Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 2xxx_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): LEU 2.A N THR 46.A O no hydrogen 2.764 N/A ILE 3.A N ASP 80.A OD2 no hydrogen 2.852 N/A VAL 4.A N GLU 48.A O no hydrogen 2.862 N/A THR 5.A N LEU 81.A O no hydrogen 2.900 N/A THR 6.A N ARG 50.A O no hydrogen 3.168 N/A THR 6.A OG1 VAL 83.A O no hydrogen 2.782 N/A ILE 7.A N THR 6.A OG1 no hydrogen 2.781 N/A GLU 9.A N VAL 13.A O no hydrogen 2.874 N/A TYR 12.A OH THR 190.A OG1 no hydrogen 3.076 N/A VAL 13.A N GLU 9.A O no hydrogen 2.837 N/A LEU 14.A N GLU 29.A O no hydrogen 2.885 N/A LYS 16.A N ARG 27.A O no hydrogen 2.757 N/A SER 18.A OG LYS 20.A O no hydrogen 2.772 N/A ASN 25.A ND2 TYR 47.A O no hydrogen 2.920 N/A ASP 26.A N TYR 23.A O no hydrogen 3.199 N/A ARG 27.A N GLY 24.A O no hydrogen 3.151 N/A ARG 27.A NE GLY 24.A O no hydrogen 2.747 N/A PHE 28.A N ASN 25.A O no hydrogen 3.077 N/A GLU 29.A N LEU 14.A O no hydrogen 2.954 N/A TYR 31.A N PRO 11.A O no hydrogen 3.026 N/A CYS 32.A N TYR 12.A O no hydrogen 2.931 N/A ASP 34.A N GLY 30.A O no hydrogen 2.918 N/A LEU 35.A N TYR 31.A O no hydrogen 2.902 N/A LEU 36.A N CYS 32.A O no hydrogen 2.882 N/A ARG 37.A N ILE 33.A O no hydrogen 2.978 N/A GLU 38.A N ASP 34.A O no hydrogen 3.010 N/A LEU 39.A N LEU 35.A O no hydrogen 2.886 N/A SER 40.A N LEU 36.A O no hydrogen 2.899 N/A SER 40.A OG PHE 45.A O no hydrogen 2.556 N/A THR 41.A N ARG 37.A O no hydrogen 3.052 N/A THR 41.A OG1 ARG 37.A O no hydrogen 3.137 N/A ILE 42.A N GLU 38.A O no hydrogen 2.973 N/A LEU 43.A N LEU 39.A O no hydrogen 2.943 N/A GLY 44.A N SER 40.A O no hydrogen 2.787 N/A PHE 45.A N SER 40.A O no hydrogen 3.176 N/A GLU 48.A N LEU 2.A O no hydrogen 2.779 N/A ILE 49.A N ASN 25.A OD1 no hydrogen 2.917 N/A ARG 50.A N VAL 4.A O no hydrogen 2.729 N/A ARG 50.A NE GLU 48.A OE2 no hydrogen 3.021 N/A VAL 52.A N THR 6.A O no hydrogen 2.871 N/A GLY 55.A N VAL 52.A O no hydrogen 3.189 N/A LYS 56.A N ASP 54.A OD1 no hydrogen 3.136 N/A LYS 56.A NZ ASP 136.A OD2 no hydrogen 3.511 N/A TYR 57.A OH GLU 9.A OE1 no hydrogen 2.568 N/A GLY 58.A N ASP 136.A O no hydrogen 3.221 N/A ALA 59.A N ASN 68.A OD1 no hydrogen 2.819 N/A GLN 60.A NE2 GLY 65.A O no hydrogen 3.002 N/A ASP 61.A N GLN 66.A O no hydrogen 2.714 N/A ASN 64.A N ASP 61.A OD1 no hydrogen 2.895 N/A GLY 65.A N ASP 61.A O no hydrogen 2.979 N/A GLN 66.A N ASN 64.A OD1 no hydrogen 2.879 N/A ASN 68.A N ALA 59.A O no hydrogen 3.133 N/A GLY 69.A N ASP 54.A OD2 no hydrogen 2.812 N/A MET 70.A N LYS 56.A O no hydrogen 3.132 N/A VAL 71.A N TYR 57.A O no hydrogen 3.312 N/A ARG 72.A N ASN 68.A O no