Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 3isx_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): HIS 2.A N GLU 314.A OE1 no hydrogen 2.703 N/A HIS 2.A NE2 ASP 318.A OD2 no hydrogen 2.551 N/A HIS 3.A N GLU 314.A OE2 no hydrogen 2.821 N/A HIS 3.A ND1 GLU 177.A OE2 no hydrogen 3.149 N/A HIS 3.A NE2 ASP 318.A OD1 no hydrogen 2.791 N/A LYS 5.A NZ GLU 157.A OE2 no hydrogen 2.673 N/A ARG 9.A N LYS 5.A O no hydrogen 2.819 N/A ARG 9.A NE GLU 6.A OE1 no hydrogen 2.854 N/A ARG 9.A NH2 GLU 6.A OE2 no hydrogen 2.866 N/A LYS 10.A N GLU 6.A O no hydrogen 2.930 N/A LYS 10.A NZ.A GLU 31.A OE2 no hydrogen 2.776 N/A LEU 11.A N LEU 7.A O no hydrogen 2.977 N/A THR 12.A N ILE 8.A O no hydrogen 2.946 N/A THR 12.A OG1 ILE 8.A O no hydrogen 2.850 N/A THR 12.A OG1 ARG 9.A O no hydrogen 3.358 N/A THR 12.A OG1 SER 164.A OG no hydrogen 2.849 N/A GLU 13.A N ARG 9.A O no hydrogen 3.009 N/A PHE 15.A N GLU 23.A OE1 no hydrogen 2.855 N/A GLY 16.A N GLU 66.A OE2 no hydrogen 2.880 N/A SER 18.A N GLU 66.A O no hydrogen 3.315 N/A SER 18.A OG ASP 65.A OD2 no hydrogen 2.684 N/A GLY 19.A N GLU 21.A OE2 no hydrogen 2.911 N/A ARG 20.A N PRO 17.A O no hydrogen 2.841 N/A GLU 21.A N GLU 21.A OE1 no hydrogen 2.852 N/A GLU 22.A N GLU 22.A OE1 no hydrogen 2.820 N/A ARG 25.A N GLU 21.A O no hydrogen 3.104 N/A ARG 25.A NE GLY 45.A O no hydrogen 2.904 N/A ARG 25.A NH2 GLU 21.A OE1 no hydrogen 3.047 N/A ARG 25.A NH2 GLY 45.A O no hydrogen 2.888 N/A SER 26.A N GLU 22.A O no hydrogen 3.010 N/A SER 26.A OG GLU 22.A O no hydrogen 3.457 N/A ILE 27.A N GLU 23.A O no hydrogen 2.975 N/A ILE 28.A N VAL 24.A O no hydrogen 2.930 N/A LEU 29.A N ARG 25.A O no hydrogen 2.951 N/A GLU 30.A N SER 26.A O no hydrogen 2.957 N/A GLU 31.A N ILE 27.A O no hydrogen 2.988 N/A LEU 32.A N ILE 28.A O no hydrogen 2.921 N/A GLU 33.A N GLU 30.A O no hydrogen 3.270 N/A HIS 35.A N LEU 32.A O no hydrogen 2.827 N/A ASP 37.A N TRP 50.A O no hydrogen 2.788 N/A ARG 40.A N ILE 48.A O no hydrogen 2.869 N/A ARG 40.A NH2 TYR 208.A O no hydrogen 2.608 N/A ASP 42.A N ASN 46.A O no hydrogen 2.961 N/A LEU 44.A N ASP 42.A OD1 no hydrogen 2.926 N/A GLY 45.A N ASP 42.A O no hydrogen 3.064 N/A ASN 46.A N ASP 42.A OD1 no hydrogen 2.950 N/A ASN 46.A ND2 ASP 42.A OD1 no hydrogen 3.296 N/A ASN 46.A ND2 ASP 42.A OD2 no hydrogen 2.941 N/A LEU 47.A N PHE 192.A O no hydrogen 3.010 N/A ILE 48.A N ARG 40.A O no hydrogen 2.826 