Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 2x9k_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): HIS 5.A N ALA 37.A O no hydrogen 2.852 N/A PHE 6.A N PHE 278.A OXT no hydrogen 2.704 N/A ASN 7.A N ASN 35.A O no hydrogen 2.905 N/A ASN 7.A ND2 ASN 275.A OD1 no hydrogen 3.061 N/A ILE 8.A N TYR 276.A O no hydrogen 2.940 N/A GLY 9.A N TYR 33.A O no hydrogen 3.059 N/A ALA 10.A N VAL 274.A O no hydrogen 3.085 N/A MET 11.A N SER 31.A O no hydrogen 2.825 N/A TYR 12.A N VAL 272.A O no hydrogen 2.870 N/A GLU 13.A N GLU 29.A O no hydrogen 3.043 N/A ILE 14.A N ALA 270.A O no hydrogen 2.812 N/A GLU 15.A N LEU 27.A O no hydrogen 3.068 N/A ASN 16.A N HIS 268.A O no hydrogen 3.039 N/A VAL 17.A N ASP 25.A O no hydrogen 2.999 N/A GLU 18.A N LYS 266.A O no hydrogen 2.736 N/A GLY 19.A N GLU 22.A O no hydrogen 3.190 N/A GLU 22.A N GLY 19.A O no hydrogen 3.195 N/A MET 24.A N VAL 17.A O no hydrogen 2.826 N/A LEU 27.A N GLU 15.A O no hydrogen 2.700 N/A ALA 28.A N GLY 51.A O no hydrogen 2.853 N/A GLU 29.A N GLU 13.A O no hydrogen 2.798 N/A SER 31.A N MET 11.A O no hydrogen 2.823 N/A VAL 32.A N TYR 47.A O no hydrogen 2.900 N/A TYR 33.A N GLY 9.A O no hydrogen 2.895 N/A PHE 34.A N LEU 45.A O no hydrogen 2.839 N/A ASN 35.A N ASN 7.A O no hydrogen 2.769 N/A ALA 36.A N ILE 43.A O no hydrogen 2.742 N/A ALA 37.A N HIS 5.A O no hydrogen 2.788 N/A ASN 38.A N TRP 41.A O no hydrogen 2.952 N/A ARG 42.A N HIS 72.A O no hydrogen 2.957 N/A ILE 43.A N ALA 36.A O no hydrogen 2.751 N/A ALA 44.A N GLU 70.A O no hydrogen 2.917 N/A LEU 45.A N PHE 34.A O no hydrogen 2.849 N/A ALA 46.A N GLU 68.A O no hydrogen 3.049 N/A TYR 47.A N VAL 32.A O no hydrogen 2.829 N/A TYR 47.A OH ASP 65.A OD1 no hydrogen 2.396 N/A TYR 48.A OH GLU 50.A OE2 no hydrogen 2.596 N/A GLN 49.A N PRO 30.A O no hydrogen 3.041 N/A GLU 50.A N PHE 64.A O no hydrogen 2.950 N/A GLY 51.A N ALA 28.A O no hydrogen 3.359 N/A VAL 53.A N GLY 26.A O no hydrogen 2.950 N/A ARG 60.A NH1 GLY 26.A O no hydrogen 3.368 N/A THR 62.A N ASP 98.A OD1 no hydrogen 2.762 N/A THR 62.A OG1 GLU 99.A OE2 no hydrogen 2.979 N/A TRP 63.A N HIS 95.A O no hydrogen 3.102 N/A PHE 64.A N GLU 50.A O no hydrogen 2.889 N/A ASP 65.A N GLY 93.A O no hydrogen 3.159 N/A ARG 66.A N TYR 48.A O no hydrogen 2.773 N/A GLU 68.A N ALA 46.A O no hydrogen 2.846 N/A LEU 69.A N PHE 89.A O no hydrogen 2.898 N/A GLU 70.A N ALA 44.A O no hydrogen 2.792 N/A VAL 71.A N GLY 87.A O no hydrogen 