Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4c2x_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): ALA 4.A N ASP 2.A O no hydrogen 2.610 N/A ARG 8.A NE HIS 7.A O no hydrogen 2.861 N/A ARG 8.A NH1 ASP 13.A OD2 no hydrogen 3.326 N/A ARG 8.A NH2 HIS 7.A O no hydrogen 2.632 N/A TYR 9.A OH VAL 178.A O no hydrogen 2.911 N/A GLN 10.A N ARG 8.A O no hydrogen 2.781 N/A ASP 13.A N TYR 9.A O no hydrogen 2.714 N/A THR 14.A N PHE 11.A O no hydrogen 3.145 N/A THR 14.A OG1 PHE 11.A O no hydrogen 2.553 N/A GLN 15.A N TRP 12.A O no hydrogen 3.191 N/A VAL 17.A N GLN 15.A O no hydrogen 2.808 N/A GLU 22.A N LYS 19.A O no hydrogen 3.075 N/A GLY 28.A N ARG 374.A O no hydrogen 2.895 N/A GLU 31.A N ASN 372.A OD1 no hydrogen 2.808 N/A LYS 34.A NZ GLU 31.A OE2 no hydrogen 2.731 N/A MET 49.A N ARG 107.A O no hydrogen 2.795 N/A TRP 50.A NE1 TYR 42.A O no hydrogen 2.818 N/A ASP 51.A N GLY 105.A O no hydrogen 3.114 N/A LEU 53.A N HIS 103.A O no hydrogen 2.911 N/A SER 56.A OG ASP 54.A OD2 no hydrogen 3.357 N/A ASP 57.A N ASP 54.A O no hydrogen 3.151 N/A GLU 59.A N ASP 57.A OD1 no hydrogen 3.021 N/A LEU 61.A N ASP 57.A O no hydrogen 3.109 N/A LYS 62.A N ALA 58.A O no hydrogen 3.316 N/A GLU 63.A N GLU 59.A O no hydrogen 3.082 N/A LEU 64.A N VAL 60.A O no hydrogen 2.816 N/A TYR 65.A N LEU 61.A O no hydrogen 2.661 N/A TYR 65.A OH ASP 83.A OD1 no hydrogen 2.977 N/A THR 66.A N LYS 62.A O no hydrogen 3.147 N/A THR 66.A OG1 LYS 62.A O no hydrogen 2.798 N/A LEU 67.A N GLU 63.A O no hydrogen 2.888 N/A LEU 68.A N LEU 64.A O no hydrogen 3.169 N/A LEU 68.A N TYR 65.A O no hydrogen 3.174 N/A ASN 69.A N TYR 65.A O no hydrogen 2.803 N/A ASN 69.A ND2 ASP 83.A OD1 no hydrogen 2.882 N/A GLU 70.A N THR 66.A O no hydrogen 3.181 N/A ASN 71.A N LEU 67.A O no hydrogen 2.733 N/A ASN 71.A ND2 LEU 67.A O no hydrogen 3.042 N/A TYR 72.A N LEU 68.A O no hydrogen 2.832 N/A TYR 72.A OH ASN 138.A OD1 no hydrogen 3.306 N/A ASP 75.A N PHE 80.A O no hydrogen 3.214 N/A ASN 78.A N ASP 75.A OD2 no hydrogen 3.235 N/A MET 79.A N ASP 75.A OD1 no hydrogen 2.937 N/A PHE 80.A N ASP 75.A OD1 no hydrogen 2.791 N/A ARG 81.A N THR 298.A O no hydrogen 2.839 N/A ARG 81.A NE GLU 74.A OE2 no hydrogen 3.016 N/A ARG 81.A NH1 ASN 69.A O no hydrogen 3.205 N/A ARG 81.A NH2 GLU 74.A OE2 no hydrogen 3.154 N/A PHE 82.A N VAL 73.A O no hydrogen 3.114 N/A ASP 83.A N PRO 296.A O no hydrogen 2.711 N/A TYR 84.A OH GLN 388.A O no hydrogen 2.566 N/A PHE 88.A N SER 85.A OG no hydrogen 3.149 N/A LEU 89.A N SER 85.A O no hydrogen 2.871 