N/A VAL 49.A N GLY 190.A O no hydrogen 2.835 N/A TRP 50.A N GLY 38.A O no hydrogen 3.242 N/A LYS 51.A N LEU 188.A O no hydrogen 2.922 N/A LYS 51.A NZ PHE 179.A O no hydrogen 2.665 N/A LYS 51.A NZ ILE 182.A O no hydrogen 3.048 N/A GLY 52.A N ASP 37.A OD2 no hydrogen 3.351 N/A LYS 56.A NZ GLU 214.A OE2 no hydrogen 2.973 N/A LYS 57.A N ASP 213.A OD2 no hydrogen 2.861 N/A VAL 58.A N THR 187.A O no hydrogen 3.007 N/A ILE 59.A N GLU 214.A O no hydrogen 2.901 N/A LEU 60.A N TYR 189.A O no hydrogen 2.798 N/A ASP 61.A N ILE 216.A O no hydrogen 2.978 N/A ALA 62.A N VAL 191.A O no hydrogen 2.989 N/A HIS 63.A N ASP 168.A OD2 no hydrogen 3.154 N/A HIS 63.A ND1.A SER 193.A OG no hydrogen 3.250 N/A ILE 64.A N SER 193.A O no hydrogen 2.778 N/A GLU 66.A N GLY 16.A O no hydrogen 2.931 N/A GLY 68.A N VAL 85.A O no hydrogen 3.000 N/A VAL 69.A N GLY 149.A O no hydrogen 2.886 N/A VAL 70.A N GLU 83.A O no hydrogen 2.915 N/A VAL 71.A N SER 147.A O no hydrogen 2.851 N/A THR 72.A N THR 81.A O no hydrogen 2.826 N/A THR 72.A OG1 THR 81.A O no hydrogen 3.352 N/A ASP 75.A N PHE 79.A O no hydrogen 2.889 N/A LYS 77.A N ASP 75.A OD1 no hydrogen 2.915 N/A GLY 78.A N ASP 75.A O no hydrogen 3.034 N/A PHE 79.A N ASP 75.A OD1 no hydrogen 2.858 N/A LEU 80.A N ILE 130.A O no hydrogen 2.913 N/A THR 81.A N ASN 73.A O no hydrogen 2.882 N/A GLU 83.A N VAL 70.A O no hydrogen 2.980 N/A VAL 85.A N GLY 68.A O no hydrogen 2.851 N/A VAL 88.A N.A GLY 86.A O no hydrogen 2.941 N/A TYR 91.A N SER 89.A OG no hydrogen 3.107 N/A TYR 91.A OH VAL 120.A O no hydrogen 2.772 N/A LEU 93.A N PRO 90.A O no hydrogen 3.316 N/A GLY 94.A N.A VAL 107.A O no hydrogen 3.140 N/A GLY 94.A N.B VAL 107.A O no hydrogen 3.248 N/A LYS 95.A N.A LEU 92.A O no hydrogen 3.064 N/A LYS 95.A NZ.A LEU 93.A O no hydrogen 3.425 N/A ILE 97.A N GLY 105.A O no hydrogen 2.860 N/A ARG 98.A N VAL 150.A O no hydrogen 2.796 N/A ARG 98.A NE.A ASP 152.A OD1.B no hydrogen 2.710 N/A ARG 98.A NE.B ASP 152.A OD1.B no hydrogen 3.031 N/A ARG 98.A NH1.B GLY 102.A O no hydrogen 2.477 N/A ARG 98.A NH2.A ASP 152.A O.B no hydrogen 2.693 N/A ARG 98.A NH2.A ASP 152.A OD1.A no hydrogen 3.436 N/A ARG 98.A NH2.A ASP 152.A OD1.B no hydrogen 2.913 N/A ARG 98.A NH2.B ASP 152.A OD1.B no hydrogen 3.043 N/A PHE 99.A N THR 103.A O no hydrogen 2.871 N/A GLY 102.A N PHE 99.A O no hydrogen 2.961 N/A THR 103.A N ASN 101.A OD1 no hydrogen 3.106 N/A THR 103.A