Finding intermodel H-bonds Finding intramodel H-bonds Constraints relaxed by 0.4 angstroms and 20 degrees Models used: #0 4e15_A.cif H-bonds (donor, acceptor, hydrogen, D..A dist, D-H..A dist): HIS 3.A N ASN 6.A O no hydrogen 2.790 N/A MET 4.A N GLU 197.A OE2 no hydrogen 2.822 N/A TYR 5.A OH ASP 194.A OD2 no hydrogen 2.642 N/A ASN 6.A N HIS 3.A O no hydrogen 3.270 N/A ASN 6.A ND2 ASP 15.A OD2 no hydrogen 2.991 N/A ARG 8.A N ASN 6.A OD1 no hydrogen 3.032 N/A CYS 9.A N ASN 6.A O no hydrogen 3.136 N/A LYS 10.A NZ ARG 8.A O no hydrogen 2.853 N/A ARG 14.A N ASP 11.A OD1 no hydrogen 3.014 N/A ASP 15.A N ASP 11.A O no hydrogen 3.083 N/A TYR 16.A N LEU 12.A O no hydrogen 3.254 N/A TYR 16.A N ASP 13.A O no hydrogen 2.984 N/A TYR 16.A OH GLU 197.A OE1 no hydrogen 2.612 N/A PHE 17.A N ARG 14.A O no hydrogen 3.061 N/A TYR 20.A N PHE 17.A O no hydrogen 3.106 N/A HIS 21.A N PRO 18.A O no hydrogen 2.950 N/A THR 22.A OG1 ASP 277.A OD2 no hydrogen 2.623 N/A ARG 24.A N THR 22.A OG1 no hydrogen 2.845 N/A ARG 24.A NE ASP 277.A OD2 no hydrogen 2.864 N/A ARG 24.A NH1 GLU 283.A OE1 no hydrogen 2.902 N/A ARG 24.A NH2 ASP 277.A OD1 no hydrogen 3.224 N/A ARG 24.A NH2 ASP 277.A OD2 no hydrogen 3.297 N/A ARG 24.A NH2 GLU 283.A OE2 no hydrogen 3.004 N/A GLN 28.A N PHE 25.A O no hydrogen 3.061 N/A GLN 28.A NE2 ASP 27.A OD2 no hydrogen 2.748 N/A LEU 33.A N GLU 30.A O no hydrogen 3.009 N/A ALA 34.A N GLU 30.A O no hydrogen 3.149 N/A VAL 35.A N PRO 31.A O no hydrogen 2.874 N/A LEU 36.A N ASN 32.A O no hydrogen 3.388 N/A GLU 37.A N LEU 33.A O no hydrogen 2.999 N/A HIS 38.A N ALA 34.A O no hydrogen 2.883 N/A PHE 39.A N VAL 35.A O no hydrogen 2.879 N/A VAL 40.A N LEU 36.A O no hydrogen 2.981 N/A ARG 41.A N GLU 37.A O no hydrogen 3.083 N/A VAL 42.A N HIS 38.A O no hydrogen 2.827 N/A THR 43.A N PHE 39.A O no hydrogen 2.972 N/A THR 43.A OG1 PHE 39.A O no hydrogen 2.815 N/A THR 43.A OG1 VAL 40.A O no hydrogen 3.311 N/A THR 43.A OG1 MET 100.A O no hydrogen 3.400 N/A LYS 44.A N VAL 40.A O no hydrogen 3.033 N/A LYS 44.A NZ SER 99.A OG no hydrogen 2.875 N/A GLN 45.A N ARG 41.A O no hydrogen 3.059 N/A GLN 45.A NE2 GLU 49.A OE2 no hydrogen 3.034 N/A HIS 46.A N VAL 42.A O no hydrogen 2.901 N/A GLY 47.A N THR 43.A O no hydrogen 3.015 N/A ARG 48.A N LYS 44.A O no hydrogen 3.040 N/A GLU 49.A N GLN 45.A O no hydrogen 2.942 N/A LEU 50.A N GLY 47.A O no hydrogen 3.392 N/A THR 51.A OG1 ARG 48.A O no hydrogen 3.504 N/A GLU 52.A N ARG 48.A O no hydrogen 2.954 N/A LYS 