Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4bik_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ALA 5.A N ASN 1.A O no hydrogen 3.120 N/A LYS 6.A N SER 2.A O no hydrogen 2.935 N/A LYS 7.A N GLU 3.A O no hydrogen 2.868 N/A ALA 8.A N ALA 4.A O no hydrogen 2.927 N/A LEU 9.A N ALA 5.A O no hydrogen 2.912 N/A ASN 10.A N LYS 6.A O no hydrogen 2.895 N/A TYR 12.A N ALA 8.A O no hydrogen 3.060 N/A GLY 15.A N TYR 12.A O no hydrogen 2.732 N/A LEU 16.A N TYR 12.A O no hydrogen 3.097 N/A LEU 16.A N ILE 13.A O no hydrogen 3.044 N/A LYS 20.A NZ ASP 324.A OD2 no hydrogen 3.327 N/A ASN 22.A N ASP 19.A O no hydrogen 3.044 N/A ILE 23.A N ASP 19.A O no hydrogen 2.991 N/A THR 25.A OG1 ASN 22.A O no hydrogen 2.727 N/A HIS 26.A N GLN 331.A O no hydrogen 3.399 N/A GLY 28.A N ASN 333.A O no hydrogen 3.299 N/A GLU 29.A N THR 334.A OG1 no hydrogen 3.045 N/A LEU 31.A N ASP 335.A OD2 no hydrogen 3.176 N/A SER 35.A OG LYS 51.A O no hydrogen 3.340 N/A SER 36.A N LYS 51.A O no hydrogen 2.840 N/A ARG 37.A NH1 GLU 376.A OE2 no hydrogen 3.162 N/A GLU 38.A N ILE 49.A O no hydrogen 2.940 N/A PHE 40.A N VAL 47.A O no hydrogen 2.857 N/A ARG 42.A N GLU 45.A O no hydrogen 2.910 N/A ARG 42.A NH2 LYS 188.A O no hydrogen 3.355 N/A GLU 45.A N ARG 42.A O no hydrogen 2.715 N/A TYR 46.A N TYR 344.A O no hydrogen 2.836 N/A VAL 47.A N PHE 40.A O no hydrogen 2.910 N/A VAL 48.A N THR 342.A O no hydrogen 2.858 N/A ILE 49.A N GLU 38.A O no hydrogen 2.878 N/A GLU 50.A N LYS 340.A O no hydrogen 2.911 N/A LYS 51.A N SER 36.A O no hydrogen 2.904 N/A LYS 52.A N GLU 338.A O no hydrogen 2.914 N/A LYS 52.A NZ GLN 54.A OE1 no hydrogen 2.466 N/A LYS 52.A NZ GLU 338.A OE1 no hydrogen 2.272 N/A LYS 53.A NZ LEU 31.A O no hydrogen 2.453 N/A LYS 53.A NZ ASP 335.A OD2 no hydrogen 2.854 N/A GLN 54.A N TYR 336.A O no hydrogen 2.945 N/A ILE 56.A N THR 334.A O no hydrogen 2.896 N/A SER 57.A OG ASN 333.A OD1 no hydrogen 3.094 N/A ASN 58.A N ASN 332.A O no hydrogen 2.855 N/A THR 60.A N ILE 330.A O no hydrogen 2.880 N/A SER 61.A OG THR 329.A OG1 no hydrogen 3.108 N/A LEU 63.A N TYR 317.A O no hydrogen 2.935 N/A SER 64.A OG ASN 88.A OD1 no hydrogen 2.964 N/A SER 64.A OG ASP 171.A OD2 no hydrogen 3.066 N/A VAL 65.A N ILE 315.A O no hydrogen 3.104 N/A SER 66.A N ASN 69.A OD1 no hydrogen 2.458 N/A SER 66.A OG VAL 65.A O no hydrogen 2.643 N/A SER 66.A OG ASP 171.A OD2 no hydrogen 3.227 N/A ASN 69.A ND2 SER 64.A O no hydrogen 2.888 N/A ASN 69.A ND2 ASN 88.A O no hydrogen 3.326 N/A ASP 70.A N SER 66.A O no hydrogen 2.706 N/A ARG 72.A N ASN 69.A O no