Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 3mfs_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ASP 7.A N LEU 4.A O no hydrogen 3.146 N/A VAL 8.A N PHE 5.A O no hydrogen 3.094 N/A TYR 9.A N PHE 5.A O no hydrogen 3.037 N/A TYR 9.A OH GLU 76.A OE2 no hydrogen 2.432 N/A GLU 10.A N ILE 27.A O no hydrogen 2.812 N/A CYS 12.A N ARG 25.A O no hydrogen 2.771 N/A CYS 12.A SG GLU 10.A O no hydrogen 3.818 N/A ILE 15.A N VAL 23.A O no hydrogen 2.785 N/A GLY 16.A N VAL 23.A O no hydrogen 3.322 N/A GLY 18.A N SER 21.A O no hydrogen 2.814 N/A VAL 22.A N ILE 39.A O no hydrogen 2.992 N/A VAL 23.A N GLY 16.A O no hydrogen 2.851 N/A ARG 24.A N VAL 37.A O no hydrogen 2.778 N/A ARG 24.A NE CYS 12.A O no hydrogen 2.774 N/A ARG 24.A NH1 CYS 12.A O no hydrogen 2.756 N/A ARG 25.A N GLU 13.A O no hydrogen 2.954 N/A ARG 25.A NE GLU 13.A OE1 no hydrogen 3.145 N/A ARG 25.A NE GLU 13.A OE2 no hydrogen 2.772 N/A ARG 25.A NH1 GLU 13.A OE2 no hydrogen 2.497 N/A CYS 26.A N PHE 35.A O no hydrogen 2.925 N/A ILE 27.A N GLU 10.A O no hydrogen 2.925 N/A ASN 28.A N GLN 33.A O no hydrogen 2.979 N/A ARG 29.A N VAL 8.A O no hydrogen 2.946 N/A ARG 29.A NE GLU 6.A O no hydrogen 2.899 N/A ARG 29.A NH1 GLU 6.A O no hydrogen 3.024 N/A THR 31.A N ASN 28.A OD1 no hydrogen 3.032 N/A GLY 32.A N ASN 28.A O no hydrogen 2.681 N/A GLN 33.A N THR 31.A OG1 no hydrogen 3.335 N/A PHE 35.A N CYS 26.A O no hydrogen 2.763 N/A ALA 36.A N PHE 88.A O no hydrogen 3.039 N/A VAL 37.A N ARG 24.A O no hydrogen 2.703 N/A LYS 38.A N MET 86.A O no hydrogen 2.762 N/A LYS 38.A NZ GLU 59.A OE2 no hydrogen 3.256 N/A ILE 39.A N VAL 22.A O no hydrogen 2.819 N/A VAL 40.A N LEU 84.A O no hydrogen 2.829 N/A ASP 41.A N PHE 20.A O no hydrogen 3.144 N/A VAL 42.A N GLY 82.A O no hydrogen 3.032 N/A LYS 44.A N ASP 41.A OD2 no hydrogen 3.283 N/A PHE 45.A N ASP 41.A O no hydrogen 3.012 N/A THR 46.A N VAL 42.A O no hydrogen 2.947 N/A THR 46.A OG1 VAL 42.A O no hydrogen 2.906 N/A SER 47.A N ALA 43.A O no hydrogen 2.707 N/A SER 47.A OG ALA 43.A O no hydrogen 3.272 N/A LEU 51.A N SER 48.A O no hydrogen 3.276 N/A SER 52.A OG ASP 55.A OD1 no hydrogen 3.449 N/A LYS 57.A N THR 53.A O no hydrogen 2.796 N/A ARG 58.A N GLU 54.A O no hydrogen 2.740 N/A ARG 58.A NH2 GLY 161.A O no hydrogen 3.315 N/A GLU 59.A N ASP 55.A O no hydrogen 3.410 N/A ALA 60.A N LEU 56.A O no hydrogen 3.141 N/A SER 61.A N LYS 57.A O no hydrogen 3.028 N/A ILE 62.A N ARG 58.A O no hydrogen 2.885 N/A CYS 63.A N GLU 59.A O no hydrogen 2.845 N/A CYS 63.A SG GLU 59.A O no hydrogen 3.137 N/A HIS 64.A N ALA 60.A O no hydrogen 2.927 N/A MET 65.A N.A SER 61.A O no hydrogen 