Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 2xnm_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): SER 1.A OG ASP 70.A OD1 no hydrogen 2.746 N/A SER 1.A OG ASP 70.A OD2 no hydrogen 3.220 N/A ARG 2.A N ASP 5.A OD2 no hydrogen 3.135 N/A GLU 4.A N GLU 4.A OE2 no hydrogen 3.002 N/A ASP 5.A N ARG 2.A O no hydrogen 2.918 N/A TYR 6.A N ALA 3.A O no hydrogen 2.871 N/A TYR 6.A OH ASP 70.A OD2 no hydrogen 3.029 N/A GLU 7.A N ARG 24.A O no hydrogen 2.957 N/A LEU 9.A N LYS 22.A O no hydrogen 2.794 N/A TYR 10.A N LYS 22.A O no hydrogen 3.391 N/A ILE 12.A N CYS 20.A O no hydrogen 2.784 N/A GLY 13.A N CYS 20.A O no hydrogen 3.168 N/A GLY 15.A N GLY 18.A O no hydrogen 2.823 N/A TYR 17.A N LEU 155.A O no hydrogen 2.976 N/A ARG 19.A N GLU 36.A O no hydrogen 3.186 N/A ARG 19.A NE GLU 36.A OE1 no hydrogen 2.921 N/A ARG 19.A NH2 GLU 36.A OE1 no hydrogen 3.016 N/A CYS 20.A N GLY 13.A O no hydrogen 2.885 N/A GLN 21.A N TRP 34.A O no hydrogen 2.939 N/A GLN 21.A NE2 THR 11.A OG1 no hydrogen 3.124 N/A LYS 22.A N TYR 10.A O no hydrogen 2.849 N/A LYS 22.A NZ TYR 10.A OH no hydrogen 3.257 N/A LYS 22.A NZ TYR 86.A OH no hydrogen 3.143 N/A ILE 23.A N LEU 32.A O no hydrogen 2.946 N/A ARG 24.A N GLU 7.A O no hydrogen 2.886 N/A ARG 24.A NH2 GLU 7.A OE1 no hydrogen 3.127 N/A ARG 25.A N LYS 30.A O no hydrogen 2.819 N/A ARG 25.A NE ASP 28.A OD1 no hydrogen 3.005 N/A ARG 25.A NH2 ASP 28.A OD2 no hydrogen 2.717 N/A LYS 26.A N ASP 5.A O no hydrogen 2.943 N/A LYS 26.A NZ GLU 4.A O no hydrogen 3.168 N/A GLY 29.A N ARG 25.A O no hydrogen 2.734 N/A LYS 30.A N ASP 28.A OD1 no hydrogen 3.008 N/A LEU 32.A N ILE 23.A O no hydrogen 2.926 N/A VAL 33.A N MET 84.A O no hydrogen 2.924 N/A TRP 34.A N GLN 21.A O no hydrogen 2.856 N/A TRP 34.A NE1 GLN 21.A OE1 no hydrogen 2.899 N/A LYS 35.A N ILE 82.A O no hydrogen 2.869 N/A GLU 36.A N ARG 19.A O no hydrogen 2.762 N/A LEU 37.A N LEU 80.A O no hydrogen 2.802 N/A TYR 39.A N THR 78.A O no hydrogen 2.957 N/A GLY 40.A N ASP 38.A OD1 no hydrogen 2.884 N/A MET 42.A N TYR 39.A O no hydrogen 3.012 N/A THR 43.A N GLU 46.A OE1 no hydrogen 3.003 N/A GLU 46.A N THR 43.A OG1 no hydrogen 3.136 N/A LYS 47.A N THR 43.A O no hydrogen 2.969 N/A GLN 48.A N GLU 44.A O no hydrogen 2.860 N/A MET 49.A N ALA 45.A O no hydrogen 3.080 N/A LEU 50.A N LYS 47.A O no hydrogen 3.122 N/A VAL 