Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 2xik_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): PHE 5.A N LEU 2.A O no hydrogen 3.224 N/A HIS 9.A N ALA 6.A O no hydrogen 3.092 N/A HIS 9.A ND1 SER 81.A OG no hydrogen 2.560 N/A SER 10.A N SER 81.A O no hydrogen 3.098 N/A ARG 11.A NH1 ALA 6.A O no hydrogen 2.706 N/A GLU 16.A N ASP 13.A O no hydrogen 3.284 N/A PHE 18.A N PRO 14.A O no hydrogen 2.908 N/A THR 19.A N ILE 36.A O no hydrogen 3.147 N/A THR 19.A OG1 ASN 38.A OD1 no hydrogen 2.629 N/A LEU 21.A N LYS 34.A O no hydrogen 2.808 N/A ARG 23.A NE GLU 31.A OE1 no hydrogen 2.762 N/A ARG 23.A NH2 GLU 31.A OE1 no hydrogen 3.343 N/A ILE 24.A N VAL 32.A O no hydrogen 2.865 N/A GLY 25.A N VAL 32.A O no hydrogen 3.402 N/A GLY 27.A N GLY 30.A O no hydrogen 2.748 N/A SER 28.A N ASP 155.A OD2 no hydrogen 3.240 N/A VAL 32.A N GLY 25.A O no hydrogen 2.850 N/A TYR 33.A N ILE 46.A O no hydrogen 2.680 N/A LYS 34.A N ASP 22.A O no hydrogen 2.824 N/A GLY 35.A N VAL 44.A O no hydrogen 2.748 N/A ILE 36.A N THR 19.A O no hydrogen 3.201 N/A ASP 37.A N GLU 42.A O no hydrogen 3.109 N/A ASN 38.A N LEU 17.A O no hydrogen 3.017 N/A ASN 38.A ND2 GLU 16.A O no hydrogen 2.819 N/A THR 40.A N ASP 37.A OD1 no hydrogen 3.049 N/A THR 40.A OG1 ASP 37.A OD1 no hydrogen 3.167 N/A LYS 41.A N ASP 37.A O no hydrogen 2.596 N/A VAL 44.A N GLY 35.A O no hydrogen 2.813 N/A ALA 45.A N MET 92.A O no hydrogen 2.944 N/A ILE 46.A N TYR 33.A O no hydrogen 2.726 N/A LYS 47.A N ILE 90.A O no hydrogen 2.888 N/A ILE 48.A N GLU 31.A O no hydrogen 3.106 N/A ILE 49.A N LEU 88.A O no hydrogen 2.935 N/A LEU 51.A N THR 86.A O no hydrogen 2.741 N/A GLU 53.A N ASP 50.A OD1 no hydrogen 3.026 N/A ALA 54.A N ASP 50.A O no hydrogen 2.949 N/A ASP 59.A N GLU 56.A O no hydrogen 3.095 N/A ILE 60.A N GLU 56.A O no hydrogen 3.138 N/A GLN 61.A N ILE 57.A O no hydrogen 3.077 N/A GLN 61.A NE2 GLN 8.A OE1 no hydrogen 2.744 N/A GLN 62.A N GLU 58.A O no hydrogen 2.948 N/A GLN 62.A NE2 ALA 159.A O no hydrogen 3.057 N/A GLU 63.A N ASP 59.A O no hydrogen 3.007 N/A ILE 64.A N ILE 60.A O no hydrogen 3.117 N/A THR 65.A N GLN 61.A O no hydrogen 3.134 N/A THR 65.A OG1 GLN 61.A O no hydrogen 3.008 N/A THR 65.A OG1 GLN 61.A OE1 no hydrogen 3.306 N/A VAL 66.A N GLN 62.A O no hydrogen 2.883 N/A LEU 67.A N GLU 63.A O no hydrogen 3.048 N/A SER 68.A N ILE 64.A O no hydrogen 3.116 N/A SER 68.A OG ILE 64.A O no hydrogen 3.367 N/A SER 68.A OG THR 65.A O no hydrogen 3.011 N/A GLN 69.A