3.139 N/A MET 65.A N.B SER 61.A O no hydrogen 3.147 N/A MET 65.A N.B ILE 62.A O no hydrogen 3.184 N/A LEU 66.A N ILE 62.A O no hydrogen 2.957 N/A LYS 67.A N TYR 128.A OH no hydrogen 3.023 N/A LYS 67.A NZ GLU 73.A OE1 no hydrogen 2.986 N/A LYS 67.A NZ LEU 74.A O no hydrogen 2.938 N/A HIS 70.A N HIS 68.A ND1 no hydrogen 3.063 N/A HIS 70.A ND1 VAL 155.A O no hydrogen 2.995 N/A ILE 71.A N HIS 68.A O no hydrogen 3.060 N/A VAL 72.A N LEU 157.A O no hydrogen 3.074 N/A GLU 73.A N GLU 89.A OE1 no hydrogen 2.854 N/A LEU 75.A N VAL 87.A O no hydrogen 2.637 N/A GLU 76.A N VAL 87.A O no hydrogen 3.411 N/A TYR 78.A N TYR 85.A O no hydrogen 2.782 N/A TYR 78.A OH GLU 76.A OE2 no hydrogen 2.775 N/A SER 80.A N MET 83.A O no hydrogen 3.139 N/A LEU 84.A N VAL 40.A O no hydrogen 2.887 N/A TYR 85.A N TYR 78.A O no hydrogen 2.849 N/A MET 86.A N LYS 38.A O no hydrogen 2.741 N/A VAL 87.A N GLU 76.A O no hydrogen 2.906 N/A PHE 88.A N ALA 36.A O no hydrogen 2.722 N/A GLU 89.A N GLU 73.A O no hydrogen 2.853 N/A ASP 92.A N ALA 147.A O no hydrogen 2.860 N/A ALA 94.A N GLU 99.A OE1 no hydrogen 2.709 N/A LEU 96.A N VAL 144.A O no hydrogen 3.009 N/A PHE 98.A N ASP 95.A OD2 no hydrogen 3.005 N/A GLU 99.A N ASP 95.A O no hydrogen 2.971 N/A ILE 100.A N LEU 96.A O no hydrogen 2.865 N/A LYS 102.A N PHE 98.A O no hydrogen 3.416 N/A LYS 102.A NZ GLU 99.A OE1 no hydrogen 3.342 N/A ARG 103.A N GLU 99.A O no hydrogen 2.828 N/A ARG 103.A NE VAL 109.A O no hydrogen 3.264 N/A ARG 103.A NH1 ASN 151.A O no hydrogen 3.524 N/A ALA 104.A N ILE 100.A O no hydrogen 3.000 N/A ASP 105.A N VAL 101.A O no hydrogen 2.756 N/A ALA 106.A N LYS 102.A O no hydrogen 2.760 N/A GLY 107.A N ALA 104.A O no hydrogen 3.107 N/A PHE 108.A N ARG 103.A O no hydrogen 3.090 N/A TYR 110.A N HIS 284.A ND1 no hydrogen 3.199 N/A TYR 110.A OH LEU 209.A O no hydrogen 2.513 N/A ALA 113.A N TYR 281.A O no hydrogen 3.077 N/A ALA 115.A N SER 111.A O no hydrogen 3.212 N/A SER 116.A N GLU 112.A O no hydrogen 2.655 N/A SER 116.A OG TRP 272.A O no hydrogen 2.613 N/A HIS 117.A N ALA 113.A O no hydrogen 3.007 N/A TYR 118.A N VAL 114.A O no hydrogen 3.008 N/A MET 119.A N ALA 115.A O no hydrogen 2.893 N/A ARG 120.A N SER 116.A O no hydrogen 3.020 N/A GLN 121.A N HIS 117.A O no hydrogen 3.367 N/A GLN 121.A NE2 HIS 117.A O no hydrogen 3.486 N/A ILE 122.A N TYR 118.A O no hydrogen 3.194 N/A LEU 123.A N MET 119.A O no hydrogen 2.857 N/A GLU 124.A N ARG 120.A O no hydrogen 2.664 N/A ALA 125.A N GLN 121.A O no hydrogen 3.060 N/A LEU 126.A N ILE 122.A O no hydrogen 3.048 N/A ARG 127.A N LEU 123.A O no hydrogen 2.725 N/A TYR 128.A N GLU 124.A