N/A LEU 90.A N PRO 86.A O no hydrogen 3.140 N/A TRP 91.A N GLU 87.A O no hydrogen 2.944 N/A TRP 91.A NE1 HIS 265.A O no hydrogen 2.940 N/A ALA 92.A N PHE 88.A O no hydrogen 2.940 N/A LEU 93.A N LEU 89.A O no hydrogen 3.048 N/A ARG 94.A NE.A LEU 90.A O no hydrogen 3.482 N/A ARG 94.A NH2.B ASP 54.A OD1 no hydrogen 3.455 N/A TRP 98.A N PRO 95.A O no hydrogen 3.277 N/A TRP 102.A N LEU 99.A O no hydrogen 3.088 N/A TRP 102.A NE1 ARG 162.A O no hydrogen 3.053 N/A HIS 103.A N LEU 100.A O no hydrogen 3.084 N/A HIS 103.A NE2 LEU 93.A O no hydrogen 2.811 N/A CYS 104.A N ILE 118.A O no hydrogen 2.966 N/A GLY 105.A N ASP 51.A O no hydrogen 2.654 N/A VAL 106.A N GLY 116.A O no hydrogen 2.987 N/A ARG 107.A N MET 49.A O no hydrogen 2.730 N/A ARG 107.A NH1 GLU 63.A OE2 no hydrogen 2.606 N/A ARG 107.A NH1 LYS 112.A O no hydrogen 2.488 N/A ARG 107.A NH2 GLU 63.A OE1 no hydrogen 2.163 N/A VAL 108.A N LYS 113.A O no hydrogen 2.836 N/A SER 109.A N GLY 47.A O no hydrogen 2.706 N/A LYS 112.A N VAL 108.A O no hydrogen 2.699 N/A LYS 113.A N ASN 111.A OD1 no hydrogen 2.998 N/A VAL 115.A N VAL 106.A O no hydrogen 2.873 N/A GLY 116.A N VAL 106.A O no hydrogen 3.171 N/A PHE 117.A N CYS 141.A O no hydrogen 2.971 N/A ILE 118.A N CYS 104.A O no hydrogen 2.892 N/A SER 119.A N ASN 138.A O no hydrogen 3.041 N/A SER 119.A OG ASN 138.A O no hydrogen 2.639 N/A ALA 120.A N TRP 102.A O no hydrogen 3.013 N/A ILE 121.A N GLU 136.A O no hydrogen 3.166 N/A ALA 123.A N MET 134.A O no hydrogen 3.042 N/A ILE 125.A N LYS 132.A O no hydrogen 2.753 N/A ARG 126.A N ALA 255.A O no hydrogen 2.795 N/A ARG 126.A NE TYR 128.A O no hydrogen 3.209 N/A ARG 126.A NH1 LEU 249.A O no hydrogen 2.715 N/A ARG 126.A NH2 PHE 252.A O no hydrogen 1.883 N/A ILE 127.A N SER 130.A O no hydrogen 2.748 N/A TYR 128.A N HIS 253.A O no hydrogen 2.751 N/A TYR 128.A OH PRO 376.A O no hydrogen 2.706 N/A SER 130.A N ILE 127.A O no hydrogen 2.908 N/A LYS 132.A N ILE 125.A O no hydrogen 2.658 N/A MET 134.A N ALA 123.A O no hydrogen 2.783 N/A VAL 135.A N GLN 170.A O no hydrogen 3.354 N/A GLU 136.A N ILE 121.A O no hydrogen 2.843 N/A ILE 137.A N VAL 172.A O no hydrogen 3.144 N/A ASN 138.A N SER 119.A O no hydrogen 3.157 N/A ASN 138.A ND2 GLN 388.A OXT no hydrogen 2.529 N/A PHE 139.A N ASN 138.A OD1 no hydrogen 2.805 N/A CYS 141.A N PHE 117.A O no hydrogen 2.888 N/A CYS 141.A SG LEU 67.A O no hydrogen 4.038 N/A CYS 141.A SG ASN 71.A O no hydrogen 3.209 N/A HIS 143.A N VAL 115.A O no hydrogen 2.779 N/A LYS 144.A N ASN 71.A OD1 no hydrogen 