Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 3o7l_D.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): GLU 5.A N GLU 1.A O no hydrogen 3.005 N/A PHE 6.A N SER 2.A O no hydrogen 2.899 N/A LEU 7.A N VAL 3.A O no hydrogen 3.327 N/A ALA 8.A N GLU 5.A O no hydrogen 3.213 N/A LYS 9.A N GLU 5.A O no hydrogen 3.354 N/A ALA 10.A N PHE 6.A O no hydrogen 3.111 N/A LYS 11.A N LEU 7.A O no hydrogen 2.742 N/A GLU 12.A N ALA 8.A O no hydrogen 2.780 N/A ASP 13.A N LYS 9.A O no hydrogen 3.172 N/A PHE 14.A N ALA 10.A O no hydrogen 2.897 N/A LEU 15.A N LYS 11.A O no hydrogen 2.796 N/A LYS 16.A N GLU 12.A O no hydrogen 3.076 N/A LYS 17.A N ASP 13.A O no hydrogen 3.349 N/A TRP 18.A N PHE 14.A O no hydrogen 2.882 N/A GLU 19.A N LEU 15.A O no hydrogen 3.091 N/A THR 20.A N LYS 16.A O no hydrogen 2.940 N/A THR 20.A OG1 LYS 16.A O no hydrogen 3.209 N/A GLN 23.A NE2 PHE 333.A O no hydrogen 3.497 N/A THR 25.A N SER 97.A O no hydrogen 2.923 N/A THR 25.A OG1 SER 97.A O no hydrogen 3.389 N/A GLN 30.A N GLN 27.A O no hydrogen 3.255 N/A PHE 31.A N LEU 28.A O no hydrogen 3.165 N/A ASP 32.A N LYS 49.A O no hydrogen 2.748 N/A ILE 34.A N LEU 47.A O no hydrogen 2.927 N/A LYS 35.A N LEU 47.A O no hydrogen 3.299 N/A LYS 35.A NZ ASP 312.A O no hydrogen 3.364 N/A LEU 37.A N VAL 45.A O no hydrogen 2.702 N/A GLY 38.A N VAL 45.A O no hydrogen 3.333 N/A GLY 40.A N GLY 43.A O no hydrogen 2.785 N/A ARG 44.A N ILE 61.A O no hydrogen 3.083 N/A ARG 44.A NH2 GLU 317.A O no hydrogen 2.816 N/A ARG 44.A NH2 GLU 318.A O no hydrogen 3.227 N/A VAL 45.A N GLY 38.A O no hydrogen 2.847 N/A MET 46.A N MET 59.A O no hydrogen 2.609 N/A LEU 47.A N LYS 35.A O no hydrogen 2.543 N/A VAL 48.A N TYR 57.A O no hydrogen 2.864 N/A LYS 49.A N ASP 32.A O no hydrogen 2.954 N/A HIS 50.A N ASN 55.A O no hydrogen 2.746 N/A LYS 51.A N GLN 30.A O no hydrogen 2.906 N/A LYS 51.A NZ ASP 29.A O no hydrogen 3.012 N/A GLY 54.A N HIS 50.A O no hydrogen 2.749 N/A TYR 57.A N VAL 48.A O no hydrogen 2.852 N/A ALA 58.A N MET 108.A O no hydrogen 3.055 N/A MET 59.A N MET 46.A O no hydrogen 2.648 N/A LYS 60.A N MET 106.A O no hydrogen 2.782 N/A ILE 61.A N ARG 44.A O no hydrogen 2.905 N/A LEU 62.A N LEU 104.A O no hydrogen 2.929 N/A ASP 63.A N PHE 42.A O no hydrogen 2.988 N/A LYS 64.A N SER 102.A O no hydrogen 2.887 N/A LYS 64.A NZ ASP 100.A O no hydrogen 2.881 N/A LYS 64.A NZ ASN 101.A O no hydrogen 2.985 N/A LYS 64.A NZ LYS 325.A O no hydrogen 2.826 N/A GLN 65.A N ASP 63.A OD2 no hydrogen 2.947 N/A LYS 66.A N ASP 63.A OD2 no hydrogen 3.491 N/A VAL 67.A N ASP 63.A O no hydrogen 3.039 N/A VAL 68.A N LYS 64.A O no hydrogen 3.312 N/A LYS 69.A N GLN 65.A O no hydrogen 2.910 N/A LEU 70.A N LYS 66.A O no hydrogen 2.904 N/A LYS 71.A N VAL 68.A O no hydrogen 3.052 N/A GLN 72.A N VAL 67.A O no hydrogen 2.802 N/A THR 76.A N GLN 72.A O no hydrogen 2.834 N/A