O no hydrogen 3.244 N/A TYR 128.A OH MET 65.A O.B no hydrogen 3.362 N/A CYS 129.A N ALA 125.A O no hydrogen 2.962 N/A CYS 129.A SG ALA 125.A O no hydrogen 3.380 N/A HIS 130.A N LEU 126.A O no hydrogen 2.768 N/A HIS 130.A ND1 ILE 134.A O no hydrogen 3.229 N/A ASP 131.A N ARG 127.A O no hydrogen 2.809 N/A ASN 132.A N CYS 129.A O no hydrogen 3.053 N/A ASN 132.A ND2 TYR 128.A O no hydrogen 2.710 N/A ASN 133.A N HIS 130.A O no hydrogen 2.759 N/A ILE 134.A N CYS 129.A O no hydrogen 3.004 N/A ILE 135.A N ILE 164.A O no hydrogen 2.876 N/A HIS 136.A N ASP 198.A OD2 no hydrogen 2.797 N/A HIS 136.A NE2 GLY 158.A O no hydrogen 2.635 N/A ARG 137.A N ASP 198.A OD1 no hydrogen 2.853 N/A ARG 137.A NE VAL 162.A O no hydrogen 2.690 N/A ARG 137.A NH1 VAL 162.A O no hydrogen 2.613 N/A ARG 137.A NH2 TYR 193.A OH no hydrogen 3.002 N/A ASP 138.A N HIS 136.A ND1 no hydrogen 3.115 N/A LYS 140.A NZ THR 179.A OG1 no hydrogen 2.784 N/A GLU 142.A N GLU 142.A OE1 no hydrogen 2.838 N/A ASN 143.A N LYS 140.A O no hydrogen 2.905 N/A ASN 143.A ND2 ASP 138.A O no hydrogen 2.650 N/A VAL 144.A N PRO 141.A O no hydrogen 3.051 N/A LEU 145.A N.A LYS 156.A O no hydrogen 3.028 N/A LEU 145.A N.B LYS 156.A O no hydrogen 3.042 N/A LEU 146.A N ALA 94.A O no hydrogen 3.183 N/A ALA 147.A N PRO 154.A O no hydrogen 2.877 N/A LYS 149.A NZ ASP 92.A O no hydrogen 3.211 N/A LYS 149.A NZ ASP 92.A OD2 no hydrogen 3.305 N/A ALA 153.A N GLU 150.A O no hydrogen 3.142 N/A VAL 155.A N GLN 121.A OE1 no hydrogen 2.798 N/A LYS 156.A N LEU 145.A O.A no hydrogen 2.885 N/A LYS 156.A N LEU 145.A O.B no hydrogen 2.887 N/A LYS 156.A NZ GLU 89.A OE1 no hydrogen 3.220 N/A LYS 156.A NZ GLU 89.A OE2 no hydrogen 2.589 N/A LEU 157.A N HIS 70.A O no hydrogen 2.959 N/A GLY 158.A N ASN 143.A O no hydrogen 2.776 N/A ALA 163.A N PHE 160.A O no hydrogen 3.266 N/A ILE 164.A N ILE 135.A O no hydrogen 2.966 N/A GLN 165.A NE2 ASN 132.A O no hydrogen 3.071 N/A LEU 166.A N ASN 133.A O no hydrogen 2.779 N/A LEU 171.A N SER 169.A OG no hydrogen 3.120 N/A VAL 172.A N TYR 193.A O no hydrogen 2.809 N/A ARG 176.A NE VAL 188.A O no hydrogen 2.769 N/A ARG 176.A NH1 VAL 188.A O no hydrogen 3.086 N/A THR 179.A OG1 ASP 138.A OD1 no hydrogen 2.749 N/A HIS 181.A ND1 PHE 216.A O no hydrogen 3.159 N/A PHE 182.A N THR 179.A O no hydrogen 2.735 N/A MET 183.A N PRO 180.A O no hydrogen 3.242 N/A GLU 186.A N GLU 186.A OE1 no hydrogen 2.823 N/A VAL 187.A N ALA 184.A O no hydrogen 2.897 N/A VAL 188.A N ALA 184.A O no hydrogen 3.021 N/A LYS 189.A N PRO 185.A O no hydrogen 2.898 N/A ARG 190.A N VAL 187.A O no hydrogen 2.886 N/A GLU 191.A N GLU 186.A O no