2.624 N/A LYS 144.A NZ GLU 74.A OE2 no hydrogen 2.564 N/A LYS 145.A N HIS 143.A ND1 no hydrogen 3.033 N/A LEU 146.A N HIS 143.A O no hydrogen 2.721 N/A ARG 147.A N LYS 144.A O no hydrogen 3.036 N/A ARG 147.A NE VAL 142.A O no hydrogen 2.871 N/A ARG 147.A NH2 VAL 142.A O no hydrogen 3.460 N/A LYS 149.A NZ ARG 147.A O no hydrogen 3.367 N/A LYS 149.A NZ SER 148.A O no hydrogen 3.364 N/A VAL 154.A N VAL 151.A O no hydrogen 3.023 N/A LEU 155.A N VAL 151.A O no hydrogen 3.159 N/A ILE 156.A N ALA 152.A O no hydrogen 3.032 N/A ARG 157.A N PRO 153.A O no hydrogen 3.139 N/A GLU 158.A N VAL 154.A O no hydrogen 2.822 N/A ILE 159.A N LEU 155.A O no hydrogen 2.939 N/A THR 160.A N ILE 156.A O no hydrogen 2.895 N/A THR 160.A OG1 ILE 156.A O no hydrogen 2.501 N/A ARG 161.A N ARG 157.A O no hydrogen 2.769 N/A ARG 161.A NE GLU 158.A OE1 no hydrogen 2.681 N/A ARG 161.A NH1 ARG 38.A O no hydrogen 3.444 N/A ARG 161.A NH2 GLU 158.A OE1 no hydrogen 3.067 N/A ARG 161.A NH2 GLU 158.A OE2 no hydrogen 2.802 N/A ARG 162.A N GLU 158.A O no hydrogen 2.929 N/A ARG 162.A NE GLU 158.A OE2 no hydrogen 3.501 N/A ARG 162.A NH1 THR 52.A OG1 no hydrogen 3.121 N/A ARG 162.A NH1 GLN 101.A O no hydrogen 2.763 N/A VAL 163.A N ILE 159.A O no hydrogen 3.093 N/A ASN 164.A N THR 160.A O no hydrogen 3.213 N/A LEU 165.A N ARG 161.A O no hydrogen 3.091 N/A GLU 166.A N VAL 163.A O no hydrogen 2.977 N/A GLY 167.A N ASN 164.A O no hydrogen 3.097 N/A ILE 168.A N VAL 163.A O no hydrogen 3.355 N/A GLN 170.A NE2 ASN 372.A O no hydrogen 2.908 N/A VAL 172.A N VAL 135.A O no hydrogen 3.012 N/A TYR 173.A N TYR 369.A O no hydrogen 2.957 N/A ALA 175.A N GLN 367.A O no hydrogen 3.224 N/A LEU 179.A N TYR 369.A OH no hydrogen 2.805 N/A ILE 183.A N TYR 368.A O no hydrogen 3.029 N/A CYS 186.A N LEU 366.A O no hydrogen 2.687 N/A ARG 187.A N ASP 346.A OD1 no hydrogen 3.045 N/A ARG 187.A NH2 GLY 362.A O no hydrogen 3.499 N/A TRP 189.A N ALA 344.A O no hydrogen 2.897 N/A HIS 190.A N GLY 360.A O no hydrogen 2.779 N/A HIS 190.A ND1.A ASN 343.A OD1 no hydrogen 2.464 N/A ARG 191.A N PHE 342.A O no hydrogen 2.701 N/A ARG 191.A NE LEU 357.A O no hydrogen 2.600 N/A ARG 191.A NH1 SER 192.A O no hydrogen 2.768 N/A ARG 191.A NH1 TYR 219.A O no hydrogen 3.242 N/A ARG 191.A NH2 LEU 357.A O no hydrogen 3.422 N/A LEU 193.A N ASP 340.A O no hydrogen 3.039 N/A ASN 194.A N ASP 340.A O no hydrogen 3.096 N/A LYS 197.A N ASN 194.A OD1 no hydrogen 3.212 N/A LYS 197.A NZ SER 307.A O no hydrogen 2.706 N/A LYS 197.A NZ ASP 340.A OD2 no hydrogen 