Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4aez_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): THR 26.A N ASN 24.A OD1 no hydrogen 2.994 N/A GLU 28.A N PHE 321.A O no hydrogen 2.861 N/A LEU 31.A N LEU 319.A O no hydrogen 2.794 N/A ALA 33.A N GLU 317.A O no hydrogen 2.815 N/A GLY 35.A N GLU 317.A OE2 no hydrogen 2.837 N/A ASP 39.A N TYR 300.A OH no hydrogen 3.426 N/A TYR 41.A N ASP 39.A OD1 no hydrogen 2.910 N/A TYR 41.A OH ASN 183.A OD1 no hydrogen 2.882 N/A LEU 42.A N ASP 39.A O no hydrogen 3.259 N/A ASN 43.A N ALA 84.A O no hydrogen 2.890 N/A ASN 43.A ND2 GLY 126.A O no hydrogen 2.494 N/A ASP 46.A N ALA 54.A O no hydrogen 2.931 N/A TRP 47.A N ASP 46.A OD1 no hydrogen 2.830 N/A TRP 47.A NE1 ASN 51.A OD1 no hydrogen 2.787 N/A SER 48.A N VAL 52.A O no hydrogen 2.725 N/A ASN 49.A ND2 HIS 90.A O no hydrogen 2.699 N/A LEU 50.A N SER 48.A OG no hydrogen 2.996 N/A ASN 51.A N SER 48.A O no hydrogen 2.854 N/A ASN 51.A ND2 ASP 67.A OD1 no hydrogen 3.326 N/A ASN 51.A ND2 ASP 67.A OD2 no hydrogen 3.278 N/A VAL 52.A N SER 48.A OG no hydrogen 3.090 N/A VAL 53.A N TRP 64.A O no hydrogen 2.872 N/A ALA 54.A N ASP 46.A O no hydrogen 2.813 N/A VAL 55.A N TYR 62.A O no hydrogen 2.921 N/A ALA 56.A N LEU 44.A O no hydrogen 2.855 N/A LEU 57.A N ASN 60.A O no hydrogen 2.645 N/A ARG 59.A NH1 THR 77.A O no hydrogen 3.069 N/A ASN 60.A N LEU 57.A O no hydrogen 2.887 N/A VAL 61.A N ALA 75.A O no hydrogen 2.901 N/A TYR 62.A N VAL 55.A O no hydrogen 2.927 N/A VAL 63.A N SER 72.A O no hydrogen 2.790 N/A TRP 64.A N VAL 53.A O no hydrogen 2.837 N/A ASN 65.A N SER 70.A O no hydrogen 2.975 N/A ALA 66.A N ASN 51.A O no hydrogen 3.116 N/A SER 68.A N ASN 65.A OD1 no hydrogen 2.696 N/A SER 68.A OG SER 70.A OG no hydrogen 3.171 N/A GLY 69.A N ASN 65.A O no hydrogen 2.537 N/A SER 70.A N SER 68.A OG no hydrogen 3.299 N/A SER 70.A OG SER 68.A OG no hydrogen 3.171 N/A SER 72.A N VAL 63.A O no hydrogen 2.948 N/A SER 72.A OG GLN 112.A OE1 no hydrogen 2.466 N/A LEU 74.A N VAL 61.A O no hydrogen 2.644 N/A ALA 75.A N VAL 61.A O no hydrogen 3.047 N/A THR 77.A N ARG 59.A O no hydrogen 2.858 N/A THR 77.A OG1 ASP 78.A O no hydrogen 2.970 N/A THR 77.A OG1 THR 81.A O no hydrogen 3.185 N/A SER 80.A N ASP 78.A OD1 no hydrogen 2.421 N/A SER 80.A OG ASP 78.A OD1 no hydrogen 2.480 N/A THR 81.A N ASP 78.A O no hydrogen 3.127 N/A TYR 82.A N THR 81.A OG1 no hydrogen 2.747 N/A VAL 83.A N GLU 58.A O no hydrogen 3.228 N/A ALA 84.A N GLY 98.A O no hydrogen 2.854 N/A SER 85.A N