53.A N GLU 49.A O no hydrogen 2.853 N/A GLN 54.A N GLU 49.A O no hydrogen 2.927 N/A ILE 56.A N LEU 50.A O no hydrogen 3.093 N/A THR 57.A N TYR 74.A O no hydrogen 2.753 N/A ASP 59.A N VAL 72.A O no hydrogen 2.797 N/A LEU 61.A N VAL 70.A O no hydrogen 2.898 N/A ARG 62.A NH1 GLY 64.A O no hydrogen 2.851 N/A ARG 62.A NH1 GLY 66.A O no hydrogen 2.893 N/A TYR 63.A N GLN 68.A O no hydrogen 2.896 N/A TYR 63.A OH ASP 119.A O no hydrogen 2.674 N/A GLY 64.A N GLN 68.A O no hydrogen 3.108 N/A ARG 67.A NE TYR 120.A O no hydrogen 2.923 N/A ARG 67.A NH2 MET 96.A O no hydrogen 2.701 N/A ARG 67.A NH2 ASP 119.A OD1 no hydrogen 2.918 N/A GLN 68.A N GLU 65.A O no hydrogen 3.237 N/A LEU 69.A N ARG 67.A O no hydrogen 2.805 N/A VAL 70.A N LEU 61.A O no hydrogen 2.950 N/A ASP 71.A N VAL 117.A O no hydrogen 2.948 N/A VAL 72.A N ASP 59.A O no hydrogen 2.973 N/A PHE 73.A N VAL 115.A O no hydrogen 2.758 N/A TYR 74.A N THR 57.A O no hydrogen 3.074 N/A TYR 74.A OH ASP 59.A OD1 no hydrogen 2.685 N/A TYR 74.A OH ASP 59.A OD2 no hydrogen 3.340 N/A SER 75.A N THR 78.A OG1 no hydrogen 2.876 N/A GLU 76.A N GLU 76.A OE1 no hydrogen 2.693 N/A LYS 77.A N SER 75.A OG no hydrogen 2.998 N/A THR 78.A N SER 75.A O no hydrogen 3.294 N/A THR 78.A OG1 SER 75.A O no hydrogen 3.265 N/A ALA 82.A N THR 79.A O no hydrogen 3.117 N/A LEU 84.A N SER 153.A O no hydrogen 2.991 N/A PHE 85.A N ARG 114.A O no hydrogen 2.934 N/A VAL 86.A N THR 155.A O no hydrogen 2.817 N/A PHE 87.A N ALA 116.A O no hydrogen 2.892 N/A VAL 88.A N ALA 157.A O no hydrogen 2.833 N/A HIS 89.A ND1 GLY 90.A O no hydrogen 2.676 N/A HIS 89.A NE2 ASP 119.A OD1 no hydrogen 2.742 N/A TYR 92.A OH TYR 16.A O no hydrogen 2.652 N/A TRP 93.A NE1 HIS 163.A ND1 no hydrogen 3.058 N/A GLN 94.A N GLY 91.A O no hydrogen 2.921 N/A GLU 95.A N GLY 91.A O no hydrogen 3.053 N/A MET 98.A N ASP 119.A OD2 no hydrogen 2.939 N/A SER 99.A OG ASP 97.A OD1 no hydrogen 2.617 N/A MET 100.A N ASP 97.A O no hydrogen 3.033 N/A SER 101.A N MET 98.A O no hydrogen 2.986 N/A SER 101.A OG ASP 97.A O no hydrogen 2.767 N/A CYS 102.A SG MET 98.A O no hydrogen 3.444 N/A VAL 105.A N CYS 102.A O no hydrogen 3.120 N/A VAL 109.A N VAL 105.A O no hydrogen 2.976 N/A ARG 110.A N GLY 106.A O no hydrogen 2.961 N/A ARG 110.A NE ASP 288.A OD2 no hydrogen 2.867 N/A ARG 110.A NH1 GLN 54.A OE1 no hydrogen 2.817 N/A ARG 110.A NH2 ASP 288.A OD1 no hydrogen 2.872 N/A ARG 110.A NH2 ASP 288.A OD2 no hydrogen 3.514 N/A ARG 111.A N PRO 107.A O no hydrogen 3.063 