Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4c4e_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): SER 2.A OG TYR 10.A O no hydrogen 3.308 N/A MET 3.A N TYR 10.A O no hydrogen 2.914 N/A SER 4.A OG ARG 8.A O no hydrogen 3.569 N/A VAL 5.A N ARG 8.A O no hydrogen 2.892 N/A LYS 6.A N GLU 77.A OE1 no hydrogen 2.762 N/A ARG 8.A N VAL 5.A O no hydrogen 3.188 N/A TYR 10.A N MET 3.A O no hydrogen 2.752 N/A SER 11.A N LEU 28.A O no hydrogen 2.788 N/A ILE 12.A N GLN 1.A O no hydrogen 2.972 N/A LEU 13.A N GLN 26.A O no hydrogen 2.776 N/A GLN 15.A NE2 GLY 17.A O no hydrogen 3.368 N/A ILE 16.A N VAL 24.A O no hydrogen 2.717 N/A LYS 23.A N TYR 39.A O no hydrogen 2.947 N/A VAL 24.A N GLY 17.A O no hydrogen 3.432 N/A PHE 25.A N ILE 37.A O no hydrogen 2.952 N/A GLN 26.A N LYS 14.A O no hydrogen 2.765 N/A VAL 27.A N TYR 35.A O no hydrogen 2.810 N/A LEU 28.A N SER 11.A O no hydrogen 2.904 N/A ASN 29.A N GLN 33.A O no hydrogen 3.035 N/A ASN 29.A ND2 GLN 33.A OE1 no hydrogen 3.124 N/A LYS 32.A N ASN 29.A O no hydrogen 2.996 N/A GLN 33.A N ASN 29.A OD1 no hydrogen 2.846 N/A TYR 35.A N VAL 27.A O no hydrogen 3.094 N/A TYR 35.A OH GLN 33.A OE1 no hydrogen 3.131 N/A ALA 36.A N MET 87.A O no hydrogen 3.020 N/A ILE 37.A N PHE 25.A O no hydrogen 2.801 N/A LYS 38.A N MET 85.A O no hydrogen 2.871 N/A TYR 39.A N LYS 23.A O no hydrogen 2.758 N/A VAL 40.A N ILE 83.A O no hydrogen 2.829 N/A ASN 41.A N SER 21.A O no hydrogen 2.782 N/A LEU 42.A N GLN 81.A O no hydrogen 2.884 N/A GLU 43.A N ASN 41.A OD1 no hydrogen 3.151 N/A THR 49.A N ASP 46.A OD1 no hydrogen 3.339 N/A THR 49.A OG1 ASP 46.A OD1 no hydrogen 2.665 N/A LEU 50.A N ASP 46.A O no hydrogen 3.021 N/A ASP 51.A N ASN 47.A O no hydrogen 2.987 N/A SER 52.A N GLN 48.A O no hydrogen 3.036 N/A SER 52.A OG THR 49.A O no hydrogen 2.713 N/A TYR 53.A N THR 49.A O no hydrogen 3.076 N/A ARG 54.A N LEU 50.A O no hydrogen 2.939 N/A ARG 54.A NH2 ASP 51.A OD2 no hydrogen 3.264 N/A ASN 55.A N ASP 51.A O no hydrogen 2.864 N/A GLU 56.A N SER 52.A O no hydrogen 3.129 N/A ILE 57.A N TYR 53.A O no hydrogen 2.993 N/A ALA 58.A N ARG 54.A O no hydrogen 3.071 N/A TYR 59.A N ASN 55.A O no hydrogen 3.025 N/A LEU 60.A N GLU 56.A O no hydrogen 2.812 N/A ASN 61.A N ILE 57.A O no hydrogen 2.866 N/A LYS 62.A N ALA 58.A O no hydrogen 2.966 N/A LEU 63.A N TYR 59.A O no hydrogen 2.963 N/A GLN 64.A NE2 LEU 60.A O no hydrogen 3.135 N/A GLN 64.A NE2 ILE 71.A O no hydrogen 2.857 N/A SER 67.A OG GLU 118.A OE2 no hydrogen 2.991 N/A LYS 69.A N SER 67.A OG no hydrogen 2.916 N/A LYS 69.A NZ ASP 68.A OD1 no hydrogen 2.750 N/A LYS 69.A NZ GLU 118.A OE1 no hydrogen 2.801 N/A ILE 71.A N LEU 147.A O no hydrogen 3.073 N/A ARG 72.A N GLU 88.A OE1 no hydrogen 3.003 N/A ARG 72.A NH1 GLN 64.A O no hydrogen 2.828 N/A ARG 