OG1 ASN 101.A OD1 no hydrogen 2.582 N/A GLY 105.A N ILE 97.A O no hydrogen 2.855 N/A VAL 106.A N ASP 131.A O no hydrogen 2.873 N/A VAL 107.A N LYS 95.A O.A no hydrogen 3.001 N/A VAL 107.A N LYS 95.A O.B no hydrogen 2.997 N/A GLY 108.A N PHE 129.A O no hydrogen 2.897 N/A GLU 111.A N GLU 115.A OE1 no hydrogen 2.695 N/A THR 112.A N GLU 115.A OE1 no hydrogen 2.542 N/A GLU 115.A N THR 112.A OG1 no hydrogen 2.886 N/A ARG 116.A N THR 112.A O no hydrogen 2.948 N/A ARG 116.A NH1 GLY 110.A O no hydrogen 2.985 N/A GLN 117.A N THR 113.A O no hydrogen 2.708 N/A GLU 118.A N GLU 114.A O no hydrogen 2.795 N/A ASN 119.A N GLU 115.A O no hydrogen 2.810 N/A ASN 119.A ND2 GLU 109.A O no hydrogen 2.925 N/A VAL 120.A N ARG 116.A O no hydrogen 2.668 N/A ARG 121.A N GLN 117.A O no hydrogen 2.976 N/A LYS 122.A N ASN 119.A O no hydrogen 3.219 N/A LEU 123.A N TYR 91.A OH no hydrogen 2.979 N/A SER 124.A OG ASP 126.A OD1 no hydrogen 2.677 N/A LYS 127.A N SER 124.A O no hydrogen 3.003 N/A LEU 128.A N PHE 125.A O no hydrogen 3.004 N/A PHE 129.A N GLY 108.A O no hydrogen 2.963 N/A ILE 130.A N LEU 80.A O no hydrogen 2.855 N/A ASP 131.A N VAL 106.A O no hydrogen 2.860 N/A GLY 133.A N ASP 131.A OD1 no hydrogen 2.926 N/A ASN 135.A N GLU 139.A OE1 no hydrogen 2.787 N/A ARG 137.A NE VAL 74.A O no hydrogen 3.017 N/A ARG 137.A NH1 ASP 76.A OD1 no hydrogen 2.163 N/A ARG 137.A NH2 VAL 74.A O no hydrogen 3.211 N/A GLU 139.A N SER 136.A OG no hydrogen 3.146 N/A ALA 140.A N SER 136.A O no hydrogen 3.096 N/A GLN 141.A N ARG 137.A O no hydrogen 2.860 N/A LYS 142.A N GLU 138.A O no hydrogen 3.367 N/A GLY 146.A N VAL 71.A O no hydrogen 2.813 N/A SER 147.A N PRO 144.A O no hydrogen 2.968 N/A SER 147.A OG PRO 144.A O no hydrogen 2.711 N/A GLY 149.A N VAL 69.A O no hydrogen 2.901 N/A VAL 150.A N ARG 98.A O no hydrogen 2.943 N/A TYR 151.A OH HIS 303.A O no hydrogen 2.887 N/A ASP 152.A N.A ARG 96.A O no hydrogen 2.993 N/A ASP 152.A N.B ARG 96.A O no hydrogen 3.084 N/A SER 153.A OG.A PRO 305.A O no hydrogen 2.876 N/A SER 153.A OG.B ASP 152.A O.A no hydrogen 2.972 N/A PHE 155.A N GLU 13.A OE2 no hydrogen 2.820 N/A VAL 156.A N VAL 163.A O no hydrogen 2.823 N/A VAL 158.A N LYS 161.A O no hydrogen 2.890 N/A LYS 161.A N VAL 158.A O no hydrogen 2.898 N/A TYR 162.A N ILE 308.A O no hydrogen 3.006 N/A VAL 163.A N VAL 156.A O no hydrogen 2.851 N/A SER 164.A N GLU 307.A O no hydrogen 2.997 N/A SER 