N/A ARG 111.A N LEU 108.A O no hydrogen 2.972 N/A ARG 111.A NE GLU 300.A OE1 no hydrogen 2.777 N/A ARG 111.A NE GLU 300.A OE2 no hydrogen 3.468 N/A ARG 111.A NH2 GLU 300.A OE2 no hydrogen 2.781 N/A GLY 112.A N VAL 109.A O no hydrogen 3.001 N/A TYR 113.A N LEU 108.A O no hydrogen 3.108 N/A ARG 114.A N PRO 83.A O no hydrogen 2.918 N/A ARG 114.A NH2 THR 79.A O no hydrogen 3.002 N/A VAL 115.A N PHE 73.A O no hydrogen 2.925 N/A ALA 116.A N PHE 85.A O no hydrogen 2.839 N/A VAL 117.A N ASP 71.A O no hydrogen 2.834 N/A MET 118.A N PHE 87.A O no hydrogen 3.347 N/A ASP 119.A N LEU 69.A O no hydrogen 2.871 N/A TYR 120.A N ASP 119.A OD1 no hydrogen 2.913 N/A TYR 120.A OH HIS 89.A O no hydrogen 2.666 N/A CYS 123.A N TRP 93.A O no hydrogen 2.853 N/A CYS 123.A SG VAL 126.A O no hydrogen 3.269 N/A VAL 126.A N LEU 122.A O no hydrogen 3.070 N/A THR 127.A N GLN 130.A OE1 no hydrogen 3.123 N/A THR 127.A OG1 GLN 130.A OE1 no hydrogen 3.555 N/A LEU 128.A N LEU 210.A O no hydrogen 2.970 N/A GLN 130.A N THR 127.A OG1 no hydrogen 2.907 N/A LEU 131.A N THR 127.A O no hydrogen 2.861 N/A MET 132.A N LEU 128.A O no hydrogen 2.886 N/A THR 133.A N GLU 129.A O no hydrogen 2.940 N/A THR 133.A OG1 GLU 129.A O no hydrogen 3.188 N/A GLN 134.A N GLN 130.A O no hydrogen 2.900 N/A PHE 135.A N LEU 131.A O no hydrogen 2.721 N/A THR 136.A N MET 132.A O no hydrogen 2.954 N/A THR 136.A OG1 MET 132.A O no hydrogen 3.138 N/A THR 136.A OG1 GLN 167.A OE1 no hydrogen 2.626 N/A HIS 137.A N THR 133.A O no hydrogen 3.071 N/A HIS 137.A NE2 TYR 63.A O no hydrogen 2.607 N/A PHE 138.A N GLN 134.A O no hydrogen 2.841 N/A LEU 139.A N PHE 135.A O no hydrogen 2.856 N/A ASN 140.A N THR 136.A O no hydrogen 2.995 N/A TRP 141.A N HIS 137.A O no hydrogen 2.821 N/A ILE 142.A N PHE 138.A O no hydrogen 2.786 N/A PHE 143.A N LEU 139.A O no hydrogen 3.028 N/A ASP 144.A N ASN 140.A O no hydrogen 2.919 N/A TYR 145.A N TRP 141.A O no hydrogen 2.912 N/A THR 146.A N ILE 142.A O no hydrogen 2.939 N/A THR 146.A OG1 ILE 142.A O no hydrogen 3.333 N/A THR 146.A OG1 PHE 143.A O no hydrogen 3.139 N/A GLU 147.A N PHE 143.A O no hydrogen 2.993 N/A MET 148.A N ASP 144.A O no hydrogen 2.951 N/A THR 149.A N TYR 145.A O no hydrogen 3.006 N/A THR 149.A OG1 TYR 145.A O no hydrogen 2.869 N/A LYS 150.A N GLU 147.A O no hydrogen 3.451 N/A VAL 151.A N THR 146.A O no hydrogen 3.065 N/A SER 152.A N GLN 81.A O no hydrogen 2.916 N/A SER 152.A OG GLN 81.A O no hydrogen 3.177 N/A LEU 154.A N MET 182.A O no