hydrogen 3.187 N/A ARG 72.A NE ASP 76.A OD2 no hydrogen 2.570 N/A ARG 72.A NH1 TRP 67.A O no hydrogen 2.940 N/A GLU 73.A N GLY 69.A O no hydrogen 3.366 N/A LEU 74.A N MET 70.A O no hydrogen 3.103 N/A ILE 75.A N VAL 71.A O no hydrogen 2.901 N/A ASP 76.A N ARG 72.A O no hydrogen 2.909 N/A HIS 77.A N LEU 74.A O no hydrogen 2.941 N/A LYS 78.A N GLU 73.A O no hydrogen 2.786 N/A ALA 79.A N GLU 73.A O no hydrogen 3.393 N/A ASP 80.A N ILE 3.A O no hydrogen 2.849 N/A LEU 81.A N ILE 3.A O no hydrogen 3.298 N/A ALA 82.A N GLY 216.A O no hydrogen 2.788 N/A VAL 83.A N THR 5.A O no hydrogen 3.263 N/A LEU 86.A N ALA 84.A O no hydrogen 2.655 N/A ILE 88.A N GLY 212.A O no hydrogen 2.835 N/A ARG 92.A N THR 89.A OG1 no hydrogen 3.283 N/A ARG 92.A NH1 ALA 87.A O no hydrogen 3.081 N/A ARG 92.A NH2 GLY 58.A O no hydrogen 2.874 N/A GLU 93.A N THR 89.A O no hydrogen 2.959 N/A VAL 95.A N ARG 92.A O no hydrogen 2.912 N/A ILE 96.A N ARG 92.A O no hydrogen 2.792 N/A ASP 97.A N THR 217.A O no hydrogen 2.967 N/A SER 99.A N VAL 215.A O no hydrogen 2.874 N/A SER 99.A OG LYS 100.A O no hydrogen 2.775 N/A LYS 100.A N THR 228.A OG1 no hydrogen 2.946 N/A PHE 102.A N TYR 213.A O no hydrogen 2.820 N/A LEU 105.A N LYS 211.A O no hydrogen 2.820 N/A GLY 106.A N SER 188.A OG no hydrogen 2.976 N/A ILE 107.A N ASP 209.A OD1 no hydrogen 2.848 N/A SER 108.A N MET 186.A O no hydrogen 2.726 N/A SER 108.A OG ILE 204.A O no hydrogen 3.491 N/A SER 108.A OG GLY 206.A O no hydrogen 2.807 N/A ILE 109.A N SER 108.A OG no hydrogen 2.730 N/A LEU 110.A N PHE 184.A O no hydrogen 2.735 N/A TYR 111.A N THR 202.A O no hydrogen 3.172 N/A TYR 111.A OH ASP 181.A OD1 no hydrogen 2.667 N/A ARG 112.A NH1 ASP 181.A OD1 no hydrogen 2.856 N/A LYS 113.A N ASN 200.A O no hydrogen 3.041 N/A LYS 113.A NZ CYS 199.A O no hydrogen 2.884 N/A ASP 118.A N ASP 122.A OD2 no hydrogen 2.901 N/A ASP 122.A N SER 119.A OG no hydrogen 3.295 N/A LEU 123.A N SER 119.A O no hydrogen 3.466 N/A ALA 124.A N ALA 120.A O no hydrogen 2.875 N/A LYS 125.A N ASP 121.A O no hydrogen 3.236 N/A LYS 125.A NZ ASP 121.A OD2 no hydrogen 3.517 N/A GLN 126.A N LEU 123.A O no hydrogen 3.302 N/A GLN 126.A NE2 LEU 123.A O no hydrogen 2.786 N/A GLN 126.A NE2 ILE 129.A O no hydrogen 2.951 N/A LYS 128.A NZ ASP 181.A OD2 no hydrogen 3.288 N/A ILE 129.A N GLN 126.A OE1 no hydrogen 2.624 N/A GLU 130.A N ASP 181.A O no hydrogen 3.172 N/A GLY 132.A N ALA 183.A O no hydrogen 3.346 N/A GLU 135.A N VAL 167.A O no hydrogen 2.825 N/A GLY 137.A N VAL 134.A O no hydrogen 3.279 N/A THR 141.A N GLY 137.A O no hydrogen 3.158 N/A THR 141.A OG1 GLY 137.A O no hydrogen 2.981 