72.A NH2 GLN 64.A O no hydrogen 3.014 N/A ARG 72.A NH2 SER 67.A O no hydrogen 2.681 N/A ARG 72.A NH2 ILE 70.A O no hydrogen 2.771 N/A LEU 73.A N GLN 64.A OE1 no hydrogen 3.022 N/A TYR 74.A N VAL 86.A O no hydrogen 2.807 N/A ASP 75.A N VAL 86.A O no hydrogen 3.430 N/A TYR 76.A N ASP 75.A OD1 no hydrogen 3.136 N/A GLU 77.A N TYR 84.A O no hydrogen 2.870 N/A THR 79.A N TYR 82.A O no hydrogen 2.836 N/A GLN 81.A N THR 79.A OG1 no hydrogen 3.265 N/A TYR 82.A N THR 79.A OG1 no hydrogen 3.322 N/A TYR 82.A OH GLU 77.A OE2 no hydrogen 2.681 N/A ILE 83.A N VAL 40.A O no hydrogen 2.923 N/A TYR 84.A N GLU 77.A O no hydrogen 2.825 N/A MET 85.A N LYS 38.A O no hydrogen 2.899 N/A VAL 86.A N ASP 75.A O no hydrogen 2.813 N/A MET 87.A N ALA 36.A O no hydrogen 2.807 N/A GLU 88.A N ARG 72.A O no hydrogen 2.917 N/A CYS 89.A SG GLN 26.A OE1 no hydrogen 4.021 N/A CYS 89.A SG TYR 35.A O no hydrogen 4.031 N/A ASN 91.A N ILE 140.A O no hydrogen 2.832 N/A LEU 94.A N PHE 138.A O no hydrogen 2.891 N/A SER 96.A N ASP 93.A OD2 no hydrogen 2.987 N/A SER 96.A OG ASP 93.A OD1 no hydrogen 2.734 N/A SER 96.A OG ASP 93.A OD2 no hydrogen 3.400 N/A TRP 97.A N ASP 93.A O no hydrogen 3.163 N/A TRP 97.A NE1 GLU 108.A OE2 no hydrogen 3.117 N/A LEU 98.A N LEU 94.A O no hydrogen 2.842 N/A LYS 99.A N ASN 95.A O no hydrogen 2.929 N/A LYS 100.A N SER 96.A O no hydrogen 3.024 N/A LYS 101.A N TRP 97.A O no hydrogen 2.883 N/A GLU 108.A N ASP 105.A OD2 no hydrogen 3.211 N/A ARG 109.A N ASP 105.A O no hydrogen 3.004 N/A ARG 109.A NH1 MET 189.A O no hydrogen 2.812 N/A ARG 109.A NH2 GLU 223.A OE1 no hydrogen 2.948 N/A LYS 110.A N PRO 106.A O no hydrogen 3.227 N/A LYS 110.A NZ TYR 252.A O no hydrogen 2.785 N/A SER 111.A N TRP 107.A O no hydrogen 3.036 N/A TYR 112.A N GLU 108.A O no hydrogen 2.974 N/A TYR 112.A OH GLU 108.A OE2 no hydrogen 2.948 N/A TRP 113.A N ARG 109.A O no hydrogen 2.786 N/A LYS 114.A N LYS 110.A O no hydrogen 2.945 N/A ASN 115.A N SER 111.A O no hydrogen 3.283 N/A MET 116.A N TYR 112.A O no hydrogen 2.923 N/A LEU 117.A N TRP 113.A O no hydrogen 2.956 N/A GLU 118.A N LYS 114.A O no hydrogen 3.000 N/A ALA 119.A N ASN 115.A O no hydrogen 3.023 N/A VAL 120.A N MET 116.A O no hydrogen 3.126 N/A HIS 121.A N LEU 117.A O no hydrogen 2.810 N/A THR 122.A N GLU 118.A O no hydrogen 3.114 N/A THR 122.A OG1 GLU 118.A O no hydrogen 2.722 N/A ILE 123.A N ALA 119.A O no hydrogen 3.357 N/A HIS 124.A N VAL 120.A O no hydrogen 3.146 N/A HIS 124.A NE2 ASP 178.A OD2 no hydrogen 2.738 N/A GLN 125.A N HIS 121.A O no hydrogen 3.056 N/A HIS 126.A N ILE 123.A O no hydrogen 3.042 N/A HIS 126.A ND1 THR 122.A O no hydrogen 2.798 N/A GLY 127.A N HIS 124.A O no hydrogen 3.051 N/A ILE 128.A N ILE 123.A O no hydrogen 3.012 N/A HIS 130.A N ASP 178.A OD2 no hydrogen 2.878 