Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4c35_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): LYS 6.A N GLN 2.A O no hydrogen 3.398 N/A GLU 7.A N GLU 3.A O no hydrogen 3.234 N/A PHE 8.A N SER 4.A O no hydrogen 3.010 N/A LEU 9.A N VAL 5.A O no hydrogen 2.927 N/A ALA 10.A N LYS 6.A O no hydrogen 3.016 N/A LYS 11.A N GLU 7.A O no hydrogen 3.117 N/A ALA 12.A N PHE 8.A O no hydrogen 2.882 N/A LYS 13.A N LEU 9.A O no hydrogen 2.910 N/A LYS 13.A NZ SER 148.A O no hydrogen 2.975 N/A LYS 13.A NZ ASP 150.A OD2 no hydrogen 3.079 N/A GLU 14.A N ALA 10.A O no hydrogen 3.292 N/A ASP 15.A N LYS 11.A O no hydrogen 2.926 N/A PHE 16.A N ALA 12.A O no hydrogen 2.999 N/A LEU 17.A N LYS 13.A O no hydrogen 2.932 N/A LYS 18.A N GLU 14.A O no hydrogen 3.393 N/A LYS 19.A N ASP 15.A O no hydrogen 3.332 N/A TRP 20.A N PHE 16.A O no hydrogen 2.807 N/A GLU 21.A N LEU 17.A O no hydrogen 2.926 N/A ASN 22.A N.A LYS 18.A O no hydrogen 3.167 N/A ASN 22.A N.B LYS 18.A O no hydrogen 3.165 N/A ALA 24.A N GLN 86.A OE1 no hydrogen 3.282 N/A GLN 25.A NE2 SER 335.A O no hydrogen 3.281 N/A GLN 25.A NE2 PHE 337.A O no hydrogen 3.176 N/A THR 27.A N SER 99.A O no hydrogen 2.978 N/A THR 27.A OG1 SER 99.A O no hydrogen 3.567 N/A HIS 29.A N GLN 32.A OE1 no hydrogen 3.351 N/A ASP 31.A N HIS 29.A ND1 no hydrogen 2.985 N/A GLN 32.A N HIS 29.A O no hydrogen 3.294 N/A PHE 33.A N LEU 30.A O no hydrogen 3.125 N/A GLU 34.A N LYS 51.A O no hydrogen 2.836 N/A ARG 35.A NH1 GLU 321.A O no hydrogen 2.862 N/A ARG 35.A NH2 GLU 320.A OE1 no hydrogen 2.843 N/A ARG 35.A NH2 GLU 321.A O no hydrogen 3.133 N/A ILE 36.A N LEU 49.A O no hydrogen 2.805 N/A LYS 37.A N LEU 49.A O no hydrogen 3.478 N/A LYS 37.A NZ ASP 317.A OD1 no hydrogen 2.730 N/A THR 38.A N GLU 320.A OE1 no hydrogen 3.257 N/A THR 38.A N GLU 320.A OE2 no hydrogen 2.889 N/A THR 38.A OG1 GLU 320.A OE1 no hydrogen 2.885 N/A LEU 39.A N VAL 47.A O no hydrogen 2.693 N/A GLY 40.A N VAL 47.A O no hydrogen 3.194 N/A ARG 46.A N ILE 63.A O no hydrogen 3.092 N/A ARG 46.A NH1 GLU 321.A O no hydrogen 2.945 N/A ARG 46.A NH1 GLU 322.A O no hydrogen 3.048 N/A ARG 46.A NH2 GLU 322.A O no hydrogen 2.929 N/A VAL 47.A N GLY 40.A O no hydrogen 2.881 N/A MET 48.A N MET 61.A O no hydrogen 2.824 N/A LEU 49.A N LYS 37.A O no hydrogen 2.724 N/A VAL 50.A N TYR 59.A O no hydrogen 2.740 N/A LYS 51.A N GLU 34.A O no hydrogen 2.752 N/A HIS 52.A N ASN 57.A O no hydrogen 2.750 N/A HIS 52.A ND1 THR 55.A OG1 no hydrogen 2.754 N/A MET 53.A N GLN 32.A O no hydrogen 2.852 N/A THR 55.A OG1 HIS 52.A ND1 no hydrogen 2.754 N/A GLY 56.A N HIS 52.A O no hydrogen 2.723 N/A ASN 57.A N THR 55.A OG1 no hydrogen 3.288 N/A TYR 59.A N VAL 50.A O no hydrogen 2.965 N/A ALA 60.A N LEU 110.A O no hydrogen 2.878 N/A MET 61.A N MET 48.A O no hydrogen 