Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 2xf8_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): THR 1.A OG1 THR 30.A OG1 no hydrogen 3.116 N/A VAL 2.A N GLU 28.A O no hydrogen 3.014 N/A ARG 3.A N ASP 93.A OD1 no hydrogen 3.093 N/A VAL 4.A N THR 30.A O no hydrogen 2.718 N/A ALA 5.A N VAL 94.A O no hydrogen 3.157 N/A ILE 6.A N ALA 33.A O no hydrogen 2.922 N/A ASN 7.A N LEU 96.A O no hydrogen 2.896 N/A ASN 7.A ND2 ASP 97.A OD1 no hydrogen 2.632 N/A GLY 8.A N ASN 35.A O no hydrogen 2.999 N/A PHE 9.A N GLU 36.A OE1 no hydrogen 2.601 N/A ARG 11.A NH2 GLU 308.A OE1 no hydrogen 2.821 N/A ARG 11.A NH2 GLU 308.A OE2 no hydrogen 3.542 N/A ARG 14.A N GLY 10.A O no hydrogen 3.084 N/A ARG 14.A NH1 ASP 50.A OD1 no hydrogen 3.113 N/A ASN 15.A N ARG 11.A O no hydrogen 3.091 N/A ASN 15.A ND2 HIS 53.A NE2 no hydrogen 3.413 N/A VAL 16.A N ILE 12.A O no hydrogen 2.849 N/A VAL 17.A N GLY 13.A O no hydrogen 3.198 N/A ARG 18.A N ARG 14.A O no hydrogen 2.952 N/A ARG 18.A NH1 ASP 50.A OD1 no hydrogen 2.924 N/A ARG 18.A NH2 LEU 46.A O no hydrogen 3.240 N/A ARG 18.A NH2 LEU 47.A O no hydrogen 2.616 N/A ARG 18.A NH2 ASP 50.A OD1 no hydrogen 3.375 N/A ALA 19.A N ASN 15.A O no hydrogen 2.694 N/A LEU 20.A N VAL 16.A O no hydrogen 2.808 N/A TYR 21.A N VAL 17.A O no hydrogen 3.350 N/A TYR 21.A OH ASP 72.A OD2 no hydrogen 2.779 N/A GLU 22.A N ARG 18.A O no hydrogen 3.044 N/A SER 23.A N ALA 19.A O no hydrogen 2.864 N/A SER 23.A OG ALA 19.A O no hydrogen 2.328 N/A SER 23.A OG LEU 20.A O no hydrogen 3.244 N/A ALA 27.A N GLY 24A.A O no hydrogen 3.141 N/A THR 30.A N VAL 2.A O no hydrogen 2.676 N/A THR 30.A OG1 THR 1.A OG1 no hydrogen 3.116 N/A VAL 32.A N VAL 4.A O no hydrogen 3.004 N/A ILE 34.A N ARG 75.A O no hydrogen 2.823 N/A ASN 35.A N ILE 6.A O no hydrogen 2.805 N/A ASN 35.A ND2 ASN 7.A OD1 no hydrogen 2.844 N/A ASN 35.A ND2 GLU 79.A O no hydrogen 3.002 N/A GLU 36.A N LEU 77.A O no hydrogen 2.791 N/A LEU 37.A N GLU 36.A OE2 no hydrogen 2.931 N/A ALA 38.A N GLU 36.A OE2 no hydrogen 3.188 N/A ASP 39.A N ASP 39.A OD1 no hydrogen 2.437 N/A MET 43.A N ASP 39.A O no hydrogen 2.841 N/A ALA 44.A N ALA 40.A O no hydrogen 3.190 N/A HIS 45.A N ALA 41.A O no hydrogen 3.118 N/A LEU 46.A N GLY 42.A O no hydrogen 3.179 N/A LEU 47.A N MET 43.A O no hydrogen 3.075 N/A LYS 48.A N ALA 44.A O no hydrogen 3.095 N/A LYS 48.A NZ PHE 56.A O no hydrogen 3.138 N/A LYS 48.A NZ TRP 58.A O no hydrogen 2.930 N/A TYR 49.A N HIS 45.A