hydrogen 2.878 N/A THR 155.A N LEU 84.A O no hydrogen 2.911 N/A PHE 156.A N ALA 185.A O no hydrogen 3.078 N/A ALA 157.A N VAL 86.A O no hydrogen 2.776 N/A GLY 158.A N ILE 187.A O no hydrogen 2.958 N/A HIS 159.A N VAL 88.A O no hydrogen 2.973 N/A HIS 159.A NE2 HIS 278.A O no hydrogen 2.809 N/A GLY 161.A N HIS 159.A O no hydrogen 2.818 N/A HIS 163.A NE2 VAL 220.A O no hydrogen 2.771 N/A LEU 164.A N ALA 160.A O no hydrogen 2.919 N/A LEU 165.A N GLY 161.A O no hydrogen 2.936 N/A ALA 166.A N ALA 162.A O no hydrogen 3.218 N/A ALA 166.A N HIS 163.A O no hydrogen 3.229 N/A GLN 167.A N LEU 164.A O no hydrogen 3.330 N/A GLN 167.A NE2 MET 132.A O no hydrogen 2.923 N/A ILE 168.A N LEU 165.A O no hydrogen 2.920 N/A LEU 169.A N ALA 166.A O no hydrogen 3.236 N/A MET 170.A N GLN 167.A O no hydrogen 2.889 N/A ARG 171.A NH1 MET 170.A O no hydrogen 2.776 N/A VAL 174.A N ARG 171.A O no hydrogen 2.967 N/A ILE 175.A N ARG 171.A O no hydrogen 2.740 N/A ARG 179.A N THR 176.A OG1 no hydrogen 3.249 N/A ARG 179.A NE GLU 147.A OE2 no hydrogen 2.858 N/A ARG 179.A NH1 ASN 140.A OD1 no hydrogen 2.874 N/A ARG 179.A NH1 VAL 174.A O no hydrogen 2.905 N/A ARG 179.A NH2 GLU 147.A OE1 no hydrogen 2.997 N/A SER 180.A N THR 176.A O no hydrogen 2.875 N/A SER 180.A OG THR 176.A O no hydrogen 3.389 N/A LYS 181.A N ALA 177.A O no hydrogen 3.012 N/A LYS 181.A NZ SER 235.A OG no hydrogen 2.929 N/A MET 182.A N GLN 178.A O no hydrogen 3.295 N/A MET 182.A N ARG 179.A O no hydrogen 2.982 N/A VAL 183.A N SER 180.A O no hydrogen 2.965 N/A TRP 184.A N LEU 154.A O no hydrogen 2.713 N/A TRP 184.A NE1 ILE 299.A O no hydrogen 2.805 N/A LEU 186.A N LYS 237.A O no hydrogen 2.871 N/A ILE 187.A N PHE 156.A O no hydrogen 2.770 N/A PHE 188.A N TYR 239.A O no hydrogen 2.868 N/A LEU 189.A N GLY 158.A O no hydrogen 2.808 N/A CYS 190.A N VAL 241.A O no hydrogen 2.779 N/A TYR 193.A N GLN 253.A OE1 no hydrogen 2.895 N/A ASP 194.A N GLN 253.A OE1 no hydrogen 2.859 N/A LEU 195.A N SER 221.A OG no hydrogen 3.008 N/A ARG 196.A N ASP 194.A OD1 no hydrogen 3.136 N/A ARG 196.A NE ASP 194.A OD1 no hydrogen 2.919 N/A ARG 196.A NE ASP 194.A OD2 no hydrogen 3.362 N/A ARG 196.A NH2 ASP 194.A OD2 no hydrogen 2.795 N/A SER 199.A N LEU 195.A O no hydrogen 2.980 N/A SER 199.A OG ARG 196.A O no hydrogen 2.765 N/A ASN 200.A N GLU 197.A O no hydrogen 3.131 N/A LEU 201.A N LEU 198.A O no hydrogen 2.964 N/A SER 203.A OG ASP 13.A OD2 no hydrogen 2.684 N/A ASN 205.A N LEU 201.A O no hydrogen 2.777 N/A