N/A PHE 142.A N ALA 138.A O no hydrogen 2.878 N/A PHE 143.A N THR 139.A O no hydrogen 3.226 N/A LYS 144.A N MET 140.A O no hydrogen 2.943 N/A LYS 144.A NZ ASP 62.A OD1 no hydrogen 2.528 N/A LYS 144.A NZ ASP 62.A OD2 no hydrogen 2.847 N/A LYS 145.A N THR 141.A O no hydrogen 3.038 N/A LYS 145.A N PHE 142.A O no hydrogen 3.203 N/A SER 146.A N PHE 143.A O no hydrogen 3.396 N/A ILE 148.A N SER 146.A OG no hydrogen 3.226 N/A ASP 152.A N ILE 148.A O no hydrogen 2.898 N/A LYS 153.A N SER 149.A O no hydrogen 3.011 N/A LYS 153.A NZ ALA 124.A O no hydrogen 3.169 N/A MET 154.A N THR 150.A O no hydrogen 2.967 N/A TRP 155.A N TYR 151.A O no hydrogen 2.811 N/A ALA 156.A N ASP 152.A O no hydrogen 2.915 N/A PHE 157.A N LYS 153.A O no hydrogen 2.974 N/A MET 158.A N MET 154.A O no hydrogen 2.829 N/A SER 159.A N TRP 155.A O no hydrogen 2.869 N/A SER 159.A OG TRP 155.A O no hydrogen 2.777 N/A SER 159.A OG ALA 156.A O no hydrogen 3.235 N/A SER 160.A N ALA 156.A O no hydrogen 3.244 N/A SER 160.A OG ALA 156.A O no hydrogen 3.204 N/A SER 160.A OG PHE 157.A O no hydrogen 3.022 N/A ARG 161.A N PHE 157.A O no hydrogen 3.306 N/A ARG 161.A N MET 158.A O no hydrogen 3.205 N/A SER 164.A N ARG 161.A O no hydrogen 2.779 N/A SER 164.A OG ARG 161.A O no hydrogen 3.207 N/A VAL 165.A N ARG 161.A O no hydrogen 3.077 N/A LEU 166.A N ARG 162.A O no hydrogen 3.408 N/A VAL 167.A N ALA 133.A O no hydrogen 3.029 N/A LYS 168.A N GLU 172.A OE1 no hydrogen 2.898 N/A ASN 170.A ND2 GLU 9.A OE1 no hydrogen 2.920 N/A ASN 170.A ND2 GLU 9.A OE2 no hydrogen 3.237 N/A GLU 172.A N SER 169.A OG no hydrogen 3.212 N/A GLY 173.A N SER 169.A O no hydrogen 3.133 N/A ILE 174.A N ASN 170.A O no hydrogen 2.856 N/A GLN 175.A N GLU 171.A O no hydrogen 2.929 N/A ARG 176.A N GLU 172.A O no hydrogen 2.937 N/A ARG 176.A NH2 GLU 172.A OE2 no hydrogen 3.385 N/A VAL 177.A N GLY 173.A O no hydrogen 3.111 N/A LEU 178.A N ILE 174.A O no hydrogen 2.955 N/A THR 179.A N GLN 175.A O no hydrogen 2.955 N/A THR 179.A N ARG 176.A O no hydrogen 3.303 N/A THR 179.A OG1 GLN 175.A O no hydrogen 2.863 N/A SER 180.A OG ARG 176.A O no hydrogen 2.777 N/A TYR 182.A OH VAL 165.A O no hydrogen 2.677 N/A ALA 183.A N GLU 130.A O no hydrogen 2.780 N/A PHE 184.A N LEU 110.A O no hydrogen 2.787 N/A LEU 185.A N GLY 132.A O no hydrogen 2.857 N/A MET 186.A N SER 108.A O no hydrogen 2.911 N/A SER 188.A N GLY 106.A O no hydrogen 2.771 N/A SER 188.A OG GLY 106.A O no hydrogen 3.075 N/A THR 189.A OG1 TYR 12.A OH no hydrogen 3.029 N/A THR 189.A OG1 TYR 213.A OH no hydrogen 3.121 N/A THR 190.A OG1 TYR 12.A OH no hydrogen 3.076 N/A ILE 191.A N GLU 187.A