Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 2z22_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): GLU 1.A N GLY 28.A O no hydrogen 3.400 N/A ALA 2.A N ASN 29.A OD1 no hydrogen 3.090 N/A LEU 4.A N LYS 30.A O no hydrogen 2.803 N/A THR 5.A N ASP 51.A OD2 no hydrogen 2.747 N/A THR 5.A OG1 ASP 51.A OD2 no hydrogen 3.502 N/A GLY 6.A N ASN 32.A O no hydrogen 2.904 N/A ALA 7.A N PHE 52.A O no hydrogen 3.253 N/A GLY 8.A N GLN 34.A O no hydrogen 2.961 N/A ALA 9.A N ALA 54.A O no hydrogen 2.933 N/A ALA 13.A N THR 10.A O no hydrogen 3.037 N/A TYR 16.A N PRO 12.A O no hydrogen 3.070 N/A TYR 16.A OH THR 74.A OG1 no hydrogen 2.706 N/A ALA 17.A N ALA 13.A O no hydrogen 2.903 N/A LYS 18.A N PRO 14.A O no hydrogen 3.163 N/A TRP 19.A N VAL 15.A O no hydrogen 2.843 N/A TRP 19.A NE1 GLY 284.A O no hydrogen 2.957 N/A ALA 20.A N TYR 16.A O no hydrogen 2.882 N/A ASP 21.A N ALA 17.A O no hydrogen 3.034 N/A SER 22.A N LYS 18.A O no hydrogen 3.063 N/A SER 22.A OG LYS 18.A O no hydrogen 3.311 N/A SER 22.A OG GLN 287.A OE1 no hydrogen 2.850 N/A TYR 23.A N TRP 19.A O no hydrogen 2.761 N/A GLN 24.A N ALA 20.A O no hydrogen 2.954 N/A LYS 25.A N ASP 21.A O no hydrogen 3.158 N/A GLU 26.A N SER 22.A O no hydrogen 2.926 N/A THR 27.A N TYR 23.A O no hydrogen 2.757 N/A THR 27.A OG1 TYR 23.A O no hydrogen 2.683 N/A GLY 28.A N GLN 24.A O no hydrogen 2.715 N/A ASN 29.A N THR 27.A OG1 no hydrogen 3.167 N/A LYS 30.A N ALA 2.A O no hydrogen 2.890 N/A ASN 32.A N LEU 4.A O no hydrogen 2.850 N/A TYR 33.A OH ALA 9.A O no hydrogen 2.616 N/A GLN 34.A N GLY 6.A O no hydrogen 2.947 N/A GLN 34.A NE2 TYR 33.A O no hydrogen 3.203 N/A ILE 36.A N GLY 8.A O no hydrogen 2.982 N/A GLY 37.A N GLY 8.A O no hydrogen 2.972 N/A SER 38.A OG ASP 56.A OD2 no hydrogen 3.301 N/A GLY 41.A N GLY 37.A O no hydrogen 2.999 N/A VAL 42.A N SER 38.A O no hydrogen 3.016 N/A LYS 43.A N SER 39.A O no hydrogen 3.282 N/A GLN 44.A N GLY 40.A O no hydrogen 2.938 N/A ILE 45.A N GLY 41.A O no hydrogen 3.062 N/A ILE 46.A N VAL 42.A O no hydrogen 3.018 N/A ALA 47.A N LYS 43.A O no hydrogen 2.880 N/A ASN 48.A N ILE 45.A O no hydrogen 3.056 N/A THR 49.A N GLN 44.A O no hydrogen 2.815 N/A ASP 51.A N THR 5.A O no hydrogen 2.740 N/A GLY 53.A N LEU 259.A O no hydrogen 2.932 N/A ALA 54.A N ALA 7.A O no hydrogen 2.995 N/A SER 55.A N PHE 257.A O no hydrogen 2.955 N/A SER 55.A OG ALA 57.A O no hydrogen 2.735 N/A ASP 56.A N SER 38.A OG no hydrogen 2.957 N/A ALA 57.A N SER 55.A OG no hydrogen 3.229 N/A LEU 59.A N GLN 71.A OE1 no hydrogen 2.816 N/A LYS 63.A N THR 60.A OG1 no hydrogen 2.986 N/A LEU 64.A N THR 60.A O no hydrogen 2.935 N/A ALA 65.A N ASP 61.A O no hydrogen 2.912 N/A THR 66.A N GLU 62.A O no hydrogen 2.993 N/A THR 66.A OG1 GLU 62.A O no hydrogen 3.093 N/A GLU 67.A N LYS 63.A