O no hydrogen 2.993 N/A HIS 53.A N ASP 50.A O no hydrogen 2.817 N/A HIS 53.A ND1 HIS 279.A ND1 no hydrogen 2.887 N/A GLY 54.A N ASP 50.A O no hydrogen 3.076 N/A PHE 56.A N LYS 48.A O no hydrogen 2.824 N/A ARG 61.A N PHE 68.A O no hydrogen 3.035 N/A GLN 66.A N GLU 63.A O no hydrogen 3.244 N/A GLN 66.A NE2 ASP 65.A OD2 no hydrogen 2.958 N/A LEU 67.A N ILE 74.A O no hydrogen 2.566 N/A PHE 68.A N ARG 61.A O no hydrogen 2.740 N/A VAL 69.A N ASP 72.A O no hydrogen 3.139 N/A GLY 70.A N GLU 59.A O no hydrogen 3.123 N/A ASP 72.A N VAL 69.A O no hydrogen 3.071 N/A ILE 74.A N LEU 67.A O no hydrogen 2.767 N/A ARG 75.A N VAL 32.A O no hydrogen 2.933 N/A ARG 75.A NH1 GLU 89.A OE2 no hydrogen 2.929 N/A VAL 76.A N ASP 65.A O no hydrogen 2.858 N/A LEU 77.A N ILE 34.A O no hydrogen 2.855 N/A GLU 79.A N ASN 35.A OD1 no hydrogen 3.040 N/A SER 84.A OG GLU 79.A OE1 no hydrogen 2.651 N/A SER 84.A OG SER 81.A O no hydrogen 3.203 N/A LEU 85.A N LEU 82.A O no hydrogen 3.435 N/A TRP 87.A NE1 HIS 111.A ND1 no hydrogen 2.909 N/A ARG 88.A N ALA 114.A O no hydrogen 3.003 N/A LEU 90.A N PRO 86.A O no hydrogen 3.248 N/A LEU 90.A N TRP 87.A O no hydrogen 3.173 N/A GLY 91.A N ARG 88.A O no hydrogen 3.134 N/A VAL 92.A N TRP 87.A O no hydrogen 3.253 N/A ASP 93.A N ARG 3.A O no hydrogen 2.825 N/A VAL 94.A N ARG 3.A O no hydrogen 3.366 N/A VAL 95.A N LYS 118.A O no hydrogen 2.874 N/A LEU 96.A N ALA 5.A O no hydrogen 2.875 N/A ASP 97.A N LEU 120.A O no hydrogen 2.868 N/A CYS 98.A N ASN 7.A O no hydrogen 2.646 N/A CYS 98.A SG LEU 96.A O no hydrogen 3.909 N/A THR 99.A N ASP 97.A OD2 no hydrogen 3.128 N/A THR 99.A OG1 ASP 97.A OD1 no hydrogen 3.464 N/A THR 99.A OG1 ASP 97.A OD2 no hydrogen 2.367 N/A TYR 102.A OH ARG 80.A O no hydrogen 3.284 N/A GLY 103.A N HIS 107.A ND1 no hydrogen 3.291 N/A SER 104.A N HIS 107.A ND1 no hydrogen 2.881 N/A SER 104.A OG HIS 107.A ND1 no hydrogen 2.730 N/A ARG 105.A N ASN 127.A OD1 no hydrogen 3.027 N/A ARG 105.A NH1 ASP 130.A OD2 no hydrogen 2.953 N/A ARG 105.A NH2 ASP 130.A OD2 no hydrogen 2.461 N/A GLU 106.A N GLU 106.A OE2 no hydrogen 2.824 N/A HIS 107.A N SER 104.A OG no hydrogen 3.260 N/A GLY 108.A N SER 104.A O no hydrogen 3.119 N/A GLU 109.A N ARG 105.A O no hydrogen 2.726 N/A ALA 110.A N GLU 106.A O no hydrogen 2.752 N/A HIS 111.A N HIS 107.A O no hydrogen 3.052 N/A HIS 111.A NE2 ASP 97.A OD1 no hydrogen 3.141 N/A ILE 112.A N GLY 108.A O no hydrogen 3.027 N/A ALA 113.A N GLU 109.A O no