N/A SER 131.A N ASP 178.A OD1 no hydrogen 2.876 N/A ASP 132.A N HIS 130.A ND1 no hydrogen 3.005 N/A LYS 134.A NZ ASP 132.A OD2 no hydrogen 3.295 N/A ALA 136.A N GLN 159.A OE1 no hydrogen 2.997 N/A ASN 137.A N LYS 134.A O no hydrogen 3.244 N/A ASN 137.A ND2 ASP 149.A OD1 no hydrogen 2.932 N/A PHE 138.A N PRO 135.A O no hydrogen 3.161 N/A LEU 139.A N LYS 146.A O no hydrogen 2.754 N/A ILE 140.A N ILE 92.A O no hydrogen 2.792 N/A VAL 141.A N MET 144.A O no hydrogen 2.923 N/A ASP 142.A N ASN 91.A OD1 no hydrogen 3.102 N/A LEU 145.A N ASN 115.A OD1 no hydrogen 2.759 N/A LYS 146.A N LEU 139.A O no hydrogen 2.822 N/A LYS 146.A NZ ASP 68.A O no hydrogen 2.786 N/A LYS 146.A NZ GLU 88.A OE1 no hydrogen 2.837 N/A LYS 146.A NZ GLU 88.A OE2 no hydrogen 3.292 N/A LEU 147.A N LYS 69.A O no hydrogen 2.752 N/A ILE 148.A N ASN 137.A O no hydrogen 2.940 N/A PHE 150.A N GLU 56.A OE2 no hydrogen 2.705 N/A GLY 151.A N ASP 149.A OD2 no hydrogen 3.130 N/A ILE 152.A N GLU 56.A OE1 no hydrogen 3.041 N/A ALA 153.A N GLU 56.A OE1 no hydrogen 2.888 N/A ASN 154.A N SER 52.A OG no hydrogen 2.923 N/A ASN 154.A ND2 GLN 48.A OE1 no hydrogen 2.913 N/A ASN 154.A ND2 THR 49.A OG1 no hydrogen 3.129 N/A MET 165.A N VAL 162.A O no hydrogen 3.273 N/A GLU 168.A N GLU 168.A OE1 no hydrogen 3.089 N/A ALA 169.A N PRO 166.A O no hydrogen 3.196 N/A LYS 171.A N PRO 167.A O no hydrogen 3.283 N/A ASP 172.A N GLU 168.A O no hydrogen 3.283 N/A LYS 176.A N SER 174.A OG no hydrogen 3.317 N/A LYS 176.A NZ PRO 238.A O no hydrogen 3.285 N/A LYS 176.A NZ ARG 241.A O no hydrogen 2.776 N/A SER 177.A N SER 174.A O no hydrogen 2.939 N/A SER 177.A OG GLU 168.A OE2 no hydrogen 2.805 N/A SER 177.A OG SER 174.A O no hydrogen 3.183 N/A ASP 178.A N PRO 175.A O no hydrogen 3.107 N/A TRP 180.A N LYS 176.A O no hydrogen 3.279 N/A SER 181.A N SER 177.A O no hydrogen 3.373 N/A SER 181.A OG TYR 164.A O no hydrogen 2.726 N/A SER 181.A OG SER 177.A O no hydrogen 3.317 N/A LEU 182.A N ASP 178.A O no hydrogen 2.881 N/A GLY 183.A N VAL 179.A O no hydrogen 2.840 N/A CYS 184.A N TRP 180.A O no hydrogen 2.894 N/A CYS 184.A SG ASN 163.A O no hydrogen 3.499 N/A CYS 184.A SG TRP 180.A O no hydrogen 3.495 N/A ILE 185.A N SER 181.A O no hydrogen 3.120 N/A LEU 186.A N LEU 182.A O no hydrogen 3.015 N/A TYR 187.A N GLY 183.A O no hydrogen 2.923 N/A TYR 187.A OH GLU 217.A O no hydrogen 2.670 N/A TYR 188.A N CYS 184.A O no hydrogen 2.968 N/A MET 189.A N ILE 185.A O no hydrogen 2.953 N/A THR 190.A N TYR 187.A O no hydrogen 3.089 N/A THR 190.A OG1 LEU 186.A O no hydrogen 2.727 N/A TYR 191.A N TYR 187.A O no hydrogen 2.782 N/A TYR 191.A OH PRO 219.A O no hydrogen 2.726 N/A GLY 192.A N TYR 188.A O no hydrogen 2.800 N/A LYS 193.A NZ THR 194.A O no hydrogen 3.098 N/A LYS 193.A NZ GLN 198.A OE1 no