Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 3ho4_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): PHE 4.A N CYS 304.A O no hydrogen 2.841 N/A CYS 5.A SG GLY 306.A O no hydrogen 3.801 N/A ILE 6.A N ARG 312.A O no hydrogen 2.942 N/A GLN 7.A N LYS 345.A O no hydrogen 2.846 N/A VAL 9.A N LEU 343.A O no hydrogen 2.742 N/A VAL 10.A N LEU 343.A O no hydrogen 3.141 N/A LEU 13.A N GLY 341.A O no hydrogen 2.779 N/A ARG 14.A N GLU 33.A OE1 no hydrogen 2.708 N/A ARG 14.A NE GLU 33.A OE2 no hydrogen 2.765 N/A VAL 17.A N LEU 32.A O no hydrogen 2.688 N/A ALA 19.A N PHE 322.A O no hydrogen 3.166 N/A LEU 20.A N PHE 30.A O no hydrogen 2.961 N/A GLY 25.A N GLU 326.A OE2 no hydrogen 2.800 N/A SER 26.A OG ASP 24.A OD1 no hydrogen 2.456 N/A SER 26.A OG ASP 24.A OD2 no hydrogen 3.223 N/A GLN 27.A NE2 ALA 359.A O no hydrogen 3.435 N/A ARG 28.A NE SER 26.A OG no hydrogen 2.908 N/A ARG 28.A NH1 PRO 109.A O no hydrogen 3.174 N/A ARG 28.A NH2 ASP 24.A OD2 no hydrogen 2.806 N/A LEU 29.A N LEU 41.A O no hydrogen 2.927 N/A PHE 30.A N LEU 20.A O no hydrogen 2.678 N/A ILE 31.A N LYS 39.A O no hydrogen 2.740 N/A LEU 32.A N GLY 18.A O no hydrogen 2.747 N/A GLU 33.A N TYR 37.A O no hydrogen 2.874 N/A LYS 34.A N GLN 15.A O no hydrogen 2.859 N/A LYS 34.A NZ ASP 67.A O no hydrogen 2.647 N/A GLY 36.A N GLU 33.A O no hydrogen 3.107 N/A TYR 37.A N GLU 33.A O no hydrogen 3.360 N/A VAL 38.A N LEU 53.A O no hydrogen 2.727 N/A LYS 39.A N ILE 31.A O no hydrogen 2.857 N/A LYS 39.A NZ GLU 33.A OE1 no hydrogen 2.895 N/A LEU 41.A N LEU 29.A O no hydrogen 2.716 N/A THR 42.A N GLU 46.A O no hydrogen 2.858 N/A THR 42.A OG1 GLU 46.A O no hydrogen 3.525 N/A GLY 45.A N THR 42.A O no hydrogen 2.765 N/A GLU 46.A N THR 42.A OG1 no hydrogen 2.791 N/A PHE 48.A N ILE 40.A O no hydrogen 3.135 N/A TYR 52.A OH TYR 80.A OH no hydrogen 2.972 N/A LEU 53.A N VAL 38.A O no hydrogen 3.051 N/A ILE 55.A N GLY 36.A O no hydrogen 2.798 N/A HIS 56.A N ASP 54.A OD1 no hydrogen 3.248 N/A HIS 56.A ND1 ASP 54.A OD1 no hydrogen 2.770 N/A VAL 59.A N ILE 55.A O no hydrogen 3.101 N/A GLN 60.A N THR 91.A O no hydrogen 2.995 N/A ILE 63.A N ASP 67.A OD2 no hydrogen 3.454 N/A GLU 68.A N ARG 128.A O no hydrogen 3.345 N/A ARG 69.A NH1 ASP 67.A OD1 no hydrogen 3.002 N/A LEU 71.A N LYS 34.A O no hydrogen 2.775 N/A LEU 72.A N SER 89.A O no hydrogen 2.791 N/A SER 73.A N SER 89.A O no hydrogen 3.338 N/A ALA 75.A N TYR 87.A O no hydrogen 2.721 N/A HIS 77.A N