hydrogen 3.083 N/A ILE 73.A N ASP 70.A O no hydrogen 3.459 N/A GLY 76.A N VAL 240.A O no hydrogen 3.019 N/A ALA 77.A N PHE 74.A O no hydrogen 2.999 N/A LEU 79.A N VAL 238.A O no hydrogen 2.895 N/A LYS 80.A NZ GLY 230.A O no hydrogen 2.278 N/A LYS 80.A NZ THR 235.A O no hydrogen 2.307 N/A LYS 80.A NZ THR 235.A OG1 no hydrogen 2.685 N/A ALA 81.A N PRO 236.A O no hydrogen 3.064 N/A GLN 83.A N GLN 83.A OE1 no hydrogen 2.775 N/A SER 84.A OG ASP 82.A OD1 no hydrogen 2.323 N/A LEU 86.A N ASP 82.A O no hydrogen 2.880 N/A GLU 87.A N GLN 83.A O no hydrogen 2.953 N/A ASN 88.A N LEU 85.A O no hydrogen 2.914 N/A LEU 89.A N SER 84.A O no hydrogen 2.946 N/A THR 91.A N SER 84.A OG no hydrogen 3.317 N/A ILE 93.A N LEU 78.A O no hydrogen 3.403 N/A THR 100.A N VAL 118.A O no hydrogen 3.182 N/A THR 100.A OG1 GLY 98.A O no hydrogen 3.315 N/A ILE 102.A N LEU 116.A O no hydrogen 2.824 N/A SER 103.A N SER 206.A O no hydrogen 2.878 N/A SER 103.A OG SER 114.A O no hydrogen 3.462 N/A VAL 104.A N SER 114.A O no hydrogen 3.289 N/A ASN 105.A N THR 204.A O no hydrogen 3.237 N/A LYS 110.A N GLU 113.A OE1 no hydrogen 3.160 N/A GLU 113.A N LYS 110.A O no hydrogen 3.113 N/A SER 114.A OG ASN 111.A O no hydrogen 2.960 N/A SER 114.A OG ASN 115.A OD1 no hydrogen 3.021 N/A ASN 115.A N GLY 112.A O no hydrogen 3.098 N/A LEU 116.A N ILE 102.A O no hydrogen 2.889 N/A THR 117.A OG1 THR 100.A O no hydrogen 3.403 N/A VAL 118.A N THR 100.A O no hydrogen 3.233 N/A SER 122.A N THR 125.A OG1 no hydrogen 2.551 N/A ASN 123.A ND2 ILE 73.A O no hydrogen 2.763 N/A THR 125.A OG1 ASN 120.A O no hydrogen 3.373 N/A THR 125.A OG1 SER 122.A O no hydrogen 2.533 N/A VAL 126.A N SER 122.A O no hydrogen 2.709 N/A ARG 127.A N ASN 123.A O no hydrogen 2.908 N/A THR 128.A N SER 124.A O no hydrogen 2.925 N/A THR 128.A OG1 SER 124.A O no hydrogen 2.624 N/A THR 128.A OG1 THR 125.A O no hydrogen 2.978 N/A ALA 129.A N THR 125.A O no hydrogen 3.097 N/A VAL 130.A N VAL 126.A O no hydrogen 2.877 N/A ASN 131.A N ARG 127.A O no hydrogen 2.921 N/A ASN 131.A ND2 THR 128.A O no hydrogen 3.414 N/A ASN 132.A N THR 128.A O no hydrogen 2.902 N/A LEU 133.A N ALA 129.A O no hydrogen 2.920 N/A VAL 134.A N VAL 130.A O no hydrogen 2.900 N/A GLU 135.A N ASN 131.A O no hydrogen 2.954 N/A LYS 136.A N ASN 132.A O no hydrogen 2.826 N/A TRP 137.A N LEU 133.A O no hydrogen 2.981 N/A TRP 137.A NE1 PRO 107.A O no hydrogen 2.696 N/A ILE 138.A N VAL 134.A O no hydrogen 2.855 N/A TYR 141.A OH GLU 113.A OE1 no hydrogen 2.903 N/A SER 142.A N TRP 137.A O no hydrogen 2.876 N/A SER 142.A OG ILE 