N THR 65.A O no hydrogen 3.039 N/A GLN 69.A N VAL 66.A O no hydrogen 3.082 N/A CYS 70.A N VAL 66.A O no hydrogen 3.175 N/A CYS 70.A SG VAL 66.A O no hydrogen 3.361 N/A ASP 71.A N TYR 127.A OH no hydrogen 2.878 N/A TYR 74.A N SER 72.A OG no hydrogen 3.081 N/A ILE 75.A N SER 72.A O no hydrogen 3.347 N/A THR 76.A N LEU 153.A O no hydrogen 3.219 N/A THR 76.A OG1 LEU 153.A O no hydrogen 3.555 N/A ARG 77.A N GLU 93.A OE2 no hydrogen 2.758 N/A ARG 77.A NH1 ASP 71.A OD1 no hydrogen 2.768 N/A TYR 78.A OH SER 81.A OG no hydrogen 3.039 N/A PHE 79.A N ILE 91.A O no hydrogen 2.807 N/A SER 81.A OG HIS 9.A ND1 no hydrogen 2.560 N/A SER 81.A OG TYR 78.A OH no hydrogen 3.039 N/A TYR 82.A N TRP 89.A O no hydrogen 2.735 N/A LEU 83.A N SER 10.A O no hydrogen 3.162 N/A LYS 84.A N LYS 87.A O no hydrogen 2.864 N/A LYS 87.A N LYS 84.A O no hydrogen 2.905 N/A LEU 88.A N ILE 49.A O no hydrogen 2.872 N/A TRP 89.A N TYR 82.A O no hydrogen 2.655 N/A ILE 90.A N LYS 47.A O no hydrogen 2.873 N/A ILE 91.A N GLY 80.A O no hydrogen 3.039 N/A MET 92.A N ALA 45.A O no hydrogen 2.768 N/A GLU 93.A N ARG 77.A O no hydrogen 2.788 N/A GLY 97.A N LEU 145.A O no hydrogen 2.872 N/A GLY 98.A N LEU 95.A O no hydrogen 3.466 N/A SER 99.A N ASP 102.A OD2 no hydrogen 3.012 N/A ALA 100.A N VAL 143.A O no hydrogen 2.839 N/A ASP 102.A N SER 99.A OG no hydrogen 2.922 N/A LEU 103.A N SER 99.A O no hydrogen 3.023 N/A LEU 104.A N LEU 101.A O no hydrogen 3.041 N/A LYS 105.A N ASP 102.A O no hydrogen 3.078 N/A GLY 107.A N LEU 104.A O no hydrogen 3.223 N/A ILE 114.A N GLU 110.A O no hydrogen 3.302 N/A ALA 115.A N GLU 111.A O no hydrogen 2.961 N/A THR 116.A N THR 112.A O no hydrogen 3.191 N/A THR 116.A OG1 THR 112.A O no hydrogen 2.715 N/A ILE 117.A N TYR 113.A O no hydrogen 2.964 N/A LEU 118.A N ILE 114.A O no hydrogen 2.881 N/A ARG 119.A N ALA 115.A O no hydrogen 3.051 N/A ARG 119.A NE GLU 120.A OE1 no hydrogen 2.864 N/A ARG 119.A NH1 LYS 271.A O no hydrogen 2.848 N/A ARG 119.A NH2 GLU 120.A OE1 no hydrogen 3.178 N/A ARG 119.A NH2 LYS 271.A O no hydrogen 2.966 N/A GLU 120.A N THR 116.A O no hydrogen 3.205 N/A ILE 121.A N ILE 117.A O no hydrogen 2.934 N/A LEU 122.A N LEU 118.A O no hydrogen 2.972 N/A LYS 123.A N ARG 119.A O no hydrogen 3.126 N/A LYS 123.A NZ GLU 120.A OE1 no hydrogen 2.793 N/A GLY 124.A N GLU 120.A O no hydrogen 3.210 N/A LEU 125.A N ILE 121.A O no hydrogen 2.837 N/A ASP 126.A N LEU 122.A O no hydrogen 2.818 N/A TYR 127.A N LYS 123.A O no hydrogen 