51.A N LYS 47.A O no hydrogen 3.014 N/A SER 52.A N GLN 48.A O no hydrogen 3.043 N/A SER 52.A OG MET 49.A O no hydrogen 2.974 N/A GLU 53.A N MET 49.A O no hydrogen 3.234 N/A VAL 54.A N LEU 50.A O no hydrogen 2.978 N/A ASN 55.A N VAL 51.A O no hydrogen 2.967 N/A LEU 56.A N SER 52.A O no hydrogen 3.194 N/A LEU 57.A N GLU 53.A O no hydrogen 3.243 N/A ARG 58.A N VAL 54.A O no hydrogen 3.344 N/A ARG 58.A N ASN 55.A O no hydrogen 3.197 N/A GLU 59.A N LEU 56.A O no hydrogen 3.004 N/A ASN 64.A N HIS 62.A ND1 no hydrogen 2.898 N/A ASN 64.A ND2 GLN 117.A OE1 no hydrogen 2.866 N/A ASN 64.A ND2 VAL 144.A O no hydrogen 2.932 N/A ILE 65.A N HIS 62.A O no hydrogen 3.179 N/A VAL 66.A N LEU 146.A O no hydrogen 2.965 N/A ARG 67.A N GLU 85.A OE2 no hydrogen 2.868 N/A TYR 69.A N VAL 83.A O no hydrogen 2.779 N/A ASP 70.A N VAL 83.A O no hydrogen 3.378 N/A ARG 71.A N ASP 70.A OD1 no hydrogen 2.845 N/A ILE 72.A N TYR 81.A O no hydrogen 2.813 N/A ASP 74.A N THR 79.A O no hydrogen 2.824 N/A ASN 77.A N ASP 74.A OD2 no hydrogen 3.149 N/A THR 78.A OG1 ASP 38.A OD1 no hydrogen 2.980 N/A THR 78.A OG1 ASN 77.A O no hydrogen 2.841 N/A THR 79.A N ASP 74.A O no hydrogen 2.976 N/A THR 79.A OG1 ASN 77.A O no hydrogen 3.025 N/A LEU 80.A N LEU 37.A O no hydrogen 2.727 N/A TYR 81.A N ILE 72.A O no hydrogen 2.822 N/A TYR 81.A OH GLU 36.A OE2 no hydrogen 3.106 N/A ILE 82.A N LYS 35.A O no hydrogen 2.925 N/A VAL 83.A N ASP 70.A O no hydrogen 2.879 N/A MET 84.A N VAL 33.A O no hydrogen 2.865 N/A GLU 85.A N ARG 67.A O no hydrogen 2.945 N/A GLY 89.A N LEU 138.A O no hydrogen 2.804 N/A GLY 90.A N CYS 87.A O no hydrogen 2.970 N/A LEU 92.A N VAL 136.A O no hydrogen 2.785 N/A ALA 93.A N PRO 133.A O no hydrogen 3.139 N/A SER 94.A N ASP 91.A OD2 no hydrogen 3.227 N/A SER 94.A OG ASP 91.A OD1 no hydrogen 2.709 N/A VAL 95.A N ASP 91.A O no hydrogen 3.445 N/A ILE 96.A N LEU 92.A O no hydrogen 2.963 N/A THR 97.A N ALA 93.A O no hydrogen 2.976 N/A THR 97.A OG1 ALA 93.A O no hydrogen 3.188 N/A LYS 98.A N SER 94.A O no hydrogen 2.976 N/A GLY 99.A N VAL 95.A O no hydrogen 3.013 N/A THR 100.A N ILE 96.A O no hydrogen 2.845 N/A THR 100.A OG1 ILE 96.A O no hydrogen 2.824 N/A THR 100.A OG1 LEU 191.A O no hydrogen 3.530 N/A LYS 101.A N THR 97.A O no hydrogen 2.833 N/A GLU 102.A N LYS 98.A O no hydrogen 2.955 N/A ARG 103.A N THR 100.A