138.A O no hydrogen 2.148 N/A HIS 145.A N TYR 141.A O no hydrogen 2.400 N/A ARG 150.A N VAL 201.A O no hydrogen 2.901 N/A GLN 152.A N ARG 199.A O no hydrogen 2.900 N/A TYR 153.A OH ASP 267.A OD1 no hydrogen 2.165 N/A GLU 154.A N ASN 197.A O no hydrogen 3.002 N/A SER 155.A OG TYR 153.A OH no hydrogen 2.740 N/A SER 155.A OG GLN 263.A OE1 no hydrogen 2.479 N/A ILE 156.A N ILE 195.A O no hydrogen 2.892 N/A ALA 158.A N VAL 193.A O no hydrogen 2.886 N/A GLN 159.A NE2 THR 339.A O no hydrogen 3.043 N/A SER 162.A N SER 160.A OG no hydrogen 2.794 N/A SER 162.A OG THR 334.A OG1 no hydrogen 2.870 N/A LEU 164.A N SER 160.A O no hydrogen 3.340 N/A ALA 166.A N SER 162.A O no hydrogen 3.241 N/A LYS 167.A N GLN 163.A O no hydrogen 2.915 N/A PHE 168.A N LEU 164.A O no hydrogen 2.951 N/A PHE 172.A N GLY 169.A O no hydrogen 3.358 N/A SER 173.A N ALA 170.A O no hydrogen 2.952 N/A SER 173.A OG ALA 170.A O no hydrogen 2.441 N/A LYS 174.A N ASP 171.A O no hydrogen 2.964 N/A GLY 176.A N PHE 172.A O no hydrogen 2.850 N/A ALA 177.A N LYS 174.A O no hydrogen 3.450 N/A ASN 180.A N ALA 177.A O no hydrogen 3.444 N/A SER 185.A N ASP 182.A OD2 no hydrogen 2.888 N/A SER 185.A OG ASP 182.A OD2 no hydrogen 2.226 N/A HIS 187.A N PHE 183.A O no hydrogen 2.946 N/A LYS 188.A N SER 184.A O no hydrogen 2.885 N/A GLY 189.A N VAL 186.A O no hydrogen 2.880 N/A GLU 190.A N SER 185.A O no hydrogen 3.165 N/A GLN 192.A N THR 255.A O no hydrogen 2.888 N/A GLN 192.A NE2 SER 259.A O no hydrogen 3.454 N/A PHE 194.A N PHE 253.A O no hydrogen 2.885 N/A ILE 195.A N ILE 156.A O no hydrogen 2.946 N/A ALA 196.A N VAL 251.A O no hydrogen 2.927 N/A ASN 197.A N GLU 154.A O no hydrogen 2.839 N/A ASN 197.A ND2 MET 249.A O no hydrogen 2.921 N/A PHE 198.A N MET 249.A O no hydrogen 2.958 N/A ARG 199.A N GLN 152.A O no hydrogen 2.885 N/A GLN 200.A N ARG 247.A O no hydrogen 2.861 N/A VAL 201.A N ARG 150.A O no hydrogen 2.963 N/A TYR 202.A N TYR 245.A O no hydrogen 2.841 N/A TYR 202.A OH GLY 303.A O no hydrogen 2.981 N/A THR 204.A N ASN 105.A OD1 no hydrogen 2.478 N/A ALA 205.A N VAL 243.A O no hydrogen 2.844 N/A SER 206.A N SER 103.A O no hydrogen 2.898 N/A SER 206.A OG SER 103.A O no hydrogen 2.721 N/A VAL 207.A N SER 241.A O no hydrogen 2.929 N/A ASP 208.A N THR 101.A O no hydrogen 3.152 N/A SER 212.A OG SER 214.A OG no hydrogen 2.336 N/A SER 214.A N ASN 10.A OD1 no hydrogen 3.137 N/A SER 214.A OG ASN 10.A OD1 no hydrogen 3.376 N/A SER 214.A OG SER 212.A OG no hydrogen 2.336 N/A ALA 215.A N SER 212.A O no hydrogen 2.928 N/A LEU 216.A N PRO 213.A O no