GLY 98.A O no hydrogen 3.095 N/A SER 85.A OG VAL 125.A O no hydrogen 2.877 N/A VAL 86.A N ASN 43.A O no hydrogen 3.092 N/A LYS 87.A N SER 96.A O no hydrogen 2.844 N/A TRP 88.A N ASP 46.A OD2 no hydrogen 2.848 N/A TRP 88.A NE1 ASP 46.A O no hydrogen 3.154 N/A SER 89.A N PHE 94.A O no hydrogen 2.909 N/A SER 89.A OG ASP 91.A OD1 no hydrogen 2.849 N/A SER 89.A OG PHE 94.A O no hydrogen 3.445 N/A GLY 92.A N SER 89.A O no hydrogen 2.877 N/A SER 93.A N ASP 91.A OD1 no hydrogen 2.677 N/A SER 93.A OG ASP 91.A OD1 no hydrogen 3.227 N/A SER 93.A OG ASP 91.A OD2 no hydrogen 3.150 N/A PHE 94.A N SER 89.A OG no hydrogen 3.081 N/A LEU 95.A N TYR 107.A O no hydrogen 2.927 N/A SER 96.A N LYS 87.A O no hydrogen 2.903 N/A SER 96.A OG LYS 87.A O no hydrogen 2.895 N/A VAL 97.A N ASP 105.A O no hydrogen 2.813 N/A GLY 98.A N SER 85.A O no hydrogen 2.760 N/A LEU 99.A N LEU 103.A O no hydrogen 2.918 N/A GLY 100.A N TYR 82.A O no hydrogen 2.909 N/A GLY 102.A N LEU 99.A O no hydrogen 3.108 N/A LEU 103.A N ASN 101.A OD1 no hydrogen 3.136 N/A VAL 104.A N MET 118.A O no hydrogen 2.892 N/A ASP 105.A N VAL 97.A O no hydrogen 2.840 N/A ILE 106.A N ARG 116.A O no hydrogen 2.850 N/A TYR 107.A N LEU 95.A O no hydrogen 2.906 N/A ASP 108.A N THR 113.A O no hydrogen 3.098 N/A VAL 109.A N SER 93.A O no hydrogen 3.111 N/A GLU 110.A N ASP 108.A OD1 no hydrogen 3.251 N/A GLU 110.A N GLU 110.A OE1 no hydrogen 2.818 N/A SER 111.A N ASP 108.A OD2 no hydrogen 2.765 N/A SER 111.A OG ASP 108.A OD2 no hydrogen 2.694 N/A SER 111.A OG THR 113.A OG1 no hydrogen 2.700 N/A THR 113.A OG1 SER 111.A OG no hydrogen 2.700 N/A LYS 114.A NZ THR 117.A OG1 no hydrogen 2.740 N/A LEU 115.A N ILE 106.A O no hydrogen 2.629 N/A ARG 116.A N ILE 106.A O no hydrogen 3.082 N/A ARG 116.A NH1 VAL 149.A O no hydrogen 3.084 N/A ARG 116.A NH1 ILE 151.A O no hydrogen 2.811 N/A ARG 116.A NH2 ILE 151.A O no hydrogen 3.201 N/A ARG 116.A NH2 ALA 152.A O no hydrogen 3.139 N/A THR 117.A OG1 ASP 105.A OD1 no hydrogen 2.577 N/A MET 118.A N VAL 104.A O no hydrogen 2.813 N/A HIS 121.A NE2 SER 137.A OG no hydrogen 2.616 N/A ARG 124.A NE GLU 165.A OE2 no hydrogen 2.861 N/A ARG 124.A NH1 TYR 82.A OH no hydrogen 2.928 N/A ARG 124.A NH2 GLU 165.A OE1 no hydrogen 2.902 N/A VAL 125.A N LEU 99.A O no hydrogen 3.087 N/A GLY 126.A N GLY 138.A O no hydrogen 2.995 N/A CYS 127.A N GLY 138.A O no hydrogen 3.503 N/A CYS 127.A SG VAL 166.A O no hydrogen 3.335 N/A SER 129.A N SER 136.A O no hydrogen 2.919 N/A TRP 130.A NE1 LYS 87.A