2.633 N/A LYS 62.A N MET 108.A O no hydrogen 2.837 N/A LYS 62.A NZ GLU 81.A OE1 no hydrogen 3.259 N/A LYS 62.A NZ GLU 81.A OE2 no hydrogen 2.774 N/A ILE 63.A N ARG 46.A O no hydrogen 2.715 N/A LEU 64.A N LEU 106.A O no hydrogen 2.975 N/A LYS 66.A N SER 104.A O no hydrogen 2.956 N/A LYS 66.A NZ ASP 102.A O no hydrogen 2.742 N/A LYS 66.A NZ ASN 103.A O no hydrogen 3.219 N/A LYS 66.A NZ LYS 329.A O no hydrogen 2.804 N/A LYS 68.A N ASP 65.A OD1 no hydrogen 3.249 N/A VAL 69.A N ASP 65.A O no hydrogen 3.009 N/A VAL 70.A N LYS 66.A O no hydrogen 3.051 N/A LYS 71.A N GLN 67.A O no hydrogen 3.019 N/A LEU 72.A N LYS 68.A O no hydrogen 2.806 N/A LYS 73.A N VAL 70.A O no hydrogen 3.203 N/A GLN 74.A N VAL 69.A O no hydrogen 2.815 N/A GLN 74.A NE2 LEU 72.A O no hydrogen 2.801 N/A THR 78.A N GLN 74.A O no hydrogen 2.856 N/A THR 78.A OG1 GLN 74.A O no hydrogen 2.761 N/A LEU 79.A N ILE 75.A O no hydrogen 2.911 N/A ASN 80.A N GLU 76.A O no hydrogen 2.819 N/A ASN 80.A ND2 ALA 177.A O no hydrogen 2.674 N/A GLU 81.A N HIS 77.A O no hydrogen 3.044 N/A LYS 82.A N THR 78.A O no hydrogen 3.325 N/A LYS 82.A NZ ALA 24.A O no hydrogen 2.851 N/A LYS 82.A NZ PHE 337.A OXT no hydrogen 2.726 N/A ARG 83.A N LEU 79.A O no hydrogen 2.888 N/A ILE 84.A N ASN 80.A O no hydrogen 2.950 N/A LEU 85.A N GLU 81.A O no hydrogen 3.103 N/A GLN 86.A N LYS 82.A O no hydrogen 3.067 N/A GLN 86.A NE2 LYS 19.A O no hydrogen 2.860 N/A GLN 86.A NE2 ARG 83.A O no hydrogen 2.891 N/A ALA 87.A N ILE 84.A O no hydrogen 2.941 N/A VAL 88.A N ILE 84.A O no hydrogen 3.142 N/A ASN 89.A N TYR 145.A OH no hydrogen 2.922 N/A LEU 93.A N PHE 90.A O no hydrogen 3.254 N/A VAL 94.A N VAL 171.A O no hydrogen 3.081 N/A LYS 95.A N GLU 111.A OE1 no hydrogen 3.041 N/A LYS 95.A NZ ASN 89.A OD1 no hydrogen 3.250 N/A GLU 97.A N VAL 109.A O no hydrogen 2.667 N/A PHE 98.A N VAL 109.A O no hydrogen 3.156 N/A SER 99.A N THR 27.A OG1 no hydrogen 3.319 N/A PHE 100.A N TYR 107.A O no hydrogen 3.169 N/A LYS 101.A NZ PHE 334.A O no hydrogen 2.771 N/A LYS 101.A NZ PHE 337.A O no hydrogen 3.110 N/A ASP 102.A N ASN 105.A O no hydrogen 2.908 N/A SER 104.A N ASP 102.A OD1 no hydrogen 3.198 N/A ASN 105.A N ASP 102.A OD1 no hydrogen 2.721 N/A ASN 105.A ND2 TYR 107.A OH no hydrogen 2.921 N/A ASN 105.A ND2 ARG 324.A O no hydrogen 3.462 N/A LEU 106.A N LEU 64.A O no hydrogen 2.960 N/A TYR 107.A N PHE 100.A O no hydrogen 2.741 N/A TYR 107.A OH ASP 102.A OD2 no hydrogen 2.593 N/A MET 108.A N LYS 62.A O no hydrogen 2.947 N/A VAL 109.A N PHE 98.A O no hydrogen 2.771 N/A LEU 110.A N ALA 60.A O no hydrogen 2.719 N/A GLU 111.A N LYS 95.A O no hydrogen 2.873 N/A TYR 112.A OH ASP 311.A O no hydrogen 2.609 N/A GLY 116.A N LEU 113.A O no hydrogen 3.283 N/A MET 118.A N LEU 161.A O no hydrogen 2.900 N/A HIS 121.A