LYS 85.A O no hydrogen 2.751 N/A TYR 80.A N HIS 77.A O no hydrogen 2.890 N/A TYR 80.A OH TYR 52.A OH no hydrogen 2.972 N/A LYS 81.A NZ ASP 24.A O no hydrogen 3.173 N/A LYS 82.A N ASN 79.A O no hydrogen 3.074 N/A ASN 83.A N ASN 79.A O no hydrogen 2.945 N/A ASN 83.A ND2 PRO 382.A O no hydrogen 2.901 N/A GLY 84.A N TYR 80.A O no hydrogen 2.612 N/A LYS 85.A NZ GLU 101.A OE1 no hydrogen 2.416 N/A LYS 85.A NZ THR 103.A OG1 no hydrogen 2.827 N/A LYS 85.A NZ CYS 380.A O no hydrogen 2.795 N/A LEU 86.A N TYR 102.A O no hydrogen 2.804 N/A TYR 87.A N ALA 75.A O no hydrogen 2.664 N/A TYR 87.A OH GLU 101.A OE2 no hydrogen 2.793 N/A VAL 88.A N VAL 100.A O no hydrogen 2.807 N/A SER 89.A N SER 73.A O no hydrogen 2.911 N/A SER 89.A OG SER 73.A O no hydrogen 3.439 N/A SER 89.A OG GLY 133.A O no hydrogen 2.828 N/A TYR 90.A N ARG 98.A O no hydrogen 3.056 N/A THR 91.A N GLY 70.A O no hydrogen 3.194 N/A THR 91.A OG1 ARG 69.A O no hydrogen 2.897 N/A THR 92.A N ILE 96.A O no hydrogen 2.947 N/A THR 92.A OG1 LEU 58.A O no hydrogen 3.078 N/A HIS 95.A N GLU 125.A O no hydrogen 3.114 N/A LEU 97.A N VAL 123.A O no hydrogen 2.735 N/A ARG 98.A N TYR 90.A O no hydrogen 2.904 N/A ARG 98.A NE GLU 122.A OE1 no hydrogen 3.379 N/A ARG 98.A NH2 GLU 122.A OE1 no hydrogen 3.114 N/A VAL 99.A N LEU 121.A O no hydrogen 2.897 N/A VAL 100.A N VAL 88.A O no hydrogen 2.768 N/A GLU 101.A N ARG 118.A O no hydrogen 3.237 N/A TYR 102.A N LEU 86.A O no hydrogen 3.221 N/A VAL 104.A N GLY 84.A O no hydrogen 3.228 N/A SER 105.A N GLN 111.A O no hydrogen 2.833 N/A LYS 107.A N SER 105.A OG no hydrogen 3.099 N/A ASN 108.A N SER 105.A OG no hydrogen 2.910 N/A HIS 110.A N ASN 108.A OD1 no hydrogen 2.661 N/A GLN 111.A N ASN 108.A O no hydrogen 3.284 N/A VAL 112.A N TYR 52.A O no hydrogen 2.996 N/A THR 116.A N ASP 113.A O no hydrogen 3.465 N/A THR 116.A OG1 ASP 113.A O no hydrogen 3.321 N/A THR 116.A OG1 ASP 113.A OD1 no hydrogen 3.083 N/A ALA 117.A N LEU 114.A O no hydrogen 3.381 N/A ARG 118.A N GLU 101.A O no hydrogen 3.111 N/A PHE 120.A N VAL 99.A O no hydrogen 2.801 N/A LEU 121.A N VAL 99.A O no hydrogen 3.132 N/A VAL 123.A N LEU 97.A O no hydrogen 2.811 N/A GLU 125.A N HIS 95.A O no hydrogen 2.733 N/A ARG 128.A NE ASP 94.A OD1 no hydrogen 3.276 N/A ARG 128.A NE ASP 94.A OD2 no hydrogen 3.346 N/A ARG 128.A NH2 ASP 94.A OD1 no hydrogen 3.532 N/A ARG 128.A NH2 ASP 94.A OD2 no hydrogen 3.093 N/A LEU 131.A N GLU 68.A OE2 no hydrogen 2.786 N/A