hydrogen 3.326 N/A PHE 217.A N SER 214.A O no hydrogen 3.387 N/A THR 222.A N ASP 225.A OD2 no hydrogen 2.413 N/A ASN 228.A N THR 224.A O no hydrogen 2.952 N/A ARG 229.A N ASP 225.A O no hydrogen 2.909 N/A ARG 229.A NH1 ASP 225.A O no hydrogen 3.319 N/A VAL 231.A N LEU 226.A O no hydrogen 2.730 N/A THR 235.A N ASN 232.A OD1 no hydrogen 2.953 N/A THR 235.A OG1 GLY 230.A O no hydrogen 3.303 N/A THR 235.A OG1 ASN 232.A OD1 no hydrogen 3.293 N/A VAL 238.A N LEU 79.A O no hydrogen 2.941 N/A TYR 239.A N SER 320.A O no hydrogen 2.953 N/A VAL 240.A N ALA 77.A O no hydrogen 3.174 N/A SER 241.A N THR 318.A O no hydrogen 2.883 N/A SER 241.A OG THR 318.A O no hydrogen 3.532 N/A SER 241.A OG SER 320.A OG no hydrogen 2.427 N/A ASN 242.A N THR 318.A O no hydrogen 3.363 N/A VAL 243.A N ALA 205.A O no hydrogen 2.950 N/A SER 244.A N SER 316.A O no hydrogen 2.437 N/A TYR 245.A N TYR 203.A O no hydrogen 2.974 N/A GLY 246.A N VAL 313.A O no hydrogen 3.042 N/A ARG 247.A N GLN 200.A O no hydrogen 2.977 N/A ARG 247.A NH2 GLN 200.A OE1 no hydrogen 3.167 N/A ARG 247.A NH2 LEU 299.A O no hydrogen 2.278 N/A MET 249.A N PHE 198.A O no hydrogen 2.910 N/A VAL 251.A N ALA 196.A O no hydrogen 2.889 N/A LYS 252.A N CYS 283.A O no hydrogen 2.838 N/A LYS 252.A NZ LEU 179.A O no hydrogen 2.996 N/A LYS 252.A NZ ASN 180.A O no hydrogen 3.233 N/A LYS 252.A NZ GLU 254.A OE2 no hydrogen 2.927 N/A PHE 253.A N PHE 194.A O no hydrogen 2.900 N/A GLU 254.A N LYS 281.A O no hydrogen 2.706 N/A THR 255.A N GLN 192.A O no hydrogen 2.943 N/A SER 259.A N SER 257.A OG no hydrogen 3.091 N/A ILE 266.A N VAL 262.A O no hydrogen 2.913 N/A ASP 267.A N GLN 263.A O no hydrogen 2.895 N/A ALA 268.A N ALA 264.A O no hydrogen 2.881 N/A VAL 269.A N ALA 265.A O no hydrogen 2.923 N/A LYS 271.A N ASP 267.A O no hydrogen 2.879 N/A ASN 275.A N GLU 272.A O no hydrogen 3.033 N/A LEU 277.A N TYR 273.A O no hydrogen 2.956 N/A LYS 278.A N ASN 275.A O no hydrogen 3.000 N/A LYS 281.A N GLU 254.A O no hydrogen 2.680 N/A ILE 282.A N THR 290.A O no hydrogen 3.420 N/A CYS 283.A N LYS 252.A O no hydrogen 2.949 N/A CYS 283.A SG LEU 179.A O no hydrogen 3.869 N/A VAL 285.A N TYR 250.A O no hydrogen 2.962 N/A CYS 289.A SG ALA 284.A O no hydrogen 3.959 N/A THR 295.A OG1 ASN 292.A OD1 no hydrogen 2.200 N/A LYS 297.A N ILE 293.A O no hydrogen 2.968 N/A ASP 298.A N ASP 294.A O no hydrogen 2.925 N/A LEU 299.A N THR 295.A O no hydrogen 2.894 N/A ILE 300.A N LEU 296.A O no hydrogen 2.959 N/A GLN 301.A N LYS 297.A O no hydrogen 2.962 N/A LYS 302.A N ASP 298.A O no hydrogen 2.917 N/A