Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 2yis_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ARG 1.A NH1 PRO 2.A O no hydrogen 3.084 N/A ARG 1.A NH2 PRO 85.A O no hydrogen 2.669 N/A THR 3.A N GLU 18.A OE2 no hydrogen 3.215 N/A TYR 5.A N VAL 16.A O no hydrogen 2.993 N/A TYR 5.A OH TYR 20.A O no hydrogen 2.722 N/A LEU 9.A N THR 12.A O no hydrogen 2.840 N/A THR 12.A N LEU 9.A O no hydrogen 3.385 N/A THR 12.A OG1 ASN 10.A O no hydrogen 3.297 N/A TRP 14.A N GLN 7.A O no hydrogen 2.714 N/A GLU 15.A N TYR 96.A OH no hydrogen 2.822 N/A VAL 16.A N TYR 5.A O no hydrogen 3.386 N/A GLU 18.A N THR 3.A O no hydrogen 2.781 N/A ARG 19.A N GLU 18.A OE1 no hydrogen 2.768 N/A ARG 19.A NE ASP 36.A OD1 no hydrogen 3.017 N/A ARG 19.A NH2 ASP 36.A OD1 no hydrogen 2.927 N/A ARG 19.A NH2 ASP 36.A OD2 no hydrogen 2.792 N/A TYR 20.A N PRO 17.A O no hydrogen 3.165 N/A TYR 20.A OH ASP 81.A OD2 no hydrogen 2.582 N/A GLN 21.A N PHE 35.A O no hydrogen 2.904 N/A GLN 21.A NE2 GLU 18.A O no hydrogen 2.788 N/A SER 24.A N ALA 33.A O no hydrogen 2.884 N/A VAL 26.A N VAL 31.A O no hydrogen 2.968 N/A GLY 27.A N VAL 31.A O no hydrogen 3.433 N/A SER 28.A OG SER 30.A OG no hydrogen 2.685 N/A SER 30.A N LYS 47.A O no hydrogen 3.055 N/A SER 30.A OG SER 28.A OG no hydrogen 2.685 N/A VAL 31.A N GLY 27.A O no hydrogen 2.858 N/A CYS 32.A N VAL 45.A O no hydrogen 2.865 N/A ALA 33.A N SER 24.A O no hydrogen 2.694 N/A ALA 34.A N VAL 43.A O no hydrogen 2.847 N/A PHE 35.A N GLN 21.A O no hydrogen 2.691 N/A ASP 36.A N LEU 41.A O no hydrogen 2.916 N/A THR 37.A N ARG 19.A O no hydrogen 2.849 N/A LYS 38.A N ASP 36.A OD1 no hydrogen 3.141 N/A THR 39.A N ASP 36.A O no hydrogen 3.237 N/A THR 39.A OG1 ASP 36.A O no hydrogen 3.530 N/A THR 39.A OG1 ASP 36.A OD2 no hydrogen 2.787 N/A GLY 40.A N ASP 36.A O no hydrogen 2.670 N/A LEU 41.A N THR 39.A OG1 no hydrogen 3.379 N/A ARG 42.A NH2 ASN 22.A O no hydrogen 3.433 N/A VAL 43.A N ALA 34.A O no hydrogen 2.813 N/A ALA 44.A N THR 99.A O no hydrogen 2.727 N/A VAL 45.A N CYS 32.A O no hydrogen 2.813 N/A LYS 46.A N LEU 97.A O no hydrogen 2.798 N/A LYS 46.A NZ GLU 64.A OE1 no hydrogen 2.649 N/A LYS 46.A NZ GLU 64.A OE2 no hydrogen 3.084 N/A LYS 47.A N SER 30.A O no hydrogen 2.762 N/A LYS 47.A NZ ILE 13.A O no hydrogen 2.795 N/A LEU 48.A N VAL 95.A O no hydrogen 2.846 N/A ARG 50.A NH1 GLN 53.A OE1 no hydrogen 2.946 N/A GLN 53.A N ARG 50.A O no hydrogen 3.387 N/A HIS 57.A N SER 54.A OG no hydrogen 3.187 N/A