2.712 N/A LEU 198.A N ASN 194.A O no hydrogen 3.221 N/A VAL 199.A N PRO 195.A O no hydrogen 2.954 N/A GLU 200.A N LYS 196.A O no hydrogen 2.869 N/A VAL 201.A N LYS 197.A O no hydrogen 2.976 N/A LYS 202.A N VAL 199.A O no hydrogen 2.746 N/A PHE 203.A N LEU 198.A O no hydrogen 2.744 N/A SER 204.A N LEU 198.A O no hydrogen 3.226 N/A ARG 214.A N THR 211.A OG1 no hydrogen 2.794 N/A THR 215.A OG1 THR 211.A O no hydrogen 2.871 N/A MET 216.A N LEU 212.A O no hydrogen 2.863 N/A LYS 217.A N GLN 213.A O no hydrogen 3.066 N/A LEU 218.A N ARG 214.A O no hydrogen 2.947 N/A TYR 219.A N THR 215.A O no hydrogen 3.113 N/A LYS 226.A N ASP 329.A OD1 no hydrogen 2.740 N/A THR 227.A N ASP 329.A OD2 no hydrogen 2.919 N/A THR 227.A OG1 ASP 329.A OD2 no hydrogen 2.717 N/A LEU 230.A N THR 227.A O no hydrogen 3.401 N/A ARG 231.A N VAL 278.A O no hydrogen 2.820 N/A ARG 231.A NE GLU 280.A OE1 no hydrogen 3.091 N/A ARG 231.A NH1 ASP 237.A OD2 no hydrogen 3.191 N/A ARG 231.A NH2 ASP 237.A OD1 no hydrogen 3.054 N/A ARG 231.A NH2 GLU 280.A OE1 no hydrogen 3.004 N/A MET 233.A N THR 276.A O no hydrogen 2.992 N/A GLU 234.A N ASP 237.A OD2 no hydrogen 2.826 N/A ASP 237.A N GLU 234.A O no hydrogen 2.918 N/A ILE 238.A N PRO 235.A O no hydrogen 2.812 N/A VAL 241.A N ASP 237.A O no hydrogen 2.902 N/A ARG 242.A N ILE 238.A O no hydrogen 3.005 N/A ARG 242.A NE GLU 260.A OE2 no hydrogen 2.819 N/A ARG 242.A NH2 GLU 260.A OE2 no hydrogen 2.860 N/A GLU 243.A N LYS 239.A O no hydrogen 3.302 N/A LEU 244.A N SER 240.A O no hydrogen 3.007 N/A ILE 245.A N VAL 241.A O no hydrogen 2.758 N/A ILE 245.A N ARG 242.A O no hydrogen 3.042 N/A ASN 246.A N ARG 242.A O no hydrogen 2.923 N/A ASN 246.A ND2 MET 258.A O no hydrogen 2.561 N/A THR 247.A N GLU 243.A O no hydrogen 3.223 N/A THR 247.A OG1 GLU 243.A O no hydrogen 2.929 N/A TYR 248.A N LEU 244.A O no hydrogen 3.224 N/A TYR 248.A OH GLU 349.A OE2 no hydrogen 2.456 N/A LEU 249.A N ILE 245.A O no hydrogen 3.070 N/A LYS 250.A N THR 247.A O no hydrogen 3.213 N/A GLN 251.A NE2 TYR 248.A O no hydrogen 2.762 N/A PHE 252.A N LEU 249.A O no hydrogen 3.172 N/A LEU 254.A N LYS 382.A O no hydrogen 3.416 N/A ALA 255.A N ARG 126.A O no hydrogen 3.320 N/A VAL 257.A N ASN 124.A O no hydrogen 2.894 N/A MET 258.A N ASN 246.A OD1 no hydrogen 3.119 N/A ASP 259.A N GLU 262.A OE1 no hydrogen 2.785 N/A GLU 262.A N ASP 259.A OD1 no hydrogen 2.624 N/A VAL 263.A N ASP 259.A O no hydrogen 3.290 N/A ALA 264.A N GLU 260.A O no hydrogen 2.995 N/A HIS 265.A N GLU 261.A O no hydrogen 3.172 