SER 304.A OG ILE 300.A O no hydrogen 2.934 N/A SER 304.A OG GLN 301.A OE1 no hydrogen 3.222 N/A ALA 312.A N TYR 203.A OH no hydrogen 2.928 N/A ILE 315.A N SER 244.A O no hydrogen 2.815 N/A SER 316.A N SER 244.A O no hydrogen 3.380 N/A TYR 317.A N LEU 63.A O no hydrogen 3.133 N/A THR 318.A N ASN 242.A O no hydrogen 2.955 N/A SER 320.A N TYR 239.A O no hydrogen 2.864 N/A SER 320.A OG SER 241.A OG no hydrogen 2.427 N/A PHE 321.A N SER 326.A O no hydrogen 3.423 N/A LYS 323.A NZ LEU 16.A O no hydrogen 3.276 N/A SER 326.A OG ASP 324.A O no hydrogen 3.478 N/A ALA 328.A N THR 319.A O no hydrogen 3.169 N/A THR 329.A OG1 SER 61.A OG no hydrogen 3.108 N/A ILE 330.A N THR 60.A O no hydrogen 2.791 N/A GLN 331.A N LEU 24.A O no hydrogen 3.097 N/A ASN 332.A N ASN 58.A O no hydrogen 2.903 N/A ASN 332.A N GLN 331.A OE1 no hydrogen 3.200 N/A ASN 332.A ND2 ASN 58.A O no hydrogen 3.639 N/A ASN 332.A ND2 ALA 166.A O no hydrogen 3.628 N/A ASN 333.A N HIS 26.A O no hydrogen 3.181 N/A THR 334.A N ILE 56.A O no hydrogen 3.002 N/A THR 334.A OG1 GLU 29.A O no hydrogen 3.115 N/A THR 334.A OG1 SER 162.A OG no hydrogen 2.870 N/A THR 334.A OG1 ASP 335.A O no hydrogen 3.400 N/A ASP 335.A N GLU 29.A O no hydrogen 2.545 N/A TYR 336.A N GLN 54.A O no hydrogen 2.880 N/A THR 339.A N GLN 159.A OE1 no hydrogen 2.435 N/A THR 339.A OG1 GLN 159.A OE1 no hydrogen 2.775 N/A LYS 340.A N GLU 50.A O no hydrogen 2.917 N/A THR 342.A N VAL 48.A O no hydrogen 2.920 N/A SER 343.A OG GLU 45.A OE2 no hydrogen 2.420 N/A TYR 344.A N TYR 46.A O no hydrogen 2.929 N/A LYS 345.A NZ GLU 45.A OE2 no hydrogen 3.404 N/A ASP 346.A N GLY 44.A O no hydrogen 2.996 N/A GLY 347.A N PHE 400.A O no hydrogen 2.704 N/A LEU 349.A N LEU 398.A O no hydrogen 2.924 N/A THR 350.A N ARG 437.A O no hydrogen 2.866 N/A THR 350.A OG1 THR 397.A OG1 no hydrogen 2.890 N/A LEU 351.A N THR 396.A O no hydrogen 2.931 N/A ASN 352.A N ILE 439.A O no hydrogen 2.885 N/A ASN 352.A ND2 SER 440.A OG no hydrogen 2.745 N/A HIS 353.A ND1 THR 441.A OG1 no hydrogen 2.755 N/A HIS 353.A NE2 PHE 357.A O no hydrogen 2.594 N/A ASP 354.A N THR 441.A O no hydrogen 3.108 N/A ALA 359.A N HIS 353.A NE2 no hydrogen 3.389 N/A ARG 360.A N LEU 412.A O no hydrogen 3.158 N/A ARG 360.A NE ASN 389.A OD1 no hydrogen 2.433 N/A TYR 362.A N LYS 410.A O no hydrogen 2.902 N/A VAL 363.A N ASN 386.A OD1 no hydrogen 2.910 N/A TYR 364.A N ARG 408.A O no hydrogen 2.700 N/A TRP 365.A N ARG 381.A O no hydrogen 2.938 N/A GLU 366.A N ARG 405.A O no hydrogen 2.762 N/A GLU 367.A N ARG 379.A O no hydrogen 2.891 N/A LEU 368.A