O no hydrogen 3.004 N/A ASN 131.A N VAL 134.A O no hydrogen 2.664 N/A ASN 131.A ND2 GLY 175.A O no hydrogen 3.415 N/A VAL 134.A N ASN 131.A O no hydrogen 2.753 N/A LEU 135.A N HIS 147.A O no hydrogen 2.903 N/A SER 136.A N SER 129.A O no hydrogen 2.753 N/A SER 136.A OG HIS 146.A ND1 no hydrogen 2.645 N/A SER 137.A N HIS 145.A O no hydrogen 2.880 N/A SER 137.A OG HIS 121.A NE2 no hydrogen 2.616 N/A SER 137.A OG HIS 145.A O no hydrogen 3.504 N/A SER 137.A OG HIS 147.A NE2 no hydrogen 2.784 N/A GLY 138.A N CYS 127.A O no hydrogen 2.874 N/A SER 139.A N ALA 143.A O no hydrogen 3.155 N/A SER 139.A OG ALA 123.A O no hydrogen 3.118 N/A SER 139.A OG ARG 124.A O no hydrogen 3.057 N/A SER 139.A OG SER 141.A OG no hydrogen 3.300 N/A ARG 140.A N ARG 124.A O no hydrogen 2.919 N/A SER 141.A N SER 139.A OG no hydrogen 3.319 N/A SER 141.A OG SER 139.A OG no hydrogen 3.300 N/A GLY 142.A N SER 139.A O no hydrogen 2.966 N/A ALA 143.A N SER 141.A OG no hydrogen 3.289 N/A ILE 144.A N LEU 159.A O no hydrogen 2.918 N/A HIS 145.A N SER 137.A O no hydrogen 2.895 N/A HIS 146.A N GLY 157.A O no hydrogen 2.899 N/A HIS 146.A ND1 SER 136.A OG no hydrogen 2.645 N/A HIS 147.A N LEU 135.A O no hydrogen 2.837 N/A HIS 147.A ND1 HIS 154.A ND1 no hydrogen 3.044 N/A HIS 147.A NE2 SER 137.A OG no hydrogen 2.784 N/A ASP 148.A N HIS 154.A O no hydrogen 2.563 N/A VAL 149.A N HIS 133.A O no hydrogen 3.249 N/A ARG 150.A N ASP 148.A OD1 no hydrogen 3.000 N/A ARG 150.A NE ASP 148.A OD1 no hydrogen 3.105 N/A ARG 150.A NH2 ASP 148.A OD2 no hydrogen 2.922 N/A ILE 151.A N ASP 148.A O no hydrogen 3.122 N/A HIS 154.A ND1 HIS 147.A ND1 no hydrogen 3.044 N/A ILE 156.A N HIS 146.A O no hydrogen 2.755 N/A LEU 159.A N ILE 144.A O no hydrogen 2.881 N/A HIS 162.A N GLN 160.A OE1 no hydrogen 3.294 N/A HIS 162.A ND1 ASP 184.A OD1 no hydrogen 3.137 N/A HIS 162.A NE2 SER 180.A OG no hydrogen 2.632 N/A SER 163.A N ASP 184.A OD2 no hydrogen 2.940 N/A VAL 166.A N SER 139.A O no hydrogen 2.928 N/A CYS 167.A N GLY 181.A O no hydrogen 2.898 N/A CYS 167.A SG GLU 165.A O no hydrogen 3.534 N/A GLY 168.A N GLY 181.A O no hydrogen 3.068 N/A ALA 170.A N ALA 179.A O no hydrogen 2.915 N/A TRP 171.A N SER 129.A OG no hydrogen 2.813 N/A TRP 171.A NE1 SER 136.A OG no hydrogen 2.982 N/A ARG 172.A N GLN 177.A O no hydrogen 2.878 N/A ARG 172.A NE ASP 174.A OD1 no hydrogen 3.002 N/A ARG 172.A NH1 ASN 219.A OD1 no hydrogen 2.828 N/A ARG 172.A NH2 ASP 174.A OD1 no hydrogen 3.511 N/A ARG 172.A NH2 ASP 174.A OD2 no