ALA 58.A N SER 54.A O no hydrogen 2.916 N/A LYS 59.A N ILE 55.A O no hydrogen 2.903 N/A LYS 59.A NZ GLU 301.A O no hydrogen 2.767 N/A LYS 59.A NZ ARG 303.A O no hydrogen 2.997 N/A ARG 60.A N ILE 56.A O no hydrogen 2.857 N/A THR 61.A N HIS 57.A O no hydrogen 2.773 N/A THR 61.A OG1 PRO 51.A O no hydrogen 2.717 N/A THR 61.A OG1 HIS 57.A O no hydrogen 2.737 N/A TYR 62.A N ALA 58.A O no hydrogen 2.975 N/A ARG 63.A N LYS 59.A O no hydrogen 2.766 N/A ARG 63.A NE GLU 301.A OE1 no hydrogen 3.153 N/A ARG 63.A NE GLU 301.A OE2 no hydrogen 2.760 N/A ARG 63.A NH2 GLU 301.A OE1 no hydrogen 2.706 N/A GLU 64.A N ARG 60.A O no hydrogen 2.939 N/A LEU 65.A N THR 61.A O no hydrogen 3.140 N/A ARG 66.A N TYR 62.A O no hydrogen 2.909 N/A ARG 66.A NH1 TYR 62.A OH no hydrogen 2.962 N/A ARG 66.A NH2 ASP 297.A O no hydrogen 2.705 N/A LEU 67.A N ARG 63.A O no hydrogen 2.903 N/A LEU 68.A N GLU 64.A O no hydrogen 2.924 N/A LYS 69.A N LEU 65.A O no hydrogen 2.950 N/A LYS 69.A NZ GLU 317.A O no hydrogen 2.809 N/A LYS 69.A NZ GLU 317.A OE1 no hydrogen 2.841 N/A HIS 70.A N ARG 66.A O no hydrogen 3.200 N/A HIS 70.A N LEU 67.A O no hydrogen 3.049 N/A HIS 70.A NE2 ASP 294.A O no hydrogen 2.898 N/A MET 71.A N LEU 67.A O no hydrogen 3.058 N/A LYS 72.A N TYR 125.A OH no hydrogen 2.927 N/A ASN 75.A ND2 GLN 118.A OE1 no hydrogen 3.229 N/A ASN 75.A ND2 LEU 149.A O no hydrogen 2.957 N/A VAL 76.A N HIS 73.A O no hydrogen 3.285 N/A ILE 77.A N ILE 151.A O no hydrogen 3.003 N/A LEU 80.A N VAL 98.A O no hydrogen 2.810 N/A ASP 81.A N VAL 98.A O no hydrogen 3.454 N/A VAL 82.A N ASP 81.A OD1 no hydrogen 2.925 N/A PHE 83.A N TYR 96.A O no hydrogen 3.066 N/A THR 84.A OG1 ASP 94.A O no hydrogen 2.895 N/A ALA 86.A N THR 84.A OG1 no hydrogen 3.334 N/A ARG 87.A N GLU 91.A OE1 no hydrogen 2.894 N/A GLU 90.A N GLU 90.A OE1 no hydrogen 2.950 N/A GLU 91.A N SER 88.A OG no hydrogen 3.123 N/A PHE 92.A N SER 88.A O no hydrogen 2.868 N/A PHE 92.A N LEU 89.A O no hydrogen 3.077 N/A ASN 93.A ND2 PHE 92.A O no hydrogen 3.600 N/A TYR 96.A N PHE 83.A O no hydrogen 3.089 N/A LEU 97.A N LYS 46.A O no hydrogen 2.803 N/A VAL 98.A N ASP 81.A O no hydrogen 2.821 N/A THR 99.A N ALA 44.A O no hydrogen 2.901 N/A THR 99.A OG1 GLY 78.A O no hydrogen 2.566 N/A LEU 101.A N ARG 42.A O no hydrogen 3.071 N/A ALA 104.A N VAL 143.A O no hydrogen 3.348 N/A LEU 106.A N PRO 138.A O no hydrogen 3.080 N/A VAL 112.A N THR 108.A O no hydrogen 3.087 N/A GLN 113.A N ASP 109.A O no hydrogen 2.908 