164.A OG THR 12.A OG1 no hydrogen 2.849 N/A SER 164.A OG LYS 165.A O no hydrogen 3.555 N/A LYS 165.A NZ THR 12.A O no hydrogen 2.772 N/A LYS 165.A NZ ALA 14.A O no hydrogen 2.856 N/A LYS 165.A NZ GLU 66.A OE1 no hydrogen 2.756 N/A LYS 165.A NZ GLU 66.A OE2 no hydrogen 3.127 N/A ARG 169.A N ALA 166.A O no hydrogen 2.969 N/A ARG 169.A NE ILE 64.A O no hydrogen 2.888 N/A ARG 169.A NH1 LEU 11.A O no hydrogen 2.906 N/A ARG 169.A NH1 ALA 14.A O no hydrogen 3.027 N/A ARG 169.A NH1 GLU 66.A OE2 no hydrogen 3.357 N/A ARG 169.A NH2 ILE 64.A O no hydrogen 2.969 N/A ARG 169.A NH2 GLU 66.A OE2 no hydrogen 2.861 N/A GLY 171.A N ASP 168.A OD1 no hydrogen 3.182 N/A CYS 172.A N ASP 168.A O no hydrogen 3.036 N/A CYS 172.A SG HIS 63.A O no hydrogen 3.313 N/A CYS 172.A SG ASP 168.A O no hydrogen 3.545 N/A ALA 173.A N ARG 169.A O no hydrogen 2.899 N/A VAL 174.A N ILE 170.A O no hydrogen 2.964 N/A ILE 175.A N GLY 171.A O no hydrogen 3.059 N/A VAL 176.A N CYS 172.A O no hydrogen 2.953 N/A GLU 177.A N ALA 173.A O no hydrogen 2.905 N/A VAL 178.A N VAL 174.A O no hydrogen 2.885 N/A PHE 179.A N ILE 175.A O no hydrogen 2.942 N/A LYS 180.A N VAL 176.A O no hydrogen 2.967 N/A LYS 180.A NZ GLU 31.A OE1 no hydrogen 2.679 N/A ARG 181.A N GLU 177.A O no hydrogen 3.058 N/A ARG 181.A N VAL 178.A O no hydrogen 3.173 N/A ARG 181.A NE GLU 177.A OE2 no hydrogen 2.732 N/A ARG 181.A NH2 GLU 177.A OE1 no hydrogen 3.489 N/A ARG 181.A NH2 GLU 177.A OE2 no hydrogen 3.352 N/A ILE 182.A N VAL 178.A O no hydrogen 2.836 N/A ALA 185.A N LEU 324.A O no hydrogen 2.966 N/A THR 187.A N LYS 56.A O no hydrogen 2.824 N/A THR 187.A OG1 GLY 54.A O no hydrogen 2.818 N/A LEU 188.A N LYS 51.A O no hydrogen 2.893 N/A TYR 189.A N VAL 58.A O no hydrogen 2.827 N/A GLY 190.A N VAL 49.A O no hydrogen 2.880 N/A VAL 191.A N LEU 60.A O no hydrogen 2.765 N/A PHE 192.A N LEU 47.A O no hydrogen 2.805 N/A SER 193.A N ALA 62.A O no hydrogen 2.869 N/A SER 193.A OG ASP 61.A OD1 no hydrogen 2.639 N/A SER 193.A OG ALA 62.A O no hydrogen 3.397 N/A SER 193.A OG HIS 63.A ND1.A no hydrogen 3.250 N/A VAL 194.A N ASN 46.A OD1 no hydrogen 2.815 N/A GLN 195.A N ASP 65.A OD1 no hydrogen 2.939 N/A GLN 195.A N ASP 65.A OD2 no hydrogen 3.438 N/A GLN 195.A NE2 ASP 65.A OD2 no hydrogen 3.339 N/A LEU 200.A N GLU 197.A O no hydrogen 2.996 N/A SER 204.A N GLU 196.A OE2.B no hydrogen 2.843 N/A SER 204.A OG GLU 196.A OE1.A no