hydrogen 2.938 N/A TYR 193.A N VAL 172.A O no hydrogen 2.873 N/A LYS 195.A NZ HIS 130.A O no hydrogen 3.280 N/A LYS 195.A NZ ASN 133.A OD1 no hydrogen 2.961 N/A VAL 197.A N GLY 194.A O no hydrogen 3.102 N/A ASP 198.A N LYS 195.A O no hydrogen 3.005 N/A TRP 200.A N PRO 196.A O no hydrogen 3.031 N/A GLY 201.A N VAL 197.A O no hydrogen 3.120 N/A CYS 202.A N ASP 198.A O no hydrogen 3.036 N/A CYS 202.A SG ASP 198.A O no hydrogen 3.467 N/A GLY 203.A N VAL 199.A O no hydrogen 2.780 N/A VAL 204.A N TRP 200.A O no hydrogen 2.910 N/A ILE 205.A N GLY 201.A O no hydrogen 3.058 N/A LEU 206.A N CYS 202.A O no hydrogen 2.794 N/A PHE 207.A N GLY 203.A O no hydrogen 3.053 N/A ILE 208.A N VAL 204.A O no hydrogen 2.974 N/A LEU 209.A N ILE 205.A O no hydrogen 2.692 N/A LEU 210.A N LEU 206.A O no hydrogen 2.980 N/A SER 211.A N PHE 207.A O no hydrogen 3.142 N/A SER 211.A N ILE 208.A O no hydrogen 3.396 N/A SER 211.A OG PHE 207.A O no hydrogen 2.794 N/A GLY 212.A N ILE 208.A O no hydrogen 2.660 N/A CYS 213.A N SER 211.A OG no hydrogen 3.152 N/A CYS 213.A SG SER 211.A O no hydrogen 3.853 N/A ARG 222.A N THR 219.A OG1 no hydrogen 3.385 N/A LEU 223.A N THR 219.A O no hydrogen 2.850 N/A PHE 224.A N LYS 220.A O no hydrogen 3.086 N/A GLU 225.A N GLU 221.A O no hydrogen 2.971 N/A GLY 226.A N ARG 222.A O no hydrogen 2.900 N/A ILE 227.A N LEU 223.A O no hydrogen 3.065 N/A ILE 228.A N PHE 224.A O no hydrogen 2.972 N/A LYS 229.A N GLU 225.A O no hydrogen 3.008 N/A GLY 230.A N ILE 227.A O no hydrogen 2.962 N/A GLN 238.A N ASN 235.A O no hydrogen 3.196 N/A TRP 239.A N ASN 235.A O no hydrogen 3.219 N/A SER 240.A N PRO 236.A O no hydrogen 3.108 N/A SER 240.A OG PRO 236.A O no hydrogen 2.482 N/A HIS 241.A N GLN 238.A O no hydrogen 3.402 N/A ILE 242.A N TRP 239.A O no hydrogen 2.922 N/A SER 243.A N GLU 112.A OE1 no hydrogen 2.826 N/A SER 243.A OG GLU 112.A OE1 no hydrogen 3.426 N/A SER 243.A OG GLU 112.A OE2 no hydrogen 2.641 N/A ALA 246.A N SER 243.A OG no hydrogen 3.273 N/A LYS 247.A N SER 243.A O no hydrogen 3.067 N/A ASP 248.A N GLU 244.A O no hydrogen 2.628 N/A LEU 249.A N SER 245.A O no hydrogen 3.229 N/A VAL 250.A N ALA 246.A O no hydrogen 3.117 N/A ARG 251.A N LYS 247.A O no hydrogen 3.082 N/A ARG 252.A N ASP 248.A O no hydrogen 3.137 N/A ARG 252.A NE ASP 248.A OD1 no hydrogen 2.972 N/A MET 253.A N LEU 249.A O no hydrogen 2.816 N/A LEU 254.A N VAL 250.A O no hydrogen 2.847 N/A ALA 259.A N ASP 257.A OD1 no hydrogen 3.014 N/A GLU 260.A N ASP 257.A O no hydrogen 2.944 N/A ARG 261.A N ASP 257.A O no hydrogen 3.042 N/A ARG 261.A NE MET 255.A O no hydrogen 2.699 N/A ARG 261.A NH1 GLU 