NE2 GLY 115.A O no hydrogen 2.620 N/A LEU 122.A N MET 118.A O no hydrogen 2.828 N/A ARG 123.A N PHE 119.A O no hydrogen 2.998 N/A ARG 123.A NH1 GLU 218.A OE2 no hydrogen 3.010 N/A ARG 123.A NH2 GLU 218.A OE2 no hydrogen 2.614 N/A ARG 124.A N SER 120.A O no hydrogen 2.970 N/A ARG 124.A NH2 HIS 121.A ND1 no hydrogen 3.130 N/A ILE 125.A N HIS 121.A O no hydrogen 2.927 N/A GLY 126.A N LEU 122.A O no hydrogen 2.870 N/A PHE 128.A N MET 219.A O no hydrogen 2.761 N/A HIS 131.A NE2 TYR 135.A OH no hydrogen 2.935 N/A ARG 133.A N GLU 129.A O no hydrogen 2.764 N/A ARG 133.A NE TRP 284.A O no hydrogen 2.593 N/A PHE 134.A N PRO 130.A O no hydrogen 3.093 N/A TYR 135.A N HIS 131.A O no hydrogen 3.463 N/A TYR 135.A OH HIS 131.A NE2 no hydrogen 2.935 N/A ALA 136.A N ALA 132.A O no hydrogen 2.884 N/A ALA 137.A N ARG 133.A O no hydrogen 2.928 N/A GLN 138.A N TYR 135.A O no hydrogen 3.125 N/A GLN 138.A NE2 PHE 134.A O no hydrogen 3.019 N/A ILE 139.A N TYR 135.A O no hydrogen 3.196 N/A VAL 140.A N ALA 136.A O no hydrogen 2.941 N/A LEU 141.A N ALA 137.A O no hydrogen 3.125 N/A THR 142.A N GLN 138.A O no hydrogen 3.020 N/A THR 142.A OG1 GLN 138.A O no hydrogen 2.681 N/A PHE 143.A N ILE 139.A O no hydrogen 2.866 N/A GLU 144.A N VAL 140.A O no hydrogen 2.959 N/A TYR 145.A N LEU 141.A O no hydrogen 3.008 N/A LEU 146.A N THR 142.A O no hydrogen 2.822 N/A HIS 147.A N PHE 143.A O no hydrogen 2.805 N/A HIS 147.A NE2 ASP 208.A OD2 no hydrogen 2.700 N/A SER 148.A N GLU 144.A O no hydrogen 3.202 N/A SER 148.A OG GLU 144.A O no hydrogen 3.526 N/A SER 148.A OG TYR 145.A O no hydrogen 2.554 N/A LEU 149.A N LEU 146.A O no hydrogen 2.971 N/A ASP 150.A N HIS 147.A O no hydrogen 3.004 N/A LEU 151.A N LEU 146.A O no hydrogen 2.954 N/A ILE 152.A N LYS 178.A O no hydrogen 2.869 N/A TYR 153.A N ASP 208.A OD2 no hydrogen 2.852 N/A TYR 153.A OH ASP 173.A O no hydrogen 2.793 N/A ARG 154.A N ASP 208.A OD1 no hydrogen 3.002 N/A ARG 154.A NE PHE 176.A O no hydrogen 2.751 N/A ARG 154.A NH1 TYR 203.A OH no hydrogen 3.250 N/A ARG 154.A NH2 PHE 176.A O no hydrogen 3.153 N/A LYS 157.A NZ THR 189.A OG1 no hydrogen 2.726 N/A GLU 159.A N GLU 159.A OE1 no hydrogen 2.697 N/A ASN 160.A N LYS 157.A O no hydrogen 3.021 N/A ASN 160.A ND2 ASP 155.A O no hydrogen 2.757 N/A ASN 160.A ND2 ASP 155.A OD2 no hydrogen 2.971 N/A LEU 161.A N PRO 158.A O no hydrogen 3.275 N/A MET 162.A N LYS 170.A O no hydrogen 2.917 N/A ILE 163.A N GLY 116.A O no hydrogen 2.969 N/A ASP 164.A N TYR 168.A O no hydrogen 2.817 N/A GLN 165.A N GLN 165.A OE1 no hydrogen 2.706 N/A GLN 166.A N ASP 164.A OD1 no hydrogen 2.931 N/A GLN 166.A NE2 ARG 296.A O no hydrogen 2.996 N/A GLY 167.A N ASP 164.A O no hydrogen 3.152 N/A TYR 168.A N ASP 164.A OD1 no hydrogen 2.879 N/A TYR 168.A OH VAL 298.A O no