THR 76.A OG1 GLN 72.A O no hydrogen 3.143 N/A LEU 77.A N ILE 73.A O no hydrogen 2.939 N/A ASN 78.A N GLU 74.A O no hydrogen 2.594 N/A ASN 78.A ND2 ALA 176.A O no hydrogen 2.822 N/A GLU 79.A N HIS 75.A O no hydrogen 3.138 N/A LYS 80.A N THR 76.A O no hydrogen 3.075 N/A LYS 80.A NZ SER 22.A O no hydrogen 2.701 N/A LYS 80.A NZ SER 97.A OG no hydrogen 2.905 N/A LYS 80.A NZ PHE 333.A OXT no hydrogen 3.102 N/A ARG 81.A N LEU 77.A O no hydrogen 2.773 N/A ILE 82.A N ASN 78.A O no hydrogen 2.972 N/A ILE 82.A N GLU 79.A O no hydrogen 3.126 N/A LEU 83.A N GLU 79.A O no hydrogen 2.819 N/A GLN 84.A N LYS 80.A O no hydrogen 2.987 N/A GLN 84.A NE2 LYS 17.A O no hydrogen 2.708 N/A ALA 85.A N ILE 82.A O no hydrogen 2.971 N/A ASN 87.A N TYR 144.A OH no hydrogen 2.967 N/A LEU 91.A N PHE 88.A O no hydrogen 3.204 N/A VAL 92.A N VAL 170.A O no hydrogen 3.030 N/A LYS 93.A NZ GLU 95.A OE1 no hydrogen 2.720 N/A GLU 95.A N VAL 107.A O no hydrogen 2.900 N/A PHE 96.A N VAL 107.A O no hydrogen 3.434 N/A SER 97.A N THR 25.A OG1 no hydrogen 2.944 N/A PHE 98.A N TYR 105.A O no hydrogen 3.327 N/A LYS 99.A NZ PHE 330.A O no hydrogen 3.011 N/A LYS 99.A NZ PHE 333.A O no hydrogen 3.463 N/A ASP 100.A N ASN 103.A O no hydrogen 2.956 N/A ASN 103.A ND2 TYR 105.A OH no hydrogen 2.928 N/A LEU 104.A N LEU 62.A O no hydrogen 2.787 N/A TYR 105.A OH ASP 100.A OD2 no hydrogen 2.434 N/A MET 106.A N LYS 60.A O no hydrogen 3.077 N/A VAL 107.A N PHE 96.A O no hydrogen 2.849 N/A MET 108.A N ALA 58.A O no hydrogen 2.678 N/A GLU 109.A N LYS 93.A O no hydrogen 3.027 N/A MET 116.A N LEU 160.A O no hydrogen 2.843 N/A SER 118.A N GLU 115.A OE1 no hydrogen 2.651 N/A SER 118.A OG GLU 115.A O no hydrogen 2.988 N/A HIS 119.A N GLU 115.A O no hydrogen 3.504 N/A HIS 119.A NE2 GLY 113.A O no hydrogen 2.798 N/A LEU 120.A N MET 116.A O no hydrogen 2.733 N/A ARG 121.A N PHE 117.A O no hydrogen 2.922 N/A ARG 122.A N SER 118.A O no hydrogen 2.560 N/A ILE 123.A N HIS 119.A O no hydrogen 2.814 N/A GLY 124.A N ARG 121.A O no hydrogen 3.092 N/A ARG 125.A N ILE 123.A O no hydrogen 2.965 N/A PHE 126.A N MET 218.A O no hydrogen 3.048 N/A HIS 130.A N SER 127.A OG no hydrogen 2.898 N/A HIS 130.A NE2 TYR 134.A OH no hydrogen 3.249 N/A ALA 131.A N SER 127.A O no hydrogen 2.566 N/A ARG 132.A N GLU 128.A O no hydrogen 2.784 N/A ARG 132.A NE TRP 283.A O no hydrogen 2.721 N/A ARG 132.A NH2 TRP 283.A O no hydrogen 3.258 N/A PHE 133.A N PRO 129.A O no hydrogen 3.205 N/A PHE 133.A N HIS 130.A O no hydrogen 3.056 N/A TYR 134.A OH HIS 130.A NE2 no hydrogen 3.249 N/A ALA 135.A N ALA 131.A O no hydrogen 2.822 N/A ALA 136.A N ARG 132.A O no hydrogen 2.804 N/A GLN 137.A NE2 PHE 133.A O no hydrogen 3.412 N/A ILE 138.A N TYR 134.A O no hydrogen 3.244 N/A VAL 139.A N ALA 135.A O no hydrogen 3.053 N/A LEU 140.A N ALA 136.A O no hydrogen 3.344 N/A THR 141.A N