O no hydrogen 2.952 N/A GLY 68.A N ALA 65.A O no hydrogen 3.132 N/A LEU 69.A N LEU 64.A O no hydrogen 2.825 N/A PHE 70.A N VAL 260.A O no hydrogen 2.763 N/A GLN 71.A NE2 LEU 59.A O no hydrogen 3.535 N/A PHE 72.A N ILE 258.A O no hydrogen 3.152 N/A THR 74.A N THR 256.A O no hydrogen 3.044 N/A THR 74.A OG1 TYR 16.A OH no hydrogen 2.706 N/A ILE 76.A N ALA 294.A O no hydrogen 2.833 N/A GLY 77.A N SER 254.A O no hydrogen 2.935 N/A GLY 78.A N GLU 195.A OE2 no hydrogen 3.246 N/A VAL 79.A N ILE 252.A O no hydrogen 2.791 N/A VAL 80.A N VAL 194.A O no hydrogen 2.841 N/A ALA 82.A N GLY 192.A O no hydrogen 2.806 N/A VAL 83.A N ALA 205.A O no hydrogen 2.831 N/A ASN 84.A N SER 190.A O no hydrogen 3.002 N/A ASN 84.A ND2 VAL 184.A O no hydrogen 2.803 N/A LYS 89.A N GLU 92.A OE1 no hydrogen 2.809 N/A SER 90.A OG LEU 204.A O no hydrogen 3.429 N/A GLY 91.A N TYR 206.A O no hydrogen 2.702 N/A GLU 92.A N LYS 89.A O no hydrogen 3.140 N/A THR 94.A N ASN 120.A OD1 no hydrogen 2.718 N/A LEU 95.A N LYS 208.A O no hydrogen 3.206 N/A LYS 98.A NZ ASP 102.A OD2 no hydrogen 2.614 N/A THR 99.A N ASP 96.A OD1 no hydrogen 3.013 N/A THR 99.A OG1 ASP 96.A OD1 no hydrogen 3.138 N/A LEU 100.A N ASP 96.A O no hydrogen 2.962 N/A GLY 101.A N GLY 97.A O no hydrogen 2.850 N/A ASP 102.A N LYS 98.A O no hydrogen 2.955 N/A ILE 103.A N THR 99.A O no hydrogen 2.853 N/A TYR 104.A N LEU 100.A O no hydrogen 3.066 N/A TYR 104.A OH VAL 133.A O no hydrogen 2.891 N/A LEU 105.A N GLY 101.A O no hydrogen 2.787 N/A GLY 106.A N ILE 103.A O no hydrogen 3.091 N/A THR 107.A N ASP 102.A O no hydrogen 2.969 N/A THR 107.A OG1 ASP 102.A O no hydrogen 2.718 N/A VAL 108.A N ASP 102.A O no hydrogen 3.283 N/A LYS 110.A NZ ASP 127.A OD1 no hydrogen 2.532 N/A TRP 111.A N GLN 128.A O no hydrogen 2.936 N/A TRP 111.A NE1 GLY 189.A O no hydrogen 2.885 N/A ASN 112.A ND2 ASP 127.A OD1 no hydrogen 3.370 N/A ASP 113.A N LYS 110.A O no hydrogen 3.151 N/A ALA 115.A N ASP 113.A OD1 no hydrogen 2.835 N/A ILE 116.A N ASP 113.A O no hydrogen 2.845 N/A VAL 117.A N ASP 113.A O no hydrogen 3.004 N/A LYS 118.A N PRO 114.A O no hydrogen 2.940 N/A LEU 119.A N ILE 116.A O no hydrogen 3.155 N/A ASN 120.A N VAL 117.A O no hydrogen 2.873 N/A ASN 120.A ND2 THR 94.A O no hydrogen 2.830 N/A ASN 120.A ND2 ILE 116.A O no hydrogen 2.895 N/A VAL 123.A N ASN 120.A O no hydrogen 3.284 N/A ILE 130.A N LYS 109.A O no hydrogen 2.756 N/A ALA 131.A N GLY 189.A O no hydrogen 2.869 N/A VAL 133.A N ILE 191.A O no hydrogen 2.876 N/A ARG 134.A N LEU 172.A O no hydrogen 2.814 N/A ARG 134.A NH1 ARG 135.A O no hydrogen 2.967 N/A ARG 135.A N TYR 193.A OH no hydrogen 3.128 N/A ARG 135.A NE ASP 137.A OD1 no hydrogen 2.955 N/A ARG 135.A NH2 ASP 137.A OD2 no hydrogen 2.922 N/A ALA 136.A N GLY 174.A O no hydrogen 2.826 N/A SER 