2.943 N/A HIS 72.A N ARG 42.A O no hydrogen 2.782 N/A HIS 72.A NE2 ASP 115.A OD2 no hydrogen 2.956 N/A TYR 73.A N LEU 85.A O no hydrogen 2.886 N/A GLN 74.A N PRO 40.A O no hydrogen 2.808 N/A LEU 76.A N PHE 83.A O no hydrogen 3.078 N/A ASN 78.A N PHE 81.A O no hydrogen 2.928 N/A ASP 80.A N ASN 78.A OD1 no hydrogen 2.693 N/A PHE 81.A N ASN 78.A OD1 no hydrogen 2.980 N/A SER 82.A N ASP 117.A O no hydrogen 2.794 N/A PHE 83.A N LEU 76.A O no hydrogen 2.969 N/A GLY 84.A N ASP 115.A O no hydrogen 2.844 N/A LEU 85.A N TYR 73.A O no hydrogen 2.917 N/A THR 86.A N ALA 113.A O no hydrogen 2.979 N/A GLY 87.A N VAL 71.A O no hydrogen 2.906 N/A GLY 88.A N LYS 111.A O no hydrogen 2.858 N/A PHE 89.A N LEU 69.A O no hydrogen 2.909 N/A ARG 90.A N ARG 109.A O no hydrogen 3.045 N/A ARG 90.A NE GLU 68.A OE2 no hydrogen 2.958 N/A ARG 90.A NH1 TYR 92.A OH no hydrogen 2.879 N/A ARG 90.A NH2 GLU 68.A OE2 no hydrogen 3.533 N/A ASN 91.A N PRO 67.A O no hydrogen 3.095 N/A TYR 92.A N MET 107.A O no hydrogen 2.779 N/A GLY 93.A N ASP 65.A O no hydrogen 2.926 N/A TYR 94.A N ALA 105.A O no hydrogen 2.717 N/A TYR 94.A OH TYR 144.A OH no hydrogen 2.812 N/A HIS 95.A N TRP 63.A O no hydrogen 2.782 N/A TYR 96.A N ASP 103.A O no hydrogen 3.010 N/A VAL 97.A N THR 62.A OG1 no hydrogen 3.269 N/A LYS 102.A NZ ASP 223.A OD2 no hydrogen 2.919 N/A THR 104.A N ASP 103.A OD2 no hydrogen 2.952 N/A ALA 105.A N TYR 94.A O no hydrogen 2.968 N/A ASN 106.A N ASP 138.A OD2 no hydrogen 2.600 N/A MET 107.A N TYR 92.A O no hydrogen 3.011 N/A GLN 108.A N ALA 136.A O no hydrogen 2.713 N/A GLN 108.A NE2 ASN 91.A OD1 no hydrogen 2.825 N/A ARG 109.A N ARG 90.A O no hydrogen 2.916 N/A TRP 110.A N LYS 134.A O no hydrogen 2.612 N/A LYS 111.A N GLY 88.A O no hydrogen 2.945 N/A LYS 111.A NZ GLU 70.A OE1 no hydrogen 2.642 N/A ILE 112.A N MET 132.A O no hydrogen 3.017 N/A ALA 113.A N THR 86.A O no hydrogen 2.769 N/A ASP 115.A N GLY 84.A O no hydrogen 2.906 N/A TRP 116.A N GLY 128.A O no hydrogen 2.974 N/A ASP 117.A N SER 82.A O no hydrogen 2.954 N/A VAL 118.A N PHE 126.A O no hydrogen 2.753 N/A LYS 119.A N ASP 80.A O no hydrogen 2.910 N/A LYS 119.A NZ ASP 122.A OD1 no hydrogen 2.965 N/A LEU 120.A N LEU 124.A O no hydrogen 2.845 N/A THR 121.A N LEU 124.A O no hydrogen 2.993 N/A ASP 123.A N THR 121.A OG1 no hydrogen 3.126 N/A LEU 124.A N THR 121.A O no hydrogen 3.418 N/A LEU 124.A N THR 121.A OG1 no hydrogen 3.251 N/A ARG 125.A N GLN 156.A O