GLY 133.A N ILE 146.A O no hydrogen 2.839 N/A GLN 134.A NE2 CYS 209.A O no hydrogen 3.067 N/A LEU 135.A N SER 73.A OG no hydrogen 3.170 N/A LEU 136.A N TYR 144.A O no hydrogen 2.917 N/A GLY 141.A N GLY 138.A O no hydrogen 3.066 N/A LEU 143.A N LEU 170.A O no hydrogen 2.816 N/A TYR 144.A N LEU 136.A O no hydrogen 2.625 N/A ILE 145.A N LEU 168.A O no hydrogen 2.721 N/A ILE 146.A N GLN 134.A O no hydrogen 2.961 N/A LEU 147.A N SER 166.A O no hydrogen 3.005 N/A GLY 148.A N LEU 131.A O no hydrogen 3.321 N/A ASP 149.A N HIS 204.A O no hydrogen 2.617 N/A GLY 150.A N HIS 130.A O no hydrogen 2.820 N/A ASP 155.A N THR 152.A OG1 no hydrogen 3.264 N/A GLU 157.A N ASP 154.A O no hydrogen 3.157 N/A PHE 163.A N SER 161.A OG no hydrogen 2.980 N/A SER 166.A OG PHE 163.A O no hydrogen 3.070 N/A VAL 167.A N ALA 200.A O no hydrogen 2.689 N/A LEU 168.A N ILE 145.A O no hydrogen 2.571 N/A ARG 169.A N GLU 197.A O no hydrogen 3.040 N/A ARG 169.A NH1 TYR 144.A OH no hydrogen 2.921 N/A LEU 170.A N LEU 143.A O no hydrogen 2.922 N/A ASP 171.A N SER 181.A O no hydrogen 2.766 N/A ASP 173.A N ASP 171.A OD1 no hydrogen 3.293 N/A THR 174.A OG1 VAL 172.A O no hydrogen 3.137 N/A TYR 180.A OH GLU 197.A OE1 no hydrogen 2.637 N/A SER 181.A N ASP 171.A O no hydrogen 2.786 N/A ASN 186.A N PRO 183.A O no hydrogen 3.009 N/A HIS 188.A N GLU 243.A OE1 no hydrogen 2.976 N/A SER 191.A OG ASN 190.A O no hydrogen 2.761 N/A GLU 197.A N GLU 197.A OE2 no hydrogen 2.640 N/A VAL 198.A N PRO 195.A O no hydrogen 3.126 N/A PHE 199.A N VAL 167.A O no hydrogen 2.889 N/A ALA 200.A N VAL 167.A O no hydrogen 3.254 N/A GLY 202.A N GLY 165.A O no hydrogen 2.915 N/A LEU 203.A N GLY 165.A O no hydrogen 3.182 N/A HIS 204.A N ASP 222.A OD2 no hydrogen 2.899 N/A HIS 204.A ND1 ASN 224.A OD1 no hydrogen 3.200 N/A ASP 205.A N ASP 222.A OD1 no hydrogen 2.540 N/A GLY 207.A N SER 221.A O no hydrogen 2.956 N/A ARG 208.A N VAL 260.A O no hydrogen 3.103 N/A ARG 208.A NH1 GLY 262.A O no hydrogen 2.829 N/A CYS 209.A N GLN 134.A OE1 no hydrogen 2.630 N/A CYS 209.A SG GLY 207.A O no hydrogen 3.403 N/A ALA 210.A N LEU 219.A O no hydrogen 2.819 N/A ASP 212.A N THR 217.A O no hydrogen 2.778 N/A HIS 214.A N ASP 212.A OD1 no hydrogen 3.027 N/A LEU 216.A N ILE 236.A O no hydrogen 3.345 N/A THR 217.A N ASP 212.A O no hydrogen 2.923 N/A ILE 218.A N LEU 234.A O no hydrogen 3.017 N/A LEU 219.A N ALA 210.A O no hydrogen 2.914 N/A CYS 220.A N ARG 232.A O no hydrogen 2.769 