3.159 N/A LEU 128.A N GLY 124.A O no hydrogen 3.047 N/A HIS 129.A N LEU 125.A O no hydrogen 2.845 N/A HIS 129.A NE2 ASP 193.A OD2 no hydrogen 2.901 N/A SER 130.A N ASP 126.A O no hydrogen 3.133 N/A SER 130.A OG ASP 126.A O no hydrogen 3.351 N/A SER 130.A OG TYR 127.A O no hydrogen 2.616 N/A GLU 131.A N TYR 127.A O no hydrogen 3.227 N/A GLU 131.A N LEU 128.A O no hydrogen 2.971 N/A ARG 132.A N HIS 129.A O no hydrogen 3.081 N/A ARG 132.A NH1 ASP 164.A OD1 no hydrogen 2.792 N/A ARG 132.A NH2 ASP 164.A OD1 no hydrogen 2.918 N/A LYS 133.A N LEU 128.A O no hydrogen 3.036 N/A LYS 133.A NZ GLN 69.A OE1 no hydrogen 2.901 N/A LYS 133.A NZ GLN 161.A OE1 no hydrogen 2.713 N/A ILE 134.A N GLY 160.A O no hydrogen 2.847 N/A HIS 135.A N ASP 193.A OD2 no hydrogen 2.943 N/A HIS 135.A NE2 ALA 154.A O no hydrogen 2.737 N/A ARG 136.A N ASP 193.A OD1 no hydrogen 2.906 N/A ARG 136.A NH1 VAL 158.A O no hydrogen 2.912 N/A ASP 137.A N HIS 135.A ND1 no hydrogen 3.080 N/A LYS 139.A NZ THR 174.A OG1 no hydrogen 2.805 N/A ALA 140.A N GLU 203.A OE1 no hydrogen 3.002 N/A ASN 142.A N LYS 139.A O no hydrogen 3.002 N/A ASN 142.A ND2 ASP 137.A O no hydrogen 2.723 N/A ASN 142.A ND2 ASP 137.A OD2 no hydrogen 3.239 N/A VAL 143.A N ALA 140.A O no hydrogen 3.167 N/A LEU 144.A N LYS 152.A O no hydrogen 2.802 N/A LEU 145.A N GLY 98.A O no hydrogen 2.842 N/A SER 146.A N ASP 150.A O no hydrogen 2.909 N/A SER 146.A OG ASP 150.A OD2 no hydrogen 2.745 N/A GLN 148.A N SER 146.A OG no hydrogen 3.101 N/A GLY 149.A N SER 146.A O no hydrogen 3.137 N/A ASP 150.A N SER 146.A OG no hydrogen 3.105 N/A LYS 152.A N LEU 144.A O no hydrogen 2.771 N/A LYS 152.A NZ PRO 73.A O no hydrogen 3.323 N/A LYS 152.A NZ GLU 93.A OE1 no hydrogen 2.667 N/A LEU 153.A N TYR 74.A O no hydrogen 2.922 N/A ALA 154.A N ASN 142.A O no hydrogen 2.930 N/A ALA 159.A N PHE 156.A O no hydrogen 3.140 N/A GLY 160.A N ILE 134.A O no hydrogen 2.769 N/A GLN 161.A NE2 GLU 131.A O no hydrogen 3.376 N/A GLN 161.A NE2 LEU 162.A O no hydrogen 3.087 N/A LEU 162.A N ARG 132.A O no hydrogen 2.851 N/A THR 163.A N GLN 166.A O no hydrogen 2.907 N/A GLN 166.A N THR 163.A OG1 no hydrogen 2.989 N/A LYS 168.A NZ ASP 189.A OD2 no hydrogen 2.857 N/A ARG 169.A N TYR 188.A O no hydrogen 2.860 N/A THR 174.A OG1 ASP 137.A OD1 no hydrogen 2.692 N/A TRP 177.A N THR 174.A O no hydrogen 3.000 N/A TRP 177.A NE1 GLU 203.A OE1 no hydrogen 2.821 N/A MET 178.A N PRO 175.A O no hydrogen 3.353 N/A GLU 181.A N GLU 181.A OE1 no