N/A PHE 114.A N ASP 110.A O no hydrogen 2.987 N/A LEU 115.A N HIS 111.A O no hydrogen 2.888 N/A ILE 116.A N VAL 112.A O no hydrogen 2.923 N/A TYR 117.A N GLN 113.A O no hydrogen 2.992 N/A TYR 117.A OH GLU 290.A OE2 no hydrogen 2.549 N/A GLN 118.A N PHE 114.A O no hydrogen 3.172 N/A GLN 118.A NE2 PHE 114.A O no hydrogen 3.255 N/A GLN 118.A NE2 CYS 147.A O no hydrogen 3.103 N/A ILE 119.A N LEU 115.A O no hydrogen 3.157 N/A LEU 120.A N ILE 116.A O no hydrogen 2.956 N/A ARG 121.A N TYR 117.A O no hydrogen 2.842 N/A ARG 121.A NE ASP 289.A O no hydrogen 2.776 N/A ARG 121.A NH1 GLU 74.A OE1 no hydrogen 3.097 N/A ARG 121.A NH1 ASN 75.A OD1 no hydrogen 2.895 N/A ARG 121.A NH2 GLU 74.A OE1 no hydrogen 3.341 N/A ARG 121.A NH2 ASP 289.A O no hydrogen 3.149 N/A ARG 121.A NH2 ASP 289.A OD1 no hydrogen 3.251 N/A GLY 122.A N GLN 118.A O no hydrogen 3.032 N/A LEU 123.A N ILE 119.A O no hydrogen 2.753 N/A LYS 124.A N LEU 120.A O no hydrogen 2.762 N/A LYS 124.A NZ GLU 290.A O no hydrogen 3.032 N/A TYR 125.A N ARG 121.A O no hydrogen 3.384 N/A TYR 125.A OH HIS 70.A O no hydrogen 3.234 N/A ILE 126.A N GLY 122.A O no hydrogen 3.015 N/A HIS 127.A N LEU 123.A O no hydrogen 2.875 N/A HIS 127.A NE2 ASP 178.A OD2 no hydrogen 2.863 N/A SER 128.A N LYS 124.A O no hydrogen 3.036 N/A SER 128.A OG LYS 124.A O no hydrogen 3.515 N/A SER 128.A OG TYR 125.A O no hydrogen 2.663 N/A ALA 129.A N ILE 126.A O no hydrogen 3.080 N/A ASP 130.A N HIS 127.A O no hydrogen 3.043 N/A ILE 131.A N ILE 126.A O no hydrogen 3.418 N/A HIS 133.A N ASP 178.A OD2 no hydrogen 2.702 N/A ARG 134.A N ASP 178.A OD1 no hydrogen 2.813 N/A LYS 137.A NZ THR 158.A OG1 no hydrogen 2.634 N/A ASN 140.A N LYS 137.A O no hydrogen 2.884 N/A ASN 140.A ND2 ASP 135.A O no hydrogen 2.787 N/A ASN 140.A ND2 ASP 135.A OD2 no hydrogen 3.507 N/A LEU 141.A N PRO 138.A O no hydrogen 3.326 N/A ALA 142.A N LYS 150.A O no hydrogen 2.839 N/A VAL 143.A N ALA 104.A O no hydrogen 2.725 N/A ASN 144.A N GLU 148.A O no hydrogen 2.938 N/A ASN 144.A ND2 GLU 148.A OE1 no hydrogen 2.852 N/A CYS 147.A N ASN 144.A O no hydrogen 3.204 N/A GLU 148.A N ASN 144.A OD1 no hydrogen 2.927 N/A LEU 149.A N GLN 118.A OE1 no hydrogen 2.929 N/A LYS 150.A N ALA 142.A O no hydrogen 2.844 N/A LYS 150.A NZ HIS 73.A O no hydrogen 3.560 N/A LYS 150.A NZ GLU 74.A O no hydrogen 3.252 N/A LYS 150.A NZ VAL 76.A O no hydrogen 3.212 N/A ILE 151.A N ASN 75.A O no hydrogen 2.893 N/A LEU 152.A N ASN 140.A O no hydrogen 2.834 