139.A N SER 164.A O no hydrogen 2.952 N/A SER 142.A N SER 139.A OG no hydrogen 2.966 N/A SER 142.A OG TYR 193.A OH no hydrogen 2.584 N/A PHE 143.A N SER 139.A O no hydrogen 3.102 N/A VAL 144.A N GLY 140.A O no hydrogen 3.033 N/A PHE 145.A N THR 141.A O no hydrogen 2.799 N/A THR 146.A N SER 142.A O no hydrogen 2.717 N/A THR 146.A OG1 SER 142.A O no hydrogen 2.682 N/A THR 146.A OG1 PHE 143.A O no hydrogen 3.352 N/A THR 146.A OG1 GLY 163.A O no hydrogen 3.209 N/A SER 147.A N PHE 143.A O no hydrogen 2.951 N/A SER 147.A OG PHE 143.A O no hydrogen 2.700 N/A TYR 148.A N VAL 144.A O no hydrogen 3.070 N/A LEU 149.A N PHE 145.A O no hydrogen 3.050 N/A ALA 150.A N THR 146.A O no hydrogen 2.971 N/A LYS 151.A N TYR 148.A O no hydrogen 2.871 N/A LYS 151.A NZ ASP 240.A OD2 no hydrogen 2.659 N/A LYS 151.A NZ THR 242.A O no hydrogen 2.880 N/A LYS 151.A NZ THR 242.A OG1 no hydrogen 2.830 N/A VAL 152.A N TYR 148.A O no hydrogen 3.153 N/A ASN 153.A N LEU 149.A O no hydrogen 2.810 N/A ASN 153.A ND2 LYS 98.A O no hydrogen 3.062 N/A ASN 153.A ND2 ASP 102.A OD1 no hydrogen 3.221 N/A TRP 156.A N ASN 153.A OD1 no hydrogen 2.733 N/A TRP 156.A NE1 GLY 161.A O no hydrogen 2.878 N/A LYS 157.A N ASN 153.A O no hydrogen 3.015 N/A GLU 158.A N ALA 154.A O no hydrogen 2.980 N/A LYS 159.A N GLU 155.A O no hydrogen 2.947 N/A VAL 160.A N TRP 156.A O no hydrogen 2.678 N/A GLY 161.A N TRP 156.A O no hydrogen 2.979 N/A GLY 163.A N THR 146.A OG1 no hydrogen 3.016 N/A SER 164.A OG SER 139.A O no hydrogen 3.526 N/A LEU 172.A N VAL 132.A O no hydrogen 2.782 N/A GLY 174.A N ARG 134.A O no hydrogen 2.738 N/A GLY 176.A N ASP 137.A OD1 no hydrogen 2.949 N/A ASN 177.A N THR 10.A OG1 no hydrogen 3.408 N/A ASN 177.A ND2 THR 10.A OG1 no hydrogen 2.940 N/A ASN 177.A ND2 THR 141.A OG1 no hydrogen 3.360 N/A GLY 179.A N LYS 175.A O no hydrogen 2.934 N/A ILE 180.A N GLY 176.A O no hydrogen 3.222 N/A ALA 181.A N ASN 177.A O no hydrogen 2.994 N/A ALA 182.A N ASP 178.A O no hydrogen 3.048 N/A PHE 183.A N GLY 179.A O no hydrogen 3.210 N/A VAL 184.A N ILE 180.A O no hydrogen 3.111 N/A GLN 185.A N ALA 181.A O no hydrogen 3.161 N/A ARG 186.A N ALA 182.A O no hydrogen 3.188 N/A LEU 187.A N VAL 184.A O no hydrogen 3.355 N/A GLY 189.A N ASN 84.A O no hydrogen 2.601 N/A SER 190.A N LEU 187.A O no hydrogen 3.123 N/A SER 190.A OG VAL 184.A O no hydrogen 3.350 N/A SER 190.A OG LEU 187.A O no hydrogen 2.695 N/A ILE 191.A N ALA 131.A O no hydrogen 3.036 N/A GLY 192.A N ALA 82.A O no hydrogen 2.950 N/A TYR 193.A OH SER 142.A OG no hydrogen 2.584 N/A VAL 194.A N VAL 80.A O no hydrogen 2.991 N/A GLU 195.A N ASN 177.A OD1 no hydrogen 2.900 N/A TYR 196.A N GLY 78.A O no hydrogen 2.829 N/A TYR 196.A OH TYR 206.A OH no hydrogen 3.089 N/A ALA 197.A N GLU 195.A OE1 no hydrogen 2.859 N/A