hydrogen 2.920 N/A THR 194.A N GLN 197.A OE1 no hydrogen 2.968 N/A THR 194.A OG1 GLN 197.A OE1 no hydrogen 3.384 N/A GLN 197.A N THR 194.A O no hydrogen 3.195 N/A GLN 198.A N GLN 198.A OE1 no hydrogen 2.788 N/A GLN 198.A NE2 PRO 195.A O no hydrogen 3.583 N/A ILE 199.A N PHE 196.A O no hydrogen 3.004 N/A SER 204.A N ASN 201.A OD1 no hydrogen 2.916 N/A SER 204.A OG ASN 201.A OD1 no hydrogen 3.348 N/A LYS 205.A N ASN 201.A O no hydrogen 2.881 N/A LYS 205.A NZ ASN 163.A OD1 no hydrogen 3.152 N/A LYS 205.A NZ PHE 196.A O no hydrogen 3.449 N/A LYS 205.A NZ ILE 199.A O no hydrogen 2.800 N/A LEU 206.A N GLN 202.A O no hydrogen 2.940 N/A HIS 207.A N ILE 203.A O no hydrogen 2.931 N/A ALA 208.A N SER 204.A O no hydrogen 3.093 N/A ILE 209.A N LYS 205.A O no hydrogen 3.146 N/A ILE 210.A N LEU 206.A O no hydrogen 3.418 N/A ASP 211.A N ALA 208.A O no hydrogen 3.196 N/A ASN 213.A N ASP 211.A OD1 no hydrogen 3.262 N/A HIS 214.A N ASP 211.A O no hydrogen 3.089 N/A GLN 227.A N GLU 223.A O no hydrogen 3.251 N/A GLN 227.A NE2 ASP 220.A OD1 no hydrogen 3.459 N/A ASP 228.A N LYS 224.A O no hydrogen 3.003 N/A VAL 229.A N ASP 225.A O no hydrogen 3.075 N/A LEU 230.A N LEU 226.A O no hydrogen 3.198 N/A LYS 231.A N GLN 227.A O no hydrogen 3.105 N/A CYS 232.A N ASP 228.A O no hydrogen 2.948 N/A CYS 233.A N VAL 229.A O no hydrogen 2.820 N/A CYS 233.A SG VAL 229.A O no hydrogen 3.288 N/A LEU 234.A N LEU 230.A O no hydrogen 2.995 N/A ARG 236.A NE ILE 209.A O no hydrogen 2.746 N/A ARG 236.A NH1 HIS 214.A O no hydrogen 2.876 N/A ARG 236.A NH2 ALA 208.A O no hydrogen 2.804 N/A ARG 236.A NH2 HIS 214.A O no hydrogen 2.796 N/A LYS 239.A N ASP 237.A OD1 no hydrogen 3.325 N/A GLN 240.A N ASP 237.A O no hydrogen 2.971 N/A ARG 241.A N PRO 238.A O no hydrogen 3.258 N/A ARG 241.A NE LYS 235.A O no hydrogen 2.787 N/A ARG 241.A NH1 GLU 168.A OE1 no hydrogen 3.298 N/A ARG 241.A NH1 GLU 168.A OE2 no hydrogen 3.050 N/A ARG 241.A NH1 LYS 176.A O no hydrogen 2.808 N/A ARG 241.A NH2 GLU 168.A OE1 no hydrogen 2.928 N/A ARG 241.A NH2 LYS 235.A O no hydrogen 3.120 N/A ARG 241.A NH2 ARG 236.A O no hydrogen 2.916 N/A ILE 242.A N CYS 232.A O no hydrogen 3.341 N/A SER 243.A N GLU 246.A OE1 no hydrogen 3.475 N/A SER 243.A OG GLU 246.A OE1 no hydrogen 3.363 N/A LEU 247.A N SER 243.A O no hydrogen 2.909 N/A LEU 248.A N ILE 244.A O no hydrogen 2.995 N/A ALA 249.A N GLU 246.A O no hydrogen 3.194 N/A HIS 250.A N LEU 247.A O no hydrogen 3.298 N/A HIS 250.A NE2 ASP 228.A OD2 no hydrogen 2.801 N/A TYR 252.A N HIS 250.A ND1 no hydrogen 3.017 N/A VAL 253.A N HIS 250.A O no hydrogen 3.113 N/A GLN 254.A N HIS 250.A O no hydrogen 3.226 N/A GLN 254.A N PRO 251.A O no hydrogen 3.138 N/A GLN 254.A NE2 LEU 248.A O no hydrogen 2.731 N/A ILE 255.A N PRO 251.A O no hydrogen 2.760 N/A