hydrogen 2.655 N/A ILE 169.A N GLN 138.A OE1 no hydrogen 2.786 N/A LYS 170.A N MET 162.A O no hydrogen 2.779 N/A LYS 170.A NZ PRO 91.A O no hydrogen 2.810 N/A VAL 171.A N PHE 92.A O no hydrogen 2.726 N/A THR 172.A N ASN 160.A O no hydrogen 2.908 N/A GLY 175.A N ASP 173.A OD1 no hydrogen 2.914 N/A ALA 177.A N PHE 174.A O no hydrogen 3.137 N/A LYS 178.A N ILE 152.A O no hydrogen 2.876 N/A VAL 180.A N ASP 150.A O no hydrogen 2.751 N/A ARG 183.A NH1 GLY 202.A O no hydrogen 3.555 N/A THR 184.A N TYR 203.A O no hydrogen 2.944 N/A THR 189.A OG1 ASP 155.A OD1 no hydrogen 2.798 N/A GLU 191.A N GLU 191.A OE1 no hydrogen 2.706 N/A TYR 192.A N THR 189.A O no hydrogen 2.928 N/A TYR 192.A OH GLU 218.A OE1 no hydrogen 2.591 N/A LEU 193.A N PRO 190.A O no hydrogen 3.161 N/A GLU 196.A N GLU 196.A OE1 no hydrogen 2.732 N/A ILE 197.A N ALA 194.A O no hydrogen 3.145 N/A ILE 198.A N ALA 194.A O no hydrogen 3.413 N/A LEU 199.A N PRO 195.A O no hydrogen 2.756 N/A SER 200.A N ILE 197.A O no hydrogen 2.883 N/A LYS 201.A N GLU 196.A O no hydrogen 2.826 N/A TYR 203.A N THR 184.A O no hydrogen 2.706 N/A ALA 206.A N ASN 204.A OD1 no hydrogen 3.150 N/A VAL 207.A N ASN 204.A O no hydrogen 3.178 N/A ASP 208.A N LYS 205.A O no hydrogen 2.981 N/A TRP 210.A N ALA 206.A O no hydrogen 3.121 N/A ALA 211.A N VAL 207.A O no hydrogen 3.079 N/A LEU 212.A N ASP 208.A O no hydrogen 2.939 N/A GLY 213.A N TRP 209.A O no hydrogen 3.139 N/A VAL 214.A N TRP 210.A O no hydrogen 3.055 N/A LEU 215.A N ALA 211.A O no hydrogen 2.861 N/A ILE 216.A N LEU 212.A O no hydrogen 2.885 N/A TYR 217.A N GLY 213.A O no hydrogen 2.995 N/A TYR 217.A OH ARG 244.A O no hydrogen 2.536 N/A GLU 218.A N VAL 214.A O no hydrogen 2.825 N/A MET 219.A N LEU 215.A O no hydrogen 2.810 N/A ALA 220.A N ILE 216.A O no hydrogen 2.984 N/A ALA 221.A N TYR 217.A O no hydrogen 2.857 N/A GLY 222.A N GLU 218.A O no hydrogen 2.896 N/A GLN 230.A N GLN 233.A OE1 no hydrogen 3.196 N/A ILE 234.A N GLN 230.A O no hydrogen 3.255 N/A TYR 235.A N PRO 231.A O no hydrogen 2.946 N/A GLU 236.A N ILE 232.A O no hydrogen 3.247 N/A LYS 237.A NZ PHE 227.A O no hydrogen 3.447 N/A ILE 238.A N ILE 234.A O no hydrogen 3.122 N/A VAL 239.A N TYR 235.A O no hydrogen 2.978 N/A SER 240.A N GLU 236.A O no hydrogen 3.116 N/A SER 240.A OG GLU 236.A O no hydrogen 2.675 N/A GLY 241.A N LYS 237.A O no hydrogen 3.026 N/A PHE 249.A N PRO 246.A O no hydrogen 3.017 N/A SER 250.A N GLU 129.A OE2 no hydrogen 2.873 N/A SER 250.A OG GLU 129.A OE1 no hydrogen 2.609 N/A SER 250.A OG GLU 129.A OE2 no hydrogen 3.525 N/A LEU 253.A N SER 250.A OG no hydrogen 3.231 N/A LYS 254.A N SER 250.A O no hydrogen 3.135 N/A ASP 255.A N SER 251.A O no hydrogen 2.990 N/A LEU 256.A N ASP 252.A O no hydrogen 3.201 N/A LEU 257.A N LEU 253.A O no hydrogen 2.887 