hydrogen 2.665 N/A ALA 114.A N ALA 110.A O no hydrogen 2.924 N/A GLY 115.A N ILE 112.A O no hydrogen 2.821 N/A ALA 116.A N HIS 111.A O no hydrogen 3.203 N/A LYS 117.A N VAL 92.A O no hydrogen 3.274 N/A LYS 117.A NZ ASP 93.A OD2 no hydrogen 2.951 N/A LYS 118.A N ASP 93.A O no hydrogen 3.113 N/A LYS 118.A NZ MET 322.A O no hydrogen 2.703 N/A VAL 119.A N ARG 147.A O no hydrogen 2.642 N/A LEU 120.A N VAL 95.A O no hydrogen 2.791 N/A PHE 121.A N VAL 149.A O no hydrogen 2.886 N/A SER 122.A N ASP 97.A O no hydrogen 3.146 N/A SER 122.A OG ASP 97.A O no hydrogen 3.428 N/A HIS 123.A NE2 TYR 102.A O no hydrogen 2.774 N/A GLY 125.A N HIS 123.A ND1 no hydrogen 3.245 N/A ASP 130.A N ILE 148.A O no hydrogen 3.031 N/A VAL 133.A N SER 150.A O no hydrogen 2.822 N/A VAL 134.A N ASN 138.A OD1 no hydrogen 2.987 N/A GLY 136.A N GLN 139.A OE1 no hydrogen 3.110 N/A VAL 137.A N VAL 134.A O no hydrogen 3.012 N/A ASN 138.A N VAL 134.A O no hydrogen 3.485 N/A ASN 138.A ND2 THR 132.A O no hydrogen 3.057 N/A GLN 139.A N GLN 139.A OE1 no hydrogen 2.697 N/A GLN 141.A N ASN 138.A O no hydrogen 3.261 N/A LEU 142.A N GLN 139.A O no hydrogen 3.056 N/A ARG 143.A N HIS 146.A ND1 no hydrogen 2.995 N/A HIS 146.A N ARG 143.A O no hydrogen 3.063 N/A ARG 147.A N ASP 130.A OD1 no hydrogen 2.893 N/A ILE 148.A N ASP 130.A OD1 no hydrogen 3.212 N/A VAL 149.A N VAL 119.A O no hydrogen 2.990 N/A SER 150.A N ALA 131.A O no hydrogen 2.832 N/A SER 150.A OG HIS 123.A O no hydrogen 2.639 N/A ASN 151.A N PHE 121.A O no hydrogen 3.016 N/A ALA 152.A N SER 150.A OG no hydrogen 3.075 N/A SER 153.A N THR 156.A OG1 no hydrogen 2.777 N/A SER 153.A OG THR 155.A OG1 no hydrogen 3.149 N/A SER 153.A OG THR 156.A OG1 no hydrogen 2.608 N/A THR 155.A OG1 SER 153.A OG no hydrogen 3.149 N/A THR 156.A N SER 153.A OG no hydrogen 3.255 N/A THR 156.A OG1 SER 153.A O no hydrogen 2.966 N/A THR 156.A OG1 SER 153.A OG no hydrogen 2.608 N/A ASN 157.A N SER 153.A O no hydrogen 2.753 N/A ASN 157.A ND2 ASN 151.A O no hydrogen 3.052 N/A CYS 158.A N CYS 154.A O no hydrogen 2.900 N/A CYS 158.A N THR 155.A O no hydrogen 3.101 N/A ILE 159.A N THR 155.A O no hydrogen 3.010 N/A ILE 160.A N THR 156.A O no hydrogen 2.890 N/A ILE 163.A N ILE 159.A O no hydrogen 2.970 N/A LYS 164.A N ILE 160.A O no hydrogen 2.913 N/A LYS 164.A NZ ASP 168.A OD2 no hydrogen 2.860 N/A LEU 165.A N PRO 161.A O no hydrogen 2.974 N/A LEU 166.A N VAL 162.A O no hydrogen 2.913 N/A ASP 167.A N ILE 163.A O no