N/A ASP 222.A N SER 230.A O no hydrogen 2.917 N/A SER 223.A N ASP 205.A O no hydrogen 3.081 N/A SER 223.A OG ASP 205.A OD2 no hydrogen 3.332 N/A ASN 224.A N ASP 222.A OD1 no hydrogen 3.389 N/A ASN 224.A ND2 ARG 228.A O no hydrogen 2.750 N/A ASN 224.A ND2 SER 230.A OG no hydrogen 3.316 N/A SER 230.A N ASP 222.A O no hydrogen 3.024 N/A ALA 231.A N PHE 251.A O no hydrogen 2.843 N/A ARG 232.A N CYS 220.A O no hydrogen 2.879 N/A ARG 232.A NE ASP 222.A OD2 no hydrogen 2.906 N/A ARG 232.A NH2 ASN 224.A OD1 no hydrogen 2.948 N/A ILE 233.A N LEU 249.A O no hydrogen 2.908 N/A LEU 234.A N ILE 218.A O no hydrogen 2.817 N/A ILE 236.A N LEU 216.A O no hydrogen 3.084 N/A TYR 242.A N SER 185.A O no hydrogen 3.271 N/A LEU 249.A N ILE 233.A O no hydrogen 2.973 N/A PHE 251.A N ALA 231.A O no hydrogen 2.971 N/A SER 255.A OG GLU 300.A OE2 no hydrogen 2.731 N/A VAL 260.A N GLY 280.A O no hydrogen 2.930 N/A GLY 262.A N ARG 208.A O no hydrogen 2.790 N/A PHE 263.A N VAL 278.A O no hydrogen 2.827 N/A TYR 265.A N SER 276.A O no hydrogen 2.916 N/A TYR 265.A OH GLU 329.A OE2 no hydrogen 2.675 N/A CYS 268.A N GLU 329.A OE2 no hydrogen 3.063 N/A GLN 269.A N GLU 329.A OE2 no hydrogen 3.173 N/A GLN 269.A NE2 ASP 348.A O no hydrogen 2.832 N/A GLN 269.A NE2 PRO 352.A O no hydrogen 2.638 N/A SER 270.A N TYR 265.A OH no hydrogen 2.774 N/A SER 270.A OG ASP 348.A OD1 no hydrogen 3.020 N/A ARG 272.A NE ASP 348.A OD1 no hydrogen 2.946 N/A ARG 272.A NE ASP 348.A OD2 no hydrogen 3.161 N/A ARG 272.A NH1 ASN 2.A O no hydrogen 2.796 N/A ARG 272.A NH2 ASN 2.A O no hydrogen 3.530 N/A ARG 272.A NH2 CYS 3.A O no hydrogen 3.276 N/A ARG 272.A NH2 ASP 348.A OD2 no hydrogen 2.662 N/A LEU 273.A N SER 270.A OG no hydrogen 3.002 N/A TYR 274.A N GLU 271.A O no hydrogen 3.149 N/A GLY 275.A N TYR 265.A O no hydrogen 2.790 N/A SER 276.A N LEU 273.A O no hydrogen 3.035 N/A SER 276.A OG LEU 273.A O no hydrogen 2.837 N/A TYR 277.A OH ASP 212.A OD2 no hydrogen 2.979 N/A VAL 278.A N PHE 263.A O no hydrogen 2.721 N/A PHE 279.A N LEU 287.A O no hydrogen 3.298 N/A GLY 280.A N GLY 261.A O no hydrogen 2.965 N/A ASP 281.A N ASN 285.A O no hydrogen 2.990 N/A GLY 284.A N ASP 281.A O no hydrogen 3.042 N/A ASN 285.A N ASP 281.A OD2 no hydrogen 2.624 N/A ASN 285.A ND2 ASP 281.A OD1 no hydrogen 3.020 N/A ASN 285.A ND2 ASP 281.A OD2 no hydrogen 3.241 N/A LEU 287.A N PHE 279.A O no hydrogen 2.690 N/A THR 288.A N LYS 301.A O no hydrogen 2.787 N/A LEU 289.A N