O no hydrogen 3.451 N/A GLN 104.A N GLY 99.A O no hydrogen 2.968 N/A GLN 104.A NE2 TYR 105.A O no hydrogen 2.948 N/A VAL 111.A N ASP 107.A O no hydrogen 3.166 N/A LEU 112.A N GLU 108.A O no hydrogen 2.863 N/A ARG 113.A N GLU 109.A O no hydrogen 3.064 N/A VAL 114.A N PHE 110.A O no hydrogen 3.027 N/A MET 115.A N VAL 111.A O no hydrogen 2.898 N/A THR 116.A N LEU 112.A O no hydrogen 2.926 N/A THR 116.A OG1 LEU 112.A O no hydrogen 2.867 N/A GLN 117.A N ARG 113.A O no hydrogen 2.982 N/A GLN 117.A NE2 GLN 142.A O no hydrogen 3.347 N/A GLN 117.A NE2 HIS 254.A O no hydrogen 2.954 N/A LEU 118.A N VAL 114.A O no hydrogen 2.897 N/A THR 119.A N MET 115.A O no hydrogen 3.017 N/A THR 119.A OG1 MET 115.A O no hydrogen 2.692 N/A LEU 120.A N THR 116.A O no hydrogen 3.097 N/A ALA 121.A N GLN 117.A O no hydrogen 2.929 N/A LEU 122.A N LEU 118.A O no hydrogen 2.818 N/A LYS 123.A N THR 119.A O no hydrogen 2.934 N/A GLU 124.A N LEU 120.A O no hydrogen 3.065 N/A CYS 125.A N ALA 121.A O no hydrogen 3.007 N/A CYS 125.A SG ALA 121.A O no hydrogen 3.465 N/A HIS 126.A N LEU 122.A O no hydrogen 2.912 N/A HIS 126.A NE2 ASP 177.A OD2 no hydrogen 2.649 N/A ARG 127.A N LYS 123.A O no hydrogen 3.097 N/A ARG 128.A N GLU 124.A O no hydrogen 3.255 N/A ARG 129.A NE GLY 147.A O no hydrogen 2.987 N/A ARG 129.A NH2 LEU 146.A O no hydrogen 3.425 N/A ASN 135.A N LYS 132.A O no hydrogen 2.784 N/A VAL 136.A N PRO 133.A O no hydrogen 3.222 N/A PHE 137.A N LYS 145.A O no hydrogen 2.837 N/A LEU 138.A N GLY 90.A O no hydrogen 2.922 N/A ASP 139.A N ASN 143.A O no hydrogen 3.175 N/A LYS 141.A N ASP 139.A OD1 no hydrogen 2.811 N/A LYS 141.A NZ HIS 258.A O no hydrogen 2.722 N/A ASN 143.A N ASP 139.A OD1 no hydrogen 2.935 N/A ASN 143.A ND2 ASP 139.A OD2 no hydrogen 2.939 N/A ASN 143.A ND2 HIS 257.A O no hydrogen 2.866 N/A VAL 144.A N GLN 117.A OE1 no hydrogen 2.824 N/A LYS 145.A N PHE 137.A O no hydrogen 2.759 N/A LYS 145.A NZ PRO 63.A O no hydrogen 3.067 N/A LYS 145.A NZ GLU 85.A OE1 no hydrogen 2.537 N/A LYS 145.A NZ GLU 85.A OE2 no hydrogen 3.460 N/A LEU 146.A N ASN 64.A O no hydrogen 2.776 N/A GLY 147.A N ASN 135.A O no hydrogen 2.820 N/A GLY 150.A N ASP 148.A OD1 no hydrogen 3.389 N/A LEU 151.A N ASP 148.A O no hydrogen 2.949 N/A ARG 153.A N PHE 149.A O no hydrogen 3.134 N/A ILE 154.A N GLY 150.A O no hydrogen 3.134 N/A