GLN 137.A O no hydrogen 3.204 N/A THR 141.A OG1 GLN 137.A O no hydrogen 2.735 N/A PHE 142.A N ILE 138.A O no hydrogen 2.882 N/A GLU 143.A N VAL 139.A O no hydrogen 2.916 N/A TYR 144.A N LEU 140.A O no hydrogen 2.883 N/A LEU 145.A N THR 141.A O no hydrogen 2.819 N/A HIS 146.A N PHE 142.A O no hydrogen 2.705 N/A HIS 146.A ND1 LEU 150.A O no hydrogen 3.122 N/A SER 147.A N GLU 143.A O no hydrogen 3.212 N/A LEU 148.A N LEU 145.A O no hydrogen 2.873 N/A ASP 149.A N HIS 146.A O no hydrogen 2.741 N/A LEU 150.A N LEU 145.A O no hydrogen 3.157 N/A ILE 151.A N LYS 177.A O no hydrogen 2.963 N/A TYR 152.A N ASP 207.A OD2 no hydrogen 2.889 N/A TYR 152.A OH THR 171.A O no hydrogen 2.769 N/A TYR 152.A OH ASP 172.A O no hydrogen 3.270 N/A ARG 153.A N ASP 207.A OD1 no hydrogen 3.046 N/A ARG 153.A NE PHE 175.A O no hydrogen 2.869 N/A ARG 153.A NH2 PHE 175.A O no hydrogen 3.309 N/A ASN 159.A N LYS 156.A O no hydrogen 2.771 N/A ASN 159.A ND2 ASP 154.A O no hydrogen 2.839 N/A LEU 160.A N PRO 157.A O no hydrogen 3.018 N/A LEU 161.A N GLN 169.A O no hydrogen 2.905 N/A ILE 162.A N GLY 114.A O no hydrogen 2.840 N/A ASP 163.A N TYR 167.A O no hydrogen 2.963 N/A GLY 166.A N ASP 163.A O no hydrogen 2.688 N/A TYR 167.A N ASP 163.A OD1 no hydrogen 2.712 N/A TYR 167.A OH VAL 297.A O no hydrogen 2.507 N/A ILE 168.A N GLN 137.A OE1 no hydrogen 2.541 N/A GLN 169.A N LEU 161.A O no hydrogen 2.649 N/A VAL 170.A N PHE 90.A O no hydrogen 2.871 N/A THR 171.A N ASN 159.A O no hydrogen 3.008 N/A PHE 173.A N GLU 79.A OE2 no hydrogen 3.332 N/A GLY 174.A N ASP 172.A OD2 no hydrogen 3.259 N/A ALA 176.A N PHE 173.A O no hydrogen 3.276 N/A LYS 177.A N ILE 151.A O no hydrogen 3.247 N/A ARG 178.A NE LEU 148.A O no hydrogen 3.290 N/A VAL 179.A N ASP 149.A O no hydrogen 2.799 N/A THR 183.A N TYR 202.A O no hydrogen 3.003 N/A GLU 190.A N GLU 190.A OE1 no hydrogen 2.801 N/A TYR 191.A N THR 188.A O no hydrogen 3.078 N/A TYR 191.A OH GLU 217.A OE1 no hydrogen 2.347 N/A GLU 195.A N GLU 195.A OE2 no hydrogen 2.683 N/A ILE 197.A N ALA 193.A O no hydrogen 3.350 N/A LEU 198.A N PRO 194.A O no hydrogen 3.078 N/A LEU 198.A N GLU 195.A O no hydrogen 3.029 N/A SER 199.A N ILE 196.A O no hydrogen 3.001 N/A LYS 200.A N GLU 195.A O no hydrogen 3.219 N/A TYR 202.A N THR 183.A O no hydrogen 2.917 N/A VAL 206.A N ASN 203.A O no hydrogen 2.959 N/A ASP 207.A N LYS 204.A O no hydrogen 2.907 N/A TRP 209.A N ALA 205.A O no hydrogen 3.117 N/A ALA 210.A N VAL 206.A O no hydrogen 2.911 N/A LEU 211.A N ASP 207.A O no hydrogen 2.867 N/A GLY 212.A N TRP 208.A O no hydrogen 3.157 N/A VAL 213.A N TRP 209.A O no hydrogen 3.183 N/A LEU 214.A N ALA 210.A O no hydrogen 2.862 N/A ILE 215.A N LEU 211.A O no hydrogen 2.956 N/A TYR 216.A N GLY 212.A O no hydrogen 3.217 N/A TYR 216.A OH ARG 243.A O no hydrogen 2.531 N/A GLU 217.A N VAL 213.A O no hydrogen 