N ASN 403.A O no hydrogen 2.686 N/A GLY 369.A N THR 377.A O no hydrogen 2.664 N/A HIS 370.A ND1 GLY 374.A O no hydrogen 2.815 N/A ASP 371.A N TYR 375.A O no hydrogen 3.193 N/A GLY 374.A N ASP 371.A O no hydrogen 2.884 N/A THR 377.A N GLY 369.A O no hydrogen 2.949 N/A ARG 379.A N GLU 367.A O no hydrogen 2.963 N/A ARG 381.A N TRP 365.A O no hydrogen 2.888 N/A ARG 381.A NH1 GLU 367.A OE1 no hydrogen 3.061 N/A TRP 383.A N VAL 363.A O no hydrogen 2.980 N/A ASN 386.A ND2 VAL 363.A O no hydrogen 3.394 N/A ARG 390.A N ALA 359.A O no hydrogen 3.083 N/A ARG 390.A NH2 GLY 385.A O no hydrogen 3.348 N/A THR 397.A OG1 THR 350.A OG1 no hydrogen 2.890 N/A LEU 398.A N LEU 349.A O no hydrogen 2.823 N/A ARG 399.A NH2 ASP 346.A OD2 no hydrogen 2.496 N/A PHE 400.A N GLY 347.A O no hydrogen 2.678 N/A LYS 401.A NZ ARG 42.A O no hydrogen 2.308 N/A LYS 401.A NZ GLU 45.A O no hydrogen 2.955 N/A VAL 404.A N LYS 401.A O no hydrogen 3.113 N/A ARG 405.A N GLU 366.A O no hydrogen 2.816 N/A ARG 405.A NE GLU 366.A OE1 no hydrogen 2.596 N/A ARG 405.A NH2 GLU 366.A OE1 no hydrogen 3.128 N/A ASN 406.A ND2 GLU 366.A OE1 no hydrogen 2.988 N/A ILE 407.A N LEU 431.A O no hydrogen 3.274 N/A ARG 408.A N TYR 364.A O no hydrogen 2.371 N/A VAL 409.A N LYS 428.A O no hydrogen 2.916 N/A LYS 410.A N TYR 362.A O no hydrogen 2.905 N/A VAL 411.A N TYR 426.A O no hydrogen 2.936 N/A LEU 412.A N ARG 360.A O no hydrogen 2.936 N/A GLY 413.A N ARG 423.A O no hydrogen 2.578 N/A THR 415.A N PRO 421.A O no hydrogen 3.031 N/A THR 415.A OG1 GLU 420.A O no hydrogen 2.590 N/A ARG 423.A N GLY 413.A O no hydrogen 2.442 N/A ILE 425.A N VAL 411.A O no hydrogen 3.217 N/A LYS 428.A N VAL 409.A O no hydrogen 2.909 N/A LEU 431.A N ILE 407.A O no hydrogen 2.999 N/A GLN 436.A NE2 ARG 437.A O no hydrogen 2.964 N/A GLN 436.A NE2 ASN 438.A OD1 no hydrogen 3.317 N/A ARG 437.A N ALA 348.A O no hydrogen 2.921 N/A ARG 437.A NH2 PRO 432.A O no hydrogen 2.714 N/A ASN 438.A N LYS 453.A O no hydrogen 3.194 N/A ILE 439.A N THR 350.A O no hydrogen 2.922 N/A SER 440.A OG GLU 451.A OE1 no hydrogen 2.757 N/A THR 441.A OG1 ASN 352.A O no hydrogen 3.393 N/A THR 441.A OG1 HIS 353.A ND1 no hydrogen 2.755 N/A TRP 442.A N GLN 449.A O no hydrogen 2.925 N/A THR 445.A OG1 ALA 414.A O no hydrogen 2.787 N/A LEU 446.A N THR 444.A OG1 no hydrogen 2.958 N/A HIS 447.A N THR 444.A OG1 no hydrogen 2.527 N/A GLN 449.A N TRP 442.A O no hydrogen 2.870 N/A LYS 453.A N ASN 438.A O no hydrogen 3.072 N/A LYS 453.A NZ GLU 451.A OE2 no hydrogen 3.300 N/A VAL 455.A N GLN 436.A O no hydrogen 3.108 N/A