hydrogen 2.762 N/A VAL 182.A N ALA 179.A O no hydrogen 3.053 N/A ILE 183.A N ALA 179.A O no hydrogen 3.247 N/A LYS 184.A N PRO 180.A O no hydrogen 3.115 N/A GLN 185.A N VAL 182.A O no hydrogen 2.963 N/A SER 186.A N GLU 181.A O no hydrogen 2.965 N/A TYR 188.A N ARG 169.A O no hydrogen 2.780 N/A LYS 191.A N ASP 189.A OD1 no hydrogen 3.074 N/A LYS 191.A NZ PRO 251.A O.A no hydrogen 3.021 N/A LYS 191.A NZ PRO 251.A O.B no hydrogen 2.985 N/A LYS 191.A NZ ARG 254.A O no hydrogen 3.043 N/A ALA 192.A N ASP 189.A O no hydrogen 3.100 N/A ASP 193.A N PHE 190.A O.A no hydrogen 2.995 N/A ASP 193.A N PHE 190.A O.B no hydrogen 3.089 N/A TRP 195.A N LYS 191.A O no hydrogen 3.229 N/A SER 196.A N ALA 192.A O no hydrogen 3.126 N/A SER 196.A OG TRP 177.A O no hydrogen 2.646 N/A SER 196.A OG ALA 192.A O no hydrogen 3.305 N/A LEU 197.A N ASP 193.A O no hydrogen 2.786 N/A GLY 198.A N ILE 194.A O no hydrogen 3.082 N/A ILE 199.A N TRP 195.A O no hydrogen 3.116 N/A THR 200.A N SER 196.A O no hydrogen 2.992 N/A THR 200.A OG1 SER 196.A O no hydrogen 2.907 N/A ALA 201.A N LEU 197.A O no hydrogen 2.804 N/A ILE 202.A N GLY 198.A O no hydrogen 3.265 N/A GLU 203.A N ILE 199.A O no hydrogen 2.909 N/A LEU 204.A N THR 200.A O no hydrogen 2.779 N/A ALA 205.A N ALA 201.A O no hydrogen 3.188 N/A LYS 206.A N ILE 202.A O no hydrogen 2.811 N/A LYS 206.A NZ GLU 232.A O no hydrogen 2.660 N/A LYS 206.A NZ HIS 235.A NE2 no hydrogen 3.349 N/A GLY 207.A N GLU 203.A O no hydrogen 2.685 N/A SER 212.A OG PRO 209.A O no hydrogen 2.708 N/A LEU 214.A N ASN 211.A O no hydrogen 3.098 N/A MET 217.A N HIS 215.A ND1 no hydrogen 3.128 N/A ARG 218.A N HIS 215.A O no hydrogen 2.851 N/A VAL 219.A N HIS 215.A O no hydrogen 3.091 N/A LEU 220.A N PRO 216.A O no hydrogen 3.136 N/A PHE 221.A N MET 217.A O no hydrogen 3.393 N/A LEU 222.A N ARG 218.A O no hydrogen 3.004 N/A ILE 223.A N VAL 219.A O no hydrogen 2.909 N/A LYS 225.A N LEU 222.A O no hydrogen 3.018 N/A LYS 225.A NZ PHE 221.A O no hydrogen 3.014 N/A ASN 226.A N LEU 222.A O no hydrogen 2.781 N/A HIS 235.A N GLY 233.A O no hydrogen 3.183 N/A SER 236.A N GLU 111.A OE2 no hydrogen 2.855 N/A SER 236.A OG GLU 111.A OE1 no hydrogen 2.575 N/A LYS 240.A N SER 236.A O no hydrogen 3.013 N/A LYS 240.A NZ GLY 233.A O no hydrogen 2.855 N/A GLU 241.A N LYS 237.A O no hydrogen 2.947 N/A PHE 242.A N PRO 238.A O no hydrogen 3.051 N/A VAL 243.A N PHE 239.A O no hydrogen 3.189 N/A GLU 244.A N LYS 240.A O no hydrogen 3.110 N/A ALA 245.A