N/A PHE 154.A N ASN 140.A OD1 no hydrogen 2.813 N/A THR 158.A OG1 ASP 135.A OD1 no hydrogen 3.017 N/A ARG 159.A NE GLY 198.A O no hydrogen 2.865 N/A ARG 159.A NH2 GLY 198.A O no hydrogen 3.527 N/A TRP 160.A N ALA 157.A O no hydrogen 3.429 N/A TRP 160.A NE1 GLY 198.A O no hydrogen 2.807 N/A TYR 161.A N THR 158.A O no hydrogen 3.226 N/A TYR 161.A OH GLU 188.A OE1 no hydrogen 2.522 N/A TYR 161.A OH GLU 188.A OE2 no hydrogen 3.357 N/A ARG 162.A N ARG 159.A O no hydrogen 3.096 N/A ARG 162.A NH1 ARG 134.A O no hydrogen 2.728 N/A GLU 165.A N GLU 165.A OE1 no hydrogen 2.648 N/A ILE 166.A N ALA 163.A O no hydrogen 3.152 N/A MET 167.A N ALA 163.A O no hydrogen 3.413 N/A LEU 168.A N PRO 164.A O no hydrogen 2.964 N/A ASN 169.A N ILE 166.A O no hydrogen 2.866 N/A TRP 170.A N GLU 165.A O no hydrogen 2.913 N/A ASN 174.A ND2 THR 176.A OG1 no hydrogen 2.567 N/A GLN 175.A NE2 HIS 127.A O no hydrogen 2.806 N/A GLN 175.A NE2 ILE 131.A O no hydrogen 3.573 N/A THR 176.A OG1 SER 266.A O no hydrogen 3.180 N/A VAL 177.A N ASN 174.A O no hydrogen 3.201 N/A ASP 178.A N GLN 175.A O no hydrogen 3.007 N/A TRP 180.A N THR 176.A O no hydrogen 2.980 N/A SER 181.A N VAL 177.A O no hydrogen 3.393 N/A SER 181.A OG TYR 161.A O no hydrogen 2.765 N/A SER 181.A OG VAL 177.A O no hydrogen 3.206 N/A VAL 182.A N ASP 178.A O no hydrogen 3.096 N/A GLY 183.A N ILE 179.A O no hydrogen 2.906 N/A CYS 184.A N TRP 180.A O no hydrogen 2.952 N/A CYS 184.A SG TRP 180.A O no hydrogen 3.541 N/A ILE 185.A N SER 181.A O no hydrogen 2.979 N/A MET 186.A N VAL 182.A O no hydrogen 2.809 N/A ALA 187.A N GLY 183.A O no hydrogen 2.994 N/A GLU 188.A N CYS 184.A O no hydrogen 3.166 N/A LEU 189.A N ILE 185.A O no hydrogen 2.965 N/A LEU 190.A N MET 186.A O no hydrogen 3.086 N/A THR 191.A N ALA 187.A O no hydrogen 3.011 N/A THR 191.A OG1 ALA 187.A O no hydrogen 3.152 N/A GLY 192.A N GLU 188.A O no hydrogen 2.843 N/A ARG 193.A N THR 191.A OG1 no hydrogen 3.267 N/A GLY 198.A N PHE 196.A O no hydrogen 3.040 N/A GLY 198.A N GLN 204.A OE1 no hydrogen 3.129 N/A THR 199.A N ASP 203.A OD2 no hydrogen 3.010 N/A THR 199.A OG1 ASP 200.A OD2 no hydrogen 3.417 N/A THR 199.A OG1 ASP 203.A OD2 no hydrogen 3.321 N/A ASP 203.A N ASP 200.A OD1 no hydrogen 2.814 N/A GLN 204.A N ASP 200.A O no hydrogen 2.842 N/A GLN 204.A NE2 TRP 160.A O no hydrogen 3.320 N/A GLN 204.A NE2 PHE 196.A O no hydrogen 3.063 N/A LEU 205.A N HIS 201.A O no hydrogen 3.136 N/A LYS 206.A N ILE 202.A O no hydrogen 