N/A HIS 265.A NE2 TRP 91.A O no hydrogen 2.580 N/A TRP 266.A N GLU 262.A O no hydrogen 2.850 N/A PHE 267.A N VAL 263.A O no hydrogen 3.172 N/A LEU 268.A N ALA 264.A O no hydrogen 3.263 N/A ARG 270.A N ILE 274.A O no hydrogen 2.912 N/A ILE 273.A N ARG 270.A O no hydrogen 3.095 N/A ILE 274.A N ARG 270.A O no hydrogen 2.890 N/A ASP 275.A N PHE 292.A O no hydrogen 2.922 N/A THR 276.A OG1 PHE 267.A O no hydrogen 2.501 N/A PHE 277.A N LEU 290.A O no hydrogen 2.878 N/A VAL 278.A N ARG 231.A O no hydrogen 2.633 N/A VAL 279.A N ASP 288.A O no hydrogen 2.704 N/A GLU 280.A N GLY 229.A O no hydrogen 3.015 N/A SER 281.A N LYS 285.A O no hydrogen 2.795 N/A SER 281.A OG ASN 283.A OD1 no hydrogen 2.623 N/A SER 281.A OG LYS 285.A O no hydrogen 3.057 N/A GLY 284.A N ASN 283.A OD1 no hydrogen 2.764 N/A LYS 285.A N ASN 283.A OD1 no hydrogen 3.159 N/A THR 287.A N VAL 279.A O no hydrogen 3.053 N/A THR 287.A OG1 VAL 279.A O no hydrogen 3.366 N/A THR 287.A OG1 ASP 288.A OD1 no hydrogen 2.698 N/A PHE 289.A N ILE 317.A O no hydrogen 2.854 N/A LEU 290.A N PHE 277.A O no hydrogen 2.993 N/A SER 291.A N ASN 316.A OD1 no hydrogen 2.883 N/A SER 291.A OG TYR 315.A O no hydrogen 2.700 N/A PHE 292.A N ASP 275.A O no hydrogen 2.881 N/A TYR 293.A N TYR 312.A O no hydrogen 2.925 N/A TYR 293.A OH LEU 387.A O no hydrogen 3.258 N/A THR 294.A N ILE 273.A O no hydrogen 2.946 N/A LEU 295.A N ALA 310.A O no hydrogen 3.214 N/A SER 297.A N LEU 308.A O no hydrogen 2.857 N/A SER 297.A OG ARG 81.A O no hydrogen 3.366 N/A THR 298.A N ARG 81.A O no hydrogen 2.627 N/A VAL 299.A N LYS 306.A O no hydrogen 2.803 N/A MET 300.A N MET 79.A O no hydrogen 2.668 N/A SER 307.A OG SER 297.A O no hydrogen 3.261 N/A LEU 308.A N SER 297.A O no hydrogen 2.977 N/A LYS 309.A N ASP 340.A OD2 no hydrogen 3.035 N/A LYS 309.A NZ LYS 337.A O no hydrogen 3.167 N/A ALA 311.A N VAL 341.A O no hydrogen 2.905 N/A TYR 312.A N TYR 293.A O no hydrogen 2.736 N/A SER 313.A N ASN 343.A O no hydrogen 2.734 N/A PHE 314.A N SER 291.A O no hydrogen 3.380 N/A TYR 315.A N SER 291.A OG no hydrogen 2.935 N/A ASN 316.A ND2 SER 313.A OG no hydrogen 2.959 N/A ILE 317.A N PHE 289.A O no hydrogen 2.649 N/A THR 319.A N THR 287.A O no hydrogen 3.000 N/A THR 319.A N ASP 288.A OD2 no hydrogen 2.710 N/A THR 319.A OG1 THR 287.A O no hydrogen 2.210 N/A THR 321.A N ASP 288.A OD1 no hydrogen 3.241 N/A THR 321.A N ASP 288.A OD2 no hydrogen 2.943 N/A THR 321.A OG1 ASP 288.A OD1 no hydrogen 3.053 N/A ASP 325.A N PRO 322.A O no hydrogen 3.211 N/A LEU 326.A N