hydrogen 2.670 N/A GLY 175.A N ARG 172.A O no hydrogen 2.823 N/A LEU 176.A N ASP 174.A OD1 no hydrogen 3.063 N/A GLN 177.A NE2 ASP 191.A OD1 no hydrogen 3.068 N/A GLN 177.A NE2 ALA 237.A O no hydrogen 3.313 N/A LEU 178.A N TRP 190.A O no hydrogen 2.933 N/A ALA 179.A N ALA 170.A O no hydrogen 2.991 N/A SER 180.A N GLN 188.A O no hydrogen 2.917 N/A SER 180.A OG HIS 162.A NE2 no hydrogen 2.632 N/A GLY 181.A N GLY 168.A O no hydrogen 2.787 N/A ASN 183.A N GLU 165.A O no hydrogen 2.732 N/A ASN 185.A N GLY 182.A O no hydrogen 3.034 N/A VAL 186.A N ASP 184.A OD1 no hydrogen 3.095 N/A VAL 187.A N LYS 201.A O no hydrogen 2.949 N/A GLN 188.A N SER 180.A O no hydrogen 2.838 N/A GLN 188.A NE2 GLY 161.A O no hydrogen 2.942 N/A ILE 189.A N PHE 199.A O no hydrogen 2.903 N/A TRP 190.A N LEU 178.A O no hydrogen 2.897 N/A TRP 190.A NE1 SER 180.A OG no hydrogen 3.115 N/A ALA 192.A N LEU 176.A O no hydrogen 2.887 N/A SER 194.A N ASP 191.A O no hydrogen 3.115 N/A SER 194.A OG ILE 196.A O no hydrogen 2.940 N/A ILE 196.A N SER 194.A OG no hydrogen 2.819 N/A LYS 198.A N ILE 189.A O no hydrogen 2.571 N/A PHE 199.A N ILE 189.A O no hydrogen 3.053 N/A THR 200.A OG1 GLN 188.A OE1 no hydrogen 2.701 N/A LYS 201.A N VAL 187.A O no hydrogen 2.886 N/A LYS 201.A NZ GLY 240.A O no hydrogen 2.606 N/A HIS 204.A ND1 ASP 229.A OD2 no hydrogen 2.706 N/A HIS 204.A NE2 THR 223.A OG1 no hydrogen 2.816 N/A ASN 205.A N ASP 229.A OD1 no hydrogen 2.781 N/A VAL 208.A N GLY 182.A O no hydrogen 3.081 N/A LYS 209.A NZ TYR 40.A O no hydrogen 2.782 N/A LYS 209.A NZ LEU 42.A O no hydrogen 2.750 N/A LYS 209.A NZ ASN 43.A OD1 no hydrogen 3.150 N/A ALA 212.A N ALA 222.A O no hydrogen 2.897 N/A TRP 213.A NE1 ALA 170.A O no hydrogen 2.903 N/A CYS 214.A N LEU 220.A O no hydrogen 2.893 N/A LEU 220.A N GLN 217.A O no hydrogen 3.260 N/A LEU 221.A N TRP 235.A O no hydrogen 2.916 N/A ALA 222.A N ALA 212.A O no hydrogen 2.871 N/A THR 223.A N HIS 233.A O no hydrogen 2.942 N/A THR 223.A OG1 HIS 204.A NE2 no hydrogen 2.816 N/A GLY 224.A N ALA 210.A O no hydrogen 2.943 N/A GLY 225.A N GLN 231.A O no hydrogen 2.963 N/A ASP 229.A N GLY 226.A O no hydrogen 2.900 N/A LYS 230.A N GLY 226.A O no hydrogen 2.863 N/A GLN 231.A N ASP 229.A OD2 no hydrogen 3.094 N/A GLN 231.A NE2 ASP 229.A O no hydrogen 3.053 N/A GLN 231.A NE2 ASP 247.A OD1 no hydrogen 3.216 N/A ILE 232.A N VAL 246.A O no hydrogen 2.898 N/A HIS 233.A N THR 223.A O no hydrogen 2.901 N/A HIS 233.A ND1 THR 245.A OG1 no hydrogen 2.777 N/A PHE 234.A