hydrogen 2.931 N/A SER 204.A OG GLU 196.A OE1.B no hydrogen 2.763 N/A SER 204.A OG GLU 196.A OE2.A no hydrogen 3.334 N/A SER 204.A OG GLU 196.A OE2.B no hydrogen 3.094 N/A GLY 207.A N SER 204.A O no hydrogen 2.899 N/A TYR 208.A N ALA 203.A O no hydrogen 2.903 N/A TYR 208.A OH ASP 61.A OD2 no hydrogen 2.569 N/A GLY 209.A N ALA 206.A O no hydrogen 3.256 N/A VAL 210.A N GLY 207.A O no hydrogen 2.825 N/A ALA 212.A N VAL 210.A O no hydrogen 2.833 N/A ASP 213.A N LYS 57.A O no hydrogen 2.771 N/A GLU 214.A N LYS 57.A O no hydrogen 3.290 N/A ALA 215.A N PRO 291.A O no hydrogen 2.879 N/A ILE 216.A N ILE 59.A O no hydrogen 2.781 N/A ALA 217.A N ALA 293.A O no hydrogen 2.911 N/A ILE 218.A N ASP 61.A O no hydrogen 2.824 N/A ASP 219.A N VAL 295.A O no hydrogen 3.046 N/A THR 221.A N ILE 297.A O no hydrogen 3.044 N/A THR 221.A OG1 GLU 272.A OE2 no hydrogen 2.621 N/A SER 223.A N THR 299.A O no hydrogen 2.855 N/A SER 223.A OG ASP 225.A OD1 no hydrogen 2.710 N/A ALA 229.A N THR 226.A O no hydrogen 3.226 N/A LEU 236.A N SER 223.A OG no hydrogen 3.092 N/A LEU 236.A N ASP 225.A OD2 no hydrogen 3.064 N/A SER 237.A N ASP 312.A OD2 no hydrogen 2.823 N/A SER 237.A OG ASP 311.A OD2.B no hydrogen 2.850 N/A GLY 238.A N ARG 235.A O no hydrogen 3.183 N/A GLY 239.A N ASP 312.A OD1 no hydrogen 2.764 N/A ALA 241.A N SER 296.A O no hydrogen 2.893 N/A LEU 242.A N GLN 271.A O no hydrogen 2.780 N/A LYS 243.A N THR 294.A O no hydrogen 3.024 N/A LYS 243.A NZ THR 275.A OG1 no hydrogen 2.887 N/A ASP 246.A N THR 275.A O no hydrogen 2.931 N/A ARG 247.A NH1 ASN 280.A O no hydrogen 3.033 N/A ARG 247.A NH2 ASN 280.A O no hydrogen 3.079 N/A ALA 248.A N LYS 245.A O no hydrogen 3.162 N/A SER 249.A OG SER 252.A OG no hydrogen 3.212 N/A SER 252.A N SER 249.A OG no hydrogen 2.996 N/A SER 252.A OG SER 249.A OG no hydrogen 3.212 N/A SER 252.A OG SER 292.A O no hydrogen 3.434 N/A LYS 253.A N SER 249.A O no hydrogen 2.909 N/A ARG 254.A N ILE 250.A O no hydrogen 2.930 N/A ILE 255.A N SER 251.A O no hydrogen 3.355 N/A ILE 255.A N SER 252.A O no hydrogen 3.028 N/A LEU 256.A N SER 252.A O no hydrogen 3.321 N/A GLU 257.A N LYS 253.A O no hydrogen 2.909 N/A ASN 258.A N ARG 254.A O no hydrogen 2.903 N/A LEU 259.A N ILE 255.A O no hydrogen 2.888 N/A ILE 260.A N LEU 256.A O no hydrogen 2.913 N/A GLU 261.A N GLU 257.A O no hydrogen 2.940 N/A ILE 262.A N ASN 258.A O no hydrogen 2.987 N/A ALA 263.A N LEU 