ASN 205.A ND2 SER 199.A O no hydrogen 2.919 N/A ASN 205.A ND2 ASN 208.A OD1 no hydrogen 2.929 N/A LYS 207.A N GLU 202.A OE1 no hydrogen 2.914 N/A LYS 207.A NZ GLU 202.A OE2 no hydrogen 2.719 N/A ASN 208.A N ASN 205.A O no hydrogen 2.955 N/A ASN 208.A ND2 LEU 212.A O no hydrogen 2.926 N/A ILE 209.A N PRO 206.A O no hydrogen 2.941 N/A LEU 210.A N ASN 205.A OD1 no hydrogen 2.862 N/A GLY 211.A N ASN 208.A O no hydrogen 2.835 N/A LEU 212.A N ASN 208.A OD1 no hydrogen 2.913 N/A ASN 216.A N ASN 213.A O no hydrogen 3.211 N/A ASN 216.A N ASN 213.A OD1 no hydrogen 3.068 N/A SER 219.A OG GLU 129.A OE2 no hydrogen 3.171 N/A SER 219.A OG ASN 216.A O no hydrogen 2.775 N/A VAL 220.A N ASN 216.A O no hydrogen 3.177 N/A SER 221.A N GLU 218.A O no hydrogen 2.918 N/A SER 221.A OG ILE 217.A O no hydrogen 2.787 N/A MET 223.A N TYR 193.A O no hydrogen 2.915 N/A LEU 224.A N SER 221.A O no hydrogen 2.829 N/A TRP 225.A N PRO 222.A O no hydrogen 3.363 N/A TRP 225.A NE1 GLU 218.A O no hydrogen 2.971 N/A TRP 225.A NE1 SER 219.A O no hydrogen 3.139 N/A TYR 227.A OH PRO 222.A O no hydrogen 2.699 N/A VAL 232.A N ASP 229.A O no hydrogen 3.293 N/A TRP 233.A N VAL 230.A O no hydrogen 3.001 N/A ASN 234.A N THR 231.A O no hydrogen 3.035 N/A ASN 234.A ND2 THR 231.A O no hydrogen 2.757 N/A THR 236.A N TRP 233.A O no hydrogen 2.875 N/A THR 236.A OG1 VAL 183.A O no hydrogen 2.825 N/A LYS 237.A N TRP 184.A O no hydrogen 3.075 N/A LYS 237.A NZ ILE 299.A O no hydrogen 2.890 N/A ILE 238.A N LYS 267.A O no hydrogen 2.889 N/A TYR 239.A N LEU 186.A O no hydrogen 2.834 N/A VAL 240.A N SER 269.A O no hydrogen 2.807 N/A VAL 241.A N PHE 188.A O no hydrogen 2.894 N/A ALA 242.A N THR 271.A O no hydrogen 2.977 N/A GLU 244.A N PHE 273.A O no hydrogen 3.084 N/A HIS 245.A N TYR 276.A O no hydrogen 2.837 N/A ASP 246.A N ALA 243.A O no hydrogen 3.197 N/A SER 247.A N ASP 246.A OD1 no hydrogen 2.775 N/A SER 247.A OG ASP 15.A O no hydrogen 2.690 N/A THR 249.A N ASP 15.A OD2 no hydrogen 3.112 N/A THR 249.A OG1 ASP 15.A OD2 no hydrogen 2.624 N/A PHE 250.A N SER 247.A OG no hydrogen 3.007 N/A ILE 251.A N SER 247.A O no hydrogen 2.883 N/A GLU 252.A N THR 248.A O no hydrogen 2.765 N/A GLN 253.A N THR 249.A O no hydrogen 2.830 N/A GLN 253.A NE2 ASP 194.A O no hydrogen 3.093 N/A SER 254.A N PHE 250.A O no hydrogen 3.153 N/A ARG 255.A N ILE 251.A O no hydrogen 2.888 N/A HIS 256.A N GLU 252.A O no hydrogen 2.799 N/A HIS 256.A ND1 GLU 252.A O no hydrogen 3.099 N/A TYR 257.A N GLN 253.A