N GLU 241.A O no hydrogen 2.967 N/A CYS 246.A N PHE 242.A O no hydrogen 3.195 N/A CYS 246.A SG PHE 242.A O no hydrogen 3.508 N/A LEU 247.A N VAL 243.A O no hydrogen 2.935 N/A LYS 249.A NZ PRO 224.A O no hydrogen 2.806 N/A LYS 249.A NZ ASN 226.A O no hydrogen 2.945 N/A ASP 250.A N ASN 248.A OD1 no hydrogen 2.992 N/A ARG 252.A N ASP 250.A OD1 no hydrogen 3.077 N/A ARG 252.A NE ASP 250.A OD1 no hydrogen 3.110 N/A ARG 252.A NE ASP 250.A OD2 no hydrogen 3.288 N/A ARG 252.A NH2 ASP 250.A OD2 no hydrogen 2.807 N/A PHE 253.A N ASP 250.A O no hydrogen 3.239 N/A ARG 254.A N PRO 251.A O.A no hydrogen 3.034 N/A ARG 254.A N PRO 251.A O.B no hydrogen 3.124 N/A ARG 254.A NE ASN 248.A O no hydrogen 2.714 N/A ARG 254.A NH1 GLU 181.A OE1 no hydrogen 3.531 N/A ARG 254.A NH1 GLU 181.A OE2 no hydrogen 2.778 N/A ARG 254.A NH1 LYS 191.A O no hydrogen 2.845 N/A ARG 254.A NH2 GLU 181.A OE1 no hydrogen 2.839 N/A ARG 254.A NH2 ASN 248.A O no hydrogen 3.167 N/A ARG 254.A NH2 LYS 249.A O no hydrogen 3.405 N/A THR 256.A N GLU 259.A OE1 no hydrogen 3.084 N/A THR 256.A OG1 GLU 259.A OE1 no hydrogen 3.514 N/A GLU 259.A N THR 256.A OG1 no hydrogen 3.179 N/A LEU 260.A N THR 256.A O no hydrogen 2.976 N/A LEU 261.A N ALA 257.A O no hydrogen 2.992 N/A LYS 262.A N GLU 259.A O no hydrogen 2.920 N/A HIS 263.A N LEU 260.A O no hydrogen 3.017 N/A PHE 265.A N HIS 263.A ND1 no hydrogen 3.121 N/A THR 267.A N HIS 263.A O no hydrogen 2.953 N/A THR 267.A OG1 HIS 263.A O no hydrogen 3.376 N/A THR 267.A OG1 LYS 264.A O no hydrogen 3.451 N/A ARG 268.A N LYS 264.A O no hydrogen 2.801 N/A PHE 275.A N LYS 272.A O no hydrogen 3.048 N/A LEU 276.A N THR 273.A O no hydrogen 3.023 N/A THR 277.A N SER 274.A O no hydrogen 3.123 N/A THR 277.A OG1 SER 274.A O no hydrogen 2.723 N/A GLU 278.A N PHE 275.A O no hydrogen 3.445 N/A LEU 279.A N LEU 276.A O no hydrogen 2.934 N/A ILE 280.A N LEU 276.A O no hydrogen 3.358 N/A ASP 281.A N THR 277.A O no hydrogen 2.866 N/A ARG 282.A N GLU 278.A O no hydrogen 2.966 N/A ARG 282.A NH1 PRO 108.A O no hydrogen 3.033 N/A ARG 282.A NH2 LEU 103.A O no hydrogen 2.785 N/A ARG 282.A NH2 GLY 107.A O no hydrogen 2.923 N/A TYR 283.A N LEU 279.A O no hydrogen 3.032 N/A LYS 284.A N ILE 280.A O no hydrogen 2.947 N/A LYS 284.A NZ GLU 147.A OE2 no hydrogen 2.810 N/A ARG 285.A N ASP 281.A O no hydrogen 2.928 N/A TRP 286.A N ARG 282.A O no hydrogen 3.055 N/A LYS 287.A N TYR 283.A O no hydrogen 2.853 N/A SER 288.A N LYS 284.A O no hydrogen 3.105 N/A