no hydrogen 2.906 N/A ARG 125.A NH1 ASP 79.A O no hydrogen 2.822 N/A ARG 125.A NH2 ASP 79.A O no hydrogen 3.240 N/A ARG 125.A NH2 ASP 117.A OD2 no hydrogen 3.557 N/A PHE 126.A N VAL 118.A O no hydrogen 2.865 N/A ASN 127.A N GLY 154.A O no hydrogen 2.902 N/A GLY 128.A N TRP 116.A O no hydrogen 3.101 N/A TRP 129.A N GLU 152.A O no hydrogen 3.036 N/A LEU 130.A N PRO 114.A O no hydrogen 2.972 N/A SER 131.A N GLU 150.A O no hydrogen 2.677 N/A MET 132.A N ILE 112.A O no hydrogen 3.013 N/A TYR 133.A N ARG 148.A O no hydrogen 2.841 N/A TYR 133.A OH GLU 150.A OE1 no hydrogen 2.775 N/A LYS 134.A N TRP 110.A O no hydrogen 2.770 N/A LYS 134.A NZ THR 147.A OG1 no hydrogen 3.034 N/A PHE 135.A N ASP 146.A O no hydrogen 2.888 N/A ALA 136.A N GLN 108.A O no hydrogen 2.804 N/A ASN 137.A ND2 GLN 108.A OE1 no hydrogen 2.579 N/A THR 141.A N ASP 138.A O no hydrogen 2.985 N/A THR 142.A N ASP 138.A O no hydrogen 2.895 N/A THR 142.A OG1 ASP 138.A O no hydrogen 3.530 N/A GLY 143.A N LEU 139.A O no hydrogen 2.751 N/A TYR 144.A OH TYR 94.A OH no hydrogen 2.812 N/A ASP 146.A N ASN 176.A OD1 no hydrogen 2.808 N/A THR 147.A N PHE 175.A O no hydrogen 3.069 N/A THR 147.A OG1 ASP 146.A OD2 no hydrogen 2.778 N/A ARG 148.A N TYR 133.A O no hydrogen 3.029 N/A ARG 148.A NH1 GLU 172.A OE2 no hydrogen 3.216 N/A VAL 149.A N ARG 173.A O no hydrogen 2.966 N/A GLU 150.A N SER 131.A O no hydrogen 2.967 N/A THR 151.A N LEU 171.A O no hydrogen 2.992 N/A THR 151.A OG1 TRP 129.A O no hydrogen 2.724 N/A THR 151.A OG1 THR 153.A OG1 no hydrogen 2.959 N/A GLU 152.A N TRP 129.A O no hydrogen 3.313 N/A THR 153.A N TYR 169.A O no hydrogen 2.926 N/A THR 153.A OG1 THR 151.A OG1 no hydrogen 2.959 N/A GLY 154.A N ASN 127.A O no hydrogen 2.901 N/A LEU 155.A N VAL 167.A O no hydrogen 3.014 N/A GLN 156.A N ARG 125.A O no hydrogen 2.804 N/A TYR 157.A N LEU 165.A O no hydrogen 2.821 N/A THR 158.A N ASP 123.A O no hydrogen 2.822 N/A PHE 159.A N VAL 163.A O no hydrogen 2.841 N/A THR 162.A N ASN 160.A OD1 no hydrogen 2.821 N/A VAL 163.A N ASN 160.A OD1 no hydrogen 3.242 N/A ALA 164.A N PRO 196.A O no hydrogen 3.309 N/A LEU 165.A N TYR 157.A O no hydrogen 2.838 N/A ARG 166.A N TYR 194.A O no hydrogen 2.923 N/A VAL 167.A N LEU 155.A O no hydrogen 2.952 N/A ASN 168.A N ARG 192.A O no hydrogen 2.718 N/A ASN 168.A ND2 GLU 152.A OE2 no hydrogen 2.868 N/A TYR 169.A N THR 153.A O no hydrogen 2.763 N/A TYR 169.A OH GLN 189.A OE1 no hydrogen 2.466 