hydrogen 2.750 N/A ASP 168.A N LYS 164.A O no hydrogen 2.830 N/A ALA 169.A N LEU 165.A O no hydrogen 3.214 N/A TYR 170.A N LEU 166.A O no hydrogen 2.931 N/A GLY 171.A N ASP 167.A O no hydrogen 2.827 N/A ILE 172.A N ASP 167.A OD2 no hydrogen 2.810 N/A GLU 173.A N THR 239.A O no hydrogen 2.750 N/A SER 174.A OG THR 239.A OG1 no hydrogen 2.753 N/A GLY 175.A N ARG 218.A O no hydrogen 2.775 N/A THR 176.A N SER 237.A O no hydrogen 2.760 N/A VAL 177.A N GLU 220.A O no hydrogen 3.102 N/A THR 178.A N ASP 235.A O no hydrogen 2.879 N/A THR 179.A N ILE 222.A O no hydrogen 3.137 N/A ILE 180.A N ALA 233.A O no hydrogen 2.659 N/A HIS 181.A N VAL 224.A O no hydrogen 2.690 N/A SER 182.A OG VAL 231.A O no hydrogen 3.381 N/A ALA 183.A N THR 228.A O no hydrogen 3.108 N/A ARG 188.A NH1 ASP 186.A OD2 no hydrogen 3.437 N/A ARG 189.A N ASP 186.A O no hydrogen 3.000 N/A ARG 191.A N ARG 189.A O no hydrogen 2.898 N/A ILE 198.A N ARG 225.A O no hydrogen 3.051 N/A VAL 200.A N ALA 223.A O no hydrogen 2.871 N/A LEU 204.A N THR 202.A OG1 no hydrogen 2.793 N/A GLY 207.A N LYS 203.A O no hydrogen 2.764 N/A ILE 208.A N LEU 204.A O no hydrogen 2.949 N/A THR 209.A N ALA 205.A O no hydrogen 3.167 N/A THR 209.A OG1 ALA 205.A O no hydrogen 3.040 N/A THR 209.A OG1 ALA 206.A O no hydrogen 2.768 N/A ARG 210.A N ALA 206.A O no hydrogen 2.757 N/A PHE 211.A N GLY 207.A O no hydrogen 3.143 N/A PHE 212.A N ILE 208.A O no hydrogen 2.688 N/A GLN 214.A N GLN 214.A OE1 no hydrogen 2.702 N/A PHE 215.A N PHE 212.A O no hydrogen 2.993 N/A ASN 216.A N PRO 213.A O no hydrogen 3.143 N/A ARG 218.A NH1 GLU 173.A O no hydrogen 2.940 N/A GLU 220.A N GLY 175.A O no hydrogen 3.314 N/A ILE 222.A N VAL 177.A O no hydrogen 3.037 N/A VAL 224.A N THR 179.A O no hydrogen 2.875 N/A ARG 225.A N ILE 198.A O no hydrogen 2.771 N/A VAL 226.A N HIS 181.A O no hydrogen 2.921 N/A THR 228.A N VAL 226.A O no hydrogen 2.838 N/A ASN 230.A ND2 ASP 306.A OD2 no hydrogen 2.742 N/A VAL 231.A N ILE 229.A O no hydrogen 2.656 N/A THR 232.A N CYS 305.A O no hydrogen 2.851 N/A ALA 233.A N ILE 180.A O no hydrogen 3.043 N/A ILE 234.A N VAL 303.A O no hydrogen 2.672 N/A ASP 235.A N THR 178.A O no hydrogen 2.638 N/A LEU 236.A N THR 301.A O no hydrogen 2.885 N/A SER 237.A N THR 176.A O no hydrogen 2.831 N/A VAL 238.A N ILE 299.A O no hydrogen 2.924 N/A THR 239.A N SER 174.A O no hydrogen 2.831 N/A THR 239.A OG1 SER 174.A O no hydrogen 3.044 N/A THR 239.A OG1 SER 174.A OG no hydrogen 