O no hydrogen 3.022 N/A GLU 192.A N SER 188.A O no hydrogen 2.975 N/A PHE 193.A N THR 189.A O no hydrogen 3.313 N/A VAL 194.A N THR 190.A O no hydrogen 2.937 N/A THR 195.A N ILE 191.A O no hydrogen 2.808 N/A THR 195.A OG1 ILE 191.A O no hydrogen 2.984 N/A THR 195.A OG1 GLU 192.A O no hydrogen 3.376 N/A GLN 196.A N GLU 192.A O no hydrogen 3.244 N/A GLN 196.A N PHE 193.A O no hydrogen 3.207 N/A ARG 197.A N VAL 194.A O no hydrogen 3.182 N/A ARG 197.A NH1 PHE 193.A O no hydrogen 3.285 N/A ARG 197.A NH1 GLN 196.A OE1 no hydrogen 3.173 N/A ARG 197.A NH2 TRP 248.A O no hydrogen 3.329 N/A ASN 198.A ND2 VAL 194.A O no hydrogen 3.195 N/A LEU 201.A N ASN 198.A O no hydrogen 2.950 N/A THR 202.A N TYR 111.A O no hydrogen 2.965 N/A THR 202.A OG1 GLN 203.A O no hydrogen 3.106 N/A GLN 203.A NE2 GLY 205.A O no hydrogen 2.981 N/A ILE 204.A N ILE 109.A O no hydrogen 2.702 N/A ILE 208.A N ILE 107.A O no hydrogen 2.713 N/A LYS 211.A N LEU 105.A O no hydrogen 2.917 N/A TYR 213.A N MET 103.A O no hydrogen 2.867 N/A TYR 213.A OH GLU 187.A OE1 no hydrogen 2.560 N/A TYR 213.A OH THR 189.A OG1 no hydrogen 3.121 N/A GLY 214.A N LEU 86.A O no hydrogen 3.199 N/A VAL 215.A N SER 99.A OG no hydrogen 2.999 N/A GLY 216.A N ALA 82.A O no hydrogen 2.976 N/A THR 217.A N ASP 97.A O no hydrogen 2.974 N/A THR 217.A OG1 PRO 218.A O no hydrogen 3.069 N/A GLY 220.A N ASP 97.A OD2 no hydrogen 2.883 N/A SER 221.A N PRO 218.A O no hydrogen 3.066 N/A TYR 223.A N SER 221.A OG no hydrogen 3.107 N/A ILE 227.A N TYR 223.A O no hydrogen 2.777 N/A THR 228.A N ARG 224.A O no hydrogen 2.808 N/A THR 228.A OG1 ARG 224.A O no hydrogen 3.306 N/A ILE 229.A N LYS 225.A O no hydrogen 3.039 N/A ALA 230.A N LYS 226.A O no hydrogen 3.011 N/A ILE 231.A N ILE 227.A O no hydrogen 2.811 N/A LEU 232.A N THR 228.A O no hydrogen 2.997 N/A GLN 233.A N ILE 229.A O no hydrogen 3.024 N/A LEU 234.A N ALA 230.A O no hydrogen 2.836 N/A GLN 235.A N ILE 231.A O no hydrogen 2.792 N/A GLU 236.A N LEU 232.A O no hydrogen 2.925 N/A GLU 237.A N GLN 233.A O no hydrogen 2.978 N/A GLY 238.A N GLN 235.A O no hydrogen 3.094 N/A LYS 239.A N LEU 234.A O no hydrogen 3.019 N/A MET 242.A N GLY 238.A O no hydrogen 3.015 N/A MET 243.A N LYS 239.A O no hydrogen 2.932 N/A LYS 244.A N LEU 240.A O no hydrogen 2.977 N/A GLU 245.A N HIS 241.A O no hydrogen 3.001 N/A LYS 246.A N MET 242.A O no hydrogen 3.054 N/A LYS 246.A NZ ASP 34.A OD2 no hydrogen 2.810 N/A TRP 247.A N MET 243.A O no hydrogen 3.188 N/A TRP 247.A NE1 ASP 34.A OD2 no hydrogen 2.728 N/A TRP 248.A N LYS 244.A O no hydrogen 2.904 N/A TRP 248.A NE1 THR 189.A O no hydrogen 2.927 N/A