LEU 155.A N LEU 151.A O no hydrogen 3.169 N/A TYR 161.A N THR 159.A O no hydrogen 2.869 N/A TYR 162.A OH GLU 187.A OE1 no hydrogen 2.677 N/A MET 163.A N PRO 160.A O no hydrogen 3.106 N/A GLU 166.A N GLU 166.A OE1 no hydrogen 2.746 N/A GLN 167.A N SER 164.A OG no hydrogen 3.242 N/A MET 168.A N SER 164.A O no hydrogen 3.038 N/A ASN 169.A N GLU 166.A O no hydrogen 3.035 N/A SER 171.A OG GLN 167.A OE1 no hydrogen 2.871 N/A ASN 173.A ND2 ASP 235.A OD1 no hydrogen 2.748 N/A LYS 175.A N ASN 173.A OD1 no hydrogen 2.815 N/A LYS 175.A NZ ASP 235.A O no hydrogen 3.357 N/A LYS 175.A NZ ARG 238.A O no hydrogen 2.857 N/A SER 176.A N ASN 173.A O no hydrogen 2.950 N/A SER 176.A OG GLU 166.A OE2 no hydrogen 2.678 N/A SER 176.A OG ASN 173.A O no hydrogen 3.340 N/A ASP 177.A N GLU 174.A O no hydrogen 3.119 N/A ILE 178.A N LYS 175.A O no hydrogen 3.067 N/A TRP 179.A N LYS 175.A O no hydrogen 3.180 N/A SER 180.A N SER 176.A O no hydrogen 3.179 N/A SER 180.A OG TYR 162.A O no hydrogen 3.483 N/A SER 180.A OG SER 176.A O no hydrogen 3.408 N/A LEU 181.A N ASP 177.A O no hydrogen 2.946 N/A GLY 182.A N ILE 178.A O no hydrogen 2.863 N/A CYS 183.A N TRP 179.A O no hydrogen 2.937 N/A CYS 183.A SG TRP 179.A O no hydrogen 3.639 N/A LEU 184.A N SER 180.A O no hydrogen 2.970 N/A LEU 185.A N LEU 181.A O no hydrogen 2.903 N/A TYR 186.A N GLY 182.A O no hydrogen 2.841 N/A TYR 186.A OH ARG 213.A O no hydrogen 2.589 N/A GLU 187.A N CYS 183.A O no hydrogen 2.910 N/A LEU 188.A N LEU 184.A O no hydrogen 2.976 N/A CYS 189.A N LEU 185.A O no hydrogen 3.134 N/A CYS 189.A SG LEU 185.A O no hydrogen 3.426 N/A ALA 190.A N TYR 186.A O no hydrogen 2.759 N/A LEU 191.A N GLU 187.A O no hydrogen 2.651 N/A PHE 198.A N GLU 202.A OE1 no hydrogen 2.739 N/A GLU 202.A N SER 199.A OG no hydrogen 3.272 N/A LEU 203.A N SER 199.A O no hydrogen 3.016 N/A ALA 204.A N GLN 200.A O no hydrogen 2.844 N/A GLY 205.A N LYS 201.A O no hydrogen 3.167 N/A LYS 206.A N GLU 202.A O no hydrogen 3.135 N/A LYS 206.A NZ THR 196.A O no hydrogen 2.709 N/A ILE 207.A N LEU 203.A O no hydrogen 2.924 N/A ARG 208.A N ALA 204.A O no hydrogen 2.976 N/A ARG 208.A NH1 ASN 169.A OD1 no hydrogen 3.090 N/A GLU 209.A N GLY 205.A O no hydrogen 3.244 N/A GLY 210.A N LYS 206.A O no hydrogen 3.082 N/A ARG 214.A NH1 ILE 215.A O no hydrogen 2.829 N/A ARG 214.A NH1 TYR 