2.753 N/A VAL 240.A N HIS 297.A O no hydrogen 2.807 N/A LYS 241.A N TYR 170.A O no hydrogen 3.159 N/A LYS 241.A N GLY 171.A O no hydrogen 3.045 N/A LYS 241.A NZ GLU 173.A OE2 no hydrogen 3.154 N/A LYS 242.A N TYR 170.A O no hydrogen 3.103 N/A VAL 244.A N ALA 296.A O no hydrogen 2.796 N/A GLU 248.A N LYS 245.A O no hydrogen 2.912 N/A VAL 249.A N LYS 245.A O no hydrogen 3.167 N/A ASN 250.A N ALA 246.A O no hydrogen 3.024 N/A ASN 250.A ND2 GLY 288.A O no hydrogen 2.980 N/A LEU 251.A N ASN 247.A O no hydrogen 2.903 N/A LEU 252.A N GLU 248.A O no hydrogen 2.881 N/A LEU 253.A N VAL 249.A O no hydrogen 3.068 N/A GLN 254.A N ASN 250.A O no hydrogen 2.861 N/A LYS 255.A N LEU 251.A O no hydrogen 2.997 N/A ALA 256.A N LEU 252.A O no hydrogen 3.031 N/A ALA 257.A N LEU 253.A O no hydrogen 2.949 N/A GLN 258.A N GLN 254.A O no hydrogen 3.359 N/A GLY 259.A N LYS 255.A O no hydrogen 2.819 N/A PHE 261.A N ALA 256.A O no hydrogen 2.846 N/A HIS 262.A N GLY 259.A O no hydrogen 3.099 N/A ILE 264.A N PHE 261.A O no hydrogen 2.957 N/A VAL 265.A N PHE 261.A O no hydrogen 2.863 N/A ASP 266.A N ALA 284.A O no hydrogen 2.789 N/A TYR 267.A N ASP 266.A OD2 no hydrogen 2.627 N/A TYR 267.A OH GLU 269.A OE2 no hydrogen 2.728 N/A THR 268.A N VAL 286.A O no hydrogen 2.920 N/A LEU 270.A N THR 268.A OG1 no hydrogen 3.285 N/A VAL 273.A N ASP 276.A OD1 no hydrogen 2.892 N/A ASP 276.A N VAL 273.A O no hydrogen 2.898 N/A PHE 277.A N SER 274.A O no hydrogen 2.890 N/A ASN 278.A N VAL 275.A O no hydrogen 3.192 N/A ASN 278.A ND2 SER 52.A O no hydrogen 3.124 N/A HIS 279.A N ASP 306.A OD2 no hydrogen 2.664 N/A HIS 279.A ND1 HIS 53.A ND1 no hydrogen 2.887 N/A HIS 279.A NE2 GLU 22.A OE1 no hydrogen 2.705 N/A ASP 280.A N PHE 277.A O no hydrogen 3.064 N/A HIS 282.A N ASP 280.A OD2 no hydrogen 2.873 N/A HIS 282.A ND1 ASP 280.A OD2 no hydrogen 2.744 N/A SER 283.A N ILE 264.A O no hydrogen 2.772 N/A SER 283.A OG ASN 157.A OD1 no hydrogen 3.253 N/A ALA 284.A N ILE 264.A O no hydrogen 3.294 N/A ILE 285.A N TRP 304.A O no hydrogen 2.784 N/A VAL 286.A N ASP 266.A O no hydrogen 2.638 N/A ASP 287.A N LEU 302.A O no hydrogen 3.111 N/A GLY 288.A N THR 268.A O no hydrogen 2.724 N/A THR 289.A N ASP 287.A OD1 no hydrogen 3.265 N/A THR 289.A OG1 ASP 287.A OD1 no hydrogen 2.723 N/A GLN 290.A N ASP 287.A O no hydrogen 3.029 N/A GLN 290.A NE2 THR 289.A OG1 no hydrogen 2.832 N/A THR 291.A N GLY 288.A O no hydrogen 3.058 N/A THR 291.A OG1 ASN 250.A OD1 no