TYR 198.A N GLU 195.A O no hydrogen 2.898 N/A TYR 198.A OH THR 10.A O no hydrogen 2.549 N/A ALA 199.A N TYR 196.A O no hydrogen 2.963 N/A LYS 200.A N TYR 196.A O no hydrogen 3.060 N/A GLN 201.A N ALA 197.A O no hydrogen 2.721 N/A ASN 202.A N ALA 199.A O no hydrogen 3.185 N/A ASN 203.A N LYS 200.A O no hydrogen 3.193 N/A LEU 204.A N ALA 199.A O no hydrogen 2.826 N/A TYR 206.A N SER 90.A OG no hydrogen 3.338 N/A THR 207.A N LEU 81.A O no hydrogen 3.231 N/A THR 207.A OG1 LYS 208.A O no hydrogen 2.914 N/A LYS 208.A N LEU 93.A O no hydrogen 2.785 N/A LEU 209.A N VAL 217.A O no hydrogen 3.205 N/A ILE 210.A N LEU 95.A O no hydrogen 3.198 N/A SER 211.A N LYS 215.A O no hydrogen 2.736 N/A SER 211.A OG LYS 215.A O no hydrogen 3.062 N/A GLY 214.A N SER 211.A O no hydrogen 2.834 N/A LYS 215.A N SER 211.A OG no hydrogen 3.109 N/A LYS 215.A NZ ASP 247.A OD1 no hydrogen 3.086 N/A VAL 217.A N LEU 209.A O no hydrogen 2.848 N/A THR 220.A N SER 223.A OG no hydrogen 2.721 N/A SER 223.A N THR 220.A OG1 no hydrogen 3.025 N/A SER 223.A OG SER 218.A O no hydrogen 2.865 N/A SER 223.A OG THR 220.A O no hydrogen 3.092 N/A PHE 224.A N THR 220.A O no hydrogen 2.944 N/A SER 225.A N GLU 221.A O no hydrogen 3.017 N/A SER 226.A N HIS 222.A O no hydrogen 2.943 N/A SER 226.A OG HIS 222.A O no hydrogen 2.698 N/A ALA 227.A N PHE 224.A O no hydrogen 3.205 N/A ALA 228.A N SER 225.A O no hydrogen 3.107 N/A LYS 229.A N SER 226.A O no hydrogen 3.185 N/A VAL 231.A N ALA 228.A O no hydrogen 3.022 N/A SER 234.A N ASP 232.A OD2 no hydrogen 2.743 N/A SER 234.A OG ASP 232.A OD1 no hydrogen 2.956 N/A SER 234.A OG ASP 232.A OD2 no hydrogen 2.641 N/A ALA 238.A N SER 236.A OG no hydrogen 3.120 N/A GLN 239.A N PHE 237.A O no hydrogen 2.858 N/A GLN 239.A NE2 SER 236.A O no hydrogen 2.727 N/A THR 242.A N ASP 240.A OD1 no hydrogen 2.991 N/A THR 242.A OG1 ASP 240.A OD1 no hydrogen 2.783 N/A THR 242.A OG1 ASP 240.A OD2 no hydrogen 3.412 N/A ASN 243.A N PRO 251.A O no hydrogen 2.699 N/A GLN 244.A NE2 THR 242.A O no hydrogen 2.774 N/A LYS 245.A NZ ASP 213.A OD1 no hydrogen 2.871 N/A GLY 246.A N ASP 213.A OD2 no hydrogen 2.561 N/A TRP 250.A N SER 223.A O no hydrogen 3.012 N/A TRP 250.A NE1 VAL 79.A O no hydrogen 2.944 N/A THR 253.A OG1 TRP 250.A O no hydrogen 2.768 N/A SER 254.A N GLY 77.A O no hydrogen 3.120 N/A SER 254.A OG THR 255.A O no hydrogen 2.748 N/A THR 255.A OG1 VAL 75.A O no hydrogen 2.736 N/A THR 256.A N THR 255.A OG1 no hydrogen 2.836 N/A THR 256.A OG1 ASP 56.A OD1 no hydrogen 2.586 N/A PHE 257.A N SER 55.A O no hydrogen 2.813 N/A ILE 258.A N PHE 72.A O no hydrogen 2.841 N/A LEU 259.A N GLY 53.A O no hydrogen 2.704 N/A VAL 260.A N PHE 70.A O no hydrogen 3.112 N/A HIS 261.A NE2 ILE 45.A O no hydrogen 2.823 N/A LYS 262.A N GLY 68.A O no hydrogen 2.900 N/A