259.A O no hydrogen 2.919 N/A GLU 264.A N ILE 260.A O no hydrogen 2.918 N/A LYS 265.A N GLU 261.A O no hydrogen 2.902 N/A PHE 266.A N ILE 262.A O no hydrogen 3.013 N/A ASP 267.A N GLU 264.A O no hydrogen 3.385 N/A ILE 268.A N ALA 263.A O no hydrogen 2.878 N/A LYS 269.A NZ SER 237.A O no hydrogen 2.792 N/A TYR 270.A OH GLU 264.A OE2 no hydrogen 2.689 N/A GLN 271.A N PRO 240.A O no hydrogen 2.898 N/A GLN 271.A NE2 ARG 235.A O no hydrogen 2.983 N/A GLN 271.A NE2 GLY 239.A O no hydrogen 2.865 N/A THR 275.A N VAL 244.A O no hydrogen 3.160 N/A TYR 283.A N ASN 280.A O no hydrogen 3.290 N/A GLN 284.A N ALA 281.A O no hydrogen 3.117 N/A GLN 284.A NE2.A GLU 288.A OE1 no hydrogen 3.341 N/A THR 286.A OG1 ARG 247.A O no hydrogen 2.793 N/A THR 286.A OG1 TYR 283.A O no hydrogen 3.005 N/A ARG 287.A N GLN 284.A O no hydrogen 2.958 N/A ARG 287.A NH1 ARG 247.A O no hydrogen 2.793 N/A ARG 287.A NH1 TYR 283.A O no hydrogen 3.360 N/A SER 292.A N SER 252.A OG no hydrogen 2.927 N/A SER 292.A OG.A ILE 290.A O no hydrogen 2.675 N/A ALA 293.A N ALA 215.A O no hydrogen 3.084 N/A THR 294.A N LYS 243.A O no hydrogen 2.896 N/A VAL 295.A N ALA 217.A O no hydrogen 2.837 N/A SER 296.A N ALA 241.A O no hydrogen 2.853 N/A ILE 297.A N ASP 219.A O no hydrogen 2.817 N/A THR 299.A N THR 221.A O no hydrogen 2.844 N/A THR 299.A OG1 ILE 297.A O no hydrogen 2.967 N/A ARG 300.A NE ASP 225.A OD1 no hydrogen 2.852 N/A ARG 300.A NH2 ASP 225.A OD2 no hydrogen 2.934 N/A HIS 303.A N GLU 307.A OE2 no hydrogen 2.698 N/A SER 304.A N TYR 301.A O no hydrogen 3.064 N/A SER 304.A OG TYR 301.A O no hydrogen 2.756 N/A SER 306.A N SER 304.A OG no hydrogen 2.962 N/A GLU 307.A N SER 164.A O no hydrogen 2.891 N/A ASP 312.A N ALA 309.A O no hydrogen 2.918 N/A GLU 314.A N PRO 310.A O no hydrogen 3.000 N/A ALA 315.A N ASP 311.A O no hydrogen 2.931 N/A THR 316.A N ASP 312.A O no hydrogen 3.048 N/A THR 316.A OG1 ASP 312.A O no hydrogen 2.816 N/A VAL 317.A N VAL 313.A O no hydrogen 3.021 N/A ASP 318.A N GLU 314.A O no hydrogen 2.921 N/A LEU 319.A N ALA 315.A O no hydrogen 2.888 N/A LEU 320.A N THR 316.A O no hydrogen 3.061 N/A ILE 321.A N VAL 317.A O no hydrogen 2.905 N/A ARG 322.A N ASP 318.A O no hydrogen 3.092 N/A ARG 322.A NH1 ASP 318.A O no hydrogen 3.224 N/A TYR 323.A N LEU 319.A O no hydrogen 2.917 N/A TYR 323.A OH GLU 214.A OE1 no hydrogen 2.513 N/A LEU 324.A N LEU 320.A O no hydrogen 2.899 N/A