3.001 N/A LEU 207.A N ASP 203.A O no hydrogen 2.909 N/A ILE 208.A N GLN 204.A O no hydrogen 2.994 N/A LEU 209.A N LEU 205.A O no hydrogen 2.958 N/A ARG 210.A N LYS 206.A O no hydrogen 3.092 N/A ARG 210.A N LEU 207.A O no hydrogen 3.260 N/A LEU 211.A N ILE 208.A O no hydrogen 3.019 N/A VAL 212.A N ILE 208.A O no hydrogen 3.010 N/A GLY 213.A N LEU 209.A O no hydrogen 2.873 N/A THR 214.A N MET 238.A O no hydrogen 2.934 N/A THR 214.A OG1 MET 238.A O no hydrogen 3.104 N/A LEU 220.A N GLY 216.A O no hydrogen 2.993 N/A LYS 221.A N ALA 217.A O no hydrogen 3.257 N/A LYS 222.A N LEU 219.A O no hydrogen 2.872 N/A LYS 222.A NZ ASP 265.A OD1 no hydrogen 3.379 N/A LYS 222.A NZ ASP 265.A OD2 no hydrogen 2.587 N/A LYS 222.A NZ ASP 267.A OD2 no hydrogen 2.855 N/A ILE 223.A N LEU 220.A O no hydrogen 3.353 N/A SER 227.A OG SER 225.A OG no hydrogen 3.097 N/A ALA 228.A N SER 225.A OG no hydrogen 3.294 N/A ARG 229.A N SER 225.A O no hydrogen 3.010 N/A ARG 229.A NH1 ILE 223.A O no hydrogen 2.910 N/A ARG 229.A NH1 SER 224.A O no hydrogen 2.881 N/A ASN 230.A N GLU 226.A O no hydrogen 2.736 N/A TYR 231.A N SER 227.A O no hydrogen 2.865 N/A ILE 232.A N ALA 228.A O no hydrogen 2.916 N/A GLN 233.A N ARG 229.A O no hydrogen 2.810 N/A SER 234.A OG ASN 230.A O no hydrogen 2.579 N/A LEU 235.A N ILE 232.A O no hydrogen 3.258 N/A MET 238.A N THR 214.A OG1 no hydrogen 2.806 N/A LYS 240.A NZ MET 241.A O no hydrogen 2.783 N/A LYS 240.A NZ GLU 259.A OE1 no hydrogen 3.019 N/A MET 241.A N LEU 211.A O no hydrogen 2.816 N/A ALA 244.A N ASN 242.A OD1 no hydrogen 3.113 N/A ASN 245.A N ASN 242.A O no hydrogen 3.152 N/A VAL 246.A N ASN 242.A O no hydrogen 3.083 N/A PHE 247.A N PHE 243.A O no hydrogen 2.726 N/A ALA 250.A N PHE 247.A O no hydrogen 3.063 N/A ASN 251.A ND2 ASP 109.A OD2 no hydrogen 2.812 N/A LEU 253.A N ASN 251.A OD1 no hydrogen 2.887 N/A ALA 254.A N ASN 251.A O no hydrogen 2.827 N/A VAL 255.A N ASN 251.A O no hydrogen 3.170 N/A ASP 256.A N PRO 252.A O no hydrogen 3.092 N/A LEU 257.A N LEU 253.A O no hydrogen 3.164 N/A LEU 258.A N ALA 254.A O no hydrogen 3.046 N/A GLU 259.A N VAL 255.A O no hydrogen 2.997 N/A LYS 260.A N ASP 256.A O no hydrogen 3.327 N/A LYS 260.A NZ ASP 256.A OD2 no hydrogen 3.025 N/A MET 261.A N LEU 257.A O no hydrogen 2.991 N/A LEU 262.A N LEU 258.A O no hydrogen 2.890 N/A SER 266.A OG ASN 174.A OD1 no hydrogen 3.265 N/A ASP 267.A N ASP 265.A OD1 no hydrogen 3.111 N/A LYS 268.A N ASP 265.A O no hydrogen 2.768 N/A ARG 