TYR 277.A O no hydrogen 3.073 N/A GLN 290.A N GLN 299.A O no hydrogen 3.017 N/A GLN 290.A NE2 GLN 291.A O no hydrogen 3.594 N/A GLN 291.A NE2 LYS 296.A O no hydrogen 2.751 N/A SER 292.A N GLN 297.A O no hydrogen 2.932 N/A SER 292.A OG THR 295.A OG1 no hydrogen 2.787 N/A THR 295.A N SER 292.A OG no hydrogen 2.698 N/A THR 295.A OG1 SER 292.A OG no hydrogen 2.787 N/A LYS 296.A N SER 292.A O no hydrogen 2.813 N/A GLN 299.A N GLN 290.A O no hydrogen 2.962 N/A LYS 301.A N THR 288.A O no hydrogen 2.868 N/A GLY 306.A N PHE 4.A O no hydrogen 2.732 N/A SER 308.A N CYS 311.A O no hydrogen 2.739 N/A CYS 311.A SG ILE 6.A O no hydrogen 3.771 N/A ARG 312.A N ILE 6.A O no hydrogen 2.975 N/A SER 316.A N TYR 344.A OH no hydrogen 3.047 N/A HIS 318.A N SER 335.A O no hydrogen 2.966 N/A ILE 319.A N ARG 282.A O no hydrogen 2.822 N/A LEU 320.A N LEU 333.A O no hydrogen 2.746 N/A GLY 323.A N TYR 331.A O no hydrogen 2.974 N/A GLU 324.A N ALA 19.A O no hydrogen 3.231 N/A ASP 325.A N GLU 329.A O no hydrogen 2.777 N/A GLY 328.A N ASP 325.A O no hydrogen 2.983 N/A TYR 331.A N GLY 323.A O no hydrogen 2.950 N/A TYR 331.A OH ASP 325.A OD1 no hydrogen 2.602 N/A TYR 331.A OH ASP 325.A OD2 no hydrogen 3.039 N/A ILE 332.A N TYR 344.A O no hydrogen 2.870 N/A LEU 333.A N GLY 321.A O no hydrogen 2.938 N/A SER 334.A N LYS 342.A O no hydrogen 2.885 N/A SER 334.A OG SER 316.A O no hydrogen 3.215 N/A SER 335.A N HIS 318.A O no hydrogen 3.021 N/A GLY 341.A N LEU 13.A O no hydrogen 2.719 N/A LYS 342.A N SER 334.A O no hydrogen 2.755 N/A LEU 343.A N VAL 10.A O no hydrogen 2.700 N/A TYR 344.A N ILE 332.A O no hydrogen 2.874 N/A LYS 345.A N GLN 7.A O no hydrogen 2.651 N/A LYS 345.A NZ ASP 325.A OD2 no hydrogen 3.196 N/A ILE 346.A N VAL 330.A O no hydrogen 2.996 N/A VAL 347.A N CYS 5.A O no hydrogen 2.592 N/A ASP 348.A N GLN 269.A OE1 no hydrogen 2.802 N/A LYS 350.A N ASP 348.A OD2 no hydrogen 3.400 N/A LYS 350.A NZ HIS 1.A O no hydrogen 3.047 N/A LYS 350.A NZ ASN 2.A OD1 no hydrogen 3.227 N/A ARG 351.A N ASP 348.A O no hydrogen 3.218 N/A ARG 351.A NH1 GLN 269.A O no hydrogen 3.020 N/A ARG 351.A NH2 GLU 356.A OE1 no hydrogen 2.735 N/A ARG 351.A NH2 GLU 356.A OE2 no hydrogen 3.154 N/A CYS 357.A N PRO 354.A O no hydrogen 3.012 N/A ARG 358.A N GLU 355.A O no hydrogen 3.385 N/A GLN 362.A N GLY 25.A O no hydrogen 3.247 N/A GLN 365.A NE2 PRO 363.A O no hydrogen 2.760 N/A CYS 371.A SG LYS 385.A O no hydrogen 3.685 N/A SER 372.A N SER 