N/A TYR 170.A N GLU 190.A O no hydrogen 2.893 N/A TYR 170.A OH GLU 150.A OE2 no hydrogen 2.626 N/A LEU 171.A N THR 151.A O no hydrogen 2.922 N/A GLU 172.A N THR 188.A O no hydrogen 2.860 N/A ARG 173.A N VAL 149.A O no hydrogen 2.894 N/A GLY 174.A N PHE 186.A O no hydrogen 2.902 N/A PHE 175.A N THR 147.A O no hydrogen 3.051 N/A ASN 176.A ND2 ASN 183.A O no hydrogen 2.851 N/A MET 177.A N ASP 146.A OD2 no hydrogen 2.743 N/A ASP 178.A N ASP 146.A OD1 no hydrogen 3.199 N/A SER 180.A N ASP 178.A OD1 no hydrogen 2.832 N/A ARG 181.A N ASP 178.A O no hydrogen 2.988 N/A ARG 181.A NH1 ASN 140.A OD1 no hydrogen 3.256 N/A ARG 181.A NH2 ASN 140.A OD1 no hydrogen 2.867 N/A ARG 181.A NH2 ASN 183.A OD1 no hydrogen 2.910 N/A ASN 182.A ND2 GLU 185.A OE1 no hydrogen 3.561 N/A PHE 186.A N GLY 174.A O no hydrogen 3.138 N/A SER 187.A N TRP 215.A O no hydrogen 2.783 N/A THR 188.A N GLU 172.A O no hydrogen 2.834 N/A GLN 189.A N ASP 213.A O no hydrogen 2.888 N/A GLU 190.A N TYR 170.A O no hydrogen 2.928 N/A ILE 191.A N ILE 210.A O no hydrogen 2.873 N/A ARG 192.A N ASN 168.A O no hydrogen 2.766 N/A ARG 192.A NE GLU 190.A OE1 no hydrogen 2.836 N/A ARG 192.A NH1 GLU 152.A OE1 no hydrogen 3.008 N/A ARG 192.A NH2 GLU 190.A OE1 no hydrogen 2.982 N/A ALA 193.A N THR 208.A O no hydrogen 2.914 N/A TYR 194.A N ARG 166.A O no hydrogen 2.870 N/A TYR 194.A OH GLU 152.A OE2 no hydrogen 2.597 N/A LEU 195.A N PRO 206.A O no hydrogen 3.001 N/A LEU 197.A N VAL 204.A O no hydrogen 2.663 N/A THR 198.A N THR 162.A O no hydrogen 2.790 N/A LEU 199.A N HIS 202.A O no hydrogen 2.880 N/A HIS 202.A N LEU 199.A O no hydrogen 3.221 N/A HIS 202.A ND1 TYR 238.A OH no hydrogen 2.852 N/A SER 203.A N GLY 239.A O no hydrogen 2.828 N/A VAL 204.A N LEU 197.A O no hydrogen 3.060 N/A THR 205.A N PHE 237.A O no hydrogen 2.776 N/A TYR 207.A N GLY 235.A O no hydrogen 2.979 N/A TYR 207.A OH GLU 251.A OE2 no hydrogen 2.477 N/A THR 208.A N ALA 193.A O no hydrogen 2.877 N/A THR 208.A OG1 ARG 233.A O no hydrogen 3.046 N/A ARG 209.A N ARG 233.A O no hydrogen 2.813 N/A ILE 210.A N ILE 191.A O no hydrogen 2.734 N/A GLY 211.A N PHE 231.A O no hydrogen 3.005 N/A LEU 212.A N GLN 189.A O no hydrogen 2.777 N/A ASP 213.A N GLN 189.A O no hydrogen 3.261 N/A ARG 214.A NH1 GLN 221.A OE1 no hydrogen 3.236 N/A ARG 214.A NH2 GLN 221.A OE1 no hydrogen 3.431 N/A TRP 215.A N SER 187.A O no hydrogen 2.964 N/A SER 216.A N GLU 227.A O no hydrogen 3.239 N/A SER 