269.A N SER 266.A O no hydrogen 3.234 N/A ARG 269.A NH1 GLU 165.A OE1 no hydrogen 3.400 N/A ARG 269.A NH1 VAL 263.A O no hydrogen 3.475 N/A ARG 269.A NH1 LEU 264.A O no hydrogen 3.033 N/A ARG 269.A NH2 GLU 165.A OE2 no hydrogen 2.641 N/A ARG 269.A NH2 THR 176.A O no hydrogen 3.232 N/A ILE 270.A N LYS 260.A O no hydrogen 3.108 N/A THR 271.A N GLN 274.A OE1 no hydrogen 3.206 N/A GLN 274.A N THR 271.A OG1 no hydrogen 3.115 N/A ALA 275.A N THR 271.A O no hydrogen 2.963 N/A LEU 276.A N ALA 272.A O no hydrogen 3.051 N/A ALA 277.A N GLN 274.A O no hydrogen 3.154 N/A HIS 278.A N ALA 275.A O no hydrogen 3.012 N/A HIS 278.A NE2 ASP 256.A OD2 no hydrogen 2.712 N/A TYR 280.A N HIS 278.A ND1 no hydrogen 3.105 N/A TYR 280.A OH ASP 109.A OD1 no hydrogen 2.976 N/A PHE 281.A N HIS 278.A O no hydrogen 3.063 N/A ALA 282.A N ALA 279.A O no hydrogen 3.128 N/A TYR 284.A N PHE 281.A O no hydrogen 2.913 N/A TYR 284.A OH ASP 110.A OD1 no hydrogen 2.719 N/A HIS 285.A N PHE 281.A O no hydrogen 2.823 N/A HIS 285.A ND1 GLU 290.A OE2 no hydrogen 2.816 N/A ASP 286.A N GLU 290.A OE2 no hydrogen 3.162 N/A ASP 288.A N ASP 286.A OD1 no hydrogen 3.149 N/A ASP 289.A N ASP 286.A O no hydrogen 2.932 N/A ALA 293.A N SER 128.A OG no hydrogen 2.812 N/A GLN 298.A NE2 ASP 130.A O no hydrogen 2.829 N/A SER 299.A N ASP 297.A OD1 no hydrogen 3.178 N/A SER 299.A OG ASP 297.A OD1 no hydrogen 2.696 N/A GLU 301.A N GLN 298.A O no hydrogen 3.126 N/A SER 302.A N SER 299.A O no hydrogen 3.086 N/A SER 302.A OG SER 299.A O no hydrogen 2.883 N/A ARG 303.A N PHE 300.A O no hydrogen 3.099 N/A ARG 303.A NH1 SER 299.A OG no hydrogen 3.250 N/A LEU 306.A N GLU 309.A OE1 no hydrogen 2.977 N/A GLU 309.A N LEU 306.A O no hydrogen 2.971 N/A TRP 310.A N LEU 306.A O no hydrogen 3.092 N/A LYS 311.A N ILE 307.A O no hydrogen 2.788 N/A LYS 311.A NZ PHE 92.A O no hydrogen 2.920 N/A SER 312.A N ASP 308.A O no hydrogen 2.939 N/A LEU 313.A N GLU 309.A O no hydrogen 2.949 N/A THR 314.A N TRP 310.A O no hydrogen 2.962 N/A THR 314.A OG1 TRP 310.A O no hydrogen 2.768 N/A TYR 315.A N LYS 311.A O no hydrogen 2.890 N/A ASP 316.A N SER 312.A O no hydrogen 2.936 N/A GLU 317.A N LEU 313.A O no hydrogen 3.073 N/A VAL 318.A N THR 314.A O no hydrogen 2.964 N/A ILE 319.A N TYR 315.A O no hydrogen 3.113 N/A SER 320.A N ASP 316.A O no hydrogen 2.934 N/A SER 320.A OG ASP 316.A O no hydrogen 3.117 N/A SER 320.A OG GLU 317.A O no hydrogen 3.397 N/A PHE 321.A N VAL 318.A O no hydrogen 3.285 N/A