219.A O no hydrogen 3.298 N/A ARG 214.A NH2 TYR 219.A O no hydrogen 2.906 N/A ARG 214.A NH2 ASP 221.A OD1 no hydrogen 2.856 N/A TYR 219.A N PRO 216.A O no hydrogen 2.964 N/A TYR 219.A OH LEU 106.A O no hydrogen 2.625 N/A SER 220.A N GLU 108.A OE1 no hydrogen 2.871 N/A SER 220.A OG GLU 108.A OE1 no hydrogen 3.491 N/A SER 220.A OG GLU 108.A OE2 no hydrogen 2.623 N/A GLU 222.A N GLU 222.A OE1 no hydrogen 2.744 N/A LEU 223.A N SER 220.A OG no hydrogen 2.987 N/A ASN 224.A N SER 220.A O no hydrogen 2.948 N/A GLU 225.A N ASP 221.A O no hydrogen 2.878 N/A ILE 226.A N GLU 222.A O no hydrogen 3.144 N/A ILE 227.A N LEU 223.A O no hydrogen 3.124 N/A THR 228.A N ASN 224.A O no hydrogen 2.835 N/A THR 228.A OG1 ASN 224.A O no hydrogen 2.811 N/A ARG 229.A N GLU 225.A O no hydrogen 2.966 N/A MET 230.A N ILE 226.A O no hydrogen 3.131 N/A LEU 231.A N ILE 227.A O no hydrogen 3.220 N/A LEU 231.A N THR 228.A O no hydrogen 3.071 N/A ASN 232.A N ARG 229.A O no hydrogen 3.181 N/A LYS 234.A N ASN 232.A OD1 no hydrogen 2.932 N/A HIS 237.A N LYS 234.A O no hydrogen 3.045 N/A ARG 238.A N ASP 235.A O no hydrogen 3.154 N/A ARG 238.A NE ASN 232.A O no hydrogen 2.904 N/A ARG 238.A NH1 GLU 166.A OE1 no hydrogen 3.397 N/A ARG 238.A NH1 GLU 166.A OE2 no hydrogen 2.590 N/A ARG 238.A NH1 LYS 175.A O no hydrogen 3.052 N/A ARG 238.A NH2 GLU 166.A OE1 no hydrogen 2.789 N/A ARG 238.A NH2 ASN 232.A O no hydrogen 3.287 N/A SER 240.A N GLU 243.A OE2 no hydrogen 3.007 N/A SER 240.A OG.A GLU 242.A OE2 no hydrogen 3.565 N/A SER 240.A OG.B GLU 242.A OE2 no hydrogen 2.515 N/A GLU 242.A N GLU 242.A OE2 no hydrogen 2.828 N/A GLU 243.A N SER 240.A OG.A no hydrogen 3.017 N/A ILE 244.A N SER 240.A O no hydrogen 2.873 N/A LEU 245.A N VAL 241.A O no hydrogen 3.007 N/A GLU 246.A N GLU 242.A O no hydrogen 3.099 N/A ASN 247.A N ILE 244.A O no hydrogen 2.962 N/A LEU 249.A N ASN 247.A OD1 no hydrogen 2.898 N/A ILE 250.A N ASN 247.A O no hydrogen 3.041 N/A LEU 251.A N HIS 254.A ND1 no hydrogen 2.991 N/A HIS 253.A NE2 GLU 109.A OE2 no hydrogen 2.722 N/A HIS 254.A N LEU 251.A O no hydrogen 3.017 N/A HIS 254.A NE2 GLU 109.A OE1 no hydrogen 2.960 N/A HIS 255.A N GLU 252.A O no hydrogen 2.970 N/A HIS 255.A ND1 LEU 251.A O no hydrogen 2.915 N/A HIS 257.A N ASN 143.A OD1 no hydrogen 2.863 N/A HIS 257.A NE2 GLU 252.A OE2 no hydrogen 2.805 N/A