PRO 322.A O no hydrogen 3.063 N/A MET 327.A N LEU 323.A O no hydrogen 2.828 N/A SER 328.A N LEU 324.A O no hydrogen 3.210 N/A ASP 329.A N ASP 325.A O no hydrogen 3.276 N/A ALA 330.A N LEU 326.A O no hydrogen 2.949 N/A LEU 331.A N MET 327.A O no hydrogen 2.878 N/A ILE 332.A N SER 328.A O no hydrogen 3.179 N/A LEU 333.A N ASP 329.A O no hydrogen 2.766 N/A ALA 334.A N ALA 330.A O no hydrogen 2.918 N/A LYS 335.A N LEU 331.A O no hydrogen 2.806 N/A SER 336.A N ILE 332.A O no hydrogen 3.000 N/A SER 336.A OG ILE 332.A O no hydrogen 3.310 N/A SER 336.A OG LEU 333.A O no hydrogen 2.962 N/A LYS 337.A N ALA 334.A O no hydrogen 2.990 N/A LYS 337.A NZ ASP 275.A OD1 no hydrogen 2.682 N/A GLY 338.A N LYS 335.A O no hydrogen 2.786 N/A PHE 339.A N ALA 334.A O no hydrogen 3.250 N/A ASP 340.A N LYS 309.A O no hydrogen 2.764 N/A PHE 342.A N ARG 191.A O no hydrogen 2.844 N/A ASN 343.A N ALA 311.A O no hydrogen 2.761 N/A ALA 344.A N TRP 189.A O no hydrogen 3.160 N/A MET 348.A N VAL 383.A O no hydrogen 2.812 N/A ASN 350.A N LEU 347.A O no hydrogen 3.006 N/A ASN 350.A ND2 LEU 345.A O no hydrogen 3.028 N/A THR 352.A N GLU 349.A O no hydrogen 2.727 N/A THR 352.A OG1 GLU 349.A O no hydrogen 2.786 N/A PHE 353.A N ASN 350.A O no hydrogen 3.125 N/A LEU 354.A N ASN 350.A O no hydrogen 3.212 N/A LEU 357.A N PHE 353.A O no hydrogen 2.703 N/A LEU 357.A N LEU 354.A O no hydrogen 3.252 N/A LYS 358.A N GLU 355.A O no hydrogen 3.307 N/A LYS 358.A NZ LEU 218.A O no hydrogen 3.422 N/A PHE 359.A N LEU 354.A O no hydrogen 2.907 N/A GLY 360.A N HIS 190.A O no hydrogen 2.698 N/A GLY 362.A N TYR 188.A O no hydrogen 3.002 N/A LEU 366.A N CYS 186.A O no hydrogen 2.921 N/A GLN 367.A N ALA 175.A O no hydrogen 2.991 N/A GLN 367.A NE2.A THR 185.A OG1 no hydrogen 2.405 N/A TYR 368.A N ALA 184.A O no hydrogen 3.028 N/A TYR 368.A OH LEU 385.A O no hydrogen 2.589 N/A TYR 369.A N TYR 173.A O no hydrogen 2.852 N/A TYR 369.A OH VAL 177.A O no hydrogen 2.775 N/A TYR 371.A N ALA 171.A O no hydrogen 2.733 N/A TYR 371.A OH GLN 15.A OE1 no hydrogen 2.599 N/A ASN 372.A N PRO 16.A O no hydrogen 3.051 N/A ASN 372.A ND2 GLU 31.A O no hydrogen 3.197 N/A ASN 372.A ND2 PHE 169.A O no hydrogen 3.053 N/A ARG 374.A N GLY 28.A O no hydrogen 2.599 N/A CYS 375.A SG PRO 376.A O no hydrogen 3.884 N/A SER 380.A OG ASP 346.A O no hydrogen 3.461 N/A LYS 382.A N ASP 379.A O no hydrogen 2.928 N/A VAL 383.A N SER 380.A O no hydrogen 2.768 N/A GLY 384.A N LEU 254.A O no hydrogen 2.541 N/A VAL 386.A N TYR 315.A OH no hydrogen 2.919 N/A