186.A OE1 no hydrogen 3.540 N/A ARG 261.A NH1 GLU 186.A OE2 no hydrogen 2.825 N/A ARG 261.A NH1 PRO 196.A O no hydrogen 2.929 N/A ARG 261.A NH2 GLU 186.A OE1 no hydrogen 2.962 N/A ARG 261.A NH2 MET 255.A O no hydrogen 2.908 N/A ARG 261.A NH2 LEU 256.A O no hydrogen 3.078 N/A ILE 262.A N ARG 252.A O no hydrogen 3.338 N/A THR 263.A N GLU 266.A OE2 no hydrogen 2.923 N/A TYR 265.A OH ASP 131.A OD2 no hydrogen 2.553 N/A GLU 266.A N THR 263.A OG1 no hydrogen 2.955 N/A ALA 267.A N THR 263.A O no hydrogen 2.915 N/A LEU 268.A N VAL 264.A O no hydrogen 2.981 N/A ASN 269.A N TYR 265.A O no hydrogen 3.294 N/A HIS 270.A N ALA 267.A O no hydrogen 3.014 N/A HIS 270.A NE2 ASP 248.A OD1 no hydrogen 2.755 N/A TRP 272.A N HIS 270.A ND1 no hydrogen 3.144 N/A TRP 272.A NE1 GLU 112.A OE2 no hydrogen 2.799 N/A LEU 273.A N HIS 270.A O no hydrogen 2.960 N/A LYS 274.A N HIS 270.A O no hydrogen 2.838 N/A GLU 275.A N PRO 271.A O no hydrogen 2.852 N/A ARG 278.A N GLU 275.A O no hydrogen 3.192 N/A TYR 279.A N GLU 275.A O no hydrogen 2.774 N/A ALA 280.A N ARG 276.A O no hydrogen 3.088 N/A TYR 281.A N GLU 112.A OE2 no hydrogen 3.221 N/A LYS 282.A NZ ASP 277.A O no hydrogen 3.402 N/A LYS 282.A NZ ALA 280.A O no hydrogen 3.124 N/A LEU 285.A N TYR 110.A O no hydrogen 2.931 N/A THR 288.A OG1 LEU 210.A O no hydrogen 2.878 N/A VAL 289.A N LEU 285.A O no hydrogen 3.022 N/A GLU 290.A N PRO 286.A O no hydrogen 2.900 N/A GLN 291.A N GLU 287.A O no hydrogen 2.923 N/A LEU 292.A N THR 288.A O no hydrogen 2.775 N/A ARG 293.A N VAL 289.A O no hydrogen 2.949 N/A ARG 293.A NE GLU 290.A OE1 no hydrogen 3.007 N/A ARG 293.A NE GLU 290.A OE2 no hydrogen 3.433 N/A ARG 293.A NH1 ASP 105.A OD2 no hydrogen 2.781 N/A ARG 293.A NH1 GLU 290.A OE2 no hydrogen 2.999 N/A ARG 293.A NH2 ASP 105.A OD1 no hydrogen 2.843 N/A ARG 293.A NH2 ASP 105.A OD2 no hydrogen 3.504 N/A LYS 294.A N GLU 290.A O no hydrogen 3.299 N/A PHE 295.A N GLN 291.A O no hydrogen 2.787 N/A ASN 296.A N LEU 292.A O no hydrogen 2.743 N/A ASN 296.A ND2 CYS 97.A O no hydrogen 2.914 N/A ALA 297.A N ARG 293.A O no hydrogen 3.041 N/A ARG 298.A N LYS 294.A O no hydrogen 3.164 N/A ARG 299.A N PHE 295.A O no hydrogen 3.174 N/A ARG 299.A NE ASN 296.A OD1 no hydrogen 3.251 N/A ARG 299.A NH1 ASP 95.A OD1 no hydrogen 2.692 N/A ARG 299.A NH1 GLU 142.A OE2 no hydrogen 2.960 N/A ARG 299.A NH2 ASP 95.A OD1 no hydrogen 3.311 N/A ARG 299.A NH2 ASP 95.A OD2 no hydrogen 2.954 N/A ARG 299.A NH2 ASN 296.A OD1 no hydrogen 2.691 N/A LYS 300.A N ASN 296.A O no hydrogen 2.982 N/A LEU 301.A N ALA 297.A O no hydrogen 3.103 N/A LYS 302.A N ARG 298.A O no hydrogen 3.366 N/A