O no hydrogen 2.914 N/A TYR 257.A OH TYR 227.A OH no hydrogen 2.812 N/A ALA 258.A N SER 254.A O no hydrogen 2.920 N/A ASP 259.A N ARG 255.A O no hydrogen 2.916 N/A VAL 260.A N HIS 256.A O no hydrogen 2.900 N/A LEU 261.A N TYR 257.A O no hydrogen 3.013 N/A ARG 262.A N ALA 258.A O no hydrogen 2.917 N/A ARG 262.A NH1 ALA 268.A O no hydrogen 2.838 N/A LYS 263.A N ASP 259.A O no hydrogen 2.948 N/A LYS 264.A N VAL 260.A O no hydrogen 3.101 N/A LYS 264.A NZ GLU 226.A OE1 no hydrogen 3.045 N/A GLY 265.A N LEU 261.A O no hydrogen 3.136 N/A GLY 265.A N ARG 262.A O no hydrogen 2.916 N/A TYR 266.A N LEU 261.A O no hydrogen 3.054 N/A LYS 267.A NZ SER 235.A O no hydrogen 3.057 N/A SER 269.A N ILE 238.A O no hydrogen 2.931 N/A THR 271.A N VAL 240.A O no hydrogen 2.945 N/A PHE 273.A N ALA 242.A O no hydrogen 2.772 N/A GLY 275.A N GLU 244.A OE1 no hydrogen 2.792 N/A TYR 276.A N PHE 273.A O no hydrogen 3.429 N/A TYR 276.A OH GLU 284.A OE1 no hydrogen 2.631 N/A ASP 277.A N ASP 280.A OD1 no hydrogen 2.803 N/A HIS 278.A ND1 ASP 246.A OD2 no hydrogen 2.772 N/A PHE 279.A N ASP 277.A OD1 no hydrogen 2.833 N/A ASP 280.A N ASP 277.A OD1 no hydrogen 2.887 N/A ILE 281.A N ASP 277.A O no hydrogen 3.341 N/A ILE 282.A N PHE 279.A O no hydrogen 2.988 N/A GLU 283.A N PHE 279.A O no hydrogen 2.994 N/A GLU 284.A N ASP 280.A O no hydrogen 2.928 N/A THR 285.A N ILE 282.A O no hydrogen 2.915 N/A THR 285.A OG1 ILE 282.A O no hydrogen 2.683 N/A ALA 286.A N GLU 283.A O no hydrogen 3.282 N/A ILE 287.A N GLU 284.A O no hydrogen 3.079 N/A SER 290.A N ILE 287.A O no hydrogen 3.052 N/A SER 290.A OG GLU 284.A O no hydrogen 2.706 N/A SER 290.A OG ILE 287.A O no hydrogen 3.155 N/A SER 290.A OG SER 293.A OG no hydrogen 3.042 N/A VAL 292.A N TYR 276.A OH no hydrogen 2.956 N/A SER 293.A N SER 290.A OG no hydrogen 2.958 N/A SER 293.A OG GLU 284.A O no hydrogen 3.260 N/A SER 293.A OG THR 285.A O no hydrogen 3.297 N/A SER 293.A OG ILE 287.A O no hydrogen 2.820 N/A SER 293.A OG SER 290.A OG no hydrogen 3.042 N/A ARG 294.A N SER 290.A O no hydrogen 2.921 N/A PHE 295.A N ASP 291.A O no hydrogen 2.974 N/A LEU 296.A N VAL 292.A O no hydrogen 3.048 N/A ARG 297.A N SER 293.A O no hydrogen 2.921 N/A ARG 297.A NH1 ASN 298.A OD1 no hydrogen 2.561 N/A ASN 298.A N ARG 294.A O no hydrogen 2.848 N/A ILE 299.A N PHE 295.A O no hydrogen 3.264 N/A ILE 299.A N LEU 296.A O no hydrogen 3.194 N/A GLU 300.A N ARG 297.A O no hydrogen 2.927 N/A ILE 301.A N ASN 298.A O no hydrogen 3.297 N/A