hydrogen 2.417 N/A THR 291.A OG1 GLY 288.A O no hydrogen 3.110 N/A ARG 292.A N LYS 300.A O no hydrogen 2.973 N/A ARG 292.A NH1 THR 289.A O no hydrogen 3.036 N/A ARG 292.A NH1 THR 291.A O no hydrogen 2.848 N/A SER 294.A N LEU 298.A O no hydrogen 2.788 N/A HIS 297.A ND1 VAL 240.A O no hydrogen 2.882 N/A LEU 298.A N SER 294.A O no hydrogen 3.208 N/A ILE 299.A N VAL 238.A O no hydrogen 2.759 N/A LYS 300.A N ARG 292.A O no hydrogen 2.877 N/A LYS 300.A NZ ASP 235.A OD1 no hydrogen 3.217 N/A LYS 300.A NZ ASP 235.A OD2 no hydrogen 2.834 N/A LYS 300.A NZ SER 237.A OG no hydrogen 3.073 N/A THR 301.A N LEU 236.A O no hydrogen 2.933 N/A VAL 303.A N ILE 234.A O no hydrogen 2.784 N/A TRP 304.A N ILE 285.A O no hydrogen 2.819 N/A TRP 304.A NE1 ASP 287.A OD2 no hydrogen 3.146 N/A CYS 305.A N THR 232.A O no hydrogen 2.862 N/A ASN 307.A ND2 SER 182.A OG no hydrogen 3.286 N/A ASN 307.A ND2 THR 232.A OG1 no hydrogen 2.667 N/A GLU 308.A N ASP 306.A OD1 no hydrogen 3.220 N/A TRP 309.A N ASP 306.A OD1 no hydrogen 3.240 N/A GLY 310.A N ASP 306.A O no hydrogen 3.225 N/A ALA 312.A N GLU 308.A O no hydrogen 2.877 N/A ASN 313.A N TRP 309.A O no hydrogen 3.048 N/A ASN 313.A ND2 TRP 309.A O no hydrogen 2.750 N/A ARG 314.A N GLY 310.A O no hydrogen 3.013 N/A ARG 314.A NE ASP 317.A OD2 no hydrogen 2.850 N/A ARG 314.A NH1 PRO 281.A O no hydrogen 2.874 N/A ARG 314.A NH1 SER 283.A OG no hydrogen 3.168 N/A ARG 314.A NH2 PRO 281.A O no hydrogen 3.315 N/A ARG 314.A NH2 ASP 317.A OD2 no hydrogen 3.067 N/A MET 315.A N PHE 311.A O no hydrogen 2.915 N/A LEU 316.A N ALA 312.A O no hydrogen 3.361 N/A ASP 317.A N ASN 313.A O no hydrogen 2.841 N/A THR 318.A N ARG 314.A O no hydrogen 2.750 N/A THR 318.A OG1 ASN 151.A OD1 no hydrogen 2.687 N/A THR 318.A OG1 ARG 314.A O no hydrogen 2.893 N/A THR 319.A N MET 315.A O no hydrogen 2.954 N/A THR 319.A OG1 MET 315.A O no hydrogen 2.849 N/A LEU 320.A N LEU 316.A O no hydrogen 3.026 N/A ALA 321.A N ASP 317.A O no hydrogen 3.186 N/A MET 322.A N THR 318.A O no hydrogen 2.907 N/A ALA 323.A N THR 319.A O no hydrogen 2.951 N/A THR 324.A N LEU 320.A O no hydrogen 2.986 N/A THR 324.A N ALA 321.A O no hydrogen 3.213 N/A THR 324.A OG1 LEU 320.A O no hydrogen 3.112 N/A VAL 325.A N ALA 321.A O no hydrogen 2.928 N/A ARG 25B.A NH2 ASN 313.A OD1 no hydrogen 2.455 N/A ARG 26C.A NH1 ASP 72.A OD1 no hydrogen 3.131 N/A ARG 26C.A NH2 ILE 29.A O no hydrogen 3.037 N/A ARG 26C.A NH2 THR 30.A OG1 no hydrogen 3.366 N/A