216.A OG GLN 221.A OE1 no hydrogen 3.188 N/A SER 216.A OG GLU 227.A O no hydrogen 3.568 N/A ASN 217.A N GLU 185.A O no hydrogen 2.800 N/A TRP 220.A N ASN 217.A O no hydrogen 2.920 N/A GLU 225.A N ASP 223.A O no hydrogen 2.623 N/A ARG 226.A NE ARG 226.A O no hydrogen 2.866 N/A GLU 227.A N GLN 221.A OE1 no hydrogen 3.284 N/A PHE 231.A N ASP 230.A OD1 no hydrogen 2.756 N/A ASN 232.A N TRP 256.A O no hydrogen 2.994 N/A ARG 233.A N ARG 209.A O no hydrogen 2.986 N/A ARG 233.A NH1 GLU 255.A OE2 no hydrogen 2.913 N/A VAL 234.A N PHE 254.A O no hydrogen 2.892 N/A GLY 235.A N TYR 207.A O no hydrogen 2.929 N/A LEU 236.A N TYR 252.A O no hydrogen 2.904 N/A PHE 237.A N THR 205.A O no hydrogen 2.787 N/A TYR 238.A N LEU 250.A O no hydrogen 2.727 N/A TYR 238.A OH HIS 202.A ND1 no hydrogen 2.852 N/A GLY 239.A N SER 203.A O no hydrogen 2.732 N/A TYR 240.A N VAL 248.A O no hydrogen 2.759 N/A ASP 241.A N ASN 201.A O no hydrogen 2.918 N/A PHE 242.A N LEU 246.A O no hydrogen 2.912 N/A GLN 243.A N ASP 241.A OD1 no hydrogen 2.820 N/A LEU 246.A N ASN 244.A OD1 no hydrogen 2.925 N/A SER 247.A N ASN 275.A O no hydrogen 2.997 N/A VAL 248.A N TYR 240.A O no hydrogen 3.074 N/A SER 249.A N GLY 273.A O no hydrogen 2.912 N/A LEU 250.A N TYR 238.A O no hydrogen 2.808 N/A GLU 251.A N GLY 271.A O no hydrogen 2.861 N/A TYR 252.A N LEU 236.A O no hydrogen 3.106 N/A TYR 252.A OH HIS 268.A ND1 no hydrogen 2.778 N/A ALA 253.A N TYR 269.A O no hydrogen 2.803 N/A PHE 254.A N VAL 234.A O no hydrogen 2.720 N/A GLU 255.A N PHE 267.A O no hydrogen 2.879 N/A TRP 256.A N ASN 232.A O no hydrogen 2.930 N/A LYS 266.A N GLU 18.A O no hydrogen 3.041 N/A LYS 266.A NZ ASP 263.A OD1 no hydrogen 2.790 N/A PHE 267.A N GLU 255.A O no hydrogen 2.953 N/A HIS 268.A N ASN 16.A O no hydrogen 2.999 N/A HIS 268.A ND1 TYR 252.A OH no hydrogen 2.778 N/A HIS 268.A NE2 GLU 18.A OE2 no hydrogen 2.802 N/A TYR 269.A N ALA 253.A O no hydrogen 2.915 N/A TYR 269.A OH GLU 255.A OE1 no hydrogen 3.024 N/A ALA 270.A N ILE 14.A O no hydrogen 3.087 N/A GLY 271.A N GLU 251.A O no hydrogen 3.055 N/A VAL 272.A N TYR 12.A O no hydrogen 2.908 N/A GLY 273.A N SER 249.A O no hydrogen 2.825 N/A VAL 274.A N ALA 10.A O no hydrogen 2.931 N/A ASN 275.A N SER 247.A O no hydrogen 2.810 N/A ASN 275.A ND2 TYR 33.A OH no hydrogen 2.613 N/A TYR 276.A N ILE 8.A O no hydrogen 2.674 N/A SER 277.A N GLY 245.A O no hydrogen 2.830 N/A PHE 278.A N PHE 6.A O no hydrogen 2.791 N/A