2.895 N/A MET 218.A N LEU 214.A O no hydrogen 2.776 N/A ALA 219.A N ILE 215.A O no hydrogen 2.995 N/A ALA 219.A N TYR 216.A O no hydrogen 3.190 N/A ALA 220.A N GLU 217.A O no hydrogen 3.293 N/A GLY 221.A N GLU 217.A O no hydrogen 2.635 N/A ILE 233.A N GLN 229.A O no hydrogen 3.301 N/A GLU 235.A N ILE 231.A O no hydrogen 3.132 N/A LYS 236.A N GLN 232.A O no hydrogen 2.962 N/A LYS 236.A NZ PHE 226.A O no hydrogen 2.983 N/A ILE 237.A N ILE 233.A O no hydrogen 3.224 N/A VAL 238.A N TYR 234.A O no hydrogen 3.161 N/A SER 239.A N GLU 235.A O no hydrogen 2.805 N/A GLY 240.A N LYS 236.A O no hydrogen 3.140 N/A SER 249.A N GLU 128.A OE2 no hydrogen 2.995 N/A SER 249.A OG GLU 128.A OE1 no hydrogen 2.707 N/A LEU 252.A N SER 249.A OG no hydrogen 2.951 N/A LYS 253.A N SER 249.A O no hydrogen 3.066 N/A ASP 254.A N SER 250.A O no hydrogen 3.219 N/A LEU 255.A N ASP 251.A O no hydrogen 2.939 N/A LEU 256.A N LEU 252.A O no hydrogen 2.998 N/A ARG 257.A N LYS 253.A O no hydrogen 3.005 N/A ASN 258.A N ASP 254.A O no hydrogen 3.313 N/A LEU 259.A N LEU 255.A O no hydrogen 2.899 N/A LEU 260.A N LEU 256.A O no hydrogen 2.706 N/A GLN 261.A N LEU 259.A O no hydrogen 2.896 N/A ASP 263.A N GLN 261.A OE1 no hydrogen 2.684 N/A THR 265.A N ASP 263.A OD1 no hydrogen 3.079 N/A THR 265.A OG1 ASP 263.A OD1 no hydrogen 2.565 N/A LYS 266.A N ASP 263.A O no hydrogen 2.606 N/A LYS 266.A NZ ASP 263.A OD2 no hydrogen 3.014 N/A ARG 267.A NE GLN 261.A O no hydrogen 2.824 N/A ARG 267.A NH1 GLU 195.A OE1 no hydrogen 2.665 N/A ARG 267.A NH1 ALA 205.A O no hydrogen 3.046 N/A ARG 267.A NH2 GLU 195.A OE1 no hydrogen 3.501 N/A ARG 267.A NH2 GLU 195.A OE2 no hydrogen 2.905 N/A ARG 267.A NH2 GLN 261.A O no hydrogen 2.717 N/A PHE 268.A N ASN 258.A O no hydrogen 3.022 N/A ASN 270.A N ARG 267.A O no hydrogen 3.126 N/A GLY 274.A N LEU 271.A O no hydrogen 3.085 N/A ASN 276.A N ASN 273.A O no hydrogen 3.293 N/A ASP 277.A N GLY 274.A O no hydrogen 3.255 N/A LYS 279.A N VAL 275.A O no hydrogen 2.798 N/A LYS 279.A NZ GLU 143.A OE1 no hydrogen 3.057 N/A LYS 279.A NZ GLU 143.A OE2 no hydrogen 3.076 N/A ASN 280.A N ASN 276.A O no hydrogen 2.970 N/A HIS 281.A N ASP 277.A O no hydrogen 3.248 N/A HIS 281.A N ILE 278.A O no hydrogen 3.082 N/A TRP 283.A N HIS 281.A ND1 no hydrogen 2.710 N/A TRP 283.A NE1 GLU 128.A OE1 no hydrogen 2.969 N/A PHE 284.A N HIS 281.A O no hydrogen 2.849 N/A ILE 292.A N ASP 288.A O no hydrogen 3.112 N/A TYR 293.A N TRP 289.A O no hydrogen 3.194 N/A GLN 294.A N ILE 290.A O no hydrogen 3.004 N/A ARG 295.A N ILE 292.A O no hydrogen 2.957 N/A LYS 296.A N ALA 291.A O no hydrogen 2.740 N/A VAL 297.A N TYR 167.A OH no hydrogen 3.010 N/A PHE 311.A N THR 308.A O no hydrogen 2.948 N/A LYS 325.A N ASN 101.A O no hydrogen 2.613 N/A THR 331.A OG1 LYS 328.A O no hydrogen 3.384 N/A PHE 333.A N PHE 330.A O no hydrogen 3.042 N/A