369.A OG no hydrogen 3.268 N/A ARG 373.A N SER 369.A O no hydrogen 3.177 N/A ARG 373.A NH1 THR 368.A O no hydrogen 3.113 N/A LEU 374.A N GLU 370.A O no hydrogen 3.017 N/A CYS 375.A N CYS 371.A O no hydrogen 3.083 N/A CYS 375.A SG GLY 378.A O no hydrogen 3.884 N/A CYS 375.A SG TYR 379.A O no hydrogen 3.301 N/A ARG 376.A N PHE 396.A O no hydrogen 3.194 N/A ARG 376.A NH1 ASN 377.A O no hydrogen 2.998 N/A ARG 376.A NH2 ASN 377.A O no hydrogen 3.320 N/A TYR 379.A OH CYS 176.A O no hydrogen 3.096 N/A THR 381.A N LYS 385.A O no hydrogen 2.847 N/A THR 381.A OG1 THR 174.A O no hydrogen 2.965 N/A THR 381.A OG1 THR 383.A OG1 no hydrogen 2.719 N/A THR 381.A OG1 LYS 385.A O no hydrogen 3.358 N/A THR 383.A OG1 THR 174.A O no hydrogen 2.565 N/A THR 383.A OG1 ASP 175.A OD1 no hydrogen 2.880 N/A THR 383.A OG1 THR 381.A OG1 no hydrogen 2.719 N/A GLY 384.A N THR 381.A O no hydrogen 2.723 N/A LYS 385.A N THR 381.A OG1 no hydrogen 3.270 N/A LYS 385.A NZ ASP 175.A O no hydrogen 3.014 N/A CYS 386.A SG TYR 379.A O no hydrogen 3.949 N/A CYS 387.A N TYR 379.A O no hydrogen 3.025 N/A CYS 388.A SG GLY 394.A O no hydrogen 3.678 N/A SER 389.A OG ASN 377.A O no hydrogen 3.266 N/A TRP 392.A N SER 389.A O no hydrogen 3.081 N/A GLU 393.A N THR 399.A O no hydrogen 2.912 N/A CYS 397.A N GLY 394.A O no hydrogen 2.781 N/A CYS 397.A SG CYS 386.A O no hydrogen 3.724 N/A CYS 397.A SG GLY 394.A O no hydrogen 3.894 N/A THR 399.A N GLU 393.A O no hydrogen 3.115 N/A THR 399.A OG1 GLU 393.A O no hydrogen 3.560 N/A LYS 401.A N GLY 391.A O no hydrogen 3.009 N/A CYS 402.A SG ARG 414.A O no hydrogen 3.713 N/A CYS 402.A SG LYS 417.A O no hydrogen 3.774 N/A GLU 403.A N ASN 416.A OD1 no hydrogen 2.969 N/A ARG 407.A N GLN 428.A O no hydrogen 2.707 N/A GLY 410.A N ARG 407.A O no hydrogen 2.823 N/A VAL 411.A N LEU 419.A O no hydrogen 3.098 N/A CYS 412.A SG ARG 414.A O no hydrogen 3.621 N/A VAL 413.A N LYS 417.A O no hydrogen 3.122 N/A ASN 416.A N LYS 401.A O no hydrogen 2.894 N/A LYS 417.A N ARG 414.A O no hydrogen 3.021 N/A CYS 418.A SG PRO 427.A O no hydrogen 3.436 N/A LEU 419.A N VAL 411.A O no hydrogen 2.776 N/A CYS 420.A SG GLY 426.A O no hydrogen 3.946 N/A LYS 421.A NZ GLY 409.A O no hydrogen 2.804 N/A TYR 424.A N LYS 421.A O no hydrogen 3.133 N/A GLN 428.A N GLU 430.A OE1 no hydrogen 2.816 N/A CYS 429.A N GLY 426.A O no hydrogen 2.887 N/A GLU 430.A N GLU 430.A OE1 no hydrogen 2.723 N/A HIS 431.A N LEU 425.A O no hydrogen 3.194 N/A