LYS 262.A NZ GLN 311.A OE1 no hydrogen 3.084 N/A GLN 264.A N LYS 313.A O no hydrogen 2.842 N/A GLN 264.A NE2 HIS 261.A O no hydrogen 2.737 N/A ASN 269.A ND2 ASP 51.A OD1 no hydrogen 2.851 N/A GLY 270.A N ASN 266.A O no hydrogen 3.059 N/A THR 271.A N ALA 267.A O no hydrogen 2.860 N/A THR 271.A OG1 ALA 267.A O no hydrogen 2.809 N/A THR 271.A OG1 ILE 320.A O no hydrogen 3.141 N/A GLU 272.A N ALA 268.A O no hydrogen 2.950 N/A VAL 273.A N ASN 269.A O no hydrogen 2.874 N/A LEU 274.A N GLY 270.A O no hydrogen 3.158 N/A LYS 275.A N THR 271.A O no hydrogen 3.028 N/A PHE 276.A N GLU 272.A O no hydrogen 3.127 N/A PHE 276.A N VAL 273.A O no hydrogen 3.199 N/A PHE 277.A N VAL 273.A O no hydrogen 3.326 N/A ASP 278.A N LEU 274.A O no hydrogen 2.847 N/A TRP 279.A N LYS 275.A O no hydrogen 2.975 N/A TRP 279.A NE1 GLU 26.A OE2 no hydrogen 3.259 N/A GLY 280.A N PHE 276.A O no hydrogen 2.956 N/A TYR 281.A N PHE 277.A O no hydrogen 3.030 N/A TYR 281.A OH PRO 73.A O no hydrogen 2.604 N/A THR 282.A N ASP 278.A O no hydrogen 2.919 N/A THR 282.A OG1 ASP 278.A O no hydrogen 2.995 N/A HIS 283.A N TRP 279.A O no hydrogen 2.663 N/A GLY 284.A N GLY 280.A O no hydrogen 2.963 N/A GLN 287.A NE2 LYS 18.A O no hydrogen 3.648 N/A GLN 287.A NE2 SER 22.A OG no hydrogen 2.915 N/A ALA 288.A N GLY 284.A O no hydrogen 2.999 N/A ASN 289.A N ALA 285.A O no hydrogen 2.913 N/A ASN 289.A ND2 TYR 293.A O no hydrogen 2.891 N/A GLU 290.A N LYS 286.A O no hydrogen 2.986 N/A LEU 291.A N GLN 287.A O no hydrogen 3.304 N/A LEU 291.A N ALA 288.A O no hydrogen 3.044 N/A ASP 292.A N ASN 289.A O no hydrogen 2.858 N/A TYR 293.A N ALA 288.A O no hydrogen 2.941 N/A TYR 293.A OH PHE 11.A O no hydrogen 2.744 N/A ALA 294.A N ILE 76.A O no hydrogen 2.718 N/A VAL 301.A N PRO 297.A O no hydrogen 3.035 N/A GLU 302.A N ALA 298.A O no hydrogen 3.303 N/A GLN 303.A N GLU 299.A O no hydrogen 3.159 N/A VAL 304.A N VAL 300.A O no hydrogen 2.883 N/A ARG 305.A N VAL 301.A O no hydrogen 2.993 N/A ARG 305.A NE ASP 278.A OD1 no hydrogen 2.652 N/A ARG 305.A NH2 ASP 278.A OD1 no hydrogen 2.919 N/A ALA 306.A N GLU 302.A O no hydrogen 2.956 N/A ALA 307.A N GLN 303.A O no hydrogen 2.923 N/A TRP 308.A N VAL 304.A O no hydrogen 2.777 N/A LYS 309.A N ARG 305.A O no hydrogen 3.257 N/A THR 310.A N ALA 307.A O no hydrogen 3.079 N/A THR 310.A OG1 ALA 306.A O no hydrogen 3.567 N/A THR 310.A OG1 ALA 307.A O no hydrogen 3.287 N/A GLN 311.A N ALA 307.A O no hydrogen 2.725 N/A GLN 311.A NE2 THR 310.A OG1 no hydrogen 3.270 N/A ILE 312.A N TRP 308.A O no hydrogen 3.258 N/A LYS 313.A N LYS 262.A O no hydrogen 2.829 N/A ASP 314.A N LYS 318.A O no hydrogen 2.858 N/A SER 316.A N ASP 314.A OD1 no hydrogen 2.707 N/A GLY 317.A N ASP 314.A O no hydrogen 2.822 N/A LYS 318.A N ASP 314.A OD1 no hydrogen 3.016 N/A