydrogen 2.756 N/A