N ASN 244.A O no hydrogen 2.927 N/A TRP 235.A N LEU 221.A O no hydrogen 2.843 N/A TRP 235.A NE1 THR 223.A OG1 no hydrogen 2.983 N/A ASN 236.A N ALA 241.A O no hydrogen 2.833 N/A ALA 237.A N ASN 219.A O no hydrogen 2.688 N/A ALA 238.A N ASN 236.A OD1 no hydrogen 2.700 N/A THR 239.A N ASN 236.A OD1 no hydrogen 3.038 N/A GLY 240.A N ASN 236.A O no hydrogen 2.741 N/A ALA 241.A N THR 239.A OG1 no hydrogen 3.259 N/A VAL 243.A N PHE 234.A O no hydrogen 2.801 N/A ASN 244.A ND2 TYR 280.A OH no hydrogen 3.230 N/A ASN 244.A ND2 SER 281.A O no hydrogen 2.894 N/A THR 245.A OG1 ILE 232.A O no hydrogen 3.478 N/A THR 245.A OG1 HIS 233.A ND1 no hydrogen 2.777 N/A VAL 246.A N ILE 232.A O no hydrogen 2.887 N/A ALA 248.A N LYS 230.A O no hydrogen 2.720 N/A GLY 249.A N ASP 247.A OD1 no hydrogen 2.964 N/A GLN 251.A N PHE 270.A O no hydrogen 2.900 N/A VAL 252.A N GLY 225.A O no hydrogen 2.991 N/A THR 253.A N THR 267.A O no hydrogen 2.889 N/A THR 253.A OG1 THR 267.A OG1 no hydrogen 2.787 N/A THR 253.A OG1 VAL 298.A O no hydrogen 2.460 N/A SER 254.A OG THR 267.A OG1 no hydrogen 2.705 N/A SER 254.A OG SER 301.A OG no hydrogen 2.619 N/A ILE 256.A N MET 265.A O no hydrogen 2.805 N/A TRP 257.A NE1 ALA 212.A O no hydrogen 2.994 N/A SER 258.A N GLU 263.A O no hydrogen 3.084 N/A SER 258.A OG SER 261.A O no hydrogen 3.477 N/A SER 258.A OG SER 261.A OG no hydrogen 2.640 N/A HIS 260.A NE2 ASP 306.A O no hydrogen 2.587 N/A SER 261.A N SER 258.A OG no hydrogen 3.219 N/A SER 261.A OG SER 258.A OG no hydrogen 2.640 N/A SER 261.A OG GLU 263.A OE1 no hydrogen 3.093 N/A ILE 264.A N TRP 278.A O no hydrogen 2.929 N/A MET 265.A N ILE 256.A O no hydrogen 2.806 N/A SER 266.A N SER 276.A O no hydrogen 2.888 N/A SER 266.A OG HIS 268.A NE2 no hydrogen 2.875 N/A THR 267.A N SER 254.A O no hydrogen 3.090 N/A THR 267.A OG1 THR 253.A OG1 no hydrogen 2.787 N/A THR 267.A OG1 SER 254.A OG no hydrogen 2.705 N/A HIS 268.A N ASN 274.A O no hydrogen 3.107 N/A GLY 269.A N GLN 251.A O no hydrogen 2.739 N/A PHE 270.A N GLN 251.A OE1 no hydrogen 3.227 N/A ASP 272.A N SER 250.A OG no hydrogen 3.306 N/A ASN 273.A N GLY 269.A O no hydrogen 3.176 N/A LEU 275.A N ILE 291.A O no hydrogen 2.886 N/A SER 276.A N SER 266.A O no hydrogen 2.895 N/A SER 276.A OG ASP 290.A OD1 no hydrogen 2.494 N/A ILE 277.A N VAL 289.A O no hydrogen 2.808 N/A TRP 278.A N ILE 264.A O no hydrogen 2.892 N/A TRP 278.A NE1 SER 266.A OG no hydrogen 2.982 N/A SER 279.A N THR 286.A O no hydrogen 2.847 N/A SER 279.A OG THR 286.A O