N/A ARG 258.A N LYS 254.A O no hydrogen 2.817 N/A ASN 259.A N ASP 255.A O no hydrogen 3.113 N/A ASN 259.A ND2 ASP 255.A O no hydrogen 3.010 N/A LEU 260.A N LEU 256.A O no hydrogen 2.954 N/A LEU 260.A N LEU 257.A O no hydrogen 3.139 N/A LEU 261.A N LEU 257.A O no hydrogen 2.681 N/A ASP 264.A N GLN 262.A OE1 no hydrogen 3.142 N/A THR 266.A N ASP 264.A OD1 no hydrogen 3.331 N/A THR 266.A OG1 ASP 264.A OD1 no hydrogen 3.151 N/A THR 266.A OG1 ASP 264.A OD2 no hydrogen 2.923 N/A LYS 267.A N ASP 264.A O no hydrogen 2.901 N/A LYS 267.A NZ ASP 264.A OD2 no hydrogen 2.597 N/A ARG 268.A N ASP 264.A O no hydrogen 3.174 N/A ARG 268.A NE GLN 262.A O no hydrogen 2.734 N/A ARG 268.A NH1 GLU 196.A OE2 no hydrogen 2.671 N/A ARG 268.A NH1 ALA 206.A O no hydrogen 3.154 N/A ARG 268.A NH2 GLU 196.A OE1 no hydrogen 2.850 N/A ARG 268.A NH2 GLU 196.A OE2 no hydrogen 3.163 N/A ARG 268.A NH2 GLN 262.A O no hydrogen 2.981 N/A PHE 269.A N ASN 259.A O no hydrogen 2.859 N/A ASN 271.A N ARG 268.A O no hydrogen 3.158 N/A ASN 271.A ND2 LEU 265.A O no hydrogen 2.588 N/A GLY 275.A N LEU 272.A O no hydrogen 3.242 N/A ASN 277.A N ASN 274.A O no hydrogen 3.059 N/A ASP 278.A N GLY 275.A O no hydrogen 3.448 N/A ILE 279.A N VAL 276.A O no hydrogen 3.070 N/A LYS 280.A N VAL 276.A O no hydrogen 3.026 N/A LYS 280.A NZ GLU 144.A OE1 no hydrogen 2.793 N/A ASN 281.A N ASN 277.A O no hydrogen 2.902 N/A HIS 282.A N ILE 279.A O no hydrogen 2.917 N/A HIS 282.A NE2 ASP 255.A OD2 no hydrogen 2.726 N/A TRP 284.A N HIS 282.A ND1 no hydrogen 3.103 N/A TRP 284.A NE1 GLU 129.A OE1 no hydrogen 2.910 N/A PHE 285.A N HIS 282.A O no hydrogen 3.063 N/A ALA 286.A N LYS 283.A O no hydrogen 3.028 N/A THR 288.A N PHE 285.A O no hydrogen 3.109 N/A TRP 290.A NE1 LYS 280.A O no hydrogen 3.130 N/A ALA 292.A N ASP 289.A OD1 no hydrogen 3.224 N/A ILE 293.A N ASP 289.A O no hydrogen 3.057 N/A TYR 294.A N TRP 290.A O no hydrogen 3.092 N/A GLN 295.A N ILE 291.A O no hydrogen 2.824 N/A ARG 296.A N ILE 293.A O no hydrogen 2.966 N/A ARG 296.A NE GLN 166.A OE1 no hydrogen 3.310 N/A ARG 296.A NH1 ASP 164.A OD2 no hydrogen 3.564 N/A ARG 296.A NH2 ASP 164.A OD2 no hydrogen 2.616 N/A ARG 296.A NH2 GLN 166.A OE1 no hydrogen 3.380 N/A LYS 297.A N ALA 292.A O no hydrogen 2.768 N/A LYS 297.A NZ GLN 295.A OE1 no hydrogen 2.922 N/A ASP 311.A N GLY 308.A O no hydrogen 3.477 N/A SER 313.A N ASP 311.A OD1 no hydrogen 3.192 N/A SER 313.A OG ASP 311.A OD1 no hydrogen 2.605 N/A ASN 314.A ND2 PRO 114.A O no hydrogen 3.323 N/A PHE 315.A N THR 312.A O no hydrogen 3.007 N/A LYS 329.A N ASN 103.A O no hydrogen 2.806 N/A GLU 333.A N GLU 333.A OE1 no hydrogen 2.793 N/A PHE 334.A N CYS 330.A O no hydrogen 3.458 N/A SER 335.A N LYS 332.A O no hydrogen 3.410 N/A PHE 337.A N PHE 334.A O no hydrogen 3.250 N/A