no hydrogen 3.290 N/A SER 279.A OG GLN 288.A OE1 no hydrogen 3.103 N/A TYR 280.A N LYS 262.A O no hydrogen 3.132 N/A SER 281.A N GLY 284.A O no hydrogen 3.226 N/A SER 281.A OG GLY 284.A O no hydrogen 3.377 N/A SER 283.A N SER 281.A OG no hydrogen 3.066 N/A GLY 284.A N SER 281.A O no hydrogen 2.966 N/A GLY 284.A N SER 281.A OG no hydrogen 3.366 N/A THR 286.A N SER 279.A O no hydrogen 3.220 N/A LYS 287.A NZ ASP 290.A OD1 no hydrogen 2.905 N/A GLN 288.A N ILE 277.A O no hydrogen 2.822 N/A VAL 289.A N ILE 277.A O no hydrogen 3.018 N/A ILE 291.A N LEU 275.A O no hydrogen 2.918 N/A ALA 293.A N ASN 273.A O no hydrogen 3.180 N/A HIS 294.A ND1 ASP 316.A OD1 no hydrogen 2.961 N/A HIS 294.A ND1 ASP 316.A OD2 no hydrogen 3.019 N/A HIS 294.A NE2 THR 312.A OG1 no hydrogen 2.783 N/A ASP 295.A N ASP 316.A OD2 no hydrogen 3.028 N/A THR 296.A OG1 SER 315.A OG no hydrogen 2.961 N/A ARG 297.A NH1 GLN 251.A OE1 no hydrogen 3.130 N/A ARG 297.A NH2 ASP 38.A OD1 no hydrogen 2.878 N/A VAL 298.A N HIS 268.A O no hydrogen 2.945 N/A TYR 300.A N ALA 313.A O no hydrogen 3.283 N/A TYR 300.A OH ILE 37.A O no hydrogen 2.676 N/A TYR 300.A OH ASP 39.A O no hydrogen 3.264 N/A SER 301.A OG SER 254.A OG no hydrogen 2.619 N/A ALA 302.A N SER 311.A O no hydrogen 2.890 N/A SER 304.A N ILE 309.A O no hydrogen 2.726 N/A SER 304.A OG ASP 306.A OD1 no hydrogen 2.585 N/A SER 304.A OG ILE 309.A O no hydrogen 3.348 N/A GLY 307.A N SER 304.A O no hydrogen 2.815 N/A ARG 308.A N ASP 306.A OD1 no hydrogen 2.879 N/A ILE 309.A N SER 304.A OG no hydrogen 3.077 N/A LEU 310.A N TRP 322.A O no hydrogen 2.874 N/A SER 311.A N ALA 302.A O no hydrogen 2.868 N/A SER 311.A OG ALA 302.A O no hydrogen 2.853 N/A THR 312.A N LYS 320.A O no hydrogen 2.874 N/A THR 312.A OG1 HIS 294.A NE2 no hydrogen 2.783 N/A ALA 313.A N TYR 300.A O no hydrogen 2.887 N/A SER 315.A N THR 296.A OG1 no hydrogen 3.094 N/A SER 315.A OG ASP 38.A OD2 no hydrogen 2.675 N/A SER 315.A OG THR 296.A OG1 no hydrogen 2.961 N/A GLU 317.A N ALA 314.A O no hydrogen 3.065 N/A ASN 318.A N ASP 316.A OD1 no hydrogen 3.139 N/A LEU 319.A N LEU 31.A O no hydrogen 2.765 N/A LYS 320.A N THR 312.A O no hydrogen 2.854 N/A LYS 320.A NZ ALA 293.A O no hydrogen 2.817 N/A PHE 321.A N ARG 29.A O no hydrogen 2.925 N/A TRP 322.A N LEU 310.A O no hydrogen 2.853 N/A TRP 322.A NE1 THR 312.A OG1 no hydrogen 2.887 N/A ARG 323.A NH1 GLU 28.A OE2 no hydrogen 2.494 N/A VAL 324.A N ARG 308.A O no hydrogen 2.903 N/A TYR 325.A N ARG 308.A O no hydrogen 3.338 N/A